Article
Biochemistry & Molecular Biology
Malgorzata Grzanka, Anna Stachurska-Skrodzka, Anna Adamiok-Ostrowska, Ewa Gajda, Barbara Czarnocka
Summary: Thyroid cancer-derived extracellular vesicles (EVs) can impact gene expression in normal thyroid cells, inhibit tube formation in endothelial cells, and have a correlation with angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jihun Song, Gun-Jae Jeong, Tae-Jin Lee, Sung-Won Kim, Yu-Jin Kim, Suk Ho Bhang
Summary: A new method of delivering ECMs-enriched human adipose derived stem cells using a novel polymer significantly improved therapeutic angiogenesis in ischemic wound sites, enhancing blood flow and blood vessel regeneration in mouse models compared to traditional enzyme-based methods.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yaru Guo, Siqin Ma, Mingming Xu, Yan Wei, Xuehui Zhang, Ying Huang, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: Angiogenesis is crucial in tissue engineering and regenerative medicine, and the interplay between ECs and the ECM plays a significant role in tip cell specification. HtrA3 protein is shown to be involved in this process, promoting tip cell morphogenesis through ECM degradation and integrin beta 1-related signaling pathways. This study suggests that HtrA3 could potentially serve as a therapeutic agent for enhancing angiogenesis and targeting pathological angiogenesis.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Mariela Puebla, Pablo J. Tapia, Hilda Espinoza
Summary: This review focuses on the role of astrocytes in angiogenesis, highlighting their function as scaffolds and stabilizing factors, as well as the phenotypic differences in glioblastoma. Understanding the interaction between endothelial cells and astrocytes is crucial for comprehending the process of angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yaru Guo, Feng Mei, Ying Huang, Siqin Ma, Yan Wei, Xuehui Zhang, Mingming Xu, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: This study demonstrates that matrix stiffness promotes sprouting of endothelial cells and regulates the formation of tip cells through a specific signaling axis. The findings have significant implications for biomaterial design and treatment of pathological conditions.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yunhui Xing, Saigopalakrishna S. Yerneni, Weitao Wang, Rebecca E. Taylor, Phil G. Campbell, Xi Ren
Summary: This article describes a strategy for long-term in vivo retention of chemoselectively immobilized metabolically incorporated azido ligand-bearing extracellular vesicles (EVs) through click chemistry. The immobilized EVs exhibited enhanced therapeutic effects compared to non-immobilized EVs, promoting host cell infiltration, angiogenesis, and immunoregulatory responses.
Article
Gastroenterology & Hepatology
Guido Carpino, Vincenzo Cardinale, Alessandra Di Giamberardino, Diletta Overi, Samantha Donsante, Tania Colasanti, Gaia Amato, Gianluca Mennini, Matteo Franchitto, Fabrizio Conti, Massimo Rossi, Mara Riminucci, Eugenio Gaudio, Domenico Alvaro, Carmine Mancone
Summary: The study identified THBS1, THBS2, and PEDF released in iCCA inhibit vessel growth and promote tumor-associated lymphangiogenesis, offering potential targets for interventions to counteract the dissemination process in iCCA.
JOURNAL OF HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yucai Wang, Guangfu Wang, Hao Liu
Summary: This study provides a comprehensive review of the dynamic changes and functions of Tenascin-C (TNC) during tissue regeneration. The review highlights the multiple mechanisms of TNC at different stages of restoration, with a specific emphasis on its role in angiogenesis and wound healing.
Review
Medicine, Research & Experimental
Ping Xiao, Yanli Zhang, Yuting Zeng, Dehong Yang, Jiayao Mo, Ziting Zheng, Jilei Wang, Yuxin Zhang, Zhiyan Zhou, Xincen Zhong, Wenjuan Yan
Summary: Ageing-related changes in the extracellular matrix (ECM) driven by cellular senescence lead to reduced angiogenesis, decreased microvascular density, and increased risk of tissue ischaemic injury. Understanding the interactions between the ECM and cells during angiogenesis in the context of ageing is necessary to clarify the mechanisms underlying reduced angiogenesis in older adults.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Shingo Saio, Kanna Konishi, Hirofumi Hohjoh, Yuki Tamura, Teruaki Masutani, Arunasiri Iddamalgoda, Masamitsu Ichihashi, Hiroshi Hasegawa, Ken-ichi Mizutani
Summary: Endothelial cells acquire different phenotypes to establish functional vascular networks, with Vascular Endothelial Growth Factor (VEGF) playing a key role in regulating vascular development. The spatiotemporal localization of angiogenic factors and the extracellular matrix are crucial for proper regulation of angiogenesis. Close interactions between the vascular and neural systems involve shared molecular mechanisms to coordinate developmental and regenerative processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Daniela Vega-Mendoza, Alicia Canas-Linares, Angel Flores-Alcantar, Roberto Espinosa-Neira, Erika Melchy-Perez, Rosario Vera-Estrella, Constance Auvynet, Yvonne Rosenstein
Summary: The aberrant expression of CD43 in nonhematopoietic malignant tumors has been shown to correlate with poor prognosis, promoting tumor development by enhancing motility, growth, and protection against cell lysis. In lung cancer, CD43 plays a significant role in remodeling the tumor microenvironment through the secretion of specific molecules.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Developmental Biology
Gopalan Gnanaguru, Steven J. Tabor, Gracia M. Bonilla, Ruslan Sadreyev, Kentaro Yuda, Jorg Kohl, Kip M. Connor
Summary: Microglia play a crucial role in neurovascular development, specifically in regulating the spatial patterning of astrocytes and promoting the formation of superficial blood vessels in the neuroretina. This study demonstrates that microglia achieve this through the complement C3/C3aR axis, which regulates the formation of the spatially organized astrocyte template necessary for subsequent vascular growth. Lack of C3 or C3aR leads to increased astrocyte density and elevated vascular density due to abnormal extracellular matrix gene expression.
