Article
Endocrinology & Metabolism
Naho Yokota, Shota Takemi, Ichiro Sakata
Summary: A cyclic rhythmic migrating motor complex (MMC) with three phases exists in the fasting gastrointestinal tract, and phase III contractions propagate from the stomach to the lower intestine. The mechanism of contractions originating in the small intestine during the gastric phase II has not been clarified. This study found that exogenous cholecystokinin (CCK) stimulates contractions of the small intestine via CCK1 receptors, while endogenous CCK is not involved in the strong contractions of small intestinal origin.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuki Kobayashi, Shota Takemi, Takafumi Sakai, Chikashi Shibata, Ichiro Sakata
Summary: This study investigated the mechanisms of colonic motility in the house musk suncus as an animal model, finding diurnal changes in colonic motility and a potential gastrocolic reflex. Factors regulating suncus colonic motility were examined, suggesting the suncus could be a novel model for studying colonic motility similar to humans and dogs.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Yanyan Jiang, Julia E. Zimmerman, Kirsteen N. Browning, R. Alberto Travagli
Summary: This study reveals that stress can alter the modulation of oxytocin (OXT) on gastric tone and motility in rats, leading to neuroplasticity changes in the neurocircuits. Under stress conditions, OXT's regulation of brainstem GABAergic currents and gastric responses to vagal stimulation are disrupted.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed A. Rahman, Philenkosini Masango, Rhian Stavely, Paul Bertrand, Amanda Page, Kulmira Nurgali
Summary: Nausea and vomiting are common side effects of oxaliplatin chemotherapy, and this study found that oxaliplatin treatment affects the stomach's neuronal population, gastric motility, and serotonin levels, leading to pica and gastric dysmotility.
Article
Veterinary Sciences
Stephanie Rutherford, Frederic Gaschen, Roman Husnik, Jon Fletcher, Lorrie Gaschen
Summary: This study evaluated the effects of azithromycin on gastric emptying (GE) and gastric motility in healthy cats. It found that azithromycin and erythromycin both shortened GE time in a comparable manner. Further evaluation of their efficacy in cats with gastric dysmotility is warranted.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Dolyce H. W. Low, Lena Ch'ng, Yvonne C. F. Su, Martin Linster, Rong Zhang, Yan Zhuang, Mackenzie L. Kwak, Sophie A. Borthwick, Alan T. Hitch, Gavin J. D. Smith, Ian H. Mendenhall
Summary: CENC virus, a novel Orthonairovirus, has been detected in Asian house shrews in Singapore and is primarily transmitted by ectoparasites. Its discovery highlights the importance of surveillance of small mammals in Southeast Asia.
Article
Clinical Neurology
Kenan Steidel, Kristina Krause, Katja Menzler, Adam Strzelczyk, Ilka Immisch, Sven Fuest, Iris Gorny, Peter Mross, Lukas Hakel, Laura Schmidt, Lars Timmermann, Felix Rosenow, Sebastian Bauer, Susanne Knake
Summary: This study demonstrated for the first time that 4 hours of taVNS can influence gastric motility in healthy participants, with high-frequency stimulation associated with higher amplitudes of peristaltic waves. Further research is needed to investigate the effects of different frequencies of taVNS and its therapeutic properties in conditions with impaired gastric motility.
Article
Biochemistry & Molecular Biology
So Shinya, Yusuke Kawai, Mitsuki Kondo, Shouta M. M. Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka
Summary: This study used the musk shrew as a model organism to assess the toxicity response to the neonicotinoid insecticide acetamiprid. The musk shrew exhibited more efficient metabolic responses toward acetamiprid compared to mice or rats. Analysis of cytochrome P450 revealed unique metabolic traits in the musk shrew, highlighting the need for further research to fully understand xenobiotic metabolism in this species.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Takio Kitazawa, Hiroyuki Kaiya
Summary: Motilin, produced in the upper intestine, acts as an important regulator of gastrointestinal motility and mediates the phase III of interdigestive migrating motor complex in the stomach of humans, dogs, and musk shrews. It helps maintain normal GI functions and transmits hunger signals from the stomach to the brain. The structure, distribution, receptor, and regulatory function of motilin vary among vertebrates from fish to mammals.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Veterinary Sciences
Tohru Kimura
Summary: This study describes a case of polycystic kidney disease with chronic renal failure in a house musk shrew. The clinical presentation, biochemical profile, and histopathological findings provide insights into the pathogenesis of this disease.
