Article
Peripheral Vascular Disease
Caitlin C. Fermoyle, Ryan M. Broxterman, D. Taylor La Salle, Stephen M. Ratchford, Paul N. Hopkins, Russell S. Richardson, Joel D. Trinity
Summary: Despite a nonpharmacological approach (sodium restriction) to reduce blood pressure, vascular dysfunction persists in hypertensive individuals, both at the conduit and microvascular levels.
JOURNAL OF HYPERTENSION
(2022)
Article
Computer Science, Interdisciplinary Applications
Yingjie Wang, Xueqing Yin
Summary: This study developed an integrated computational model combining coronary flow and myocardial perfusion models to achieve physiologically accurate simulations. The model has the potential for clinical application in diagnosing insufficient myocardial perfusion.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2024)
Article
Cardiac & Cardiovascular Systems
Josep Gomez-Lara, Montserrat Gracida, Fernando Rivero, Alejandro Gutierrez-Barrios, Guillem Muntane-Carol, Rafael Romaguera, Lara Fuentes, Ana Marcano, Gerard Roura, Jose Luis Ferreiro, Luis Teruel, Salvatore Brugaletta, Fernando Alfonso, Josep Comin-Colet, Joan-Antoni Gomez-Hospital
Summary: This study compared the efficacy of pharmacologic-mediated hyperemia and flow-mediated hyperemia in restoring coronary flow in patients with ST-segment-elevation myocardial infarction complicated with no reflow. The results showed that both treatments had similar and limited efficacy in restoring coronary flow. Flow-mediated hyperemia with thermodilution pattern assessment allowed the simultaneous characterization of the no reflow degree and response to hyperemia. No reflow was associated with a high rate of adverse outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Worawut Roongsangmanoon, Arthit Wongsoasup, Teeranan Angkananard, Nattapun Rattanajaruskul, Somboon Jirapattrathamrong
Summary: This study compared the efficacy and safety of intracoronary (IC) nicardipine and adenosine for assessing fractional flow reserve (FFR). The results showed that IC nicardipine has similar hyperemic efficacy and fewer side effects compared to IC adenosine.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Matthieu Bailly, Frederique Thibault, Maxime Courtehoux, Gilles Metrard, Denis Angoulvant, Maria Joao Ribeiro
Summary: The study assessed the use of CZT-SPECT myocardial flow reserve in CAD screening, showing a significant inverse correlation between MFR and the 10-year risk of cardiovascular death. MFR may help identify high-risk patients and assist physicians in deciding whether to perform ICA for further evaluation.
FRONTIERS IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elia von Felten, Dominik C. Benz, Georgios Benetos, Jessica Baehler, Dimitri Patriki, Georgios P. Rampidis, Andreas A. Giannopoulos, Adam Bakula, Christoph Graeni, Aju P. Pazhenkottil, Catherine Gebhard, Tobias A. Fuchs, Philipp A. Kaufmann, Ronny R. Buechel
Summary: Assessing regional quantitative myocardial flow measures through N-13-ammonia PET myocardial perfusion imaging can predict adverse cardiac outcomes and all-cause death in patients with suspected coronary artery disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Food Science & Technology
Rosa M. Valls, Anna Pedret, Lorena Calderon-Perez, Elisabet Llaurado, Laura Pla-Paga, Judit Companys, Ana Moragas, Francisco Martin-Lujan, Yolanda Ortega, Montse Giralt, Laura Rubio, Nuria Canela, Francesc Puiggros, Antoni Caimari, Josep M. Del Bas, Lluis Arola, Rosa Sola
Summary: After 12 weeks of sustained consumption, orange juice enriched with hesperidin significantly increased ischaemic reactive hyperemia, improved endothelial function, reduced systemic inflammatory levels, and affected transcriptomic levels, suggesting a potential mechanism for the observed increase in IRH.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Cardiac & Cardiovascular Systems
Masashi Ichinose, Mikie Nakabayashi, Yumie Ono
