Article
Toxicology
Tz-ju Hong, Chandrasekar Sivakumar, Chih-Wei Luo, Mon-Shu Ho
Summary: Nanoparticles are widely present in the environment and have been extensively studied for their impact on cells. The size of TiO2 nanoparticles determines their effect on cell growth, with smaller particles promoting uncontrolled cell growth and larger particles suppressing cell growth. The internalization of nanoparticles also affects the cell's cytoskeleton.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Emergency Medicine
Shaobin Huang, Wuguo Deng, Yunxian Dong, Zhicheng Hu, Yi Zhang, Peng Wang, Xiaoling Cao, Miao Chen, Pu Cheng, Hailin Xu, Wenkai Zhu, Bing Tang, Jiayuan Zhu
Summary: The study found that melatonin can inhibit the growth and migration of keloid fibroblasts, suppress collagen production, and inhibit the cAMP/PKA/Erk and Smad signaling pathways through the MT2 membrane receptor. Combination with 5-fluorouracil can enhance the inhibitory effects.
Article
Cell Biology
Jinhuan Wu, Yuping Chen, Rui Li, Yaping Guan, Mu Chen, Hui Yin, Xiaoning Yang, Mingpeng Jin, Bingsong Huang, Xin Ding, Jie Yang, Zhe Wang, Yiming He, Qianwen Wang, Jian Luo, Ping Wang, Zhiyong Mao, Michael S. Y. Huen, Zhenkun Lou, Jian Yuan, Fanghua Gong
Summary: The study reveals that CDK2 regulates the ERK pathway through USP37, promoting cancer cell proliferation. Additionally, the combination of CDK1/2 and EGFR inhibitors shows a synergistic anticancer effect by reducing the stability and activity of ERK1/2.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Tsuyoshi Hirashima, Naoya Hino, Kazuhiro Aoki, Michiyuki Matsuda
Summary: This article reviews the critical regulatory role of extracellular signal-regulated kinase (ERK) in various physiological and pathological processes and highlights the signaling mechanisms governing ERK activation via biochemical regulations with upstream molecules, particularly receptor tyrosine kinases (RTKs). However, recent research has revealed the role of mechanical forces in activating the RTK-ERK signaling pathways, opening new avenues of research into mechanochemical interplay in multicellular tissues.
CURRENT OPINION IN CELL BIOLOGY
(2023)
Article
Microbiology
Monique Michels, Emily Corneo, Luana Bezerra Goncalves Rocha, Rodrigo Dias, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Felipe Dal-Pizzol, Gabriel Fernandes Alves Jesus
Summary: This study aimed to evaluate the potential and specificity of Microbe-Associated Molecular Patterns (MAMPs) in inflammatory and antioxidant response in NIH-3T3 fibroblast cells and wound healing process. The findings showed that MAMPs significantly promoted wound healing and exhibited specific effects in anti-inflammatory and antioxidant activities.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Marian N. Aziz, Linh Nguyen, Yan Chang, Delphine Gout, Zui Pan, Carl J. Lovely
Summary: The discovery of a new class of extracellular-signal-regulated kinase (ERK) inhibitors was achieved through the development of novel 2-imino-5-arylidene-thiazolidine analogues. These targeted thiazolidines were synthesized using a solid support-mediated reaction and showed good chemical and physical stability. The best compound among the synthesized library, (Z)-5-((Z)-4-bromobenzylidene)-N-(4-methoxy-2-nitrophenyl)-4,4-dimethylthiazolidin-2-imine (6g), demonstrated high selectivity in cell viability assays and selective inhibition of phosphorylation in the ERK pathway. Molecular modeling techniques confirmed the observed activity and suggested potential for the development of bioactive 2-imino-5-arylidene-thiazolidines.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Psychiatry
Hiram Tendilla-Beltran, Heriberto Coatl-Cuaya, Silvia Meneses-Prado, Ruben Antonio Vazquez-Roque, Eduardo Brambila, Miguel Tapia-Rodriguez, David Martin-Hernandez, Linda Garces-Ramirez, Jose L. M. Madrigal, Juan C. Leza, Gonzalo Flores
