Article
Neurosciences
Jiayan Liu, Yahui Lei, Yuyao Diao, Yamei Lu, Xingbo Teng, Qingting Chen, Lian Liu, Jingxiang Zhong
Summary: This study investigates the morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats using voxel-based morphometry (VBM) method. The results show that compared to the normal controls, the FDM group exhibits significantly decreased GMVs in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex, and bilateral molecular layer of the cerebellum, while significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Psychiatry
Jinghan Dang, Qiuying Tao, Xiaoyu Niu, Mengzhe Zhang, Xinyu Gao, Zhengui Yang, Miaomiao Yu, Weijian Wang, Shaoqiang Han, Jingliang Cheng, Yong Zhang
Summary: The study found significant differences in brain structure and function between cocaine addiction patients and normal controls, and multi-domain assessments can capture different aspects of neuronal changes in addiction patients.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Chaofan Sui, Hongwei Wen, Jingchao Han, Tao Chen, Yian Gao, Yuanyuan Wang, Linfeng Yang, Lingfei Guo
Summary: This study investigated the effects of chronic hypertension with superimposed preeclampsia on the structure and function of the human brain. It found that CHTN-PE patients showed significantly decreased gray matter volume (GMV) in the right middle temporal gyrus compared to the non-pregnant and pregnant healthy controls. This GMV decrease may be related to the decline in cognitive function in CHTN-PE patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Shuai Zhao, Yi Xia, Yinghong Huang, Haowen Zou, Xumiao Wang, Zhilu Chen, Hongliang Zhou, Yinglin Han, Hao Tang, Rui Yan, Zhijian Yao, Qing Lu
Summary: In this study, MDD patients showed reduced gray matter volume in several brain regions, including significant positive associations between serum TSH levels and altered regional gray matter volume patterns within the frontal gyrus (MFG) and executive function. Importantly, the right MFG gray matter was discovered to mediate the relationship between serum TSH levels and executive function in MDD patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Neuroimaging
Jing-Ting Sun, Bo Hu, Tian-Qi Chen, Zhu-Hong Chen, Yu-Xuan Shang, Yu-Ting Li, Rui Wang, Wen Wang
Summary: The systematic review and meta-analysis of neuroimaging studies in IA showed that IA patients have abnormal brain structure and function, including smaller gray matter volume and increased connectivity with other brain regions. These abnormalities may be related to the core symptoms of IA, such as emotional regulation disorder, distraction, and impaired executive control.
BRAIN IMAGING AND BEHAVIOR
(2023)
Review
Clinical Neurology
Xinyue Zhang, Jun Zhou, Mengyuan Guo, Shirui Cheng, Yilin Chen, Nannan Jiang, Xinling Li, Shengjie Hu, Zilei Tian, Zhengjie Li, Fang Zeng
Summary: This study comprehensively summarizes and meta-analyzes voxel-based morphometric neuroimaging studies of migraine. The findings reveal gray matter alterations in multiple brain regions in migraine patients, which may be a consequence of repeated migraine attacks.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Meng-Yan Hu, Li-Juan Zhang, Min Kang, Yi-Cong Pan, Qian-min Ge, Qiu-yu Li, Lin Yang, Chong-Gang Pei, Yi Shao
Summary: This study aimed to investigate potential morphological changes in the brain of female climacteric patients with dry eye and explore their association with behavioral performances. Magnetic resonance imaging data revealed significant differences in voxel-based morphometry between patients with dry eye during the female climacteric period and healthy controls. Correlation analysis showed a negative correlation between certain brain regions and anxiety and depression scores. These findings suggest abnormal brain activity in patients with dry eye during the climacteric period and may contribute to advancing clinical treatments.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neuroimaging
Yang Yu, Hongru Zhao, Lingling Dai, Yunyan Su, Ximing Wang, Can Chen, Yalei Shang, Jun Ke, Chunhong Hu
Summary: Neuroimaging studies have shown abnormal brain microstructure in patients with episodic migraine, with differences in gray matter volume observed in various regions. Higher headache frequency is associated with increased gray matter volume in certain brain regions but decreased volume in others.
