Article
Chemistry, Medicinal
Aamir Khan, Ashif Iqubal, Syed Ehtaishamul Haque
Summary: Cardiovascular diseases are a global concern, and the side effects of existing drugs have driven scientists to search for safer, more effective, and more cost-effective alternatives. This study found that the combination of cinnamaldehyde and quercetin can provide cardioprotection in isoproterenol-induced myocardial infarction in rats. The combination of half their individual doses showed better results compared to using cinnamaldehyde and quercetin alone.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Integrative & Complementary Medicine
Shih-Hao Wang, Kun-Ling Tsai, Wan-Ching Chou, Hui-Ching Cheng, Yu-Ting Huang, Hsiu-Chung Ou, Yun-Ching Chang
Summary: This study demonstrates that quercetin can protect against cisplatin-induced cardiotoxicity by reducing ROS-mediated mitochondrial damage and inflammation through the Nrf2/HO-1 and p38MAPK/NF-kappa Bp65/IL-8 signaling pathways. These findings provide a theoretical and experimental basis for the clinical application of quercetin as a new effective strategy to alleviate chemotherapy-induced cardiotoxicity.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Hamidreza Dorostkar, Bibi Fatemeh Haghiralsadat, Mahdie Hemati, Fatemeh Safari, Azam Hassanpour, Seyed Morteza Naghib, Mohammad Hossein Roozbahani, M. R. Mozafari, Ali Moradi
Summary: Liposomal doxorubicin with favorable characteristics was designed and synthesized, and its physicochemical properties were investigated. The co-administration of liposomal doxorubicin with free doxorubicin and quercetin showed promising results in reducing cardiac enzymes, oxidative stress, and apoptosis, as well as improving antioxidant capacity in heart tissue.
Article
Oncology
Tavga Ahmed Aziz
Summary: The study evaluated the cardioprotective effects of quercetin and sitagliptin combination in doxorubicin-induced cardiotoxicity. Results demonstrated that the combination treatment was more effective in restoring several markers compared to individual treatments. The combination showed potential for clinical testing due to its additive effects in antioxidant, anti-inflammatory, lipid lowering, and anti-atherogenic activities.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Kevin Agostinucci, Marianne K. O. Grant, Davis Seelig, Dogacan Yucel, Jop van Berlo, Alessandro Bartolomucci, Jason R. B. Dyck, Beshay N. Zordoky
Summary: This study aims to investigate whether pre-exposure to doxorubicin during adolescence would make the heart more susceptible to non-hypertensive pathologic stimuli. The results show that doxorubicin-induced latent cardiotoxicity enhances the cardiac response to hypertensive stimuli and is associated with worsened cardiac function and increased fibrosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Maha S. Lokman, Hussam A. Althagafi, Fahad Alharthi, Ola A. Habotta, Arwa A. Hassan, Mohamed A. Elhefny, Hassan Al Sberi, Abdulrahman Theyab, Ahmad Hasan Mufti, Alaa Alhazmi, Yousef M. Hawsawi, Asmaa F. Khafaga, Mahmoud S. Gewaily, Khalaf F. Alsharif, Ashraf Albrakati, Rami B. Kassab
Summary: This study aimed to evaluate the protective effect of Quercetin against 5-FU-induced cardiotoxicity. The results suggested that Quercetin has potent antioxidant, anti-inflammatory, and anti-apoptotic effects, which can ameliorate the cardiotoxic effects of 5-FU.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Honglin Han, Yuexuan Wang, Suifeng Xu, Chengzong Han, Qiwei Qin, Shina Wei
Summary: Lipid metabolism, particularly high-density lipoprotein (HDL), plays a crucial role in viral infections. This study investigates the role of Epinephelus coioides SR-B1 (Ec-SR-B1) in red-spotted grouper nervous necrosis virus (RGNNV) infection and reveals that Ec-SR-B1 can promote RGNNV infection. The study also demonstrates the involvement of HDL in facilitating RGNNV entry and the interaction between Ec-SR-B1 and RGNNV's capsid protein (CP).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Environmental Sciences
Anouar Feriani, Meriam Tir, Waleed Aldahmash, Kais Mnafgui, Alimi Hichem, Ana Maria Gomez-Caravaca, Maria Del Mar Contreras, Amani Taamalli, Saleh Alwasel, Antonio Segura-Carretero, Nizar Tlili, Abdel Halim Harrath
Summary: The aim of this study was to investigate the cardiopreventive effect of the methanolic extract of S. molle L. (MESM) on isoproterenol-induced infarction in rats. The results showed that MESM exhibited cardioprotective effects by normalizing cardiac risk parameters, reducing oxidative stress, inhibiting apoptosis, reducing DNA fragmentation and infarct size, and inhibiting fibrosis in myocardial tissue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Xiqin Lin, Yudong Xu, Tong Tong, Jingjing Zhang, Haotian He, Lingling Yang, Ping Deng, Zhengping Yu, Huifeng Pi, Huihui Hong, Zhou Zhou
Summary: This study assessed the cardiotoxicity of cadmium (Cd) exposure and explored the mechanisms by which Cd exerts its toxic effects. The results showed that Cd exposure induced cardiac injury in mice, as evidenced by histopathological changes, elevated levels of cardiac enzyme markers, and up-regulation of pro-apoptotic genes. Non-targeted lipidomic analysis revealed alterations in cardiac lipid metabolism and an increase in pro-inflammatory lipids after Cd exposure. Furthermore, Cd exposure activated the NF-KB signaling pathway and led to cardiac inflammation. These findings expand our understanding of Cd cardiotoxicity and its association with cardiovascular diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Shubham Yadav, Shriyansh Srivastava, Gaaminepreet Singh
Summary: This study investigated the cardioprotective effects of activated platelet-rich plasma (PRP) on high dose isoproterenol (ISO) induced cardiotoxicity. The results showed that PRP injection attenuated the cardiac pathological changes induced by ISO, exerting anti-inflammatory and cardiomyocyte repair promoting effects.
