期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 46, 页码 14574-14577出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b09593
关键词
-
资金
- National Institute of General Medical Sciences [ROI GM103855]
- University of North Carolina
Dynamic kinetic resolutions of alpha-stereogenic-beta-formyl amides in asymmetric 2-aza-Cope rearrangements are described. Chiral phosphoric acids catalyze this rare example of a non-hydrogenative DKR of a beta-oxo acid derivative. The [3,3]-rearrangement occurs with high diastereo- and enantiocontrol, forming beta-imino amides that can be deprotected to the primary beta-amino amide or reduced to the corresponding diamine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据