Article
Medicine, General & Internal
Dandan Mao, Huanyi Cao, Mai Shi, Chi Chiu Wang, Joseph Kwong, Joshua Jing Xi Li, Yong Hou, Xing Ming, Heung Man Lee, Xiao Yu Tian, Chun Kwok Wong, Elaine Chow, Alice Pik Shan Kong, Vivian Wai Yan Lui, Paul Kay Sheung Chan, Juliana Chung Ngor Chan
Summary: Our study revealed that the expression of PSMA2 and GLP-1R was increased and positively correlated in T2D-related cervical cancer specimens, suggesting hyperglycemia might promote cancer growth by increasing PSMA2 expression, which could be attenuated by Exendin-4.
Article
Endocrinology & Metabolism
Neil Tanday, Andrew English, Ryan A. Lafferty, Peter R. Flatt, Nigel Irwin
Summary: The combined activation of GLP-1 and CCK1 receptors through [Lys(12)Pal]Ex-4/CCK showed enhanced beneficial effects on pancreatic beta-cells, leading to improved insulin secretion and glucose homeostasis in vitro and in mice models. This hybrid peptide therapy also resulted in reductions in energy intake and body weight, as well as improvements in glucose tolerance, insulin responsiveness, and pancreatic islet morphology, highlighting its potential for treating obesity-related diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Shimpei Iikuni, Ichiro Kamei, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono
Summary: A GLP-1R imaging probe [In-111]In-E4DA1 has been developed, which can detect the location of insulinomas in vivo and has reduced renal accumulation.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Shimpei Iikuni, Takaki Ohara, Hiroyuki Watanabe, Masahiro Ono
Summary: In this study, 111In-labeled exendin-4 derivatives with specific albumin binder (ALB) moieties were designed and synthesized for noninvasive detection of insulinomas. Through in vitro and in vivo experiments, it was determined that these derivatives exhibited good affinity and tumor accumulation, while showing lower renal accumulation. These results provide important guidance for the design of novel radioligands targeting GLP-1R.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Sundararajan Mahalingam, Ramesh Bellamkonda, Madan Kumar Arumugam, Sathish Kumar Perumal, Jessica Yoon, Carol Casey, Kusum Kharbanda, Karuna Rasineni
Summary: The GLP-1 receptor agonist exendin-4 has been found to effectively mitigate alcohol-induced hepatic steatosis by regulating fat metabolism, according to an experimental rat model.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jufen Liu, Huijing Wang, Cuiting Huang
Summary: This study found that Exendin-4 has a protective effect in inhibiting the progression of DR, and it may exert its effect by regulating the expression of TGFB2.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Khaoula Errafii, Olfa Khalifa, Neyla S. Al-Akl, Abdelilah Arredouani
Summary: No therapy exists for non-alcoholic fatty liver disease (NAFLD). However, glucagon-like peptide receptor agonists (GLP-1RAs) showed a beneficial effect on NAFLD. The study examined the signaling pathways involved in the protective effect of the GLP-1RA Exendin-4 (Ex-4) using comparative transcriptomics in a cell model of steatosis. It identified several key pathways, including FXR/RXR and LXR/RXR, that may contribute to the protective effect of GLP-1RAs on NAFLD.
Article
Medicine, Research & Experimental
Khaoula Errafii, Neyla S. Al-Akl, Olfa Khalifa, Abdelilah Arredouani
Summary: This study confirmed that Ex-4 can improve steatosis in HepG2 cells and identified 379 and 180 differentially expressed LncRNAs between untreated, steatotic, and Ex-4-treated steatotic cells. Functional enrichment analysis revealed critical pathways involved in fatty acid and pyruvate metabolism, insulin, PPAR, Wnt, TGF-beta, mTOR, VEGF, NOD-like, and Toll-like receptors signaling pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Ali Ismaeil, Fawzi Babiker, Suleiman Al-Sabah
Summary: This study found that GLP-1 (9-36) can protect the heart against ischemia reperfusion injury by normalizing cardiac hemodynamic and enzyme levels, while Ex-4 (9-39) can block the protective effect mediated by Ex-4.