Article
Engineering, Biomedical
Lei Chen, Zhiyong Li, Yongtai Zheng, Fei Zhou, Jingling Zhao, Qiyi Zhai, Zhaoqiang Zhang, Tianrun Liu, Yongming Chen, Shaohai Qi
Summary: This study integrates porcine dermal extracellular matrix (dECM) into 3D-printed dermal analogues (PDA) to prevent scar contraction. The PDA with a micron-scale spatial structure exhibits excellent biocompatibility and is able to reduce scar contraction and improve cosmetic outcomes of split thickness skin grafts (STSG). It induces early neovascularization and a type-2-like immune response, suggesting its potential for clinical application in reducing scar contraction.
BIOACTIVE MATERIALS
(2022)
Review
Immunology
Seung-Jin Kim, Dipendra Khadka, Jae Ho Seo
Summary: This article discusses the process of tumors adapting to adverse environments through communication with neighboring cells. Understanding the physiology of these tumors and their interaction with the tumor environment can help in developing promising tumor treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Heejeong Yoon, Jeong Kon Seo, Tae-Eun Park
Summary: A new in vitro tool called adipose tissue microphysiological system (MPS) has been developed to mimic the pathophysiology of adipose tissue in obesity, providing valuable insights into the development of obesity-related disorders.
ACTA BIOMATERIALIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hila Tal Tamir, Dana Stav, Yitzhac Hadad, Rivka Kessner
Summary: This study aimed to characterize thyroid nodules seen on Spectral Detector computed tomography (SDCT) and compare them with their Thyroid Imaging Reporting and Data System (TI-RADS) category on Ultrasound (US). The results showed that the spectral results of SDCT can assist in differentiating thyroid nodules of different risk levels.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Volha Nizhnikava, Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Horst Olschewski, Michael Fuchsjaeger, Gert Reiter
Summary: The purpose of this study was to investigate the associations between cardiac magnetic resonance feature-tracking-derived myocardial strain parameters and volumetric function and hemodynamic parameters in patients with pulmonary hypertension. The results showed that impairment of myocardial strains was more strongly associated with alterations in ventricular function parameters than elevated pulmonary arterial pressure, limiting the diagnostic information of myocardial strain parameters in pulmonary hypertension.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ling Qian, Rui-lin Quan, Xiao-xi Chen, Yang-yi Lin, Xiao-li Jing, Qing Gu, Chang-ming Xiong, Jian-guo He, Ai-hua Zhi
Summary: The purpose of this study was to investigate the imaging characteristics and prognostic factors for the long-term survival of Behcet's disease (BD) with arterial involvement. The results showed that arterial lesions associated with BD usually involve multiple arteries and manifest differently in different types of arteries. Cardiac involvement and pulmonary artery aneurysm/dilation were independent prognostic factors for the survival of BD patients with arterial involvement.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Yong Xie, Jian Wang, Yinghua Zou
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daria Kifjak, Maximilian Hochmair, Daniel Sobotka, Alexander R. Haug, Raphael Ambros, Florian Prayer, Benedikt H. Heidinger, Sebastian Roehrich, Ruxandra-Iulia Milos, Wolfgang Wadsak, Thorsten Fuereder, Dagmar Krenbek, Andreas Fazekas, Michael Meilinger, Marius E. Mayerhoefer, Georg Langs, Christian Herold, Helmut Prosch, Lucian Beer
Summary: The ability of pretreatment PET parameters and peripheral blood biomarkers to predict PFS and OS in NSCLC patients treated with ICIT was assessed. The study found that MTV and the number of SOI were independent risk factors for progression and overall survival, and the combination of these factors improved risk stratification.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Theresa Sophie Patzer, Jan-Peter Grunz, Henner Huflage, Jan-Lucca Hennes, Pauline Pannenbecker, Philipp Gruschwitz, Saif Afat, Judith Herrmann, Thorsten Alexander Bley, Andreas Steven Kunz
Summary: This study investigated the potential of tin prefiltration and virtual monoenergetic imaging (VMI) in suppressing metal artifacts in high-resolution CT images of the lower extremities. The results showed that VMI reconstructions had better artifact reduction compared to T3D. VMI110keV had the least image noise. In terms of image quality, interpretability of bone-metal interface, and overall image quality, VMI110keV performed the best.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Li, Huan Zhang, Lei Yue, Caixia Fu, Robert Grimm, Wenhua Li, Weijian Guo, Tong Tong
Summary: This study evaluated and compared the diagnostic value of diffusion-related texture analysis parameters from different magnetic resonance diffusion models in predicting the clinical response to chemotherapy in patients with colorectal liver metastases. Among the models, DKI-derived parameters showed the best performance for early prediction, followed by IVIM-derived parameters and DWI baseline features.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Wang, ShiXiong Zhang, Jun Xin
Summary: This study aimed to determine if sex differences in abdominal visceral fat composition and metabolism can help predict the prognosis of DLBCL patients. The results showed that females with certain fat composition and metabolism characteristics had worse progression-free survival, while no significant differences were found in males with DLBCL.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-ping Wu, Lan Wu, Jing Ou, Jin-ming Cao, Mao-yong Fu, Tian-wu Chen, Erika Ouchi, Jiani Hu
Summary: This study aimed to develop CT radiomics models to preoperatively identify lymph node (LN) status in resectable esophageal squamous cell carcinoma (ESCC) patients. The results showed that the combined model, integrating ESCC and LN radiomics features with clinical features, had the highest predictive ability among the three models. The combined model's predictive ability was validated in both the test and external validation cohorts.
EUROPEAN JOURNAL OF RADIOLOGY
(2024)