Article
Chemistry, Applied
R. Rupesh, R. Mohankumar, Sarvesh Sabarathinam
Summary: Embelin, a compound found in Embelia ribes fruit, has various pharmacological activities. This study aims to investigate the impact of reduced embelin on Alzheimer's disease management. Analysis of a modified embelin derivative and docking experiments with receptors showed similar scores to positive control drugs.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Dulce C. Macias-Ceja, Maria D. Barrachina, Dolores Ortiz-Masia
Summary: Chronic inflammation is associated with excessive deposition of extracellular matrix and leads to fibrosis. Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD), and deregulated autophagy is linked to fibrosis progression. Understanding the role of autophagy in fibrosis may provide new targets for antifibrotic therapy. This review focuses on the relevance of autophagy in fibrosis, with a special emphasis on IBD-related fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Srishti Saha, Neha Patel
Summary: Inflammatory bowel disease (IBD) is a chronic disorder caused by enteric inflammation in a genetically susceptible host. Diet is widely accepted as an important factor in the pathogenesis of IBD, and various dietary components have been studied for their roles in causing enteric inflammation. Different diets, such as exclusive enteral nutrition, specific carbohydrate diet, and low FODMAPs diet, have also been explored for their effects on IBD patients. This review summarizes the current evidence on the relationship between dietary components and IBD, and provides guidance for dietary modifications in managing IBD.
Review
Cell & Tissue Engineering
Yusuke Wakisaka, Shinya Sugimoto, Toshiro Sato
Summary: This review discusses the application of adult tissue-derived organoids culture technology to elucidate the pathogenesis of IBD and to develop novel therapies, including regenerative treatments.
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Infectious Diseases
Sara Federici, Denise Kviatcovsky, Rafael Valdes-Mas, Eran Elinav
Summary: Inflammatory bowel disease (IBD) is a group of auto-inflammatory disorders affecting the gastrointestinal tract and other organs. The gut microbiome and specifically bacteriophages, which can infect bacteria, play a role in IBD pathology. Phage therapy shows potential in eradicating pathobionts associated with IBD, but further research is needed.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Endocrinology & Metabolism
Wei Xian, Dide Wu, Boyuan Liu, Shubin Hong, Zijun Huo, Haipeng Xiao, Yanbing Li
Summary: Our study used bidirectional 2-sample Mendelian randomization (MR) to infer a potential causal relationship between Graves disease (GD) and inflammatory bowel disease (IBD). The results suggest that genetically predicted IBD may increase the risk of GD, while Crohn disease (CD) may increase the risk of GD and ulcerative colitis (UC) may protect against GD. However, genetically predicted GD may slightly increase the risk of CD, but there is no evidence that GD increases the risk of UC or IBD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Martin Maronek, Irene Marafini, Roman Gardlik, Rene Link, Edoardo Troncone, Giovanni Monteleone
Summary: Inflammatory bowel diseases (IBD) refer to chronic inflammatory conditions of the gastrointestinal tract, including Crohn's disease (CD) and ulcerative colitis (UC). Excessive production of matrix metalloproteinases (MMPs) without sufficient inhibition by tissue inhibitors of metalloproteinases (TIMPs) in inflamed tissue of IBD patients contributes significantly to mucosal degradation in IBD-related pathologies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Robert H. Hollis, Nicholas Smith, Ipek Sapci, Benjamin Click, Miguel Regueiro, Tracy L. Hull, Amy L. Lightner
Summary: This retrospective cohort study found that over one third of patients who underwent total proctocolectomy for Crohn's disease were estimated to have small bowel Crohn's recurrence at 5 years after surgery. Patients with a history of small bowel surgery for Crohn's and diagnosis at any early age may have a higher risk of recurrence.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Pharmacology & Pharmacy
Shanthi Subramanian, Chamundeeswari Duraipandian, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, S. Seethalakshmi, Srikanth Jeyabalan, Sivaraman Dhanasekaran, Suresh V. Chinni, Nur Najihah Izzati Mat Rani, Shadma Wahab
Summary: This study evaluated the wound healing effect of the ethyl acetate fraction of Dodonaea viscosa leaves. The results showed that the ethyl acetate fraction promoted wound contraction, epithelialization, and increased hydroxyproline levels and tensile strength. Histopathological and Western blot analysis demonstrated the promotion of collagen formation and vascularization by the ethyl acetate fraction. These findings suggest that the flavonoid-rich fraction of D. viscosa promotes wound healing by up-regulating the expressions of COL3A, VEGF, and bFGF protein.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Nur Syafiqah Rahim, Yuan Seng Wu, Maw Shin Sim, Appalaraju Velaga, Srinivasa Reddy Bonam, Subash C. B. Gopinath, Vetriselvan Subramaniyan, Ker Woon Choy, Sin-Yeang Teow, Ismail M. M. Fareez, Chandramathi Samudi, Shamala Devi Sekaran, Mahendran Sekar, Rhanye Mac Guad
Summary: There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Among these members, TM4SF1, TM4SF4, and TM4SF5 play crucial roles in cancer angiogenesis, progression, and chemoresistance. Targeting these TM4SF members has emerged as a promising strategy for cancer therapy.