Article
Endocrinology & Metabolism
Kentaro Sakaki, Takaaki Murakami, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Daisuke Otani, Sakura Kiyobayashi, Takuya Okada, Masakazu Fujimoto, Takuro Hakata, Ichiro Yamauchi, Kotaro Shimada, Hironori Shimizu, Kazuyuki Nagai, Yuji Nakamoto, Nobuya Inagaki
Summary: F-18-exendin-4 PET/CT is a noninvasive diagnostic technique that can help localize insulinomas, and it is crucial for curative surgical resection.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Psychiatry
Daniel H. Cooper, Ranuk Ramachandra, Felicia Ceban, Joshua D. Di Vincenzo, Taeho Greg Rhee, Rodrigo B. Mansur, Kayla M. Teopiz, Hartej Gill, Roger Ho, Bing Cao, Leanna M. W. Lui, Muhammad Youshay Jawad, Juliet Arsenault, Gia Han Le, Diluk Ramachandra, Ziji Guo, Roger S. McIntyre
Summary: This study aimed to investigate whether GLP-1 receptor agonists can be used prophylactically to lower the risk of incident depression in patients with diabetes mellitus (DM). The results showed mixed findings regarding the effect of GLP-1 receptor agonists on lowering the risk of incident depression. Further research is needed to better understand the potential neuroprotective effects of GLP-1 receptor agonists on depression in patients with DM.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Olfa Khalifa, Khalid Ouararhni, Khaoula Errafii, Nehad M. Alajez, Abdelilah Arredouani
Summary: The study found that the GLP-1RA exendin-4 (Ex-4) can reverse the expression of a set of miRNAs, reducing the occurrence of fatty liver. Enrichment pathway analysis showed that the differentially expressed miRNAs were associated with hepatic fibrosis, insulin receptor, PPAR, Wnt/beta-Catenin, VEGF, mTOR receptor signaling pathways, fibrosis of the liver, cirrhosis of the liver, proliferation of hepatic stellate cells, diabetes mellitus, glucose metabolism disorder, and proliferation of liver cells. These findings suggest that miRNAs may play an important role in the process of reducing fatty liver in response to GLP-1R agonists, which warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Laura N. Deden, Jan Booij, Joanes Grandjean, Judith R. Homberg, Eric J. Hazebroek, Martin Gotthardt, Marti Boss
Summary: Stimulation of GLP-1 receptors increases insulin release and induces satiety. GLP-1 receptor agonists may have potential benefits for Parkinson's and Alzheimer's diseases, but Ga-68-NODAGA-exendin-4 PET cannot be used to analyze GLP-1 receptors in the brain of obese subjects.
Article
Dentistry, Oral Surgery & Medicine
Wei-Ren Shen, Hideki Kitaura, Jiawei Qi, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Pramusita Adya, Itaru Mizoguchi
Summary: The study found that exendin-4 inhibits orthodontic tooth movement in mice, reduces root resorption, and affects the expression levels of osteoclast-related cytokines. Therefore, orthodontic patients receiving exendin-4 for diabetes treatment need additional attention during orthodontic treatment. The GLP-1 receptor may be a treatment target for patients with severe root resorption.
ANGLE ORTHODONTIST
(2021)
Article
Health Care Sciences & Services
Chia-Jen Tsai, Cheng-Feng Tsao
Summary: This study evaluated the efficacy of glucose control in type 2 diabetes patients who switched from DPP-4 inhibitors to GLP-1 receptor agonists. The results showed that there was a significant reduction in HbA1c levels after initiating GLP-1 RAs in both DPP-4 inhibitor users and non-users. Non-users of DPP-4 inhibitors had a greater reduction in HbA1c levels compared to users, indicating better glucose control.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Sachiyo Fukushima, Nobuto Nakanishi, Kazumichi Fujioka, Kenichi Suga, Taku Shirakawa, Kayo Osawa, Kanako Hara, Rie Tsutsumi, Maki Urushihara, Ryuji Nakagawa, Hiroyuki Awano, Jun Oto, Hiroshi Sakaue, Kazumoto Iijima, Masafumi Matsuo
Summary: This study investigated the changes in urinary titin N-fragment levels in infants with postmenstrual age, revealing an exponential decline with postmenstrual age and a significant increase in catabolic state in preterm infants.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kana Beppu, Rie Tsutsumi, Satoshi Ansai, Nana Ochiai, Mai Terakawa, Marie Mori, Masashi Kuroda, Kazuki Horikawa, Takumi Tomoi, Joe Sakamoto, Yasuhiro Kamei, Kiyoshi Naruse, Hiroshi Sakaue
