Review
Immunology
Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Giovanni Santacroce, Antonio Di Sabatino
Summary: Allergic disorders are increasing in young people and are associated with significant disease burden. The altered immune system response in the gut is recognized as a relevant step in the pathogenesis of these disorders. Allergic disorders have a high prevalence in gastrointestinal autoimmune diseases, and comprehensive care for autoimmune gastrointestinal disorders should include evaluation and treatment of allergic disorders.
AUTOIMMUNITY REVIEWS
(2022)
Article
Immunology
Ekaterina O. Gubernatorova, Olga A. Namakanova, Ekaterina A. Gorshkova, Alexandra D. Medvedovskaya, Sergei A. Nedospasov, Marina S. Drutskaya
Summary: Asthma is a heterogeneous inflammatory disease characterized by airflow obstruction, wheezing, eosinophilia, and neutrophilia. Targeting different inflammatory patterns with therapeutic antibodies against cytokines has shown promising results. Combining pharmacological inhibition of multiple pathogenic cytokines may be more effective in treating asthma compared to targeting a single cytokine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Atiqur Rahman, Md Shofikul Islam, Selim Reza Tony, Abu Eabrahim Siddique, Victor Mondal, Zubaer Hosen, Zohurul Islam, Md Imam Hossain, Mizanur Rahman, Adiba Anjum, Sudip Kumar Paul, Faruk Hossen, Md Khalequzzaman Sarker, Shakhawoat Hossain, Kazi Abdus Salam, Azizul Haque, Md Ashraful Hoque, Zahangir Alam Saud, Lian Xin, Daigo Sumi, Seiichiro Himeno, Khaled Hossain
Summary: Limited information is available regarding the effects of arsenic exposure on immune function. Recent studies have shown that chronic arsenic exposure is associated with asthma, potentially through exacerbating Th2-driven immune responses. Arsenic exposure levels were positively correlated with serum Th2 mediators, while Th1 mediators remained unchanged; the ratio of Th2 to Th1 mediators significantly increased with higher exposure levels.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Microbiology
Ping Miao, Yiming Jiang, Ying Jian, Jiali Shi, Yao Liu, Pipat Piewngam, Yue Zheng, Gordon Y. C. Cheung, Qian Liu, Michael Otto, Min Li
Summary: Allergic rhinitis (AR), commonly known as hay fever, is a widespread condition that greatly impacts the lives of millions of people. This study explores the role of nasal microbiota in AR and reveals distinct differences in the nasal microbiome between AR patients and healthy individuals. Specifically, the study identifies Streptococcus salivarius as a contributing factor to AR development and highlights the potential of targeted antibacterial approaches for AR therapy.
NATURE MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Violeta Lokaj-Berisha, Besa Gacaferri Lumezi, Naser Berisha
Summary: The study revealed that serum concentrations of androgens (testosterone, p=0.0017; DHEA-S, p=0.04) were significantly lower in allergic women compared to controls, indicating the potential role of androgens in immune modulation for allergic diseases.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Jing-Yi Hou, Jia-Rong Wu, Dong Xu, Yi-Bing Chen, Dan-Dan Shang, Shu Liu, Guan-Wei Fan, Yuan-Lu Cui
Summary: This study demonstrated that Qingfei Xiaoyan Wan (QFXYW) can effectively alleviate inflammatory cell infiltration, mucus secretion, and epithelial damage in allergic asthma by suppressing key genes CXCL2, CXCL1, and the cytokine signaling pathway, offering a novel strategy for the treatment of allergic asthma with Traditional Chinese Medicine formulas.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Hiroki Morimoto, Satoshi Hayano, Naoya Ozawa, Yasuaki Ogura, Hiroaki Usui, Takahiro Usami, Ayako Ohse, Masaki Otsuka, Masahiko Miyachi, Yoshiki Tokura
Summary: The study on adverse reactions after receiving the Pfizer-BioNTech vaccine showed that different allergic histories may affect the severity of fatigue, headache, joint pain, and fever post-vaccination. These findings are important for guiding the vaccination of individuals with different allergy histories.
