Article
Immunology
Zhao Fang, Shuang Li, Feierkaiti Yushanjiang, Gaoke Feng, Shengyu Cui, Shan Hu, Xuejun Jiang, Chengyin Liu
Summary: Cardiac remodeling is a complex process that contributes to heart failure and arrhythmias in cardiovascular diseases. This study explored the protective effect of curcumol on cardiac remodeling and revealed its underlying mechanism. Curcumol attenuated cardiac dysfunction, fibrosis, and hypertrophy in an animal model of cardiac remodeling. It also alleviated cardiac electrical remodeling and inhibited inflammation and apoptosis through the AKT/NF-KB pathway. These findings suggest that curcumol holds potential as a therapeutic agent for cardiac remodeling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Azza R. Elkholy, Ahmed R. El-Sheakh, Ghada M. Suddek
Summary: The study demonstrated that nilotinib has a protective role in mitigating hepatic and pulmonary damage induced by paraquat, by reducing tissue damage, improving liver function, decreasing oxidative stress and inflammation, suppressing apoptosis, and modulating the Nrf2/Nf-kB axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Ying Tang, Shiyi Yang, Minshan Yao, Minxuan Yang, Lixiang Wei, Hong Chen, Junyan Lin, Yao Huang, Li Lin, Zhendong Qin
Summary: Hemolytic disease in grass carp leads to oxidative damage and cell death, mediated by the release of cell-free hemoglobin and activation of inflammatory pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tongde Wu, Xuebing Jia, Hang Feng, Desheng Wu
Summary: ACTG1 gene mutation leads to hearing loss in humans and is involved in regulating tumor cell proliferation and migration, as well as playing an important role in intervertebral disc degeneration. The expression of ACTG1 gene is negatively correlated with the severity of disc degeneration, and the absence of ACTG1 exacerbates IDD development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Mengying Shi, Yating Gong, Muyao Wu, Haiping Gu, Jiejie Yu, Fan Gao, Zhe Ren, Min Qian, Baoqi Dang, Gang Chen
Summary: This study aimed to investigate the inflammatory function of TREM2 in SBI and its potential regulation of cytokine release through the NF-KB p65 signaling pathway. The study found that TREM2 was upregulated after SBI, and its downregulation enhanced inflammation and brain injury. This suggests that TREM2 may have a protective role by inhibiting NF-KB p65 production after SBI.
BRAIN RESEARCH BULLETIN
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Reza Zinatizadeh, Bettina Schock, Ghanbar Mahmoodi Chalbatani, Peyman Kheirandish Zarandi, Seyed Amir Jalali, Seyed Rouhollah Miri
Summary: The NF-kB transcription factor family plays a critical role in controlling important regulatory gene expression in the cellular environment, impacting processes such as immunity, inflammation, cell death, and proliferation. Understanding NF-kB function can help in the development of treatments for rare and widespread diseases.
Article
Multidisciplinary Sciences
Guoyong Hu, Minjie Zhou, Lina Xu, Donglian Wang
Summary: This study investigates the molecular mechanisms of KLF7 in apoptosis, inflammation, and oxidative stress in H9c2 cells. The results suggest that down-regulation of KLF7 inhibits LPS-induced injury and apoptosis in H9c2 cells, as well as oxidative stress and inflammation. These findings indicate the potential use of KLF7 knockdown as a therapeutic approach for sepsis treatment.