Summary: This study demonstrates that single muscle contractions induce rapid, intensity-dependent hyperemia within the contracted skeletal muscle microvasculature in humans, showing different characteristics compared to responses in the upstream conduit artery. Through the use of diffuse correlation spectroscopy and Doppler ultrasound, the magnitude and time course of the contraction-induced rapid hyperemia and vasodilatory responses within skeletal muscle microvessels significantly differ from those in the conduit artery.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lijuan Lyu, Jichen Pan, Dumin Li, Xinhao Li, Wei Yang, Mei Dong, Chenghu Guo, Peixin Lin, Yeming Han, Yongfeng Liang, Junyan Sun, Dexin Yu, Pengfei Zhang, Mei Zhang
Summary: This study investigated the distribution and normal range of hyperemic MBF in healthy subjects using dynamic CT-MPI, and validated its accuracy in identifying functional myocardial ischemia, providing insights for understanding myocardial ischemia in CAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Anand Upadhyaya, Anita Bhandiwad, Jordan Lang, Justin S. Sadhu, Chadwick Barrs, Sudhir Jain, David L. Brown, Linda R. Peterson, Farrokh Dehdashti, Robert J. Gropler, Thomas Hellmuth Schindler
Summary: This study aimed to explore and characterize alterations in coronary circulatory function in relation to increasing body weight with medically controlled cardiovascular risk factors and metabolically unhealthy obesity. The study found that hyperemic MBF progressively decreased in overweight and obese groups, but increased again in the group of morbidly obese individuals comparable to normal weight, indicating contrasting effects of abdominal versus subcutaneous adipose tissue on coronary circulatory function.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Food Science & Technology
Monica Volino-Souza, Gustavo Vieira de Oliveira, Vivian dos Santos Pinheiro, Carlos Adam Conte-Junior, Thiago da Silveira Alvares
Summary: This review evaluates the impact of dietary nitrate on macro- and microvascular function in humans. The literature suggests that dietary nitrate ingestion seems to improve macrovascular function, while the effect on microvascular function is modest.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Sport Sciences
Andre L. Teixeira, Ayesha Gangat, Julian C. C. Bommarito, Jamie F. F. Burr, Philip J. J. Millar
Summary: Ischemic preconditioning has a sex-specific effect on functional sympatholysis, which may contribute to the beneficial effects of ischemic preconditioning on exercise performance in humans.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Hematology
An Young, Mariana Garcia, Samaah M. Sullivan, Chang Liu, Kasra Moazzami, Yi-An Ko, Amit J. Shah, Jeong Hwan Kim, Brad Pearce, Irina Uphoff, J. Douglas Bremner, Paolo Raggi, Arshed Quyyumi, Viola Vaccarino
Summary: The study found that peripheral microvascular dysfunction is associated with an increased risk of major adverse cardiovascular events (MACE) in patients with stable coronary artery disease (CAD), suggesting the role of microvascular disease in the adverse outcomes of CAD patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olga Sliwicka, Andrea Baggiano, Ioannis Sechopoulos, Gianluca Pontone
Summary: The purpose of this study was to investigate the diagnostic performance of stress-only dynamic myocardial computed tomography perfusion (CTP) without computed tomography coronary angiography (CCTA) in diagnosing ischemia. The results showed that dynamic CTP alone has good sensitivity but low specificity in diagnosing ischemia. These findings highlight the importance of combining functional tests with knowledge of coronary artery anatomy in interpretation.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Georgios-Eleftherios Kalykakis, Alexios S. Antonopoulos, Thomas Pitsargiotis, Panagiotis Siogkas, Themistoklis Exarchos, Pavlos Kafouris, Antonis Sakelarios, Riccardo Liga, Aphrodite Tzifa, Andreas Giannopoulos, Arthur J. H. A. Scholte, Philipp A. Kaufmann, Oberdan Parodi, Juhani Knuuti, Dimitrios Fotiadis, Danilo Neglia, Constantinos D. Anagnostopoulos
Summary: This study investigated the relationship between CCTA-derived computational fluid dynamics metrics, anatomic characteristics of coronary lesions, and their ability to predict impaired coronary vasodilating capability. The results showed that combining endothelial shear stress with CCTA stenosis severity improved the prediction of abnormal PET myocardial perfusion imaging results compared to CCTA stenosis severity alone.