BRAIN IMAGING AND BEHAVIOR
(2021)
Review
Psychiatry
Xiaoyu Niu, Xinyu Gao, Mengzhe Zhang, Zhengui Yang, Miaomiao Yu, Weijian Wang, Yarui Wei, Jingliang Cheng, Shaoqiang Han, Yong Zhang
Summary: This meta-analysis provides evidence for structural and functional impairments in brain regions associated with executive control, cognitive function, and reward-based decision making in internet gaming disorder (IGD). The study also highlights the relationship between gray matter volume reductions in the left anterior cingulate and addiction-related clinical features. These findings contribute to the understanding of neuronal changes in IGD and may help guide the development of effective interventions.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Clinical Neurology
Xiang Huang, Junyu Lin, Huifang Shang, Jing Yang
Summary: In this study, a meta-analysis was conducted to investigate gray matter changes in patients with idiopathic dystonia. The results showed consistent widespread gray matter abnormalities in various brain regions. These abnormalities were shared among different subtypes of idiopathic dystonia and were not limited to the corticostriatal circuits.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Sally C. Chester, Tatsuyoshi Ogawa, Maki Terao, Ryusuke Nakai, Nobuhito Abe, Stephane A. De Brito
Summary: This study investigated the neuroanatomical correlates of psychopathic traits in a Japanese sample using structural magnetic resonance imaging data. The results showed associations between psychopathic traits and gray matter volume as well as gyrification in specific brain regions. The associations varied based on sex and different levels of psychopathy factors.
Article
Neurosciences
Feifei Zhang, Song Wang, Yang Feng, Kun Qin, Huiru Li, Baolin Wu, Zhiyun Jia, Qiyong Gong
Summary: The study highlights the potential risk of exercise dependence (EXD) due to excessive exercise and the role of stress in its onset and development. The findings suggest that gray matter volume (GMV) in specific brain regions may mediate the relationship between stress and EXD, even after controlling for various factors such as sex, age, and psychological conditions.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Nanfang Pan, Song Wang, Yajun Zhao, Han Lai, Kun Qin, Jingguang Li, Bharat B. Biswal, John A. Sweeney, Qiyong Gong
Summary: The study provides an integrated delineation of gray matter substrates related to trait impulsivity, highlighting volumetric GM alterations in prefrontal, temporal, and parietal cortices. Furthermore, the modulatory effects of age and gender in impulsivity-GM volume associations were identified, advancing understanding of brain GM morphometry features underlying trait impulsivity with potential implications for clinical diagnosis and intervention.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Patrick Bach, Ulrich Frischknecht, Iris Reinhard, Nina Bekier, Traute Demirakca, Gabriele Ende, Sabine Vollstaedt-Klein, Falk Kiefer, Derik Hermann
Summary: The study found differences in working memory performance and gray matter volume in patients on opioid maintenance treatment, which were associated with the duration of heroin use. This suggests that early treatment or abstinence-oriented therapies may help reduce cognitive impairments in opioid-dependent individuals.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Neuroimaging
Fuchun Lin, Xu Han, Yao Wang, Weina Ding, Yawen Sun, Yan Zhou, Hao Lei
Summary: Recent studies have shown sex-specific differences in the etiology, course, and brain dysfunction associated with cigarette smoking, but little is known about sex-specific differences in subcortical structure and function. This study found that male smokers had a smaller volume in the left caudate, while female smokers showed a smaller volume in the right amygdala. Additionally, resting-state FC analysis revealed increased rsFC between the left caudate and left prefrontal cortex in male smokers, as well as decreased rsFC within the bilateral caudate and between the right amygdala and right orbitofrontal cortex (OFC). These findings underscore the potential for sex-specific relapse prevention therapies based on subcortical structure and function.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lifeng Gao, Mingming Huang, Xiaowen Luo, Tao Song, Xuxia Wang, Zhe Wang, Wei Zhang, Jiangyuan Chen, Hao Lei
MAGNETIC RESONANCE IMAGING
(2020)
Article
Neurosciences
Ronghui Li, Xuxia Wang, Fuchun Lin, Tao Song, Xutao Zhu, Hao Lei
Article
Clinical Neurology
Tao Song, Wei Chen, Xi Chen, Hui Zhang, Yijuan Zou, Hao Wu, Fuchun Lin, Liyi Ren, Yan Kang, Hao Lei
Summary: The study in adult rats demonstrates that repeated administration of fluoxetine induces both short-term and long-term astrocytic plasticity in the medial prefrontal cortex. Fluoxetine treatment leads to transient reductions in astrocytic metabolites and markers initially, but these levels recover to baseline after treatment cessation.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Xiaoqian Zhang, Wei Chen, Yi Wu, Weiqi Zeng, Yuhao Yuan, Chi Cheng, Xiaoman Yang, Jialing Wang, Xiaomei Yang, Yu Xu, Hao Lei, Xuebing Cao, Yan Xu