Article
Medicine, Research & Experimental
Weixin Zhao, Yixiao Yan, Zhongxiang Xiao, Meihong Wang, Mingjiang Xu, Zhe Wang, Yi Wang, Zaishou Zhuang, Daona Yang, Gaozhi Chen, Guang Liang
Summary: Bicyclol, approved as an anti-inflammatory drug in China, has shown potential in treating non-alcoholic fatty liver disease (NAFLD) by reducing inflammation and improving dyslipidemia, hepatic apoptosis, systemic and hepatic inflammation, and liver fibrosis. Further studies also indicated that Bicyclol may inhibit inflammatory responses by targeting MAPKs and NF-KB signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Constanze Buhrmann, Aranka Brockmueller, Anna-Lena Mueller, Parviz Shayan, Mehdi Shakibaei
Summary: Curcumin has shown potential in modulating the pathophysiology of osteoarthritis by inhibiting inflammation through NF-kB-Sox9 coupling, thereby contributing to the maintenance of homeostasis in OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
O. A. Afolabi, D. C. Anyogu, M. A. Hamed, A. F. Odetayo, D. H. Adeyemi, R. E. Akhigbe
Summary: This study demonstrated for the first time that glutamine administration improved testicular ischemia/reperfusion injury in a torsion/detorsion rat model by maintaining testicular redox balance, and testicular integrity and function via inhibition of ischemia/reperfusion-induced upregulation of NF-kB signaling and caspase 3 activation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Qi Guo, Meng Zhang, Yonghui Dong, Ke Liu, Desheng Wang, Jia Zheng
Summary: Isobavachalcone (IBC), an active component isolated from Psoralea corylifolia L., has shown potential therapeutic effects on osteoarthritis (OA) by inhibiting inflammation and cartilage degeneration through the NF-KB signaling pathway. These findings suggest that IBC could be a promising therapeutic drug for treating OA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Emily Sun, Aishat Motolani, Leonardo Campos, Tao Lu
Summary: This review provides an overview of the role of NF-kappa B in the pathogenesis of Alzheimer's Disease (AD), including its interaction with various molecular factors in AD models, neurons, and glial cells. With the multifactorial nature of AD development and the failure of many drugs, targeting the NF-kappa B signaling pathway may generate widespread interest in AD research and provide more therapeutic options for AD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Marine & Freshwater Biology
Tianchao Xu, Jie Cui, Ran Xu, Jingwen Cao, Meng-yao Guo
Summary: In this study, a model of carp exposed to microplastics was successfully established. It was observed that exposure to microplastics caused damage to the intestinal mucosal surface and an increase in goblet cells. The study also found that microplastic exposure led to lymphocyte proliferation and aggregation in the intestinal wall, resulting in cellular apoptosis. The activation of NF-KB pathway and ferroptosis induced by lipid peroxidation were identified as the potential mechanisms underlying microplastic-induced intestinal damage.
AQUATIC TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Ziteng Deng, Dan Li, Xue Yan, Jing Lan, Deping Han, Kai Fan, Jianyu Chang, Yunfei Ma
Summary: This study aims to evaluate the underlying mechanisms of GABA signaling on enteric glial cells (EGCs) and found that GABA receptor activation inhibits the proinflammatory factors secretion of EGCs, promotes EGCs polarization into E2 phenotype, mitigates intestinal damage in LPS-induced mice through modulating inflammatory factors expressions and inhibiting NF-KB pathway, providing potential targets for intestinal inflammatory diseases.
Article
Immunology
Jie Cui, Weifeng Tang, Wenqian Wang, La Yi, Fangzhou Teng, Fei Xu, Mihui Li, Mengyu Ma, Jingcheng Dong
Summary: Asthma is a difficult-to-cure disease and there is an urgent need for more reliable and effective medications. Acteoside, a phenylpropanoid glycoside found in various herbs, has been shown to have anti-inflammatory and antioxidant properties. However, there have been few studies on the impact of acteoside on asthma. Therefore, this study aimed to investigate the protective effects of acteoside on asthma and explore the underlying mechanisms both in vivo and in vitro.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carmela Visalli, Sergio Lucio Vinci, Stefania Mondello, Firas Kobeissy, Ignazio Salamone, Alessandra Coglitore, Renato Trimarchi, Agostino Tessitore, Pietro Impellizzeri, Enricomaria Mormina
Summary: This retrospective study compared the applications of power Doppler and MicroV in evaluating pediatric patients with early-stage scrotal pain. MicroV imaging technique showed higher reliability in vascularization detection, especially in diagnosing testicular torsion and epididymitis.
JAPANESE JOURNAL OF RADIOLOGY
(2022)
Article
Clinical Neurology
Alberto Raggi, Lorenzo Monasta, Ettore Beghi, Valeria Caso, Giulio Castelpietra, Stefania Mondello, Giorgia Giussani, Giancarlo Logroscino, Francesca Giulia Magnani, Marco Piccininni, Elisabetta Pupillo, Stefano Ricci, Luca Ronfani, Paola Santalucia, Davide Sattin, Silvia Schiavolin, Claudia Toppo, Eugenio Traini, Jaimie Steinmetz, Emma Nichols, Rui Ma, Theo Vos, Valery Feigin, Matilde Leonardi
Summary: The study shows that the incidence and prevalence of neurological conditions in Italy are increasing, mainly due to population aging and growth. Years lived with disability associated with neurological conditions have significantly increased, calling for actions to improve the situation.
