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Biochemistry & Molecular Biology
Seong Hoon Kim, Hye-Won Yum, Seung Hyeon Kim, Su-Jung Kim, Kyeojin Kim, Chaekyun Kim, Young-Ger Suh, Young-Joon Surh
Summary: Taurine chloramine (TauCl) can effectively protect the skin from photodamage by reducing oxidative damage, apoptotic cell death, and inflammation. This protective effect is associated with inhibition of STAT3 activation and induction of antioxidant enzymes.
Article
Pharmacology & Pharmacy
Jun-Way Chang, Yen-You Lin, Chun-Hao Tsai, Shan-Chi Liu, Xiu-Yuan He, Yi-Syuan Wu, Chien-Chung Huang, Chih-Hsin Tang
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune cell activation and chronic inflammation in the synovium, leading to joint destruction. Nesfatin-1, an adipokine, has been found to be increased in RA synovium and associated with proinflammatory cytokines.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Food Science & Technology
Yunhui Min, Yunji Heo, Fang Feng, Dahye Kim, Mangeun Kim, Jiwon Yang, Hyo Jin Kim, Youngheun Jee, Mrinmoy Ghosh, Inhae Kang, Young-Ok Son
Summary: Excessive consumption of sucrose leads to hepatic fibrosis and inflammation, increasing the risk of rheumatoid arthritis (RA) pathogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shih-Yao Chen, Ting-Chien Tsai, Yuan-Tsung Li, Yun-Chiao Ding, Chung-Teng Wang, Jeng-Long Hsieh, Chao-Liang Wu, Po-Ting Wu, Ai-Li Shiau
Summary: This study demonstrates that IL-23 promotes osteoclastogenesis through transcriptional regulation of miR-223 in murine macrophages and mice with CIA. Furthermore, the study suggests that LSF, a selective inhibitor of STAT4, could be an ideal therapeutic agent for treating rheumatoid arthritis by reducing miR-223-mediated osteoclastogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Hao Yuan, Si-Xian Wu, Yi-Feng Zhou, Fang Peng
Summary: The study demonstrates that SPD can protect CIA mice by inhibiting the polarization of M1 macrophages, reducing pro-inflammatory cytokines, and promoting the release of anti-inflammatory factors.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yanbei Tu, Lihua Tan, Tao Lu, Kai Wang, Haiyong Wang, Bing Han, Yuxin Zhao, Hanbin Chen, Yanfang Li, Haixia Chen, Meiwan Chen, Chengwei He
Summary: The newly reported coumestan Glytabastan B (GlyB) from Glycine tabacina has been found to effectively attenuate inflammation and bone destruction in rheumatoid arthritis. It works by blocking the activation of multiple signaling pathways.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
G. Halpert, I. Katz, O. Shovman, S. Tarasov, K. K. Ganina, N. Petrova, M. Tocut, A. Volkov, I. Barshack, M. Blank, H. Amital
Summary: Treatment with IVIG significantly reduced clinical arthritis score in DBA/1j mice with collagen-induced arthritis. IVIG showed a mode of action by decreasing circulating levels of inflammatory cytokines and inhibiting anti-collagen antibodies. Histopathological examination revealed that IVIG treatment prevented inflammatory immune cells from migrating into cartilage and synovium, reducing joint damage and preserving joint architecture. These results suggest the valuable anti-inflammatory treatment of IVIG in experimental RA.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ayda Henriques Schneider, Thaise Mayumi Taira, Gabriel Azevedo Publio, Douglas da Silva Prado, Paula Barbim Donate Yabuta, Jessica Cristina dos Santos, Caio Cavalcante Machado, Flavio Falcao Lima de Souza, Lucas Gabriel Rodrigues Venturini, Rene Donizeti Ribeiro de Oliveira, Thiago Mattar Cunha, Jose Carlos Alves-Filho, Paulo Louzada-Junior, Tarcilia Aparecida da Silva, Sandra Yasuyo Fukada, Fernando Queiroz Cunha
Summary: The study found that patients with rheumatoid arthritis had higher levels of NETs in synovial fluid, and inhibiting NETs could be a potential strategy to reduce bone erosion in arthritis patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kaja Kasarello, Iwona Koehling, Anna Kosowska, Katarzyna Pucia, Anna Lukasik, Agnieszka Cudnoch-Jedrzejewska, Leszek Paczek, Urszula Zielenkiewicz, Piotr Zielenkiewicz
Summary: Cross-kingdom gene expression regulation by xenomiRs, particularly from plants, has been found to have potential scientific significance. In this study, miR172a derived from Brassica oleracea was shown to decrease the levels of FAN protein in human and mouse cells. Furthermore, treatment with miR172a was found to mitigate inflammation in a mouse model of rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Ju-Young Kim, Yoon-Hee Cheon, Sung-Jun Ahn, Sung Chul Kwak, Chong Hyuk Chung, Chang Hoon Lee, Myeung Su Lee
Summary: The study demonstrates the beneficial effects of HAR on local symptoms and systemic bone erosion triggered by inflammatory arthritis, showing reduced clinical scores and incidence rates of CIA, localized improvements in bone and cartilage destruction, and inhibition of inflammatory cytokines expression.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Biochemistry & Molecular Biology
Ziyu Wang, Zijian Li, Guojue Wang, Ying Sun, Yuanyang Yuan, Hong Nie
Summary: Salubrinal treatment in CIA mice effectively reduces clinical scores, inhibits joint damage, and decreases the expression of destruction-related genes, showcasing its potential as a drug for RA and other bone destruction-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Richard Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Summary: This study characterizes clusters of RA cell lines with distinctive TF biology by integrating transcriptomic and epigenomic data and validates the predicted differences.
NATURE COMMUNICATIONS
(2022)