Article
Multidisciplinary Sciences
Dongmei Liu, Muriel Mari, Xia Li, Fulvio Reggiori, Susan Ferro-Novick, Peter Novick
Summary: This study discovered a process called ER-phagy, which selectively delivers fragments of the endoplasmic reticulum to the lysosome or vacuole in response to starvation or the accumulation of misfolded proteins. The loss of specific genes and proteins blocks the association between the autophagy receptor and the assembly scaffold protein, and a membrane contact site module is also found to be involved in ER-phagy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Chaofan Chen, Steffen Vanneste, Xu Chen
Summary: Cell-to-cell communication in plants occurs through nanotubular passages called plasmodesmata, composed of endoplasmic reticulum and plasma membrane, associating with the actin-cytoskeleton. The coordination of these structures plays a crucial role in maintaining the architecture and conductivity of plasmodesmata, facilitating cell-to-cell communication in plant development and response to environmental stress.
Article
Chemistry, Medicinal
Ronghui Fan, Senzhen Wang, Yalan Wu, Yongli Feng, Mengke Gao, Yue Cao, Xiaoxuan Ma, Songqiang Xie, Chaojie Wang, Lei Gao, Yanming Wang, Fujun Dai
Summary: This study aims to examine the effects of harmine on esophageal squamous cell carcinoma (ESCC) and its mechanism. The results showed that harmine inhibited the growth of ESCC cells and achieved this through regulation of endoplasmic reticulum stress. Therefore, harmine may be a promising candidate for the treatment of ESCC.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hiroki Nishiguchi, Tomohiro Omura, Ayaka Sato, Yumi Kitahiro, Kazuhiro Yamamoto, Junichi Kunimasa, Ikuko Yano
Summary: Parkinson's Disease (PD) is caused by multiple factors, with endoplasmic reticulum (ER) stress considered to be one of them. HRD1 and SEL1L proteins can suppress ER stress and cell death, making them potential targets for PD treatment. Our study found that luteolin can upregulate HRD1 expression, inhibit ER stress, and suppress cell death, suggesting it as a potential therapeutic agent for PD.
NEUROCHEMICAL RESEARCH
(2023)
Article
Plant Sciences
Xin Wang, Ming-Jing He, Xiao-Jie Chen, Yu-Ting Bai, Gang Zhou
Summary: GLA is a promising therapeutic agent that activates the ROS-mediated ATF4/CHOP/CHAC1 axis in OSCC patients. It significantly inhibits cell proliferation and induces apoptosis by disturbing the redox homeostasis and activating the mitochondrial apoptosis pathway. CHAC1 expression is lower in OSCC compared with normal tissues and is positively correlated with 4-Hydroxynonenal (4-HNE) level. High CHAC1 expression also indicates better overall survival in OSCC patients.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qian Chen, Han Jiang, Zhen Wang, Lu-Yao Cai, Yu-Chen Jiang, Liang Xie, Yu Zhou, Xin Zeng, Ning Ji, Ying-Qiang Shen, Qian-Ming Chen
Summary: Through preclinical studies, nebivolol was identified as a potential candidate for treating oral squamous cell carcinoma, demonstrating its mechanism of action in halting oral mucosa carcinogenesis. Administration of nebivolol activates the ER stress pathway, leading to cell growth arrest and ultimately cell death in OSCC cells. Repurposing nebivolol represents an effective strategy for treating OSCC by targeting adrenergic nerve fibers in the tumor microenvironment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Kiran K. K. Mangalaparthi, Krishna Patel, Aafaque Ahmad Khan, Bipin Nair, Rekha V. Kumar, Thottethodi Subrahmanya Keshav Prasad, David Sidransky, Aditi Chatterjee, Akhilesh Pandey, Harsha Gowda
Summary: In this study, we conducted proteomic profiling of esophageal squamous cell carcinoma and adjacent non-neoplastic esophageal tissue to identify potential biomarkers and targets. We identified several differentially expressed proteins, including PDPN, TOP2A, POSTN, and MMP2, that were overexpressed in ESCC. We also found overexpression of SOX2, TP63, IGF2BP2, and RNF13, which are encoded by genes in the 3q26 region, a known hotspot region in ESCC. SYVN1, a protein involved in ER-associated degradation and ER stress response, was also found to be overexpressed in ESCC and could be a potential therapeutic target.