Article
Biochemistry & Molecular Biology
Olga A. Namakanova, Ekaterina A. Gorshkova, Ruslan Zvartsev, Sergei A. Nedospasov, Marina S. Drutskaya, Ekaterina O. Gubernatorova
Summary: Combined IL-6/TNF inhibition shows therapeutic potential for steroid-resistant asthma by reducing inflammation and improving symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Lin Sun, Bo Peng, Jun Zhou, Ping Wang, Yuqing Mo, Guofang Xu, Yi Tao, Hejie Song, Wei Tang, Meiling Jin
Summary: The study compared the difference in serum cytokine profiles between allergic asthma patients with different disease severity and identified YKL-40, eotaxin-1, and MCP-1 as potential biomarkers for reflecting disease severity.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Review
Allergy
Ken Fukuda, Tatsuma Kishimoto, Tamaki Sumi, Kenji Yamashiro, Nobuyuki Ebihara
Summary: The use of biologics targeting specific antibodies and receptors has significantly improved the treatment outcomes in allergic diseases. However, these drugs have not been approved for ocular allergic diseases. While some studies have reported beneficial effects, adverse ocular symptoms have also been observed. Different biologics may have specific effects on different ocular allergies, and allergists must fully understand the effects of each drug on the eye. This review outlines the potential therapeutic and adverse effects of various biologics on allergic diseases of the eye.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Immunology
Acharya Balkrishna, Siva Kumar Solleti, Hoshiyar Singh, Rani Singh, Niti Sharma, Anurag Varshney
Summary: The study demonstrated the prophylactic and ameliorative potential of the Indian classical medicine Sahastrapufi-Abhrak-Bhasma against asthma associated airway inflammation, significantly reducing allergen-induced inflammatory responses and airway remodeling.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Chuanfeng Lv, Hui Li, Hongxia Cui, Qianyu Bi, Meng Wang
Summary: The study formulated rhynchophylline-solid lipid nanoparticles to treat allergic asthma in mice model, showing better therapeutic effects in inhibiting airway inflammation and oxidative stress. The nanoparticles relieved allergic asthma by upregulating suppressor of cytokine signaling 1 and repressing the p38 signaling pathway.
Article
Environmental Sciences
Silvia Panunzi, Pierpaolo Marchetti, Massimo Stafoggia, Chiara Badaloni, Nicola Caranci, Kees de Hoogh, Paolo Giorgi Rossi, Linda Guarda, Francesca Locatelli, Marta Ottone, Caterina Silocchi, Paolo Ricci, Alessandro Marcon
Summary: In this cohort study, it was found that exposure to pollutants such as nitrogen dioxide, formaldehyde, and particulate matter is associated with adverse respiratory and allergic outcomes among residents in the Viadana district in northern Italy. These findings highlight the importance of taking preventive measures to improve air quality, particularly targeting emissions from industrial activities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Pharmacology & Pharmacy
Dean Paes, Melissa Schepers, Ben Rombaut, Daniel van den Hove, Tim Vanmierlo, Jos Prickaerts
Summary: The PDE4 enzyme family is crucial in regulating cAMP levels and is a therapeutic target for various diseases. PDE4 inhibitors have shown potential, but their clinical use is limited due to a small therapeutic window causing adverse side effects. Targeting specific PDE4 subtypes and isoforms selectively may offer a safer and more effective approach for therapy.
PHARMACOLOGICAL REVIEWS
(2021)
Article
Allergy
Yuichi Kama, Yoshiyuki Yamada, Takashi Koike, Mayumi Enseki, Kota Hirai, Hiroyuki Mochizuki, Masahiko Kato
Summary: Allergic sensitization influences bacterial colonization and inflammation in children with asthma, and colonization of Streptococcus pneumoniae has a suppressive effect on the duration of wheezing in allergic sensitization patients with acute exacerbation of asthma.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)