Article
Endocrinology & Metabolism
Yanmei Wang, Zhijuan Ge, Lei Chen, Jun Hu, Wenting Zhou, Shanmei Shen, Dalong Zhu, Yan Bi
Summary: The study developed a risk scoring system to predict gestational diabetes mellitus (GDM) in early pregnancy, showing sensitivity and reliability in identifying high-risk women. The risk score, incorporating clinical features and biochemical measures, demonstrated good discrimination and calibration in both training and validation cohorts, performing better in the external validation group.
Article
Health Care Sciences & Services
Marija Majda Perisic, Klemo Vladimir, Sarah Karpov, Mario Storga, Ali Mostashari, Raya Khanin
Summary: A polygenic risk score for GDM was developed to investigate its genetic architecture and its relation to genetically constructed risk factors and biomarkers. The polygenic risk score can be used as an early screening tool to identify women at higher risk of GDM for comprehensive monitoring and preventative programs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ionut Bebu, Sareh Keshavarzi, Xiaoyu Gao, Barbara H. Braffett, Angelo J. Canty, William H. Herman, Trevor J. Orchard, Samuel Dagogo-Jack, David M. Nathan, John M. Lachin, Andrew D. Paterson
Summary: Genetic factors, including CAD PRS and individual single nucleotide polymorphisms, are strongly associated with the risk of subsequent cardiovascular disease in individuals with type 1 diabetes, beyond established risk factors like age, lipids, blood pressure, and glycemia.
Article
Computer Science, Artificial Intelligence
Hui Yang, Yamei Luo, Xiaolei Ren, Ming Wu, Xiaolin He, Bowen Peng, Kejun Deng, Dan Yan, Hua Tang, Hao Lin
Summary: The study designed a computational system to predict diabetes risk by combining various types of physical examination data. Statistical analysis was conducted on different physical examination indexes to develop a model that can distinguish diabetes patients from healthy individuals. A diabetes risk scorecard was established to improve the convenience and flexibility of the model. Lastly, an online diabetes risk assessment system was set up to enhance diabetes cascade screening and personal lifestyle management.
INFORMATION FUSION
(2021)
Article
Biochemistry & Molecular Biology
Ximei Huang, Youngmin Han, Kyunghye Jang, Minjoo Kim
Summary: In this study, a prediction model combining a genetic risk score and an oxidative stress score was found to have significant predictive ability for the incidence of prediabetes and type 2 diabetes in the Korean population. The genetic risk score and oxidative stress score showed significant associations with prediabetes and type 2 diabetes incidence.
Review
Nutrition & Dietetics
Tiina Jaaskelainen, Miira M. Klemetti
Summary: Gestational diabetes (GDM) is a global health challenge with significant impacts on maternal and fetal cardiovascular health. Recent studies have shown significant phenotypic and genotypic heterogeneity in GDM, and adverse obstetric and perinatal outcomes differ between GDM subtypes. However, current GDM treatment protocols do not differentiate between these subtypes, highlighting the need for research on the genetic architecture of GDM and accurate phenotypic and genotypic definitions to personalize treatment and assess long-term prognosis.
Article
Endocrinology & Metabolism
Katarzyna Dziopa, Folkert W. Asselbergs, Jasmine Gratton, Nishi Chaturvedi, Amand F. Schmidt
Summary: This study aimed to compare the performance of risk prediction scores for cardiovascular disease (CVD) in individuals with type 2 diabetes. The Systemic Coronary Risk Evaluation (SCORE) CVD rule derived in the general population performed best for both CVD and a broader definition of CVD. Simple recalibration considerably improved the performance of the scores.
Article
Endocrinology & Metabolism
Li-Na Liao, Tsai-Chung Li, Chih-Ching Yeh, Chia-Ing Li, Chiu-Shong Liu, Chuan-Wei Yang, Ya-Fei Yang, Chih-Hsueh Lin, Fuu-Jen Tsai, Cheng-Chieh Lin
Summary: This study developed and validated a risk prediction model for diabetic nephropathy (DN) in the Han Chinese population by integrating clinical factors and genetic SNPs from multiple CKD-related pathways. This model can be used as a screening tool for early intervention and prevention in clinical risk management practice.
ACTA DIABETOLOGICA
(2023)
Article
Genetics & Heredity
Paraskevi P. Chairta, Andreas Hadjisavvas, Andrea N. Georgiou, Maria A. Loizidou, Kristia Yiangou, Christiana A. Demetriou, Yiolanda P. Christou, Marios Pantziaris, Kyriaki Michailidou, Eleni Zamba-Papanicolaou
Summary: The study revealed an association between genetic and environmental factors with Parkinson's disease. The combination of a 12-SNPs PRS and seven other independent lifestyle/environmental factors was identified as the most predictive model for Parkinson's disease in the population studied.