Article
Cell Biology
Ya-Jiao Yuan, Shanshan Liu, Hong Yang, Jian-Ling Xu, Jing Zhai, Han-Ming Jiang, Beibei Sun
Summary: Acetylshikonin (AS) inhibits proliferation and induces apoptosis in oesophageal squamous carcinoma (ESCC) through ER stress-activated PERK/eIF(2 alpha)/CHOP pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Stephen M. Coscia, Cameron P. Thompson, Qing Tang, Elana E. Baltrusaitis, Joseph A. Rhodenhiser, Omar A. Quintero-Carmona, Melike Lakadamyali, Erika L. F. Holzbaur
Summary: Mitochondrial homeostasis requires a dynamic balance of fission and fusion. The actin cytoskeleton promotes fission, and Myo19, a mitochondrially localized myosin, is found to be integral to this process. Myo19 acts as a dynamic actin-binding tether that facilitates mitochondrial fragmentation.
JOURNAL OF CELL SCIENCE
(2023)
Article
Engineering, Environmental
Jia-Ying Zhou, Qing-Hua Shen, Xiao-Jing Hong, Wu-Ya Zhang, Qiao Su, Wu-Guo Li, Bin Cheng, Cai-Ping Tan, Tong Wu
Summary: This study demonstrates the potential of photodynamic therapy (PDT) in oral squamous cell carcinoma (OSCC) by designing two iridium(III) photosensitizers that target the endoplasmic reticulum (ER). The Ir1-mediated PDT treatment adaptively upregulates the expression of programmed death-ligand 1 (PD-L1) and stimulates dendritic cell maturation and T lymphocyte infiltration. It also synergizes with a PD-L1 inhibitor to transform an immune-suppressive cold tumor into an immune-responsive hot tumor.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
FuiBoon Kai, Guanqing Ou, Richard W. Tourdot, Connor Stashko, Guido Gaietta, Mark F. Swift, Niels Volkmann, Alexandra F. Long, Yulong Han, Hector H. Huang, Jason J. Northey, Andrew M. Leidal, Virgile Viasnoff, David M. Bryant, Wei Guo, Arun P. Wiita, Ming Guo, Sophie Dumont, Dorit Hanein, Ravi Radhakrishnan, Valerie M. Weaver
Summary: Patient-derived organoids and cellular spheroids, when interacting with a reconstituted basement membrane, exhibit different cellular behaviors in 3D and 2D environments. Lower cortical actin tension in 3D promotes cell survival and secretion, while higher cortical actin tension in 2D leads to ER stress and compromised cell viability. This study highlights the role of tissue mechanics in organoid homeostasis.
Article
Biochemistry & Molecular Biology
FuiBoon Kai, Guanqing Ou, Richard W. Tourdot, Connor Stashko, Guido Gaietta, Mark F. Swift, Niels Volkmann, Alexandra F. Long, Yulong Han, Hector H. Huang, Jason J. Northey, Andrew M. Leidal, Virgile Viasnoff, David M. Bryant, Wei Guo, Arun P. Wiita, Ming Guo, Sophie Dumont, Dorit Hanein, Ravi Radhakrishnan, Valerie M. Weaver
Summary: Cells interacting with a reconstituted basement membrane in a three-dimensional environment have lower levels of actin-associated filamin and decreased cortical actin tension, leading to increased negative plasma membrane curvature and protein secretion. In contrast, cells engaging a reconstituted basement membrane in a two-dimensional environment have higher cortical actin tension, resulting in filamin unfolding and endoplasmic reticulum (ER) associations. These findings highlight the role of cortical actin tension in ER function and cell viability.
Review
Medicine, Research & Experimental
Shengkai Xia, Wenzhe Duan, Wenwen Liu, Xinri Zhang, Qi Wang
Summary: GRP78 is a key protein in the pathological processes of lung cancer, involved in protein folding, cellular stress response to microenvironment stimuli, and closely associated with the progression and poor prognosis of lung cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Reproductive Biology
Huizhen Wang, Lane K. Christenson, William H. Kinsey
Summary: This study provides evidence of interactions between cortical endoplasmic reticulum clusters and fertilizing sperm, suggesting a competitive advantage for the oocyte. Global and localized changes in cortical endoplasmic reticulum cluster structure are observed during fertilization.
