期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 137, 期 44, 页码 14031-14034出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b08303
关键词
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资金
- NSF [DMR-1157490]
- State of Florida
- U.S. Department of Energy
- National Institutes of Heath NIGMS [R01GM105963, R01GM094526]
- NIH Intramural Research Program, National Cancer Institute, Center for Cancer Research
Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.
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