Summary: Long-term levodopa therapy in Parkinson's disease patients often leads to L-DOPA-induced dyskinesia (LID), a type of motor complications. This study investigated structural changes in a rat model of LID through MRI and histological analysis, revealing volume reductions in cortical and subcortical areas along with astrocyte activation and synaptic protein enrichment in the striatum. The findings underscore the potential of structural MRI, particularly VBM analysis, in understanding the morphological phenotype of LID rodent models.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Tiantian Fang, Wei Chen, Yiyu Cheng, Yanyan Zhang, Qun Luo, Kui Wu, Fuyi Wang, Hao Lei, Yao Zhao
Summary: Manganese-enhanced MRI (MEMRI) is a powerful tool for studying neuronal activity and microarchitecture. However, the effect of exogenous manganese on the brain of Parkinson's disease model mice is not well understood. This study used laser ablation connected to inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging to assess the distribution of manganese and other endogenous metal ions in the brain regions of DJ-1 knockout PD model mice. The results showed that manganese mainly deposited in subcortical regions and the enhanced signal-to-noise ratio (S/N) determined by MEMRI was closely related to the signal in LA-ICP-MS imaging. Additionally, the treatment of MnCl2 disrupted the homeostasis of iron, zinc, copper, and calcium in the DJ-1 mouse.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Psychiatry
Zhi Wen, Xu Han, Yao Wang, Weina Ding, Yawen Sun, Yan Kang, Yan Zhou, Hao Lei, Fuchun Lin
Summary: Biological sex plays a significant role in cigarette use and cessation outcomes, as well as the brain structure and function of smokers. This study found sex-specific alterations in spontaneous brain activity among smokers and non-smokers, suggesting the potential influence of sex on nicotine addiction and the effectiveness of quitting smoking.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Wei Chen, Huihui Liu, Sijie Liu, Yan Kang, Zongxiu Nie, Hao Lei
Summary: In this study, researchers used in vivo proton magnetic resonance spectroscopy (H-1-MRS) and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to investigate the neurochemical perturbations in the medial prefrontal cortex (mPFC) of DJ-1 knockout mice, a transgenic model for Parkinson's disease. The results showed increased levels of glutathione (GSH) and GSH/glutamate (Glu) ratio in the mPFC of DJ-1 knockout mice compared to wild-type mice, suggesting an astrocytic compensatory mechanism in response to oxidative stress caused by loss of DJ-1 function. The study also emphasized the caution needed in interpreting in vivo H-1-MRS results from aged transgenic animals and the importance of complementary analyses using more than one method.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Neuroimaging
Xianxin Qiu, Xu Han, Yao Wang, Weina Ding, Yawen Sun, Hao Lei, Yan Zhou, Fuchun Lin
Summary: This study investigated the interaction between smoking and internet gaming disorder (IGD) and its effects on brain functional network organization. The findings showed that the interaction between smoking and IGD led to significant changes in the functional network characteristics in specific brain regions. This provides valuable insights into the neurophysiological mechanisms of smoking and IGD, and suggests a potential target for future clinical treatment.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neurosciences
Shengjuan Wu, Zhi Wen, Wenzhong Yang, Chengcheng Jiang, Yurong Zhou, Zhiwei Zhao, Aiqin Zhou, Xinglian Liu, Xiaoyan Wang, Yue Wang, Hong Wang, Fuchun Lin
Summary: This study aimed to investigate the differences in dynamic brain activity between children with autism spectrum disorder (ASD) and language development delay (LDD), and whether these differences can be used as imaging biomarkers for the early differential diagnosis of ASD and LDD. The findings showed that the pattern of brain activity was different between children with ASD and those with LDD, suggesting that dynamic regional indices might be novel neuroimaging biomarkers to distinguish ASD from LDD in toddlers.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Yajuan Wang, Yingshuang Wang, Lihong Bu, Shaoyang Wang, Xinhui Xie, Fuchun Lin, Zheman Xiao
Summary: This study examines the differences in resting-state functional connectivity (rsFC) between migraine and tension-type headache patients, focusing on brain regions associated with cognition and emotion. The results demonstrate that rsFC alterations in the amygdala and hippocampus with the occipital lobe can be effective in distinguishing patients with migraine from patients with tension-type headaches.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hila Tal Tamir, Dana Stav, Yitzhac Hadad, Rivka Kessner