BIOLOGY OF REPRODUCTION
(2022)
Article
Pharmacology & Pharmacy
Hao Ding, Menghui Jiang, Daochuan Li, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Jingbo Pi, Rui Chen, Lianhua Cui, Yuxin Zheng, Jinmei Piao
Summary: Previous studies have shown that long-term exposure to fine particulate matter (PM2.5) increases the morbidity and mortality of pulmonary diseases. Nrf2 plays a pivotal role in protecting against oxidative stress induced by PM2.5.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chee-Hong Chan, Sheng-Nan Wu, Bo-Ying Bao, Houng-Wei Li, Te-Ling Lu
Summary: The study showed that K+ loading affects the homeostasis of Na+ and K+ in the kidneys by regulating the activity of various ion channels and protein kinases. MST3 was found to play an important role in maintaining Na+/K+ homeostasis, as its absence led to reduced Na+ and K+ excretion and hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shu-Pin Huang, Yei-Tsung Chen, Lih-Chyang Chen, Cheng-Hsueh Lee, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Te-Ling Lu, Bo-Ying Bao
Summary: This study revealed that genetic variants of NRG1 gene are significantly associated with worsening cancer-specific survival, overall survival, and progression-free survival in prostate cancer patients undergoing androgen-deprivation therapy. Low expression of NRG1 is closely related to prostate cancer progression, as indicated by a high Gleason score and shorter progression-free survival rate.
Article
Medicine, Research & Experimental
Yuan-Chin Tsai, Chao-Yuan Huang, Yu-Mei Hsueh, Yu-Ching Fan, Yu-Cin Fong, Shu-Pin Huang, Jiun-Hung Geng, Lih-Chyang Chen, Te-Ling Lu, Bo-Ying Bao
Summary: This study investigated the association of MAPK cascade genes with renal cell carcinoma risk and survival, revealing that a specific single nucleotide polymorphism in the MAPK10 gene is linked to lower RCC risk and metastasis. High MAPK10 expression is associated with a favorable prognosis, and MAPK10 activation can inhibit RCC cell growth.
Article
Multidisciplinary Sciences
Nishi Karunasinghe, Tsion Zewdu Minas, Bo-Ying Bao, Arier Lee, Alice Wang, Shuotun Zhu, Jonathan Masters, Megan Goudie, Shu-Pin Huang, Frank J. Jenkins, Lynnette R. Ferguson
Summary: This study analyzed multiple datasets and found significant associations between prostate-specific antigen (PSA) and demographic, lifestyle, and clinical data. The study also found variability in the correlation of PSA with age and genetic factors among different populations. The findings suggest that unique PSA cut-off thresholds, factored with demographics, lifestyle, and genetics, may be more appropriate for prostate cancer screening.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Hao-Han Chang, Cheng-Hsueh Lee, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Jiun-Hung Geng, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao
Summary: The MSH2 gene, particularly the rs1400633 variant, is found to be associated with patient survival during androgen deprivation therapy for advanced prostate cancer. High expression of MSH2 is also correlated with poor prognosis for this disease.
Article
Oncology
Chia-Yang Li, Shu-Pin Huang, Yei-Tsung Chen, Hsin-En Wu, Wei-Chung Cheng, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Jiun-Hung Geng, Te-Ling Lu, Bo-Ying Bao
Summary: This study suggests that immunodeficiency pathway-related genes, particularly TNFRSF13B, may play a potential role in the progression of prostate cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Hsin-Chih Yeh, Chia-Cheng Su, Yen-Hsuan Wu, Cheng Hsueh Lee, Bo-Ying Bao, Wei-Chung Cheng, Shu-Chi Wang, Po-Len Liu, Chien-Chih Chiu, Chih-Pin Chuu, Chien-Chih Ke, Hsin-En Wu, Yuan-Ru Chen, Wei-Ju Chung, Shu-Pin Huang, Chia-Yang Li
Summary: This study found that 3-BP effectively inhibits growth and motility of prostate cancer cells, particularly castration-resistant prostate cancer (CRPC) cells. Additionally, 3-BP attenuates tumor growth in a xenograft murine model and significantly regulates the cell cycle pathway. Therefore, 3-BP shows promise as a potential drug for treating CRPC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Yo-Liang Lai, Chia-Hsin Liu, Shu-Chi Wang, Shu-Pin Huang, Yi-Chun Cho, Bo-Ying Bao, Chia-Cheng Su, Hsin-Chih Yeh, Cheng-Hsueh Lee, Pai-Chi Teng, Chih-Pin Chuu, Deng-Neng Chen, Chia-Yang Li, Wei-Chung Cheng
Summary: This study identified an eight-gene signature that can predict the prognosis of prostate cancer patients and regulate the steroid hormone pathway. These gene signatures may serve as potential targets for developing novel treatments for castration-resistant prostate cancer.