JOURNAL OF NEUROLOGY
(2022)
Review
Spectroscopy
Wenjing Peng, Cristian D. Gutierrez Reyes, Sakshi Gautam, Aiying Yu, Byeong Gwan Cho, Mona Goli, Kaitlyn Donohoo, Stefania Mondello, Firas Kobeissy, Yehia Mechref
Summary: Glycosylation is a significant posttranslational modification in mammalian cells, involved in various biofunctions and diseases. Mass spectrometry is a powerful tool for glycan and glycopeptide isomeric analysis, but its comprehensive characterization remains a challenge. Separation methods and bioinformatic tools are applied to address this challenge.
MASS SPECTROMETRY REVIEWS
(2023)
Review
Public, Environmental & Occupational Health
Periklis Charalampous, Vanessa Gorasso, Dietrich Plass, Sara M. Pires, Elena von der Lippe, Alibek Mereke, Jane Idavain, Katarzyna Kissimova-Skarbek, Joana Nazare Morgado, Che Henry Ngwa, Isabel Noguer, Alicia Padron-Monedero, Maria Jose Santi-Cano, Rodrigo Sarmiento, Brecht Devleesschauwer, Juanita A. Haagsma
Summary: This study aims to assess the disability-adjusted life years (DALYs) resulting from non-communicable diseases (NCDs) in Europe and provide an overview of the calculation methods and data sources used. The study found an increasing number of national assessments of NCD burden in Europe, but ambiguity in reporting the use of NCD-specific methods highlights the need for enhanced transparency.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Oncology
Xinyi Tang, Zhi-Zhang Yang, Hyo Jin Kim, Theodora Anagnostou, Yue Yu, Xiaosheng Wu, Jun Chen, Jordan E. Krull, Kerstin Wenzl, Patrizia Mondello, Vaishali Bhardwaj, Junwen Wang, Anne J. Novak, Stephen M. Ansell
Summary: This study found that regulatory T-cells (Treg) are more abundant in the spleens of patients with splenic marginal zone lymphoma (SMZL) compared to reactive spleens. These Tregs can be separated into CD161(+)Treg and CD26(+)Treg subsets. CD161(+)Tregs are increased in SMZL but have dysregulated immune function. CD161(+)Tregs are associated with a favorable prognosis in SMZL, while CD26(+)Tregs are associated with a poor prognosis. Activation of the IL2/STAT5 pathway contributes to the expansion of CD26(+)Tregs and may lead to a poor clinical outcome in SMZL.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Grzegorz S. Nowakowski, Dok Hyun Yoon, Anthea Peters, Patrizia Mondello, Erel Joffe, Isabelle Fleury, Richard Greil, Matthew Ku, Reinhard Marks, Kibum Kim, Pier Luigi Zinzani, Judith Trotman, Dan Huang, Eva E. Waltl, Mark Winderlich, Nuwan C. Kurukulasuriya, Sumeet Ambarkhane, Georg Hess, Gilles Salles
Summary: In this retrospective study, the combination of tafasitamab and lenalidomide showed a significant improvement in overall survival compared to other treatment regimens for relapsed/refractory diffuse large B-cell lymphoma.
CLINICAL CANCER RESEARCH
(2022)
Article
Clinical Neurology
Isabel R. A. Retel Helmrich, Endre Czeiter, Krisztina Amrein, Andras Buki, Hester F. Lingsma, David K. Menon, Stefania Mondello, Ewout W. Steyerberg, Nicole von Steinbuchel, Kevin K. W. Wang, Lindsay Wilson, Haiyan Xu, Zhihui Yang, David van Klaveren, Andrew I. R. Maas
Summary: This study aimed to examine the value of serum biomarkers in predicting functional outcome after traumatic brain injury. The results showed that higher levels of serum biomarkers were associated with worse outcome, and adding them to established prognostic models improved the prediction accuracy, with UCH-L1 showing the greatest prognostic value.