VETERINARY SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Zengbing Lu, Dexuan Cui, Julia Yuen Hang Liu, Bin Jiang, Man Piu Ngan, Ichiro Sakata, Shota Takemi, Takafumi Sakai, Ge Lin, Sze Wa Chan, John A. Rudd
Summary: NESFATIN-1, encoded by NUCB2, is a potent regulator of feeding and emesis in Suncus murinus, with its expression level in the brain and gastrointestinal tract being influenced by fasting. It can induce emesis, suppress food intake and water intake, but has no significant effect on locomotor activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Naoko Inoue, Akinori Hotta, Teppei Goto, Masumi Hirabayashi, Yoshihisa Uenoyama, Hiroko Tsukamura
Summary: The present study established techniques to induce pseudopregnancy, in vitro oocyte cultures, and embryo transfer in musk shrews, resulting in successful offspring production, which may be valuable for producing transgenic musk shrews.
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2022)
Article
Neurosciences
Janell Richardson, Ghazaul Dezfuli, Allen W. Mangel, Richard A. Gillis, Stefano Vicini, Niaz Sahibzada
Summary: The study investigated the neuroanatomical connections and functional brain neurocircuitry involved in controlling the pyloric sphincter. Results showed that the pyloric sphincter is connected to the hindbrain raphe nuclei, midbrain Edinger-Westphal nucleus, ventral tegmental area, lateral habenula, and arcuate nucleus. Stimulation of different sites within the dorsal motor nucleus of the vagus (DMV) had differential effects on the tone and motility of the pyloric sphincter.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Xi-yang Wang, Xiao-qi Chen, Guo-quan Wang, Rong-lin Cai, Hao Wang, Hai-tao Wang, Xiao-qi Peng, Meng-ting Zhang, Shun Huang, Guo-ming Shen
Summary: In this study, a mouse model of gastric dilation was used to investigate the neural pathways underlying gastric motility disorders. It was found that activation of PVNCRH neurons is associated with gastric motility disorders, and inhibition of PVNCRH neuron activity can alleviate these disorders. Furthermore, it was discovered that PVNCRH neurons project to DMVChAT neurons, suggesting a potential pathway by which somatic stimulation affects gastric motility.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Lorenza Bellusci, Selena N. Garcia DuBar, Michelle Kuah, David Castellano, Vinona Muralidaran, Elizabeth Jones, Aaron M. Rozeboom, Richard A. Gillis, Stefano Vicini, Niaz Sahibzada
Summary: NPY neurons in the DVC play a crucial role in the network that controls vagal transmission to the stomach, and their interactions with SST neurons affect gastric motility.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Weigang Cai, Raj Makwana, Marilisa Straface, Armen Gharibans, Paul L. R. Andrews, Gareth J. Sanger
Summary: The mouse isolated stomach exhibited myogenic contractions that were resistant to neural activity blockade by TTX. Compounds blocking interstitial cells of Cajal activity or atropine could prevent or reduce these contractions in the presence of TTX, while neostigmine enhanced the contractions (which were antagonized by atropine), suggesting the involvement of non-neuronal acetylcholine in their regulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Gareth J. Sanger
Summary: The gastrointestinal hormone motilin helps control stomach movements during hunger and promotes hunger in humans. While motilin and its receptor genes have undergone pseudonymization in rodents, some studies suggest low concentrations of motilin can still function in the gastrointestinal tract and central nervous system of these animals.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Pharmacology & Pharmacy
Marilisa Straface, Marie -Ange Koussai, Raj Makwana, Ellie Crawley, Alexandra Palmer, Weigang Cai, Armen Gharibans, Miriam Adebibe, John Loy, Greg O'Grady, Paul L. R. Andrews, Gareth J. Sanger
Summary: Software was developed to measure muscle tone and parameters defining contractions in human stomach. The study found that only E-4031 and CaCC blockers influenced myogenic contractions, not muscle tone.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Cristina Perez-Ternero, Aisah A. Aubdool, Raj Makwana, Gareth J. Sanger, Roland H. Stimson, Li F. Chan, Amie J. Moyes, Adrian J. Hobbs
Summary: C-type natriuretic peptide (CNP) plays a crucial role in lipid homeostasis and energy balance by regulating the expression of uncoupling protein-1 and lipid utilization. CNP exerts these metabolic regulatory actions by inhibiting sympathetic thermogenic programming and reducing peroxisome proliferator-activated receptor-gamma coactivator-1 alpha expression, while driving adipogenesis via NPR-B/protein kinase-G.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Nicholas Baidoo, Gareth J. Sanger, Abi Belai
Summary: Old age is associated with a higher incidence of lower bowel conditions such as constipation. This study assessed and compared the pattern of distribution of enteric glial cells (EGCs) in adult and elderly human colon. The results showed that aging does not result in a loss of Sox-10-IR EGCs in the myenteric plexus (MP) and submucosal plexus (SMP), but reduces S100-IR EGCs density within the musculature, which may contribute to colonic dysfunction.