Article
Pharmacology & Pharmacy
Pierre Morissette, Hillary K. Regan, Kevin Fitzgerald, Sylvain Bernasconi, Pamela Gerenser, Jeffrey Travis, Patrick Fanelli, Frederick Sannajust, Christopher P. Regan
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2015)
Article
Gastroenterology & Hepatology
Christopher P. Regan, Pierre Morissette, Hillary K. Regan, Jeffery J. Travis, Pamela Gerenser, Jianzhong Wen, Kevin Fitzgerald, Shaun Gruver, Joseph J. DeGeorge, Frederick J. Sannajust
Article
Pharmacology & Pharmacy
P. Morissette, C. Regan, K. Fitzgerald, P. Gerenser, J. Travis, S. Wang, P. Fanelli, F. Sannajust
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2016)
Article
Pharmacology & Pharmacy
Christopher P. Regan, Gary L. Stump, Theodore J. Detwiler, Li Chen, Hillary K. Regan, David B. Gilberto, Joseph J. DeGeorge, Frederick J. Sannajust
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2016)
Article
Chemistry, Medicinal
Douglas C. Beshore, Nigel J. Liverton, Charles J. McIntyre, Christopher F. Claiborne, Brian Libby, J. Christopher Culberson, Joseph J. Salata, Christopher P. Regan, Joseph J. Lynch, Laszlo Kiss, Robert H. Spencer, Stephanie A. Kane, Rebecca B. White, Suzie Yeh, George D. Hartman, Christopher J. Dinsmore
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2010)
Article
Chemistry, Medicinal
Austin Chen, Louis-Charles Campeau, Elizabeth Cauchon, Amandine Chefson, Yves Ducharme, Daniel Dube, Jean-Pierre Falgueyret, Pierre-Andre Fournier, Sebastien Gagne, Erich Grimm, Yongxin Han, Robert Houle, Jing-Qi Huang, Patrick Lacombe, Sebastien Laliberte, Jean-Francois Levesque, Susana Liu, Dwight MacDonald, Bruce Mackay, Dan McKay, M. David Percival, Chris Regan, Hillary Regan, Rene St-Jacques, Sylvie Toulmond
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Cardiac & Cardiovascular Systems
Behzad B. Pavri, Howard E. Greenberg, Walter K. Kraft, Nicole Lazarus, Joseph J. Lynch, Joseph J. Salata, Mark T. Bilodeau, Christopher P. Regan, Gary Stump, Li Fan, Anish Mehta, John A. Wagner, David E. Gutstein, Daniel Bloomfield
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2012)
Article
Cardiac & Cardiovascular Systems
Joseph J. Lynch, Theodore J. Detwiler, Stefanie A. Kane, Christopher P. Regan
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2010)
Article
Cardiac & Cardiovascular Systems
Joseph J. Lynch, Christopher P. Regan, Gregory N. Beatch, Gilbert W. Gleim, Christopher J. Morabito
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Sophie Parmentier-Batteur, Eleftheria N. Finger, Raghu Krishnan, Hemaka A. Rajapakse, John M. Sanders, Geeta Kandpal, Hong Zhu, Keith P. Moore, Christopher P. Regan, Sujata Sharma, J. Fred Hess, Theresa M. Williams, Ian J. Reynolds, Joseph P. Vacca, Robert J. Mark, Philippe G. Nantermet
JOURNAL OF NEUROCHEMISTRY
(2011)
Article
Pharmacology & Pharmacy
Christopher A. Salvatore, Eric L. Moore, Amy Calamari, Jacquelynn J. Cook, Maria S. Michener, Stacey O'Malley, Patricia J. Miller, Cyrille Sur, David L. Williams, Zhizhen Zeng, Andrew Danziger, Joseph J. Lynch, Christopher P. Regan, John F. Fay, Yui S. Tang, Chi-Chung Li, Nicole T. Pudvah, Rebecca B. White, Ian M. Bell, Steven N. Gallicchio, Samuel L. Graham, Harold G. Selnick, Joseph P. Vacca, Stefanie A. Kane
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2010)
Article
Neurosciences
Kelley A. Foster, Hillary K. Regan, Andrew P. Danziger, Theodore Detwiler, Nancy Kwon, Keith Rickert, Joseph J. Lynch, Christopher P. Regan
NEUROSCIENCE RESEARCH
(2009)
Article
Pharmacology & Pharmacy
Christopher Regan, Cherrie Shepherd, Alison Strack, David Weinberg, Ravi Nargund, Zhixiong Ye, Patrick Pollard, Tung Fong, Ian Reynolds, Joseph Lynch
Article
Multidisciplinary Sciences
Lei Ma, Matthew Seager, Marion Wittmann, Marlene Jacobson, Denise Bickel, Maryann Burno, Keith Jones, Valerie Kuzmick Graufelds, Guangping Xu, Michelle Pearson, Alexander McCampbell, Renee Gaspar, Paul Shughrue, Andrew Danziger, Christopher Regan, Rose Flick, Danette Pascarella, Susan Garson, Scott Doran, Constantine Kreatsoulas, Lone Veng, Craig W. Lindsley, William Shipe, Scott Kuduk, Cyrille Sur, Gene Kinney, Guy R. Seabrook, William J. Ray
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Chemistry, Medicinal
Ian M. Bell, Steven N. Gallicchio, Michael R. Wood, Amy G. Quigley, Craig A. Stump, C. Blair Zartman, John F. Fay, Chi-Chung Li, Joseph J. Lynch, Eric L. Moore, Scott D. Mosser, Thomayant Prueksaritanont, Christopher P. Regan, Shane Roller, Christopher A. Salvatore, Stefanie A. Kane, Joseph P. Vacca, Harold G. Selnick
ACS MEDICINAL CHEMISTRY LETTERS
(2010)