Article
Clinical Neurology
Andrew I. R. Maas, David K. Menon, Geoffrey T. Manley, Mathew Abrams, Cecilia Akerlund, Nada Andelic, Marcel Aries, Tom Bashford, Michael J. Bell, Yelena G. Bodien, Benjamin L. Brett, Andras Buki, Randall M. Chesnut, Giuseppe Citerio, David Clark, Betony Clasby, D. Jamie Cooper, Endre Czeiter, Marek Czosnyka, Kristen Dams-O'Connor, Veronique De Keyser, Ramon Diaz-Arrastia, Ari Ercole, Thomas A. van Essen, Eanna Falvey, Adam R. Ferguson, Anthony Figaji, Melinda Fitzgerald, Brandon Foreman, Dashiell Gantner, Guoyi Gao, Joseph Giacino, Benjamin Gravesteijn, Fabian Guiza, Deepak Gupta, Mark Gurnell, Juanita A. Haagsma, Flora M. Hammond, Gregory Hawryluk, Peter Hutchinson, Mathieu van der Jagt, Sonia Jain, Swati Jain, Ji-Yao Jiang, Hope Kent, Angelos Kolias, Erwin J. O. Kompanje, Fiona Lecky, Hester F. Lingsma, Marc Maegele, Marek Majdan, Amy Markowitz, Michael McCrea, Geert Meyfroidt, Ana Mikoli, Stefania Mondello, Pratik Mukherjee, David Nelson, Lindsay D. Nelson, Virginia Newcombe, David Okonkwo, Matej Oresic, Wilco Peul, Dana Pisica, Suzanne Polinder, Jennie Ponsford, Louis Puybasset, Rahul Raj, Chiara Robba, Cecilie Roe, Jonathan Rosand, Peter Schueler, David J. Sharp, Peter Smielewski, Murray B. Stein, Nicole von Steinbuchel, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nancy Temkin, Olli Tenovuo, Alice Theadom, Ilias Thomas, Abel Torres Espin, Alexis F. Turgeon, Andreas Unterberg, Dominique Van Praag, Ernest van Veen, Jan Verheyden, Thijs Vande Vyvere, Kevin K. W. Wang, Eveline J. A. Wiegers, W. Huw Williams, Lindsay Wilson, Stephen R. Wisniewski, Alexander Younsi, John K. Yue, Esther L. Yuh, Frederick A. Zeiler, Marina Zeldovich, Roger Zemek
Review
Neurosciences
Wenjing Peng, Firas Kobeissy, Stefania Mondello, Chloe Barsa, Yehia Mechref
Summary: Neurological diseases have a significant impact on millions of people worldwide, and their prevalence is increasing due to global aging. Glycosylation, a post-translational modification, has been found to play a vital role in neurological diseases and can provide novel biomarkers and information for disease pathology. Mass spectrometry is considered the most powerful tool for glycan analysis, and various techniques and strategies have been developed to enhance its identification and quantitation in neurological samples.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Oncology
Patrizia Mondello, Jonas Paludo, Joseph P. Novak, Kerstin Wenzl, Zhi-Zhang Yang, Shahrzad Jalali, Jordan E. Krull, Esteban Braggio, Surendra Dasari, Michelle K. Manske, Jithma A. Abeykoon, Vivekananda Sarangi, Prashant Kapoor, Aneel Paulus, Craig B. Reeder, Sikander Ailawadhi, Asher A. Chanan-Khan, Robert A. Kyle, Morie A. Gertz, Anne J. Novak, Stephen M. Ansell
Summary: This study identified three distinct molecular clusters in IgM monoclonal gammopathy of undetermined significance (MGUS) and Waldenstro euro m macroglobulinemia (WM), which corresponded to different pathological features and clinical presentations. This finding may contribute to a biological classification of these diseases, thus providing more precise treatment options.