Article
Green & Sustainable Science & Technology
Bosiljka Srebro, Bojan Mavrenski, Vesna Bogojevic Arsic, Snezana Knezevic, Marko Milasinovic, Jovan Travica
Summary: This paper applies various Z-score models to predict company bankruptcies and financial troubles, finding that certain agricultural companies were at risk of bankruptcy, and some may have engaged in fraudulent financial reporting. Additionally, it was discovered that fewer than half of the observed companies included information on environmental protection in their annual reports.
Review
Endocrinology & Metabolism
Yumeng Tian, Ping Li
Summary: This article reviews the research progress in the use of genetic risk score (GRS) in diabetes mellitus in recent years and discusses future prospects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Bernice Man, Alan Schwartz, Oksana Pugach, Yinglin Xia, Ben Gerber
Summary: A clinical prediction model was developed for personalized treatment decisions for prediabetes in women with a history of gestational diabetes mellitus. The study found that higher levels of fasting glucose and hemoglobin A1C were associated with an increased risk of developing diabetes, and metformin was more effective for individuals with higher BMI.
Article
Medicine, General & Internal
Jana Vorbeck, Manuel Bachmann, Helena Duesing, Rene Hartensuer
Summary: The aim of this study was to analyze the mortality of polytrauma patients and identify prediction parameters. A score for the prehospital predictive evaluation of 30-day survival was created based on the results. Significant influencing factors on the survival of polytrauma patients were identified, and a score combining these factors with the shock index showed high specificity and sensitivity in predicting mortality risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Tianyuan Lu, Patricia Pelufo Silveira, Celia M. T. Greenwood
Summary: This study found that both genetic and early life risk factors are important in the development and progression of adult depression. By analyzing genome-wide association studies, a polygenic risk score for depression was developed, which was moderately associated with early life risk factors. However, the polygenic risk score had a stronger association with depression phenotypes compared to most early life risk factors.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Cheng-Chieh Lin, May Jingchee Niu, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Summary: This study aimed to develop a risk prediction model for chronic kidney disease (CKD) in patients with type 2 diabetes in Taiwan. The model identified age, duration of diabetes, insulin use, estimated glomerular filtration rate, and albumin-to-creatinine ratio as significant risk factors for CKD. The model showed good accuracy in predicting CKD risk for 1 year, 3 years, and 5 years.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Sima Nazarpour, Fahimeh Ramezani Tehrani, Maryam Rahmati, Mina Amiri, Fereidoun Azizi
Summary: The study found that women with maternal hypothyroidism identified in early pregnancy are more likely to have adverse pregnancy outcomes, including preterm premature rupture of membranes (PPROM) and low birth weight (LBW), compared to women with euthyroid status. Additionally, neonatal head circumference and weight were lower in the hypothyroid group than in the euthyroid group.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Endocrinology & Metabolism
Mahdi Akbarzadeh, Parisa Riahi, Azra Ramezankhani, Saeid Rasekhi Dehkordi, Mahmoud Amiri Roudbar, Maryam Zarkesh, Kamran Guity, Davood Khalili, Asiyeh Sadat Zahedi, Fereidoun Azizi, Maryam S. Daneshpour
Summary: This study evaluated the familial aggregation, heritability, and inheritance mode of type 2 diabetes (T2D) in the Iranian population. The findings showed that T2D has a higher heritability with a polygenic mode in the Iranian population compared to the global average. It was also found that T2D is equally transmitted into siblings, with parental affect being the leading risk factor.
CANADIAN JOURNAL OF DIABETES
(2022)
Article
Psychology, Developmental
Sara Jalali-Farahani, Parisa Amiri, Fariba Zarani, Fereidoun Azizi
Summary: This study used qualitative methods to explore the perceptions of Iranian adolescents regarding their bodies, focusing on the psychological aspects that contribute to their body image perceptions. The findings revealed various beliefs, body evaluations, emotions, and behaviors among the participants.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Peripheral Vascular Disease
Seyed Saeed Tamehri Zadeh, Seyyed Saeed Moazzeni, Kunihiro Matsushita, Mitra Hasheminia, Fereidoun Azizi, Farzad Hadaegh
Summary: This study evaluated the association between hypertension and cardiovascular disease in the adult population of Tehran. The findings suggest that age is an important factor in determining the relationship between hypertension and cardiovascular disease risk.
JOURNAL OF HYPERTENSION
(2022)
Article
Nutrition & Dietetics
Ebrahim Mokhtari, Farshad Teymoori, Hossein Farhadnejad, Parvin Mirmiran, Fereidoun Azizi
Summary: In this study, we aimed to develop and validate insulinemic potential indices of diet and lifestyle in Iranian adults. We successfully developed four indices related to insulin homeostasis and these indices were found to be significantly associated with insulin-related disorders.
