Article
Biochemistry & Molecular Biology
Tamas Kovacs-Oller, Renata Zempleni, Boglarka Balogh, Gergely Szarka, Balint Fazekas, Adam J. Tengolics, Krisztina Amrein, Endre Czeiter, Istvan Hernadi, Andras Buki, Bela Volgyi
Summary: Traumatic brain injury (TBI) is a major cause of sudden death after head trauma. The retina, as part of the brain, can also be affected by TBI, both in severe and mild-repetitive cases. Our study found that the level of inflammation and cell death in the retina differs between sTBI and rmTBI, indicating different response mechanisms. Therefore, the retina may serve as a model for studying head injuries and developing new diagnostic procedures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Boglarka Balogh, Gergely Szarka, Adam J. Tengolics, Gyula Hoffmann, Bela Volgyi, Tamas Kovacs-Oller
Summary: The study found that exposure to LED light increased levels of major apoptosis-related markers and activated microglial cells and Caspase-3, suggesting that overuse of unfiltered direct LED light can have detrimental effects on human retina.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Maria I. Avrutsky, Carol M. Troy
Summary: Caspase-9, known for its role in apoptosis initiation, also plays a role in cellular differentiation, immune response, and mitochondrial function, and is linked to various diseases. Targeting supraphysiological Caspase-9 activation could be a viable approach for therapeutic interventions. However, there are still gaps in understanding the mechanistic implications of Caspase-9 in different pathologies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Kuebra Demirci Kucuk, Ecem Onder Tokuc, Aysegul Aciksari, Gokhan Duruksu, Yusufhan Yazir, Veysel Levent Karabas
Summary: The study investigated the anti-apoptotic and antioxidant effects of crocetin on an oxidative damage model of ARPE-19 cells. It was found that a dose of 10 mu M crocetin had the most effective impact on cell viability. This dose of crocetin improved the activities of SOD and GSH, reduced MDA level, and downregulated the expression of Bax1 and Nrf2 while upregulating Bcl-2 expression.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Hongxing Guo, Chenyu Ruan, Xiuhong Zhan, Hao Pan, Yumei Luo, Ke Gao
Summary: This study demonstrates that crocin can protect LO2 cells from TGF-beta-induced injury by promoting proliferation and autophagy, suppressing apoptosis and anti-inflammation, and regulating the AMPK/m-TOR signaling pathway.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Ophthalmology
Shubha Subramanya, Roshini Fernando, Moloy Goswami, Cagri G. Besirli, Eric Weh, Thomas J. Wubben
Summary: Researchers have developed flow cytometry-based assays to detect and quantify retinal cell death, which can also evaluate oxidative stress and neuroprotective agents. These methods increase efficiency and reduce analysis time without compromising sensitivity, making them valuable for studying retinal cell neuroprotection.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yadi Zheng, Na Zhu, Jing Wang, Na Zhao, Chun Yuan
Summary: The study demonstrated the protective effect of crocetin against STZ-induced GDM in rats by suppressing inflammatory, oxidative, and apoptosis parameters. Crocetin showed antioxidant and anti-inflammatory effects and could be used as a preventive medication for gestational diabetes mellitus.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Consiglia Trotta, Sami Gharbia, Hildegard Herman, Bianca Mladin, Andrei Hermenean, Cornel Balta, Coralia Cotoraci, Victor Eduard Peteu, Carlo Gesualdo, Francesco Petrillo, Marilena Galdiero, Roberto Alfano, Mihaela Gherghiceanu, Michele D'Amico, Settimio Rossi, Anca Hermenean
Summary: The study found that aged mice had decreased endogenous levels of RvD1 in the retina, as well as sex-related differences in neuroinflammation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Asal Moradi, Mohammadreza Abdihaji, Sara Barari Kouchaksaraie, Tabarek Abdulrazaq Alkinani, Aida Mahmoudi, Arash Davoudi, William Dashtmiani, Somayeh Mikaeili Ghezeljeh, Shahrzad Aghajani, Reza Ghasemian, Somayeh Maghsoomi Taramsari, Amitis Majlesi, Zahra Mahdavi Niyaki, Ali Salehzadeh
Summary: The study aimed to fabricate Bi2O3/Gln-TSC nanoparticles and investigate their anticancer mechanism. The results showed that Bi2O3/Gln-TSC had significant cytotoxicity against prostate cancer cells and induced apoptosis.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Rosa Manca, Monia Delia, Marianna Abate, Silvia Zappavigna, Sergio Papa, Chester Glomski, Alessandra Pica
Summary: Apoptosis, programmed cell death, plays a central role in haematopoiesis. This study investigates the expression and subcellular distribution of Bcl-2, Bcl-X-L, and Bax proteins in nucleated erythrocytes and the effect of X-ray irradiation on these cells. The results demonstrate the role of these proteins in the maturation of erythrocytes.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Matthias Kist, Domagoj Vucic
Summary: In recent years, research has identified various forms of cell death, each relying on different proteins for activation. Many pathways share components and signaling principles, working together rather than independently. Several cell death regulators are linked to human diseases and may be potential therapeutic targets.
Article
Medicine, General & Internal
Aleksandra Mielczarek-Palacz, Sylwia Jasinska, Anna Strzelec
Summary: Ovarian cancer is a major issue in gynecological oncology, and research on diagnostic markers like caspase-3, -8, and -9 is ongoing. This study found significantly decreased levels of these caspases in ovarian cancer patients compared to healthy controls, suggesting a link to immune system disturbances and potential for future diagnostic use, pending further research.