Article
Ophthalmology
Taraprasad Das, Shalem Raj Padakandla, Sisinthy Shivaji, Rajagopalaboopathi Jayasudha, Brijesh Takkar
Summary: This study compared the microbiome in the aqueous humour and gut of people with diabetes mellitus (DM) with and without diabetic retinopathy (DR). It was found that there are differences in the microbiome of the eye and gut regardless of disease or health. The intraocular microbiome showed more distinct features compared to the gut, but further confirmation is needed with larger studies.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Biology
Jini Sugatha, Amulya Priya, Prateek Raj, Ebsy Jaimon, Uma Swaminathan, Anju Jose, Thomas John Pucadyil, Sunando Datta, Felix Campelo
Summary: SNX32 interacts with SNX4 via its BAR domain and with TfR, CIMPR, and BSG through its PX domain, regulating cargo sorting and trafficking processes. Silencing of SNX32 leads to defects in intracellular trafficking and neuronal differentiation, suggesting its crucial role in maintaining neuroglial coordination.
Article
Pharmacology & Pharmacy
Naveen Kumar Velayutham, Tamilanban Thamaraikani, Shadma Wahab, Mohammad Khalid, Gobinath Ramachawolran, Shahabe Saquib Abullais, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Angel Jemima Ebenezer, Mrinalini Ravikumar, Vetriselvan Subramaniyan, Nur Najihah Izzati Mat Rani, Yuan Seng Wu, Srikanth Jeyabalan
Summary: This study evaluated the regulatory effects of stylopine on the VEGFR-2 signaling pathway and its anti-tumor effect on human MG-63 osteosarcoma cells. In vitro experiments showed that stylopine inhibited cell proliferation, induced mitochondrial membrane damage and apoptosis in MG-63 cells, and suppressed cell migration and VEGFR2 expression induced by VEGF-165. The findings suggest that stylopine has the potential to regulate VEGFR2 and may serve as a new drug candidate for the treatment of bone cancer in the future.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Suaidah Ramli, Yuan Seng Wu, Kalaivani Batumalaie, Rhanye Mac Guad, Ker Woon Choy, Ashok Kumar, Subash C. B. Gopinath, Md. Moklesur Rahman Sarker, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Suresh V. Chinni, Gobinath Ramachawolran
Summary: This review focuses on the therapeutic efficacy and molecular mechanisms of Withania somnifera (WS) extracts and their phytochemicals against SARS-CoV-2 infection. It also discusses the use of molecular docking in developing potential inhibitors from WS to target the virus and host cell receptors. Additionally, the review explores the use of nanoformulations or nanocarriers in enhancing WS delivery for improved bioavailability and treatment efficacy.
Article
Pharmacology & Pharmacy
Pei Teng Lum, Mahendran Sekar, Lay Jing Seow, Mohd Farooq Shaikh, Alina Arulsamy, Thaarvena Retinasamy, Siew Hua Gan, Charles Gnanaraj, Norhaizan Mohd Esa, Gobinath Ramachawolran, Vetriselvan Subramaniyan, Suresh V. Chinni, Yuan Seng Wu
Summary: Huntington's disease (HD) is a neurodegenerative disease that affects the daily performances and life quality of patients. Mangiferin, a compound found in the Mangifera indica plant, has been proven to have medicinal benefits against memory and cognitive impairment in neurodegenerative diseases. This study aims to evaluate the neuroprotective effect of mangiferin against 3-nitropropionic acid (3NP) induced HD in rat models.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
S. Nirenjen, J. Narayanan, T. Tamilanban, Vetriselvan Subramaniyan, V. Chitra, Neeraj Kumar Fuloria, Ling Shing Wong, Gobinath Ramachawolran, Mahendran Sekar, Gaurav Gupta, Shivkanya Fuloria, Suresh V. Chinni, Siddharthan Selvaraj
Summary: Impaired wound healing is a significant complication of Diabetes, and the dysregulation of pro-inflammatory cytokines plays a crucial role in delaying the healing process. This review discusses the need for proper treatment modalities and therapeutic interventions to address diabetic wounds and improve patient quality of life.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Pankaj Bhatt, Vipin Kumar, Vetriselvan Subramaniyan, Kandasamy Nagarajan, Mahendran Sekar, Suresh Chinni, Gobinath Ramachawolran
Summary: Natural polymers have gained attention in drug delivery due to their biocompatibility and biodegradability. However, their surface properties often limit their use. Plasma treatment can overcome these limitations by improving the properties of natural polymers. This review provides an overview of recent advances in plasma modification of natural polymer-based drug delivery systems.
