期刊
EUROPEAN JOURNAL OF RADIOLOGY
卷 80, 期 2, 页码 598-606出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2011.01.051
关键词
Magnetic resonance imaging; Liposomes; Integrins; Lipopeptide; Gadolinium DTPA; Nanoparticles
资金
- National High Technology and Development Program of the People's Republic of China [2008AA02Z442]
Magnetic resonance molecular imaging has emerged as a potential approach for tumor diagnosis in the last few decades. This approach consists of the delivery of MR contrast agents to the tumor by specific targeted carriers. For this purpose, a lipopeptide was constructed by using a cyclic RGD peptide headgroup coupled to palmitic acid anchors via a KGG tripeptide spacer. Targeted paramagnetic liposomes were then prepared by the incorporation of RGD-coupled-lipopeptides into lipid bilayers for specific bounding to tumor. In vitro, study demonstrated that RGD-targeted liposomes exhibited a better binding affinity to targeted cells than non-targeted liposomes. MR imaging of mice bearing A549 tumors with the RGD-targeted paramagnetic liposomes also resulted in a greater signal enhancement of tumor compared to non-targeted liposomes and pure contrast agents groups. In addition, biodistribution study also showed specific tumor targeting of RGD-targeted paramagnetic liposomes in vivo. Therefore, RGD-targeted paramagnetic liposomes prepared in the present study may be a more promising method for early tumor diagnosis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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