Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Engineering, Environmental
Steven Lelieveld, Jake Wilson, Eleni Dovrou, Ashmi Mishra, Pascale S. J. Lakey, Manabu Shiraiwa, Ulrich Poeschl, Thomas Berkemeier
Summary: Air pollutants such as aerosols and ozone can cause the generation of reactive oxygen species in the human respiratory tract, leading to oxidative stress and adverse health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Prima Buranasin, Hiromi Kominato, Koji Mizutani, Risako Mikami, Natsumi Saito, Kohei Takeda, Takanori Iwata
Summary: Diabetes mellitus is associated with periodontal disease and affects the efficacy of periodontal treatment. Increased reactive oxygen species (ROS) production in periodontal tissues of diabetic patients contributes to insulin resistance and impairs wound healing and tissue repair. Antioxidants and insulin resistance ameliorants may improve wound healing by inhibiting ROS production. This review comprehensively examines the latest evidence on ROS generation in periodontal tissues, particularly related to microbial challenge and diabetes, and discusses the impact of oxidative stress on wound healing in periodontal and dental implant therapies, as well as the potential benefits of administering antioxidants and anti-insulin resistance medications to counteract ROS production and inflammation.
Review
Environmental Sciences
Amlan Das
Summary: Plastic pollution is a significant environmental threat that can cause detrimental effects on terrestrial and marine ecosystems as well as human health. The degradation of macroplastics into microplastics or nanoparticles can lead to organ damage and activation of intracellular signaling, resulting in cell death. Accumulating evidence supports the serious toxicity of microplastics/nanoparticles at various biological levels, and their involvement in oxidative stress and reactive oxygen species production. These particles can accumulate in mitochondria, disrupt the electron transport chain, and generate reactive free radicals that induce DNA damage, protein oxidation, lipid peroxidation, and compromise antioxidant defense. Moreover, microplastic-induced oxidative stress triggers multiple signaling cascades, leading to organ damage such as pulmonary toxicity, neurotoxicity, and hepatotoxicity. Despite ongoing research, there is a lack of proper models, interdisciplinary approaches, and mitigation strategies to fully understand and address the detrimental effects of microplastics/nanoparticles on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biophysics
Priya Gaur, Suchita Prasad, Bhuvnesh Kumar, Sunil K. Sharma, Praveen Vats
Summary: The balance between oxidants and antioxidants is essential for aerobic life, but can be disrupted at high altitudes, leading to oxidative stress. Exposure to high altitude causes increased ROS production, which can lead to various pathophysiological conditions. Antioxidants play a crucial role in protecting cells from oxidative damage and reducing the risk of altitude-related illnesses.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2021)
Review
Plant Sciences
Jelena Dumanovic, Eugenie Nepovimova, Maja Natic, Kamil Kuca, Vesna Jacevic
Summary: In plants, there is a complex antioxidative system (AOS) operating to counteract reactive oxygen species (ROS) and maintain homeostasis within the cell. Plants have excellent antioxidative defense systems, and their antioxidant compounds have been utilized in various fields such as anti-aging formulations, food fortification, and designing therapies for diseases with oxidative stress.
FRONTIERS IN PLANT SCIENCE
(2021)