NUTRITION & METABOLISM
(2022)
Article
Nutrition & Dietetics
Mahdieh Golzarand, Parvin Mirmiran, Fereidoun Azizi
Summary: The study aimed to assess the association between dietary choline and betaine intake and cardiovascular disease (CVD). The results showed that overall intake of choline and betaine was not associated with CVD risk, while higher intake of free choline was associated with a lower risk of CVD.
Article
Cardiac & Cardiovascular Systems
Erfan Tasdighi, Maryam Barzin, Maryam Mahdavi, Majid Valizadeh, Pooneh Dehghan, Amin M. Moghaddam, Fereidoun Azizi, Amir A. Momenan, Farhad Hosseinpanah
Summary: This study found that obesity phenotypes during childhood and adolescence have an impact on carotid intima-media thickness in early adulthood, with children with MUO phenotype having an increased risk of high CIMT incidence.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Farshad Teymoori, Ebrahim Mokhtari, Mitra Kazemi Jahromi, Hossein Farhadnejad, Parvin Mirmiran, Mohammadreza Vafa, Fereidoun Azizi
Summary: This study aimed to investigate the association of the Empirical Dietary Index for Hyperinsulinemia (EDIH) and Empirical Lifestyle Index for Hyperinsulinemia (ELIH) with the risk of obesity phenotypes among Iranian adults. The findings revealed that higher ELIH scores were associated with greater risks for MUO and MHO incidence, while higher EDIH scores were related to an increased risk of MUO but not MHO. This suggests that a high insulinemic potential of diet and lifestyle may lead to an increase in the simultaneous occurrence of obesity with metabolic disorders in Iranian adults.
Article
Nutrition & Dietetics
Hossein Farhadnejad, Farshad Teymoori, Ebrahim Mokhtari, Parvin Mirmiran, Fereidoun Azizi
Summary: The study revealed that the inflammatory potential of diet and lifestyle, as determined by DLIS, DIS, and LIS scores, are associated with a higher risk of insulin resistance (IR). Individuals with higher LIS scores are more prone to the risk of hyperinsulinemia.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Somayeh Hosseinpour-Niazi, Parvin Mirmiran, Farzad Hadaegh, Maryan Mahdavi, Davood Khalili, Maryam S. Daneshpour, Amir Abbas Momenan, Fereidoun Azizi
Summary: The study found that a legume-enriched DASH diet can improve fasting plasma glucose levels and reduce insulin resistance in patients with type 2 diabetes. Compared to the standard DASH diet, the legume-based DASH diet had a more significant impact on fasting plasma glucose and insulin resistance.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Endocrinology & Metabolism
Azra Ramezankhani, Donna Parizadeh, Fereidoun Azizi, Farzad Hadaegh
Summary: This study aimed to evaluate the sex differences in the association between blood pressure and glucose intolerance status and the risk of stroke among Iranian adults. The results showed that the association between increased blood glucose levels and stroke risk was stronger in men than women. Each 10mmHg increase in diastolic blood pressure was also found to have a stronger association with stroke risk in men compared to women. Additionally, hypertension and type 2 diabetes were associated with a higher risk of stroke in men than women.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Endocrinology & Metabolism
M. Amiri, S. Nazarpour, F. Ramezani Tehrani, A. Sheidaei, F. Azizi
Summary: This study compares the effects of different thyroid screening methods on subclinical hypothyroidism, thyroid autoimmunity, and pregnancy outcomes. The targeted high-risk case-finding approach may overlook some women with SCH but is not associated with a higher risk of adverse pregnancy outcomes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Loyal Chaker, Salmon RazvID, Isabela M. Bensenor, Fereidoun Azizi, Elizabeth N. Pearce, Robin P. Peeters
Summary: Hypothyroidism is a common condition of insufficient thyroid hormone production or metabolism, which can be life-threatening if untreated. It has serious adverse health effects on multiple organ systems, with the cardiovascular system being the most studied target. The main treatment approach is the use of levothyroxine, but there are still persistent symptoms that cannot be relieved.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Public, Environmental & Occupational Health
Sara Sheikholeslami, Fereidoun Azizi, Asghar Ghasemi, Abbas Alibakhshi, Hossein Parsa, Setareh Shivaee, Marjan Zarif-Yeganeh, Mehdi Hedayati, Ladan Teimoori-Toolabi
Summary: This study investigated the expression and methylation of SLC5A8 in PTC and AING. It was found that the level of SLC5A8 was significantly downregulated in PTC tissues. Aberrant promoter hyper methylation of SLC5A8 was related to aggressive PTC.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Mojtaba Lotfaliany, Farzad Hadaegh, Mohammad Ali Mansournia, Fereidoun Azizi, Brian Oldenburg, Davood Khalili
Summary: This study aimed to assess the performance of different stepwise screening methods for identifying individuals at high risk of incident type 2 diabetes through the combination of non-invasive and lab-based measurements. Results showed that these methods had acceptable performance in identifying those at high risk of developing type 2 diabetes within 5 years.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2022)