期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 43, 页码 13736-13739出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b06690
关键词
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资金
- 973 Program [2012CB720600, 2012CB720603, 2012CB720604, 2015CB910603]
- National Science Foundation of China [21432008, 91413109, 91213302, 21372237, 91313303]
The FTO protein is unequivocally reported to play a critical role in human obesity and in the regulation of cellular levels of m(6)A modification, which makes FTO a significant and worthy subject of study. Here, we identified that fluorescein derivatives can selectively inhibit FTO demethylation, and the mechanisms behind these activities were elucidated after we determined the X-ray crystal structures of FTO/fluorescein and FTO/5-aminofluorescein. Furthermore, these inhibitors can also be applied to the direct labeling and enrichment of FTO protein combined with photoaffinity labeling assay.
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