Summary: This study established an engineered strain of medaka that allows direct visualization of taste receptor expression and identified potential therapeutic agents for dysgeusia. The findings provide new insights and tools for the treatment of taste disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Hirofumi Tenshin, Jumpei Teramachi, Mohannad Ashtar, Masahiro Hiasa, Yusuke Inoue, Asuka Oda, Kotaro Tanimoto, So Shimizu, Yoshiki Higa, Takeshi Harada, Masahiro Oura, Kimiko Sogabe, Tomoyo Hara, Ryohei Sumitani, Tomoko Maruhashi, Mayu Sebe, Rie Tsutsumi, Hiroshi Sakaue, Itsuro Endo, Toshio Matsumoto, Eiji Tanaka, Masahiro Abe
Summary: LLZ can alleviate inflammation and bone destruction in rheumatoid arthritis by inhibiting the formation and activation of NLRP3 inflammasome and suppressing the production of TNF-alpha and IL-6.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Hayato Tanabe, Hiroyuki Hirai, Haruka Saito, Kenichi Tanaka, Hiroaki Masuzaki, Junichiro J. Kazama, Michio Shimabukuro
Summary: This study found that patients with severe autoimmune diabetes and severe insulin-deficient diabetes had a higher risk of developing sarcopenia in the Japanese population. Clustering-based stratification may be beneficial for predicting and preventing sarcopenia in patients with diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Takahiro Seki, Yunlong Yang, Xiaoting Sun, Sharon Lim, Sisi Xie, Ziheng Guo, Wenjing Xiong, Masashi Kuroda, Hiroshi Sakaue, Kayoko Hosaka, Xu Jing, Masahito Yoshihara, Lili Qu, Xin Li, Yuguo Chen, Yihai Cao
Summary: Exposure to cold conditions inhibits the growth of various types of solid tumors by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells. Cold exposure also reduces glucose uptake in tumor tissue. These findings provide a new concept and paradigm for cancer therapy using a simple and effective approach.
Article
Endocrinology & Metabolism
Satoshi Yamaguchi, Michio Shimabukuro, Atsushi Tanaka, Takumi Imai, Shinya Hiramitsu, Naohiko Takahashi, Toshiaki Kadokami, Masayoshi Ajioka, Makoto Suzuki, Koichi Node
Summary: The aim of this study was to investigate factors associated with proteinuria regression in patients with type 2 diabetes treated with canagliflozin. The results showed that the rate of proteinuria regression was higher and the rate of progression was lower in the canagliflozin group compared to the glimepiride group. In the regression subclass, insulin level, beta-cell function, insulin resistance, and estimated plasma volume were decreased at 24 weeks. Baseline insulin level was associated with proteinuria regression in the multivariate logistic regression model.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Atsushi Tanaka, Takumi Imai, Michio Shimabukuro, Ikuko Nakamura, Kazuo Matsunaga, Yukio Ozaki, Tohru Minamino, Masataka Sata, Koichi Node
Summary: This study aimed to assess the effect of canagliflozin compared to glimepiride on white blood cell counts. The results indicated that treatment with canagliflozin for 24 weeks reduced WBC counts in patients with type 2 diabetes and heart failure compared to treatment with glimepiride.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Atsushi Tanaka, Masataka Sata, Yosuke Okada, Hiroki Teragawa, Kazuo Eguchi, Michio Shimabukuro, Isao Taguchi, Kazuo Matsunaga, Yumiko Kanzaki, Hisako Yoshida, Tomoko Ishizu, Shinichiro Ueda, Masafumi Kitakaze, Toyoaki Murohara, Koichi Node
Summary: This study aimed to examine the effects of ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients. After a 24-month treatment, it was found that ipragliflozin did not affect carotid IMT status compared to standard care for type 2 diabetes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Enbo Ma, Tetsuya Ohira, Hiroyuki Hirai, Kanako Okazaki, Masanori Nagao, Fumikazu Hayashi, Hironori Nakano, Yuriko Suzuki, Akira Sakai, Atsushi Takahashi, Junichiro J. Kazama, Hirooki Yabe, Masaharu Maeda, Seiji Yasumura, Hitoshi Ohto, Kenji Kamiya, Michio Shimabukuro
Summary: This study investigated the association between dietary patterns and new-onset type 2 diabetes mellitus (T2DM) in evacuees of the Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident. The results showed that a typical Japanese dietary pattern may be associated with a reduced risk of new-onset T2DM in evacuees, especially women.
