Article
Biology
Nagarajan Theruveethi, Bang Viet Bui, Manjunath B. Joshi, Manna Valiathan, Shonraj Ballae Ganeshrao, Sivakumar Gopalakrishnan, Shama Prasada Kabekkodu, Shailaja S. Bhat, Sudarshan Surendran
Summary: Blue light exposure can cause retinal damage and changes in visual cortex neurons, while blue light-blocking lenses can alleviate these damages.
Article
Multidisciplinary Sciences
Rong Rong, Rongliang Yang, Haibo Li, Mengling You, Zhuotao Liang, Zhou Zeng, Rongrong Zhou, Xiaobo Xia, Dan Ji
Summary: The study elucidated the association between mitochondrial dysfunction and the NLRP3 inflammasome in retinal cell death caused by light, triggering a series of inflammatory cascade reactions resulting in pyroptosis. Treatment with red light and Drp1 inhibitors partially ameliorated retinal damage and visual function decline from white light exposure.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Letter
Ophthalmology
Huanyu Liu, Yuan Yang, Jingli Guo, Jie Peng, Peiquan Zhao
Summary: This case report examines the retinal damage caused by repeated low-level red-light laser exposure in a 12-year-old female patient with myopia.
JAMA OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kitako Tabata, Eriko Sugano, Akito Hatakeyama, Yoshito Watanabe, Tomoya Suzuki, Taku Ozaki, Tomokazu Fukuda, Hiroshi Tomita
Summary: The study demonstrated that retinal ganglion cells were photosensitive after the transduction of optogenetic genes and did not induce any phototoxicity following exposure to continuous light.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Natalia Ziolkowska, Bogdan Lewczuk, Natalia Szyrynska, Aleksandra Rawicka, Alla Vyniarska
Summary: This study examined the impact of low-intensity blue light on the albino Wistar rat retina, specifically the intrinsically photosensitive retinal ganglion cells (ipRGCs). Different exposure patterns of blue light were tested, and the results showed that prolonged exposure to low-intensity blue light caused damage to the retinas of the rats. This damage included decreased dendrite length, reduced immunoreactivity, changes in dendritic arborization, increased GFAP immunoreactivity, and apoptosis.
Article
Multidisciplinary Sciences
Kuangqi Chen, Le Jin, Yingying Wen, Qianjie Yang, Xiang Li, Liyue Zhang, Liyin Wang, Yutong Xia, Zhitong Chen, Chen Xie, Jianping Tong, Ye Shen
Summary: This study investigated the long-term effects of pollution from different wavelengths of light on the corneal epithelium and identified potential biomarkers. The downregulation of VCAM1 in response to blue light pollution was observed, leading to inhibited migration, increased ROS levels and apoptosis, and inhibited AKT/p70 S6 kinase cascade. Animal experiments confirmed similar effects on the rabbit cornea. Light pollution may impair the corneal epithelium and wound healing, and promote intracellular and extracellular ROS and apoptosis.
Article
Biochemistry & Molecular Biology
Rujun Jin, Ying Li, Hui Jin, Hee Su Yoon, Ji Suk Choi, Jonghwa Kim, Hyeon Jeong Yoon, Kyung Chul Yoon
Summary: The expression of MT2 in mouse cornea can be induced by blue light exposure, and the activation of MT2 can regulate corneal epithelial damage induced by blue light exposure by increasing the expression of BAX.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ze-Hua Xu, Hang Zhang, Chang-Jun Zhang, Si-Jian Yu, Jing Yuan, Kangxin Jin, Zi-Bing Jin
Summary: With the increasing use of artificial light and optoelectronic products, light damage (LD) to the human retina has become a global issue. This study investigated the mechanism of how blue light leads to photoreceptor death and found that regenerating islet-derived 1 alpha (REG1A) prevents LD-induced apoptosis in photoreceptor cells by increasing the expression of the anti-apoptotic gene Bcl2 and decreasing the expression of the pro-apoptotic gene Bax. REG1A restores mitochondrial function and cell apoptosis after LD-induced damage, suggesting its potential application in the prevention and treatment of retinal vision loss.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Genetics & Heredity
Eiji Inoue, Takahiro Suzuki, Yasuharu Shimizu, Keiichi Sudo, Haruhisa Kawasaki, Norio Ishida
Summary: Saffron and its constituent crocetin have been found to inhibit the progression of PD in animal models, showing effects such as improving climbing ability, extending lifespan, and providing cytoprotection.
Article
Ophthalmology
Natalia Ziolkowska, Malgorzata Chmielewska-Krzesinska, Alla Vyniarska, Waldemar Sienkiewicz
Summary: This study investigated the effects of blue light on intrinsically photoreceptive retinal ganglion cells (ipRGCs). The results showed that exposure to blue light significantly reduced the number of melanopsin-positive ipRGCs and their processes, as well as causing severe retinal damage and cell apoptosis. The study also found damage to the organelles of retinal ganglion cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Environmental Sciences
Peng Xiao, Wenhua Li, Jinfang Lu, Yang Liu, Qiulan Luo, He Zhang
Summary: The study found that Bixafen has toxic effects on the retinal development of zebrafish embryos, leading to severe retinal defects and increased cell density in the ganglion cell layer.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Agriculture, Dairy & Animal Science
Davide Di Paola, Enrico Gugliandolo, Fabiano Capparucci, Marika Cordaro, Carmelo Iaria, Rosalba Siracusa, Ramona D'Amico, Roberta Fusco, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalia Crupi, Alessio Filippo Peritore
Summary: Simultaneous exposure to multiple contaminants can increase fish toxicity, and co-exposure to cadmium and imidacloprid can cause developmental damage and harm to retinal cells in zebrafish, potentially leading to apoptosis.
Article
Environmental Sciences
Xueying Ma, Yizhe Dai, Tiantong Qiu, Xin Chen, Peng Xiao, Wenhua Li
Summary: The purpose of this study was to evaluate the adverse effects of amisulbrom on retinal development in zebrafish. Zebrafish embryos were treated with different concentrations of amisulbrom and showed phenotypic abnormalities, dysregulation of gene transcription levels related to retinal cell layer differentiation, increased retinal apoptosis, and changes in glutathione and malondialdehyde content. These findings demonstrate the toxicity of amisulbrom to eye development and its potential ecotoxicological impacts on aquatic species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Gao
Summary: Cadmium, a highly toxic heavy metal pollutant, can induce mitochondrial dysfunction and endoplasmic reticulum stress (ERS) in a dose-dependent manner, leading to apoptosis in MC3T3-E1 cells. The PERK-EIF2 alpha-ATF4-CHOP signaling pathway is upregulated, while the Nrf2/NQO1 pathway is inhibited by Cd-induced oxidative stress. Moreover, NAC and 4-PBA can alleviate ERS and attenuate cell apoptosis caused by Cd.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Public, Environmental & Occupational Health
Hongxing Guo, Chenyu Ruan, Xiuhong Zhan, Hao Pan, Yumei Luo, Ke Gao
Summary: This study demonstrates that crocin can protect LO2 cells from TGF-beta-induced injury by promoting proliferation and autophagy, suppressing apoptosis and anti-inflammation, and regulating the AMPK/m-TOR signaling pathway.
FRONTIERS IN PUBLIC HEALTH
(2022)