Review
Pharmacology & Pharmacy
Zi-Liang Guo, Mao-Xing Li, Xiao-Lin Li, Peng Wang, Wei-Gang Wang, Wei-Ze Du, Zhi-Qiang Yang, Sheng-Fu Chen, Di Wu, Xiu-Yu Tian
Summary: Crocetin, an active metabolite found in saffron, exhibits diverse pharmacological activities and its application is broadened through derivatization and formulation technologies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Tomoyo Imamura, Kazuhiro Tsuruma, Yuki Inoue, Tomohiro Otsuka, Yuta Ohno, Shiho Ogami, Shinsaku Yamane, Masamitsu Shimazawa, Hideaki Hara
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Medical Laboratory Technology
Yuta Ohno, Takashi Niwa, Keita Hirai, Keiko Suzuki, Yuto Yamada, Yuichi Hayashi, Hideki Hayashi, Akio Suzuki, Yoshinori Itoh
THERAPEUTIC DRUG MONITORING
(2018)
Article
Pharmacology & Pharmacy
Yuto Yamada, Yuta Ohno, Takashi Niwa, Hiroko Kato-Hayashi, Hideki Hayashi, Takashi Ibuka, Hiroshi Araki, Tadashi Sugiyama, Masahito Shimizu, Akio Suzuki
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2019)
Article
Physiology
Yusuke Otsuka, Tomomi Furihata, Kiyoshi Nakagawa, Yuta Ohno, Yoshie Reien, Motoshi Ouchi, Hidefumi Wakashin, Shuichi Tsuruoka, Naohiko Anzai
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2019)
Article
Oncology
Yuto Yamada, Yuta Ohno, Yu Kato, Ryo Kobayashi, Hideki Hayashi, Shiho Miyahara, Keita Nakane, Kosuke Mizutani, Shigeaki Yokoi, Hironori Fujii, Hirotoshi Iihara, Takuma Ishihara, Takashi Deguchi, Tadashi Sugiyama, Akio Suzuki
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2019)
Article
Neurosciences
Shohei Tsuji, Yuta Ohno, Shinsuke Nakamura, Tetsuya Yamada, Yasuhiro Noda, Masanao Saio, Toru Iwama, Masamitsu Shimazawa, Hideaki Hara
Article
Neurosciences
Yuta Ohno, Keitaro Satoh, Akiko Shitara, Takeshi Into, Masanori Kashimata
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Pharmacology & Pharmacy
Kentaro Okunushi, Tomomi Furihata, Hanae Morio, Yasuhide Muto, Kosuke Higuchi, Meika Kaneko, Yusuke Otsuka, Yuta Ohno, Yasuhiro Watanabe, Yoshie Reien, Kiyoshi Nakagawa, Shinichi Sakamoto, Hidefumi Wakashin, Naoki Shimojo, Naohiko Anzai
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Yuta Ohno, Tomohiro Yako, Keitaro Satoh, Haruna Nagase, Akiko Shitara, Hideaki Hara, Masanori Kashimata
Summary: This study demonstrates that retinal damage can alter gene expression in the lacrimal glands, potentially providing a novel non-invasive screening method for early detection of retinal diseases.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Kenjirou Ogawa, Karin Urata, Saki Maeda, Yuta Ohno, Keitaro Satoh, Yoshiyuki Yamada, Yosuke Suzuki, Yasuko Koga, Kazuhiro Sugamoto, Makiko Kawaguchi, Hisato Kunitake, Kazuo Nishiyama, Yo Goto, Takayuki Nakayama, Masao Yamasaki
Summary: This study evaluated the effect of blueberry leaf hot water extract (BLEx) on lacrimal hyposecretion in NOD mice. The results showed that BLEx increased tear secretion and suppressed autophagy, thereby improving Sjogren's syndrome.
Review
Dentistry, Oral Surgery & Medicine
Yuta Ohno, Keitaro Satoh, Masanori Kashimata
Summary: This review presents the findings from RNA-sequencing analysis of lacrimal glands in male non-obese diabetic (NOD) mice, revealing the exocrine features and dysregulated genes. Male NOD mice show worsening lacrimal hyposecretion and dacryoadenitis, while females exhibit a complex pathophysiological condition. The identified regulated genes may serve as potential therapeutic targets for Sjogren's syndrome.
JOURNAL OF ORAL BIOSCIENCES
(2023)
Article
Medicine, Research & Experimental
Kenjirou Ogawa, Yuta Ohno, Akane Tagashira, Karin Urata, Keitaro Satoh, Naruki Fujimoto, Hiroko Sonoda, Masahiro Ikeda, Toshiyuki Matsuzaki, Kazuo Nishiyama, Hisato Kunitake, Yo Goto, Masao Yamasaki
Summary: This study investigated the effect of blueberry stem water extract (BStEx) on lacrimal hyposecretion in NOD mice. The results showed that BStEx prevented lacrimal hyposecretion in male NOD mice, possibly by opening tight junctions via the activation of AMPK in lacrimal acinar cells.
Article
Medicine, Research & Experimental
Keisuke Adachi, Yuta Ohno, Keitaro Satoh, Akiko Shitara, Yasunori Muramathu, Masanori Kashimata
Article
Microbiology
Midori Soda, Shin Ito, Naoki Matsumaru, Sakiko Nakamura, Izumi Nagase, Hikari Takahashi, Yuta Ohno, Mitsuru Yasuda, Miho Yamamoto, Katsura Tsukamoto, Yoshinori Itoh, Takashi Deguchi, Kiyoyuki Kitaichi
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Pharmacology & Pharmacy
Yuta Ohno, Yusuke Otsuka, Masakatsu Nohara, Tomomi Furihata, Yoshiki Kuse, Yoshinori Itoh, Hideaki Hara, Naohiko Anzai
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2017)