CLINICAL CANCER RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Periklis Charalampous, Juanita A. Haagsma, Lea S. Jakobsen, Vanessa Gorasso, Isabel Noguer, Alicia Padron-Monedero, Rodrigo Sarmiento, Joao Vasco Santos, Scott A. McDonald, Dietrich Plass, Grant M. A. Wyper, Ricardo Assuncao, Elena von der Lippe, Balazs Adam, Ala'a AlKerwi, Jalal Arabloo, Ana Lucia Baltazar, Boris Bikbov, Maria Borrell-Pages, Iris Brus, Genc Burazeri, Serafeim C. Chaintoutis, Jose Chen-Xu, Nino Chkhaberidze, Seila Cilovic-Lagarija, Barbara Corso, Sarah Cuschieri, Carlotta Di Bari, Keren Dopelt, Mary Economou, Theophilus Emeto, Peter Fantke, Florian Fischer, Alberto Freitas, Juan Manuel Garcia-Gonzalez, Federica Gazzelloni, Mika Gissler, Artemis Gkitakou, Hakan Gulmez, Sezgin Gunes, Sebastian Haller, Romana Haneef, Cesar A. Hincapie, Paul Hynds, Jane Idavain, Milena Ilic, Irena Ilic, Gaetano Isola, Zubair Kabir, Maria Kamusheva, Pavel Kolkhir, Naime Meric Konar, Polychronis Kostoulas, Mukhtar Kulimbet, Carlo La Vecchia, Paolo Lauriola, Miriam Levi, Marjeta Majer, Enkeleint A. Mechili, Lorenzo Monasta, Stefania Mondello, Javier Munoz Laguna, Evangelia Nena, Edmond S. W. Ng, Paul Nguewa, Vikram Niranjan, Iskra Alexandra Nola, Ronan O'Caoimh, Marija Obradovic, Elena Pallari, Mariana Peyroteo, Vera Pinheiro, Nurka Pranjic, Miguel Reina Ortiz, Silvia Riva, Cornelia Melinda Adi Santoso, Milena Santric Milicevic, Tugce Schmitt, Niko Speybroeck, Maximilian Sprugel, Paschalis Steiropoulos, Aleksandar Stevanovic, Lau Caspar Thygesen, Fimka Tozija, Brigid Unim, Hilal Bektas Uysal, Orsolya Varga, Milena Vasic, Rafael Jose Vieira, Vahit Yigit, Brecht Devleesschauwer, Sara M. Pires
Summary: This systematic literature review provides an overview of studies applying the disability-adjusted life years (DALY) concept for infectious diseases in European countries. Among the 105 included studies, food- and water-borne diseases were the most frequently studied. The number of burden of infectious disease studies has increased over time, but there is less consensus in methodological approaches.
EPIDEMIOLOGY AND INFECTION
(2023)
Editorial Material
Clinical Neurology
Anastasia Bougea, Per Svenningsson, Ioanna Markaki, Abdul Hye, Stefania Mondello
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Akeem Sanni, Mona Goli, Jingfu Zhao, Junyao Wang, Chloe Barsa, Samer El Hayek, Farid Talih, Bartolo Lanuzza, Firas Kobeissy, Giuseppe Plazzi, Monica Moresco, Stefania Mondello, Raffaele Ferri, Yehia Mechref
Summary: This study aimed to identify potential serum biomarkers for narcolepsy type 1 (NT1), a life-threatening disorder characterized by a sleep-wake cycle disorder. A proteomics analysis was conducted, which revealed 36 differentially expressed proteins associated with NT1. These findings provide insights into the pathophysiological effects and important biochemical pathways involved in NT1.
Editorial Material
Clinical Neurology
Wael M. Y. Mohamed, Firas Kobeissy, Stefania Mondello
FRONTIERS IN NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sara Conti, Carla Fornari, Pietro Ferrara, Ippazio C. Antonazzo, Fabiana Madotto, Eugenio Traini, Miriam Levi, Achille Cernigliaro, Benedetta Armocida, Nicola L. Bragazzi, Ennio Cadum, Michele Carugno, Giacomo Crotti, Silvia Deandrea, Paolo A. Cortesi, Davide Guido, Ivo Iavicoli, Sergio Iavicoli, Carlo La Vecchia, Paolo Lauriola, Paola Michelozzi, Salvatore Scondotto, Massimo Stafoggia, Francesco S. Violante, Cristiana Abbafati, Luciana Albano, Francesco Barone-Adesi, Antonio Biondi, Cristina Bosetti, Danilo Buonsenso, Giulia Carreras, Giulio Castelpietra, Alberico Catapano, Maria S. Cattaruzza, Barbara Corso, Giovanni Damiani, Francesco Esposito, Silvano Gallus, Davide Golinelli, Simon I. Hay, Gaetano Isola, Caterina Ledda, Stefania Mondello, Paolo Pedersini, Umberto Pensato, Norberto Perico, Giuseppe Remuzzi, Francesco Sanmarchi, Rocco Santoro, Biagio Simonetti, Brigid Unim, Marco Vacante, Massimiliano Veroux, Jorge H. Villafane, Lorenzo Monasta, Lorenzo G. Mantovani
Summary: We investigated the temporal variations in disease burden of PM2.5 and ozone in Italy using data from the Global Burden of Disease Study 2019. The study found that while the burden of PM2.5 significantly decreased in Italy, the burden of ozone increased, even in the context of population aging.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