Article
Environmental Sciences
Satomi Ikeda, Ai Ikeda, Tetsuya Ohira, Akira Sakai, Michio Shimabukuro, Masaharu Maeda, Hirooki Yabe, Masanori Nagao, Seiji Yasumura, Hitoshi Ohto, Kenji Kamiya, Takeshi Tanigawa
Summary: The Great East Japan Earthquake in 2011 caused changes in living environment for the residents of Fukushima Prefecture, which may have long-term effects on cardiovascular-related diseases. A study was conducted to examine the temporal relationships between these changes and blood pressure levels over a three-year period. The findings revealed that men who experienced changes in living environment had significantly higher diastolic blood pressure levels compared to those who remained in their homes. These effects were sustained even after three years, indicating the impact of the disaster on long-term blood pressure levels among middle-aged men.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Fumikazu Hayashi, Tetsuya Ohira, Shiho Sato, Hironori Nakano, Kanako Okazaki, Masanori Nagao, Michio Shimabukuro, Akira Sakai, Junichiro James Kazama, Mitsuaki Hosoya, Atsushi Takahashi, Masaharu Maeda, Hirooki Yabe, Seiji Yasumura, Hitoshi Ohto, Kenji Kamiya
Summary: This study aimed to explore the relationship between lifestyle/socio-psychological factors and the onset of hyper-LDLemia, hypo-HDLemia, and hyper-TGemia among residents in the Fukushima evacuation area after the Great East Japan Earthquake. The results showed that the evacuation experience, dietary diversity score, sleep satisfaction, exercise habit, smoking, audible nuclear power plant explosions, and drinking habits were all associated with the risk of these diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Yuka Ueda, Fumikazu Hayashi, Tetsuya Ohira, Masaharu Maeda, Seiji Yasumura, Itaru Miura, Shuntaro Itagaki, Michio Shimabukuro, Hironori Nakano, Kenji Kamiya, Hirooki Yabe
Summary: This study examined the risk and recovery factors for problem drinking among evacuees of the Great East Japan Earthquake. The findings indicated that male gender, insufficient sleep, job change, trauma symptoms, mental illness, family financial issues, and heavy drinking were significant risk factors for problem drinking. Furthermore, high blood pressure diagnosis, younger age, and diabetes mellitus diagnosis could increase problem drinking among evacuees.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Takahiro Kato, Satoshi Kamiya, Soshi Narasaki, Ayako Sumii, Yasuo M. Tsutsumi, Kyoka Machida, Kanako Hara, Yuna Izumi-Mishima, Rie Tsutsumi, Hiroshi Sakaue
Summary: The consumption of partially hydrolyzed guar gum (PHGG) can improve the gut environment, alleviate the negative effects of H1N1 influenza virus infection, by promoting the production of short-chain fatty acids (SCFAs), inhibiting the increase of inflammatory cytokines, and enhancing natural killer cell activity and regulatory T-cell differentiation.
Article
Medicine, Research & Experimental
Kana Beppu, Ayuka Kawakami, Yuna Mishima, Rie Tsutsumi, Masashi Kuroda, Hiroyasu Mori, Akio Kuroda, Munehisa Matsuhisa, Hiroshi Sakaue
Summary: Dysgeusia is associated with zinc deficiency, certain drugs, and diseases such as diabetes and renal failure. This study focused on taste receptor gene expression in diabetes and revealed a relationship between taste receptor gene expression and renal function.
JOURNAL OF MEDICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Yuya Ikezumi, Yasushi Matsuura, Teruhiro Morishita, Noriko Ide, Isao Kitada, Takafumi Katayama, Rie Tsutsumi, Hiroshi Sakaue, Yutaka Taketani, Koichi Sairyo, Eiji Takeda
Summary: This study examined the changes in serum 25-hydroxyvitamin D (25(OH)D) levels after daily intake of 1000 IU vitamin D for 3 months, 6 months, and then a cessation of vitamin D intake for 6 months. The results showed a significant increase in serum 25(OH)D levels after 3 months of intake, maintenance of higher levels after 6 months of intake, and a decrease after 6 months of cessation. The study suggests that a daily intake of 1000 IU vitamin D can maintain higher levels of 25(OH)D without causing vitamin D intoxication.
JOURNAL OF MEDICAL INVESTIGATION
(2022)