Article
Environmental Sciences
Chi-Fen Chang, Shu-Pin Huang, Yu-Mei Hsueh, Jiun-Hung Geng, Chao-Yuan Huang, Bo-Ying Bao
Summary: This study evaluated the impact of genetic variants in the SHANK gene family on the risk and survival of RCC. The results showed that the SHANK2 rs10792565 T allele was associated with an increased risk of RCC, while low expression of SHANK2 was correlated with advanced RCC stage and poor prognosis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Yuan-Ru Chen, Shu-Chi Wang, Shu-Pin Huang, Chia-Cheng Su, Po-Len Liu, Wei-Chung Cheng, Chih-Pin Chuu, Jen-Kun Chen, Bo-Ying Bao, Cheng Hsueh Lee, Chien-Chih Ke, Hsin-En Wu, Hao-Han Chang, Hsin-Chih Yeh, Chia-Yang Li
Summary: This study found that Protodioscin has inhibitory effects on cell proliferation, migration, invasion, and EMT in bladder cancer cells. Moreover, Protodioscin can induce cell apoptosis and arrest cell cycle progression, and it exerts its anti-cancer effects through regulating the MAPK and PI3K/AKT/mTOR signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Chee-Hong Chan, Pei Lin, Tse-Yen Yang, Bo-Ying Bao, Jhen-Yang Jhong, Yui-Ping Weng, Te-Hsiu Lee, Hui-Fen Cheng, Te-Ling Lu
Summary: Apical-basal cell polarity is crucial for the formation of epithelial cysts and tubules in various epithelial organs. MST3 plays a role in the establishment of cell polarity through the regulation of Cdc42.
Article
Endocrinology & Metabolism
Lih-Chyang Chen, Shu-Pin Huang, Chieh-Tien Shih, Chia-Yang Li, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Cheng-Hsueh Lee, Jiun-Hung Geng, Bo-Ying Bao
Summary: This study investigated the association between 222 single-nucleotide polymorphisms (SNPs) in eight phospholipid-transporting ATPase genes and cancer-specific survival (CSS) and overall survival (OS) of prostate cancer patients treated with androgen-deprivation therapy (ADT). After multivariate Cox regression analysis and multiple testing correction, it was found that ATP8B1 rs7239484 was significantly associated with CSS and OS after ADT. The study also found that ATP8B1 expression was downregulated in tumor tissues and higher expression was associated with a better patient prognosis.
Article
Integrative & Complementary Medicine
Hsin-En Wu, Chia-Cheng Su, Shu-Chi Wang, Po-Len Liu, Wei-Chung Cheng, Hsin-Chih Yeh, Chih-Pin Chuu, Jen-Kun Chen, Bo-Ying Bao, Cheng Hsueh Lee, Chien-Chih Ke, Yuan-Ru Chen, Yun-Hsin Yu, Shu-Pin Huang, Chia-Yang Li
Summary: This study demonstrated that morusin, a prenylated flavonoid isolated from Morus alba L., has significant inhibitory effects on the growth, migration, and invasion of prostate cancer cells. It achieves this by regulating the Akt/mTOR signaling pathway, inducing cell cycle arrest, and promoting apoptosis. These findings suggest that morusin could be a potential drug for the treatment of castration-resistant prostate cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Meeting Abstract
Urology & Nephrology
S-P Huang, C-Y Li, Y-T Chen, H-E Wu, C-Y Huang, C-C Yu, V. C. Lin, B-Y Bao, T-L Lu, J-H Geng
Article
Oncology
Shi-Heng Wang, Shu-Pin Huang, Yi-Jiun Pan, Po-Chang Hsiao, Chia-Yang Li, Lih-Chyang Chen, Chia-Cheng Yu, Chao-Yuan Huang, Victor C. Lin, Te-Ling Lu, Bo-Ying Bao
Summary: The genetic predisposition to breast cancer is associated with a low risk of prostate cancer recurrence, indicating a potential link between breast cancer susceptibility variants and prostate cancer outcomes. Further studies are needed to investigate the role of breast cancer-related genetic factors and estrogen signaling in the progression of prostate cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
