Article
Plant Sciences
Masashi Yokoya, Miku Yamazaki-Nakai, Keiyo Nakai, Natchanun Sirimangkalakitti, Supakarn Chamni, Khanit Suwanborirux, Naoki Saito
Summary: In this study, a useful intramolecular photoredox transformation of 7-methoxy-6-methyl-1,2,3,4-tetrahydroisoquinoline-5,8-dione tricyclic models into 5-hydroxy-tetrahydroisoquinol[1,3]dioxoles in excellent yields is described. This methodology was applied to the transformation of renieramycin M into renieramycins T and S and the transformation of saframycin A. The results of cytotoxicity studies are also presented.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Pharmacology & Pharmacy
Hiroko Munakata, Risa Ishikawa, Toshiaki Saitoh, Toshie Kambe, Terumasa Chiba, Kyoji Taguchi, Kenji Abe
Summary: In this study, the effects of artificially modified 1-MeTIQ derivatives on MPTP-induced PD-like signs in mice were compared. The results showed that loading an N-propargyl group on 1-MeTIQ enhanced its neuroprotective effects, while other functional groups exhibited distinct pharmacological properties. These findings are important for understanding the pathogenesis of PD and developing related therapeutic approaches.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Cell Biology
Camila Marchi-Coelho, Willian Costa-Ferreira, Lilian L. Reis-Silva, Carlos C. Crestani
Summary: The study investigated the role of angiotensinergic neurotransmissions within the medial amygdaloid nucleus in influencing behavioral changes in the forced swimming test in male rats subjected to acute restraint stress. The results suggest that angiotensin receptors play a significant role in modulating stress-induced behavioral responses.
Article
Pharmacology & Pharmacy
Hiroko Munakata, Risa Ishikawa, Toshiaki Saitoh, Toshie Kambe, Terumasa Chiba, Kyoji Taguchi, Kenji Abe
Summary: This study compared the effects of different 1-MeTIQ derivatives on MPTP-induced PD-like signs and found that 1-Me-N-propargyl-TIQ showed a significant neuroprotective effect, while other derivatives exhibited distinct pharmacological properties.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Review
Neurosciences
Tatyana Strekalova, Yanzhi Liu, Daniel Kiselev, Sharafuddin Khairuddin, Jennifer Lok Yu Chiu, Justin Lam, Ying-Shing Chan, Dmitrii Pavlov, Andrey Proshin, Klaus-Peter Lesch, Daniel C. Anthony, Lee Wei Lim
Summary: The Chronic Mild Stress (CMS) paradigm is a widely used model for finding antidepressant drugs for Major Depressive Disorder (MDD). While literature analysis supports the validity of this model, further improvements could be achieved by stratifying animals, using refined experimental protocols, and systematically evaluating non-specific effects.
PSYCHOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Beatriz Moreno-Santos, Camila Marchi-Coelho, Willian Costa-Ferreira, Carlos C. Crestani
Summary: This study demonstrates the presence of different angiotensinergic mechanisms within the MeA controlling behavioral responses in the forced swimming test and elevated plus-maze.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Najeeb Ur Rehman, Sulaiman Al-Shidhani, Nasiara Karim, Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Sajid Khan Sadozai, Satya Kumar Avula, Rene Csuk, Ahmed Al-Harrasi
Summary: Through the study of derivatives of two active substances in the resin of Boswellia papyrifera, it is found that these derivatives have good anti-depressive properties and have great application potential. Further research indicates that these compounds produce GABAergic effects by binding to the GABA binding site of the GABA(A) receptor.
BIOORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Hanane Hadj-Moussa, Matthew E. Pamenter, Kenneth B. Storey
Summary: The study revealed significant differential expression of miRNAs in naked mole-rat brains during hypoxia, primarily by suppressing energy-expensive processes to adapt to oxygen-deprived environments. Additionally, miRNAs were found to coordinate anaerobic glycolysis and induce neuroprotective, neuroinflammatory, and central signal transduction pathways during hypoxia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Felipe Fagundes Leao, Ana Paula Farias Waltrick, Waldiceu Aparecido Verri Jr, Joice Maria da Cunha, Janaina Menezes Zanoveli
Summary: The study found that a specialized pro-resolving lipid mediator called Resolvin D5 (RvD5) can prevent depression and anxiety symptoms associated with Type 1 diabetes mellitus (T1DM) and significantly improve blood glucose levels. Furthermore, RvD5 also reduces inflammation in the hippocampus and prefrontal cortex of experimental-T1DM rats. These findings suggest that RvD5 has potential preventive and therapeutic effects on emotional complications resulting from T1DM, possibly through its action on neuroinflammation.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Asmaa M. Zaazaa, Nadia N. Daoud, Ola A. El-Gendy, Ahmad Al-Shafei
Summary: This study suggests that Bacopa monnieri can improve reserpine-induced depression comparable to citalopram. In the experiment, the groups receiving Bacopa monnieri and citalopram showed lower immobility time compared to the group receiving only reserpine, and the levels of serotonin, dopamine, and norepinephrine were also restored.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Nutrition & Dietetics
Johannes de Munter, Dmitrii Pavlov, Anna Gorlova, Michael Sicker, Andrey Proshin, Allan V. Kalueff, Andrey Svistunov, Daniel Kiselev, Andrey Nedorubov, Sergey Morozov, Aleksei Umriukhin, Klaus-Peter Lesch, Tatyana Strekalova, Careen A. Schroeter
Summary: Major depression and posttraumatic stress disorder share common brain mechanisms and treatment strategies, and the rapidly developing COVID-19 situation has led to stress, psychological trauma, and high incidence of MD and PTSD, highlighting the potential of herbal medicine in treating these disorders.