Article
Biotechnology & Applied Microbiology
S. P. Surya Teja, N. Damodharan, T. Tamilanban, Vetriselvan Subramaniyan, V. Chitra, Suresh V. Chinni, Ling Shing Wong, Neeraj Kumar Fuloria, Mahendran Sekar, Shivkanya Fuloria, Gobinath Ramachawolran, Siddharthan Selvaraj
Summary: The aim of this study was to investigate the influence of excipients on retaining the particle size of methotrexate (MTX) loaded chitosan nanocarriers (CsNP) during lyophilization. The use of mannitol as a lyoprotectant resulted in restricted nanocarrier size and successful tumor targeting. This study demonstrates the potential of chitosan nanocarriers for targeted tumor drug delivery and cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
V. Manimaran, R. P. Nivetha, T. Tamilanban, J. Narayanan, Subramaniyan Vetriselvan, Neeraj Kumar Fuloria, Suresh V. Chinni, Mahendran Sekar, Shivkanya Fuloria, Ling Shing Wong, Anupam Biswas, Gobinath Ramachawolran, Siddharthan Selvaraj
Summary: Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. They effectively address the limitations of conventional drug therapy and are considered an innovative drug delivery system. This article covers topics such as the involvement of nanogels in the nanomedicine sector, their advantages and limitations, ideal properties, nanogel classification, synthesis, drug release mechanisms, and various biological applications.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Plant Sciences
Thippeswamy Boreddy Shivanandappa, Maheswari Chinnadhurai, Geetha Kandasamy, Rajalakshimi Vasudevan, Gigi Sam, Anjana Karunakarannair
Summary: In this study, the beneficial effects of Ziziphus mauritiana leaves on hormone levels and total cholesterol in polycystic ovaries were evaluated. The results showed that Ziziphus mauritiana can normalize all hormone and cholesterol levels.
Article
Toxicology
Shivkanya Fuloria, Vetriselvan Subramaniyan, Gaurav Gupta, Mahendran Sekar, Dhanalekshmi Unnikrishnan Meenakshi, Kathiresan Sathasivam, Kalvatala Sudhakar, Khalid Saad Alharbi, Sultan Saadi Almutairi, Waleed Hassan Almalki, Neeraj Kumar Fuloria
Summary: Technological advancement has enabled the discovery of various cellular biomarkers, including CSC, CTC, and EPC, which play crucial roles in cancer resistance, metastasis, and premetastatic conditions. Detecting these subpopulations assists in early diagnosis, recurrence prediction, and treatment efficacy. This review provides comprehensive information on different methods to detect CSC, CTC, and EPC, ranging from in vivo and in vitro assays to reporter systems and analytical techniques such as flow cytometry and fluorescence microscopy/spectroscopy.
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
(2023)
Article
Toxicology
Suman Rohilla, Mahaveer Singh, Sakshi Priya, Waleed Hassan Almalki, Shahril Mohamed Haniffa, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria, Mahendran Sekar, Sachin Kumar, Niraj Kumar Jha, Dinesh Kumar Chellappan, Poonam Negi, Kamal Dua, Gaurav Gupta
Summary: Melatonin is a serotonin-derived hormone that regulates various biological functions and has therapeutic effects in cancer prevention and treatment. It affects cancer cells through receptor modification, inhibition of proliferation and metastasis, and immune modulation. Melatonin also has a significant impact on gene expression through epigenetic modulation.
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
(2023)
Article
Education, Scientific Disciplines
Subhashini N. Govindan, Harvinder Singh, Lee Ling, Mahendran Sekar
Summary: This study aimed to evaluate the effectiveness of a blended learning approach on nursing students' self-directed learning readiness. The results showed that incorporating blended learning using e-books can contribute to students' readiness for self-directed learning, particularly in terms of self-management and self-control.
JOURNAL OF EDUCATION AND HEALTH PROMOTION
(2023)
