Article
Biochemistry & Molecular Biology
Edurne Tellechea, Aaron C. Asensio, Paula Ciaurriz, Javier Buezo, Pedro Lopez-Gomez, Marina Urra, Jose F. Moran
Summary: This study investigates the characteristics of the recombinant cowpea FeSOD immobilized onto gold nanoparticles (AuNPs) and the effects of NP surface chemistry and biofunctionalization methods on enzyme activity. The results highlight the importance of the biomolecule and AuNP interaction for the functionality of the hybrid and demonstrate the potential of these strategies in biomedical applications.
Article
Multidisciplinary Sciences
Xiaowen Wang, Hong Zhang, Russell Sapio, Jun Yang, Justin Wong, Xin Zhang, Jessie Y. Guo, Sharon Pine, Holly Van Remmen, Hong Li, Eileen White, Chen Liu, Megerditch Kiledjian, Dimitri G. Pestov, X. F. Steven Zheng
Summary: The study reveals a crucial role of nuclear SOD1 in ribosome biogenesis and proliferation in KRAS-driven lung cancer.
NATURE COMMUNICATIONS
(2021)
Letter
Gastroenterology & Hepatology
Mirella Mancha Chahuara, Leidhy Dhy Maruja Lopez Tufino, Carlos Andres Mugruza-Vassallo
Summary: This article discusses the impact of the gastrointestinal microbiome on gallstones and the interaction between the microbiota and the nervous system. It suggests that the microbiota and the nervous system may have similar roles in certain diseases, emphasizing the need for further research in this area.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Chemistry, Analytical
Caroline G. Sanz, Daniel N. Crisan, Ricardo J. B. Leote, Melania Onea, Madalina M. Barsan
Summary: In this study, a biosensor for quantifying superoxide in cell culture media was successfully developed using gold nanoparticles and superoxide dismutase bioconjugates. The optimized biosensor achieved a sensitivity value of 41.2 nAμMcm(-2), a detection limit of 1.0μM, and showed excellent operational stability, indicating great potential for practical applications.
Article
Biochemistry & Molecular Biology
Alessia Parascandolo, Mikko O. Laukkanen
Summary: Superoxide dismutase (SOD) family isoenzymes, including SOD1, SOD2, and SOD3, synthesize hydrogen peroxide (H2O2) to regulate signal transduction. The cellular response to SOD3 is dose-dependent, with high concentrations reducing cell survival.
Article
Immunology
Gaurav Agrahari, Shyam Kishor Sah, Chul Hwan Bang, Yeong Ho Kim, Tae-Yoon Kim
Summary: SOD3 attenuates CD4(+)T cell activation by modulating downstream signals and restricting cell differentiation. The study suggests that SOD3 has the potential to be a promising therapeutic for T cell-mediated disorders by inhibiting T cell differentiation and activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shengchao Ma, Guanjun Lu, Qing Zhang, Ning Ding, Yuzhen Jie, Hui Zhang, Lingbo Xu, Lin Xie, Xiaoling Yang, Huiping Zhang, Yideng Jiang
Summary: In this study, we found that Hcy can increase the risk of oxidative stress and atherosclerosis by affecting the DNA methylation status of EC-SOD. The key enzyme in this process was identified as DNMT1.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Review
Neurosciences
Tingyan Wu, Weili Cai, Xi Chen
Summary: Neurotransmission signaling is a conserved system with important regulatory events. The role of excitatory and inhibitory neurotransmitter systems in brain function is well established. Recent research has shown that epigenetic regulation plays a crucial role in controlling the expression of neurotransmitter-related genes and its dysregulation is associated with neurological disorders. This article explores the epigenetic regulation of dopamine, GABA, glutamate, and serotonin genes, and discusses how targeting these mechanisms can lead to improved treatments for neurological disorders.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Medicine, General & Internal
Fatma E. Hassan, Hader I. Sakr, Passant M. Mohie, Howayda Saeed Suliman, Ayman Saber Mohamed, Mohamed H. Attia, Dalia M. Eid
Summary: The study found that PPAR-gamma agonist pioglitazone can alleviate fatigue, improve muscle performance, reduce inflammatory cytokines, and enhance antioxidant activity in a rat model of fibromyalgia. Conversely, the PPAR-gamma antagonist GW9662 worsened the symptoms, indicating a promising role of PPAR-gamma agonists against fibromyalgia-related motor dysfunctions.