FRONTIERS IN NUTRITION
(2021)
Article
Neurosciences
Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wang
Summary: The study revealed that hypothyroidism induces depressive behaviors, with the influence of the serotonin system playing a significant role, and the decreased expression of the 5-HT2A receptor being a crucial factor in the depressive behaviors associated with hypothyroidism.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Shami Kanekar, Chandni Sheth, Hendrick Ombach, Jadeda Brown, Michael Hoffman, Robert Ettaro, Perry Renshaw
Summary: The study found that living at high altitude may exacerbate depressive symptoms in rats, especially in females who are more vulnerable. Males may be more resilient. Chronic hypoxic stress can cause a brain serotonin imbalance, worsening vulnerability to depression and resistance to SSRIs.
PSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siqi Jia, Ruijuan Wang, Dongyan Zhang, Zhiyu Guan, Tingting Ding, Jingnan Zhang, Xiujuan Zhao
Summary: Depression is a psychiatric disease with unclear pathogenesis. This study explores the protective effect of quercetin on liver metabolism disorders induced by chronic unpredictable mild stress (CUMS) and its mechanisms. The findings suggest that hepatic methylation damage and abnormal changes in bile acids may play a role in depression pathogenesis, indicating the involvement of the liver in depression development and providing potential treatment targets. Quercetin treatment alleviates CUMS-induced liver metabolism disorder, indicating its potential in protecting against depression by regulating liver metabolism.
Article
Neurosciences
Millie Rincon-Cortes, Anthony A. Grace
Summary: Postpartum scarcity-adversity, simulated by limited bedding and nesting materials, leads to abnormal maternal behavior and reduced VTA DA neuron activity in rats. These neurobiological changes induced by adversity may be a potential mechanism for the onset of postpartum depression.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Agnieszka Wasik, Irena Romanska, Agnieszka Zelek-Molik, Lucyna Antkiewicz-Michaluk
NEUROTOXICITY RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Agata Ziomber, Artur Dawid Surowka, Lucyna Antkiewicz-Michaluk, Irena Romanska, Pawel Wrobel, Magdalena Szczerbowska-Boruchowska
Article
Neurosciences
Agata Faron-Gorecka, Maciej Kusmider, Joanna Solich, Magdalena Kolasa, Paulina Pabian, Piotr Gruca, Irena Romanska, Dariusz Zurawek, Marta Szlachta, Mariusz Papp, Lucyna Antkiewicz-Michaluk, Marta Dziedzicka-Wasylewska
PSYCHOPHARMACOLOGY
(2018)
Article
Behavioral Sciences
Agata Ziomber, Eugeniusz Rokita, Jolanta Kaszuba-Zwoinska, Irena Romanska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Environmental Sciences
K. Dec, A. Lukomska, I. Baranowska-Bosiacka, A. Pilutin, D. Maciejewska, K. Skonieczna-Zydecka, R. Derkacz, M. Goschorska, A. Wasik, E. Rebacz-Maron, I. Gutowska
Article
Neurosciences
Agnieszka Wasik, Irena Romanska, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
NEUROTOXICITY RESEARCH
(2018)
Article
Neurosciences
Paulina Cieslik, Monika Wozniak, Katarzyna Kaczorowska, Piotr Branski, Grzegorz Burnat, Agnieszka Chocyk, Bartosz Bobula, Piotr Gruca, Ewa Litwa, Agnieszka Palucha-Poniewiera, Agnieszka Wasik, Andrzej Pilc, Joanna Wieronska
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Behavioral Sciences
Anna Partyka, Magdalena Jastrzebska-Wiesek, Lucyna Antkiewicz-Michaluk, Jerzy Michaluk, Agnieszka Wasik, Vittorio Canale, Pawel Zajdel, Marcin Kolaczkowski, Anna Wesolowska
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
Agnieszka Wasik, Magdalena Bialon, Marcelina Zarnowska, Lucyna Antkiewicz-Michaluk
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2019)
Article
Neurosciences
Magdalena Bialon, Marcelina Zarnowska, Lucyna Antkiewicz-Michaluk, Agnieszka Wasik
PSYCHOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Magdalena Bialon, Agnieszka Chocyk, Iwona Majcher-Maslanka, Marcelina Zarnowska, Krzysztof Michalski, Lucyna Antkiewicz-Michaluk, Agnieszka Wasik
Summary: 1MeTIQ, while pharmacologically effective in reversing MK-801-induced changes in monoamine activity, did not affect the social and cognitive deficits induced by MK-801. Our FM tests and SIT did not support the main pharmacological hypotheses focusing on dopamine system stabilization and dopamine-serotonin system interactions as mechanisms for inhibiting the negative symptoms of schizophrenia.
PHARMACOLOGICAL REPORTS
(2021)
Article
Neurosciences
Agnieszka Wasik, Magdalena Bialon, Danuta Jantas, Marcelina Zarnowska
Summary: The combination treatment of MK-801 and 1MeTIQ has significant effects on cell viability, antioxidant enzyme activity, and glutamate release in the rat hippocampus. 1MeTIQ partially mitigates cell death induced by MK-801; coadministration of MK-801 and 1MeTIQ restores antioxidant enzyme activity levels compared to monotherapy.
NEUROTOXICITY RESEARCH
(2021)
Article
Neurosciences
Zofia Rogoz, Marta A. Lech, Katarzyna Chamera, Agnieszka Wasik
Summary: Recent studies have found that impaired glutathione synthesis and distorted dopaminergic transmission play significant roles in the development of schizophrenia. This study demonstrated that a combined treatment with an inhibitor of glutathione synthesis and a dopamine uptake inhibitor could maintain normal activity in the monoaminergic systems of the rat brain, particularly in the frontal cortex of 16-day-old rats.
NEUROTOXICITY RESEARCH
(2022)