Summary: Increased dopaminergic activity in the striatum is associated with psychotic symptoms in schizophrenia. Risperidone treatment in adult rats with neonatal ventral hippocampus lesion improved neuronal atrophy and dendritic spine morphology impairments in the ventral striatum, while also normalizing pro-inflammatory pathways and inducing antioxidant activity. This suggests that Risperidone has neurotrophic, anti-inflammatory, and antioxidant effects in addition to its canonical antipsychotic mechanism.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jinho Park, Pavlo Kravchuk, Adithi Krishnaprasad, Tania Roy, Ellen Hyeran Kang
Summary: Actin plays critical roles in cellular functions, and graphene enhances actin filament growth and modulates cell morphology and spreading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Minmin Sun, Yaoting Ji, Shuhui Zhou, Rourong Chen, Hantao Yao, Minquan Du
Summary: This study demonstrates that ginsenoside Rb3 has the potential to inhibit osteoclastogenesis and attenuate gingivitis and alveolar bone resorption. Mechanistically, Rb3 achieves this by suppressing the activation of the ERK/NF-kappa B signaling pathway.
Article
Biochemistry & Molecular Biology
Balik Dzhambazov, Tsvetelina Batsalova, Patrick Merky, Franziska Lange, Rikard Holmdahl
Summary: This study investigates the impact of different types of fibroblasts on the pathogenesis of rheumatoid arthritis (RA). The results show that only NIH/3T3 fibroblasts can activate T-cell hybridomas specific for the RA-associated autoantigen COL2, while other types of fibroblasts cannot. This activation occurs through contact-dependent intercellular interactions and the T-cell receptor (TCR) complex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Barathi Balasubramonian, Kyle W. Selcer
Summary: This study found that curcumin competitively inhibits the enzyme steroid sulfatase (STS) in rat liver and NIH-3T3 mouse fibroblast cells, resulting in lower levels of active steroid hormones (estrogens and androgens) in tissues, possibly altering the modulation of immune responses by these steroids.
Article
Chemistry, Medicinal
Debora Bublitz Anton, Julia Galvez Bulhoes Pedreira, Maria Luiza Zvirtes, Stefan A. Laufer, Rodrigo Gay Ducati, Marcia Goettert, Luis Fernando Saraiva Macedo Timmers
Summary: The SARS-CoV-2 virus has caused a global pandemic, infecting over 688 million people and resulting in around 6.8 million deaths. The virus induces lung inflammation and the release of pro-inflammatory cytokines, making anti-inflammatory therapies important in addition to antiviral drugs. The main protease (MPro) of SARS-CoV-2 is a potential drug target as it is essential for viral replication. In this study, six kinase inhibitors were evaluated for their inhibitory activity against SARS-CoV-2 MPro, and BIRB-796 and Baricitinib were identified as potential inhibitors with dual antiviral and anti-inflammatory activity.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Biochemistry & Molecular Biology
Senem Aykul, Jordan Maust, Vijayalakshmi Thamilselvan, Monique Floer, Erik Martinez-Hackert
Summary: The study revealed the significant regulatory role of TGF-beta family growth factors and inhibitors in adipocyte development, with SMAD1/5/8 signaling playing a crucial role in 3T3-L1 adipogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yuna Du, Huiqing Zhang, Yujie Guo, Kuangyu Song, Lifeng Zeng, Yiguo Chen, Zhengyu Xie, Rong Li
Summary: The study found that CD38(-/-) mice injected with Escherichia coli resulted in more severe pulmonary injuries and higher levels of cytokine mRNA expressions. CD38 deficiency increased the expressions of IL-1 beta and MCP-1 and aggravated pulmonary injury through the TLR4/ERK/NF-kB signaling pathway in sepsis.