Review
Gastroenterology & Hepatology
Christopher Roberts, Ahmed Albusoda, Adam D. Farmer, Qasim Aziz
Summary: This study aimed to determine whether individuals with irritable bowel syndrome (IBS) have lower pain thresholds compared to healthy individuals. The results showed that reduced rectal pain threshold is more common in IBS patients than in healthy controls. Further research is needed to understand the pathophysiological and therapeutic implications of rectal sensitivity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Gareth J. Sanger, Paul L. R. Andrews
Summary: This study summarizes the drugs used to treat gastroparesis and explores the rationale behind blocking different pathways causing vomiting and increasing gastric emptying via different mechanisms. The results suggest that some drug classes lack scientific rationale for inhibiting vomiting. NK1 antagonism shows some rationale but limited efficacy against nausea. The efficacy of selective 5-HT4 agonists varies. Further research is needed to develop novel approaches targeting nausea and objective assessments of nausea.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Gareth J. Sanger, Paul L. R. Andrews
Article
Health Policy & Services
Raman Sharma, Farideh A. Javid
Summary: This study investigated the impact of COVID-19 on the uptake of electronic repeat dispensing (eRD) in general practice and identified key factors that promote its adoption. The results showed that integrating eRD into the repeat prescription reauthorization process and appointing an eRD service lead can increase its uptake. The study also found that the average eRD utilization in participating general practices increased from 7.2% in March 2020 to 10.4% in November 2020, as a response to COVID-19. This indicates the potential benefits of using eRD in clinical practice.
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Raj Makwana, Gareth J. Sanger
Summary: Interstitial cells of Cajal generate slow wave gastric electrical activity, initiating spontaneous muscle contractions. This becomes dysrhythmic during nausea when [Arg8]-vasopressin (AVP) is also released. In human stomach AVP increased spontaneous contraction activity and muscle tone, not neuronally-mediated contractions. Rodents cannot vomit, releasing the related hormone, oxytocin (OT) instead. We hypothesised that rat stomach would behave differently.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Meeting Abstract
Medicine, Research & Experimental
Cristina Perez-Ternero, Aisah Aubdool, Raj Makwana, Gareth Sanger, Roland Stimson, Li Chan, Amie Moyes, Adrian Hobbs
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Raj Makwana, Ellie Crawley, Marilisa Straface, Armen Gharibans, Kalpana Devalia, John Loy, Greg O'Grady, Paul L. R. Andrews, Gareth Sanger
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kartheek Sooda, Simon J. Allison, Farideh A. Javid
Summary: Cannabinoids such as CBD and CBG have shown selective cytotoxicity and apoptosis induction in ovarian carcinoma cells, potentially involving biological activities such as decreased mitochondrial membrane potential and apoptosis promotion. Compared to traditional chemotherapeutic drugs, cannabinoids demonstrate stronger anti-tumor effects and may be considered for combination therapies in the future.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Multidisciplinary Sciences
Nicholas Baidoo, Gareth J. Sanger, Abi Belai
Summary: This article introduces a laboratory protocol using image analysis to quantify the collagen content in the colon. It provides a systematic and reproducible method for accurately assessing the spatial distribution and localization of collagen fibers in formalin-fixed, paraffin-embedded samples. The protocol is also useful for retrospective studies.
Meeting Abstract
Pharmacology & Pharmacy
Ahmed Saleh, Arin Saha, Brian Dobbins, Roger Phillips, Farideh Javid
BRITISH JOURNAL OF PHARMACOLOGY
(2023)