Summary: This study aimed to characterize thyroid nodules seen on Spectral Detector computed tomography (SDCT) and compare them with their Thyroid Imaging Reporting and Data System (TI-RADS) category on Ultrasound (US). The results showed that the spectral results of SDCT can assist in differentiating thyroid nodules of different risk levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Volha Nizhnikava, Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Horst Olschewski, Michael Fuchsjaeger, Gert Reiter
Summary: The purpose of this study was to investigate the associations between cardiac magnetic resonance feature-tracking-derived myocardial strain parameters and volumetric function and hemodynamic parameters in patients with pulmonary hypertension. The results showed that impairment of myocardial strains was more strongly associated with alterations in ventricular function parameters than elevated pulmonary arterial pressure, limiting the diagnostic information of myocardial strain parameters in pulmonary hypertension.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ling Qian, Rui-lin Quan, Xiao-xi Chen, Yang-yi Lin, Xiao-li Jing, Qing Gu, Chang-ming Xiong, Jian-guo He, Ai-hua Zhi
Summary: The purpose of this study was to investigate the imaging characteristics and prognostic factors for the long-term survival of Behcet's disease (BD) with arterial involvement. The results showed that arterial lesions associated with BD usually involve multiple arteries and manifest differently in different types of arteries. Cardiac involvement and pulmonary artery aneurysm/dilation were independent prognostic factors for the survival of BD patients with arterial involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Yong Xie, Jian Wang, Yinghua Zou
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daria Kifjak, Maximilian Hochmair, Daniel Sobotka, Alexander R. Haug, Raphael Ambros, Florian Prayer, Benedikt H. Heidinger, Sebastian Roehrich, Ruxandra-Iulia Milos, Wolfgang Wadsak, Thorsten Fuereder, Dagmar Krenbek, Andreas Fazekas, Michael Meilinger, Marius E. Mayerhoefer, Georg Langs, Christian Herold, Helmut Prosch, Lucian Beer
Summary: The ability of pretreatment PET parameters and peripheral blood biomarkers to predict PFS and OS in NSCLC patients treated with ICIT was assessed. The study found that MTV and the number of SOI were independent risk factors for progression and overall survival, and the combination of these factors improved risk stratification.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Theresa Sophie Patzer, Jan-Peter Grunz, Henner Huflage, Jan-Lucca Hennes, Pauline Pannenbecker, Philipp Gruschwitz, Saif Afat, Judith Herrmann, Thorsten Alexander Bley, Andreas Steven Kunz
Summary: This study investigated the potential of tin prefiltration and virtual monoenergetic imaging (VMI) in suppressing metal artifacts in high-resolution CT images of the lower extremities. The results showed that VMI reconstructions had better artifact reduction compared to T3D. VMI110keV had the least image noise. In terms of image quality, interpretability of bone-metal interface, and overall image quality, VMI110keV performed the best.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Li, Huan Zhang, Lei Yue, Caixia Fu, Robert Grimm, Wenhua Li, Weijian Guo, Tong Tong
Summary: This study evaluated and compared the diagnostic value of diffusion-related texture analysis parameters from different magnetic resonance diffusion models in predicting the clinical response to chemotherapy in patients with colorectal liver metastases. Among the models, DKI-derived parameters showed the best performance for early prediction, followed by IVIM-derived parameters and DWI baseline features.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Wang, ShiXiong Zhang, Jun Xin
Summary: This study aimed to determine if sex differences in abdominal visceral fat composition and metabolism can help predict the prognosis of DLBCL patients. The results showed that females with certain fat composition and metabolism characteristics had worse progression-free survival, while no significant differences were found in males with DLBCL.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ping Wu, Lan Wu, Jing Ou, Jin-ming Cao, Mao-yong Fu, Tian-wu Chen, Erika Ouchi, Jiani Hu
Summary: This study aimed to develop CT radiomics models to preoperatively identify lymph node (LN) status in resectable esophageal squamous cell carcinoma (ESCC) patients. The results showed that the combined model, integrating ESCC and LN radiomics features with clinical features, had the highest predictive ability among the three models. The combined model's predictive ability was validated in both the test and external validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