MICROBES AND INFECTION
(2021)
Article
Cell Biology
Dongmei Zhang, Yunzhen Zhou, Yanan Ma, Ping Jiang, Hongchao Lv, Sijia Liu, Yu Mu, Chong Zhou, Shan Xiao, Guohua Ji, Peng Liu, Ning Zhang, Donglin Sun, Haiming Sun, Nan Wu, Yan Jin
Summary: In hepatocellular carcinoma (HCC), the overexpression of ribosomal protein L22-like1 (RPL22L1) is associated with malignancy and poor patient survival. RPL22L1 promotes cell proliferation, migration, invasion, and sorafenib resistance through activating ERK and inducing atypical epithelial-to-mesenchymal transition. The use of an ERK inhibitor enhances the efficacy of sorafenib in HCC patients with high RPL22L1 expression.
CELL DEATH DISCOVERY
(2022)
Article
Orthopedics
Yiyang Ma, Kaiwen Zheng, Yidan Pang, Fuzhou Xiang, Junjie Gao, Changqing Zhang, Dajiang Du
Summary: This study demonstrates that synovium-derived stromal cells (SDSCs) can help coastal chondrocytes (CCs) maintain their chondrogenic phenotype and suppress hypertrophic differentiation in cartilage repairs through both direct and indirect coculture experiments. The presence of SDSCs in osteochondral defects promotes good restoration effects and lower expression levels of type X collagen, suggesting a potential role for SDSCs in cartilage repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Orthopedics
Lenian Zhou, Hongyi Zhu, Shanyi Lin, Hanqiang Jin, Zhaoyuan Zhang, Yang Dong, Qingcheng Yang, Changqing Zhang, Ting Yuan
Summary: Extended curettage has become the preferred treatment for GCTB, but the high recurrence rate poses a challenge. CT is valuable in evaluating GCTB around the knee. Age, DTA (<2mm), and DPC were significant factors for recurrence prediction after extended curettage in a three-factor model.
INTERNATIONAL ORTHOPAEDICS
(2022)
Review
Biotechnology & Applied Microbiology
Haoyu Fang, Daoyu Zhu, Qianhao Yang, Yixuan Chen, Changqing Zhang, Junjie Gao, Youshui Gao
Summary: Bones are highly sophisticated tissues with remarkable potential for regeneration. Novel biomaterials designed to mimic bone microenvironment have significantly accelerated bone healing. These biomaterials are categorized as zero-dimensional to four-dimensional based on their dimensional structure and functional mechanism.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Yu Miao, Yiwei Chen, Feng Xue, Kexin Liu, Bin Zhu, Junjie Gao, Junhui Yin, Changqing Zhang, Guangyi Li
Summary: This study demonstrated the presence of ferroptosis in osteoarthritis (OA) and identified glutathione peroxidase 4 (GPX4) as a crucial regulator of OA. By downregulating GPX4 expression, the crosstalk between ferroptosis and extracellular matrix degradation pathways influenced the progression of OA.
Article
Biotechnology & Applied Microbiology
Di Wu, Hao Qin, Zixuan Wang, Mingzhao Yu, Zhe Liu, Hao Peng, Leilei Liang, Changqing Zhang, Xiaojuan Wei
Summary: This study developed injectable thermosensitive hydrogel-encapsulated small extracellular vesicles (sEVs) that displayed excellent biocompatibility and enhanced bone regeneration. Mechanistic studies revealed that exosomal miR-21 targeted SPRY2, thereby promoting angiogenesis. This research provides new insights and potential for tissue repair in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Biomaterials
Junjie Gao, Hong Mei, Jing Sun, Hao Li, Yuege Huang, Yanhong Tang, Linwei Duan, Delin Liu, Yidan Pang, Qiyang Wang, Youshui Gao, Ke Song, Jincun Zhao, Changqing Zhang, Jia Liu
Summary: SARS-CoV-2 infection may impair the skeletal system and disrupt the differentiation of bone marrow-derived macrophages into osteoclasts. The study also found that entry of SARS-CoV-2 into macrophages depends on the expression of neuropilin-1 (NRP1).