ANNALS OF MEDICINE
(2021)
Article
Microbiology
Nnamdi Ikeogu, Folayemi Olayinka-Adefemi, Chidalu Edechi, Chukwunonso Onyilagha, Ping Jia, Aaron Marshall, Julius Ode, Jude Uzonna
Summary: In this study, the trypanocidal efficacy of Crosspteryx fibrifuga leaf extract (C.f/L-extract) was evaluated. The extract showed a significant decrease in parasite number and an increase in apoptotic markers expression. It was not cytotoxic to murine whole splenocytes and exhibited immune regulatory effects. Treatment of infected mice with the extract led to a decrease in parasite numbers and an increase in mouse survival. The extract also affected the distribution of immune cells and the activity of superoxide dismutase.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Neurosciences
Nagalakshmi Balasubramanian, Sneha Sagarkar, Amit G. Choudhary, Dadasaheb M. Kokare, Amul J. Sakharkar
Summary: The study found that repeated mild traumatic events can exacerbate oxidative stress and negatively impact SOD2 gene expression. DNA methylation plays a critical role in neuropathology, potentially leading to oxidative damage and neuronal degeneration.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Agronomy
Ramakrushna Bastia, Elssa Pandit, Priyadarsini Sanghamitra, Saumya Ranjan Barik, Deepak Kumar Nayak, Auromira Sahoo, Arpita Moharana, Jitendriya Meher, Prasanta K. Dash, Reshmi Raj, Binod Kumar Jena, Kartik Chandra Pradhan, Devraj Lenka, Nabaneeta Basak, Srikanta Lenka, Sharat Kumar Pradhan
Summary: This study identified potential landraces carrying multiple antioxidant compounds using association mapping and discovered novel loci and antioxidant hotspots, providing valuable information for marker-assisted breeding.
Article
Medicine, Research & Experimental
Konrad A. Szychowski, Bartosz Skora, Anna Kryshchyshyn-Dylevych, Danylo Kaminskyy, Dmytro Khyluk, Roman Lesyk
Summary: The study evaluated the impact of three 4-thiazolidinone-based compounds on the expression of antioxidant enzymes in various cancer cell lines. All compounds influenced ROS production, with Les-3640 affecting caspase-3 activity in the cell lines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Tadanao Hiroki, Takashi Suto, Jo Ohta, Shigeru Saito, Hideaki Obata
Summary: This study demonstrates that dysfunction of the descending serotonergic system and functional changes in GABA A receptors contribute to the attenuated efficacy of morphine against neuropathic pain. Activation of spinal 5-HT3 receptors increases GABA concentration, and morphine activates GABAergic interneurons in the spinal dorsal horn through descending serotonergic neurons.
Article
Pharmacology & Pharmacy
Peter J. Altshuler, Alexis R. Schiazza, Lijun Luo, Mark R. Helmers, Bonirath Chhay, Jason J. Han, Robin Hu, David Alan Herbst, Andrew Tsourkas, Zhiliang Cheng, Pavan Atluri
Summary: Early revascularization is crucial in reducing post-myocardial infarction morbidity, although it can lead to additional oxidative injury. This study demonstrates the use of a novel nanoparticle carrier to enhance the retention of exogenous SOD in preserving cardiac function after ischemia-reperfusion injury. The nanoparticle-encapsulated SOD exhibits similar enzyme activity as free SOD, reduces ROS damage in vitro, and improves left ventricular function in vivo, suggesting its potential as a therapy for mitigating myocardial I/R injury.
ADVANCED THERAPEUTICS
(2021)
Article
Engineering, Biomedical
B. Amal, B. Veena, V. P. Jayachandran, Joy Shilpa
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2015)
Article
Nanoscience & Nanotechnology
J. Shilpa, T. R. Anju, M. S. Ajayan, C. S. Paulose
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2014)
Article
Engineering, Biomedical
J. Shilpa, B. T. Roshni, R. Chinthu, C. S. Paulose
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2012)
Article
Engineering, Biomedical
J. Shilpa, C. S. Paulose
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2014)
Article
Chemistry, Multidisciplinary
J. Shilpa, G. Naijil, M. S. Nandhu, C. S. Paulose
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2012)
Article
Neurosciences
J. Shilpa, M. Anitha, C. S. Paulose
JOURNAL OF NEUROSCIENCE RESEARCH
(2013)
Article
Clinical Neurology
T. R. Anju, G. Naijil, J. Shilpa, T. Roshni, C. S. Paulose
NEUROLOGICAL SCIENCES
(2013)
Article
Biochemistry & Molecular Biology
Shilpa Joy, Nebu George Thomas
Summary: Bone tissue engineering focuses on designing bone scaffolds, specifically addressing the challenges of porous scaffold selection and suppressing microbial infections. Gelatin scaffolds conjugated with gymnemic acid were designed and studied for morphological characterization, porosity, water absorption behavior, and biocompatibility. The scaffold was implanted in rat calvarial bone defects and analyzed for serum C reactive protein, alkaline phosphatase activity, and histology. Results showed that the scaffold had a porous structure, good water absorption ability, and excellent biocompatibility. The alkaline phosphatase activity increased and the presence of C reactive protein was not observed in the serum, indicating enhanced bone regeneration. Hematoxylin-eosin staining confirmed the formation of new bone tissue. This scaffold holds therapeutic significance in orthopedics and dentistry.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
