Article
Biology
Akiko Ogawa, Seiya Ohira, Yuri Kato, Tatsuya Ikuta, Shota Yanagida, Xinya Mi, Yukina Ishii, Yasunari Kanda, Motohiro Nishida, Asuka Inoue, Fan-Yan Wei
Summary: The antiviral drug remdesivir used for COVID-19 treatment has been found to have cardiovascular side effects, but the underlying mechanism was unclear. Through screening and modeling, researchers discovered that remdesivir acts as a selective, partial agonist for the UTS2R receptor, leading to cardiac malfunctions. Antagonizing UTS2R signaling was found to effectively attenuate the cardiac effects of remdesivir.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yu Qi, Jianzhou Chen, Junfeng Duan, Lina Kang, Kun Wang, Ziwei Chen, Biao Xu, Rong Gu
Summary: The study found that MVP expression was upregulated in DOX-treated murine hearts. Cardiac-specific MVP overexpression can alleviate DOX-induced cardiac dysfunction, oxidative stress, and fibrosis. Mechanistically, MVP overexpression reduces cardiomyocyte apoptosis in DiCM by activating the AKT signaling pathway.
BMC CARDIOVASCULAR DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Peipei Zhang, Hao Lu, Yuan Wu, Danbo Lu, Chenguang Li, Xiangdong Yang, Zhangwei Chen, Juying Qian, Junbo Ge
Summary: Doxorubicin (DOX) can lead to mitochondrial dysfunction and heart failure. COX5A, an important regulator of mitochondrial energy metabolism, plays a protective role in DOX-induced cardiomyopathy. The expression of COX5A is decreased in patients with dilated cardiomyopathy and after DOX treatment. Overexpression of COX5A improves cardiac function, glucose uptake, mitochondrial morphology, COX activity, and ATP content in DOX-stimulated mice. COX5A protects against oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis via the PI3K/Akt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hongbin Gao, Gaopeng Xian, Guoheng Zhong, Bihong Huang, Shi Liang, Qingchun Zeng, Yungang Liu
Summary: This study suggests that miR-147-y mediates DOX-induced cardiomyocyte mitophagy while suppressing apoptosis by targeting RAPTOR, thereby playing a protective role in DOX-induced cardiomyocyte damage.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Psychology, Developmental
Craig A. Erickson, Charles R. Tessier, Christina Gross, Ernest Pedapati, Logan K. Wink, Kelli C. Dominick, Rebecca C. Shaffer, Hilary Rosselot, Michael P. Hong, Andrew P. Bantel, Elizabeth Berry-Kravis, Paul S. Horn, Ryan Adams, John A. Sweeney
Summary: This study investigated the activity of ERK1/2 in autism spectrum disorder (ASD). The results showed that lymphocytic ERK1/2 activation was faster in individuals with ASD, and this was correlated with greater social impairment. The differences in ERK1/2 activation were more pronounced in younger individuals.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
KyoungJoo Cho, Gyung Whan Kim
Summary: This study investigated the causes of selectively striatal cell loss in mice infused with 3-nitropropionic acid (3-NP). It found that mitochondrial dysfunction was higher in the striatum than in the cortex, and autophagy that may restore energy depletion occurred less in the striatum. Inhibition of ASK1 by NQDI1 regulates MAPK signaling, apoptosis, and autophagy, improving the damaged condition in the striatum.
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hidenori Kanno, Sei Naito, Yutaro Obara, Hiromi Ito, Osamu Ichiyanagi, Takafumi Narisawa, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya
Summary: ERK5 has been found to be highly expressed in clear cell renal cell carcinoma (ccRCC) and is associated with high grade, high recurrence rate, and high cancer-specific survival. The expression of ERK5 is regulated by miR-143. Inhibition of ERK5 holds promise as a potential target for ccRCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jiang Zhu, Xia Zhang, Hong Xie, Yuye Wang, Xiaoxiao Zhang, Zhaoheng Lin
Summary: This study reveals that the binding of cardiomyocyte STIM1 to GRP78 alleviates Dox cardiotoxicity by inhibiting pro-apoptotic ER stress.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Toxicology
Yujia Xie, Jixuan Ma, Meng Yang, Lieyang Fan, Weihong Chen
Summary: Silicosis is a scarring lung disease caused by inhaling fine particles of crystalline silica in the workplace. The underlying molecular mechanisms of silicosis are not fully understood, but recent studies have highlighted the role of the activated ERK signaling pathway in regulating oxidative stress, inflammatory response, fibroblast activation, and other processes involved in the formation and development of silicosis.
TOXICOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kanako Miyano, Seiya Hasegawa, Noriho Asai, Miaki Uzu, Wakako Yatsuoka, Takao Ueno, Miki Nonaka, Hideaki Fujii, Yasuhito Uezono
Summary: The Japanese herbal medicine Hangeshashinto (HST) has been shown to improve chemotherapy-induced oral ulcerative mucositis (OUM) through enhancing the migration of human oral keratinocytes (HOK) by upregulating CXCL12 via ERK.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ruoqi Yang, Guiping Zhao, Lili Zhang, Yu Xia, Huijuan Yu, Bin Yan, Bin Cheng
Summary: This study constructed an efficient and reliable multi-stage virtual screening-in vitro biological validation system to identify potential inhibitors targeting ERK2. By using machine learning models, ADME/T prediction, and molecular docking, several candidate inhibitors were identified from natural products, and one of them exhibited acceptable inhibitory activity in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Chikako Nakai, Sachiyo Mimaki, Koutatsu Matsushima, Eiji Shinozaki, Kentaro Yamazaki, Kei Muro, Kensei Yamaguchi, Tomohiro Nishina, Satoshi Yuki, Kohei Shitara, Hideaki Bando, Yutaka Suzuki, Kiwamu Akagi, Shogo Nomura, Satoshi Fujii, Masaya Sugiyama, Nao Nishida, Masashi Mizokami, Yasuhiro Koh, Takuya Koshizaka, Hideki Okada, Yukiko Abe, Atsushi Ohtsu, Takayuki Yoshino, Katsuya Tsuchihara
Summary: This study identified a BRAF L525R mutation in colorectal cancer patient, which renders cells sensitive to selumetinib and resistant to BRAF V600E. Inhibition of AKT overcomes selumetinib resistance. These findings provide important insights for identifying effective therapies.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gunng-Shinng Chen, Shiao-Pieng Lee, Shu-Fu Huang, Shih-Chi Chao, Chung-Yi Chang, Gwo-Jang Wu, Chung-Hsing Li, Shih-Hurng Loh
ARCHIVES OF ORAL BIOLOGY
(2018)
Article
Cell Biology
Shiao-Pieng Lee, Shih-Chi Chao, Shu-Fu Huang, Yen-Lin Chen, Yi-Ting Tsai, Shih-Hurng Loh
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Yi-Ting Tsai, Li-Chin Sung, Wen-Ray Haw, Chun-Chao Chen, Shu-Fu Huang, Ju-Chi Liu, Tzu-Hurng Cheng, Po-Yuan Chen, Shih-Hurng Loh, Chien-Sung Tsai
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Lei Huang, Kuo-Ho Wu, Liyong Zhang, Qinchuan Wang, Shuangbo Tang, Qiuping Wu, Pei-Hsiu Jiang, Jim Jung-Ching Lin, Jian Guo, Lin Wang, Shih-Hurng Loh, Jianding Cheng
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Surgery
Wen-Shyan Huang, Lin-Gwei Wei, Jhen-Kai Li, Keng-Yen Fu, Tai-Chun Huang, Pai-Shan Hsieh, Nien-Chi Huang, Lien-Guo Dai, Fung-Wei Chang, Shih-Hurng Loh, Yuan-Hao Chen, Bing-Heng Yang, Chia-Yang Shiau, Gwo-Jang Wu, Niann-Tzyy Dai
ANNALS OF PLASTIC SURGERY
(2019)
Article
Medical Laboratory Technology
Chun-Ming Shih, Feng-Yen Lin, Jong-Shiuan Yeh, Yi-Wen Lin, Shih-Hurng Loh, Nai-Wen Tsao, Hironori Nakagami, Ryuichi Morishita, Tatsuya Sawamura, Chi-Yuan Li, Cheng-Yen Lin, Chun-Yao Huang
TRANSLATIONAL RESEARCH
(2019)
Article
Cell & Tissue Engineering
Shih-Chi Chao, Gwo-Jang Wu, Shu-Fu Huang, Niann-Tzyy Dai, Hsu-Kai Huang, Mei-Fang Chou, Yi-Ting Tsai, Shiao-Pieng Lee, Shih-Hurng Loh
WORLD JOURNAL OF STEM CELLS
(2018)
Article
Medical Laboratory Technology
Yi-Ting Tsai, Feng-Yen Lin, Chin-Sheng Lin, Shih-Hurng Loh, Chi-Yuan Li, Cheng-Yen Lin, Yi-Wen Lin, Chien-Sung Tsai
TRANSLATIONAL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Oscar C. Y. Yang, Shih-Hurng Loh
SCIENTIFIC REPORTS
(2019)
Article
Integrative & Complementary Medicine
Hsu-Kai Huang, Shin-Yi Lee, Shu-Fen Huang, Yu-San Lin, Shih-Chi Chao, Shu-Fu Huang, Shih-Chun Lee, Tzu-Hurng Cheng, Shih-Hurng Loh, Yi-Ting Tsai
AMERICAN JOURNAL OF CHINESE MEDICINE
(2020)
Article
Oncology
Shih-Hurng Loh, Yi-Ting Tsai, Shu-Fu Huang, Tien-Chieh Yu, Pei-Chun Kuo, Shih-Chi Chao, Mei-Fang Chou, Chien-Sung Tsai, Shiao-Pieng Lee
Article
Biochemistry & Molecular Biology
Shih-Hurng Loh, Chung-Yi Chang, Shu-Fu Huang, Shih-Chi Chao, Wei-Kuo Lin, Eagle Yi-Kung Huang, Chien-Sung Tsai, Yi-Ting Tsai
Article
Cell Biology
Yi-Ting Tsai, Shih-Hurng Loh, Chung-Yi Lee, Shiao-Ping Lee, Yen-Lin Chen, Tzu-Hurng Cheng, Chien-Sung Tsai
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Oncology
Yi-Wen Lin, Chun-Yao Huang, Chun-Min Shih, Yi-Ting Tsai, Chin-Sheng Lin, Chih-Yuan Lin, Chi-Yuan Li, Shih-Hurng Loh, Cheng-Yen Lin, Feng-Yen Lin, Chien-Sung Tsai
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2018)
Article
Cell Biology
Hung-Hsing Chao, Po-Yuan Chen, Wen-Rui Hao, Wei-Ping Chiang, Tzu-Hurng Cheng, Shih-Hurng Loh, Yuk-Man Leung, Ju-Chi Liu, Jin-Jer Chen, Li-Chin Sung
JOURNAL OF BIOMEDICAL SCIENCE
(2017)