Correction
Nanoscience & Nanotechnology
Junhui Yin, Shanshan Pan, Xiang Guo, Youshui Gao, Daoyu Zhu, Qianhao Yang, Junjie Gao, Changqing Zhang, Yu Chen
NANO-MICRO LETTERS
(2022)
Review
Endocrinology & Metabolism
Siyuan Zhu, Yidan Pang, Jun Xu, Xiaoyi Chen, Changqing Zhang, Bo Wu, Junjie Gao
Summary: Thyroid hormones play significant roles in bone growth and development, and an imbalance of thyroid hormones can impair bone homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Chunying Yang, Yidan Pang, Yigang Huang, Fang Ye, Xiaoyi Chen, Youshui Gao, Changqing Zhang, Lufeng Yao, Junjie Gao
Summary: This study investigates the effects of TERC deficiency on aging-related phenotypes in brain and bone marrow. The results show that TERC deficiency accelerates aging, leading to inflammation, suppression of neuron development, and activation of myeloid cells in both brain and bone marrow. The findings also highlight potential targets for therapy in age-related brain-bone diseases.
Article
Cell & Tissue Engineering
Kaiwen Zheng, Yiyang Ma, Cheng Chiu, Yidan Pang, Junjie Gao, Changqing Zhang, Dajiang Du
Summary: The study showed that direct co-culture of rat costal chondrocytes and human Wharton's jelly mesenchymal stem cells can effectively promote chondrogenesis and reduce hypertrophic tendency, demonstrating promising results both in vitro and in vivo experiments.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
D. Zhu, H. Fang, H. Yu, P. Liu, Q. Yang, P. Luo, C. Zhang, Y. Gao, Y-X. Chen
Summary: This study demonstrates that the miR-19a-3p/FOXF2 axis plays a pivotal role in alcohol-impaired fracture healing and may be a potential therapeutic target.
BONE & JOINT RESEARCH
(2022)
Article
Geriatrics & Gerontology
Jinhui Zhao, Qianying Cai, Dajun Jiang, Lingtian Wang, Haiyan He, Shengbao Chen, Weitao Jia, Changqing Zhang
Summary: During the COVID-19 pandemic, elderly patients with hip fractures had a poorer prognosis despite testing negative for COVID-19. Factors such as timely admission, postoperative follow-up, and rehabilitation were found to significantly improve the prognosis of elderly COVID-19 negative patients with hip fractures.
CLINICAL INTERVENTIONS IN AGING
(2022)
Article
Engineering, Biomedical
Yu-Wei Ge, Min Chu, Zi-Yang Zhu, Qin-Fei Ke, Ya-Ping Guo, Chang-Qing Zhang, Wei -Tao Jia
Summary: A novel CEF/Fe3O4/HA/CS/PQQ layered scaffold with magnetically oriented micro-cellulose fibres was developed. The scaffold exhibited enhanced compressive properties and could suppress inflammatory response and osteoclast differentiation, while promoting new blood vessel formation and collagen-I fibre processing.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Zhe Liu, Qian Tang, Ruo-Tao Liu, Ming-Zhao Yu, Hao Peng, Chang-Qing Zhang, Zhen-Zhong Zhu, Xiao-Juan Wei
Summary: This article investigates the molecular mechanism and preventive strategies for implant failure in patients using long-term glucocorticoids. A customized implant targeting WNT16 was constructed using a self-assembly coating, which was found to promote bone cell growth and integration while also exhibiting antibacterial properties.
BIOACTIVE MATERIALS
(2023)
Correction
Cell & Tissue Engineering
Peng Ding, Qiyuan Tan, Zhanying Wei, Qiyu Chen, Chun Wang, Luyue Qi, Li Wen, Changqing Zhang, Chen Yao
