期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 82, 期 8, 页码 1207-1212出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2013.02.011
关键词
Acoustic Radiation Force Impulse Imaging; Hepatitis C virus infection; Transient elastography
资金
- Siemens Healthcare AG (Munich)
Background: Acoustic Radiation Force Impulse Imaging (ARFI) is an innovative elastography for staging of liver fibrosis. We evaluated the diagnostic accuracy of different probes to perform ARFI at different insertion depths. Methods: In a prospective study, 89 chronic HCV infected patients underwent ARFI elastography using both available probes (c-ARFI: C4-1-MHz; l-ARFI: L9-4 MHz) in comparison to Fibroscan (R). Variability of ARFI elastography at different insertion depths was systematically evaluated in 39 patients (44%). According to Fibroscan (R) elastography, 32 patients (36%) presented with liver cirrhosis, 23 patients (26%) had significant fibrosis and 34 patients (38%) had no significant fibrosis. Results: Mean propagation velocity with c-ARFI was 1.70 +/- 0.67 m/s and 1.91 +/- 0.87 m/s with l-ARFI. Results of both probes were correlated to each other (p < 0.001; r = 0.70) and to Fibroscan (R) (p < 0.001, r = 0.82 and 0.84, respectively). In patients with significant fibrosis or with cirrhosis, mean values by l-ARFI were significantly higher than by c-ARFI (p < 0.001). For detection of liver cirrhosis, AUROC was 0.97 for c-ARFI (cut-off level 1.72 m/s) and 0.90 for l-ARFI (cut-off 2.04 m/s). Correlation coefficients of c-ARFI with Fibroscan (R) were highest at an insertion depth of 5-6 cm (r = 0.882 and 0.864, respectively, p < 0.001) and at 3-4 cm for l-ARFI (r = 0.850 and 0.838, respectively, p < 0.001). Conclusions: ARFI elastography with the linear and with the convex probes showed comparable validity and accuracy in the estimation of liver stiffness. The linear probe gave higher ARFI values. The most accurate insertion depth was 5-6 cm for c-ARFI and 3-4 cm for l-ARFI indicating that measurements should not be performed close to the liver capsule. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据