ENVIRONMENTAL TOXICOLOGY
(2022)
Editorial Material
Cell Biology
Shriyansh Srivastava, Newly Bagang, Shubham Yadav, Sakshi Rajput, Divya Sharma, Ashish Dahiya, Loveinder Bhardwaj, Khalid Deshmukh, Jagdish Chandra Joshi, Gaaminepreet Singh
Summary: Research shows that the activation of Wnt could up-regulate key energy sensor and cell growth regulator mTOR by inhibiting the GSK-3 beta mediator. GSK-3 beta negatively influences mTOR activity under stress or hypoxic conditions, leading to energy dysregulation. Therefore, inhibiting GSK-3 beta by Wnt signaling may up-regulate mTOR levels and restore early myocardial tissue energy balance to prevent cardiac toxicity in rodents.
INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shriyansh Srivastava, Shubham Yadav, Gaaminepreet Singh, Shamsher Singh Bajwa
Summary: This study investigated the cardioprotective effects of Wnt/β-catenin inhibition on isoproterenol-induced cardiotoxicity. The results showed that inhibiting the Wnt/β-catenin pathway can alleviate pathological manifestations and has antioxidant, anti-inflammatory, and anti-fibrotic effects.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Medicinal
Zehua Shao, Ran Li, Dongxing Shao, Hao Tang, Yu Han
Summary: Doxorubicin is a chemotherapeutic agent that is known for its cardiotoxicity. To reduce the cardiotoxicity, scavenging of reactive oxygen species is a practical strategy. Researchers have developed a novel enzyme mimic that increases the biocompatibility and antioxidant activity of quercetin, an antioxidant, without causing significant side effects.
Article
Agriculture, Multidisciplinary
Xu Zhang, Ling Ni, Yamin Zhu, Ning Liu, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: The research investigated the inhibitory mechanism of quercetin against aldehyde formation in thermally treated soybean oil. It was found that quercetin reacted with early intermediates of lipid oxidation to inhibit aldehyde formation, while the derivatives formed in the process showed weaker antioxidant activity. Notably, quercetin-3-O-hexanoate exhibited improved cellular antioxidant activity compared to quercetin itself.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Joana Varlla de Lacerda Alexandre, Yuana Ivia Ponte Viana, Cicera Edna Barbosa David, Pedro Lourenzo Oliveira Cunha, Amanda Cabral Albuquerque, Anna Lidia Nunes Varela, Alicia J. Kowaltowski, Heberty Tarso Facundo
Summary: Quercetin is capable of attenuating cardiac hypertrophy by restoring cellular redox balance and protecting mitochondria.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ponnian Stanely Mainzen Prince, Koothan Dhanasekar, Sundaresan Rajakumar
CHEMICO-BIOLOGICAL INTERACTIONS
(2015)
Article
Pharmacology & Pharmacy
Kunchupillai Lakshmanan Hemalatha, Ponnian Stanely Mainzen Prince
EUROPEAN JOURNAL OF PHARMACOLOGY
(2015)
Article
Biochemistry & Molecular Biology
K. L. Hemalatha, P. Stanely Mainzen Prince
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2015)
Article
Pharmacology & Pharmacy
K. L. Hemalatha, P. Stanely Mainzen Prince
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Kunchpillai Lakshmanan Hemalatha, Ponnian Stanely Mainzen Prince
Article
Pharmacology & Pharmacy
Sharmila Queenthy Sabarimuthu, Stanely Mainzen Prince Ponnian, Babu John
EUROPEAN JOURNAL OF PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
Ponnian Stanely Mainzen Prince, Kunchupillai Lakhsmanan Hemalatha
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
P. Stanely Mainzen Prince, Abhro Jyoti Roy
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
K. L. Hemalatha, P. Stanely Mainzen Prince
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2015)
Article
Biochemistry & Molecular Biology
P. Stanely Mainzen Prince, Pinaki Dey, S. J. Roy
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Anita Yovas, Stanely Mainzen Prince Ponnian
Summary: The study demonstrated that beta-caryophyllene exerts protective effects against myocardial infarction in rats induced with isoproterenol, by reducing heart damage, improving cardiac function, inhibiting apoptosis signaling pathways, and alleviating endothelial dysfunction. These findings suggest the potential use of beta-caryophyllene in the treatment of human myocardial infarction after clinical trials.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Stanely Mainzen Prince Ponnian
Summary: This study assessed the preventive effects of (-) epicatechin on tachycardia, cardiac hypertrophy, and inflammation in myocardial infarction, and found that it improved cardiac function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
S. Shervin Prince, P. Stanely Mainzen Prince, V. M. Berlin Grace
Summary: This study found that valencene has anti-cardiac hypertrophic, antioxidant, anti-inflammatory, and myocardial infarct size limiting effects. Treatment with valencene can reverse the structural, biochemical, molecular, and histological abnormalities caused by isoproterenol-induced myocardial infarction. Therefore, valencene has potential cardioprotective effects in myocardial infarction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anita Yovas, Shervin Prince Stanely, Reya Issac, Stanely Mainzen Prince Ponnian
Summary: Beta-caryophyllene was found to have anti-hyperlipidemic and antioxidant effects, which could inhibit the risk of isoproterenol-induced myocardial infarction in rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
S. Sharmila Queenthy, P. Stanely Mainzen Prince, Babu John
CARDIOVASCULAR TOXICOLOGY
(2018)
