Article
Biochemistry & Molecular Biology
Dae Ki Hong, Jae-Won Eom, A. Ra Kho, Song Hee Lee, Beom Seok Kang, Si Hyun Lee, Jae-Young Koh, Yang-Hee Kim, Bo Young Choi, Sang Won Suh
Summary: The compound 2G11 has been found to have neuroprotective effects by blocking zinc translocation and AMPK phosphorylation, thus protecting hippocampal neurons from ischemia-induced damage.
Article
Environmental Sciences
Yiteng Xia, Karl W. K. Tsim, Wen-Xiong Wang
Summary: The subcellular trafficking of zinc ion in rabbitfish fin cells was found to be dose- and time-dependent. Zinc exhibited cytotoxicity when its concentration reached a certain threshold and homeostasis was disrupted when the concentration exceeded a certain level and exposure time exceeded 3 hours. Lysosomes played a major role in regulating zinc homeostasis, while mitochondria were found to be the primary organelles affected by zinc toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Lionel Mendes Dias, Farangis Sharifi, Mark J. de Keijzer, Barbara Mesquita, Emilie Desclos, Jakub A. Kochan, Daniel J. de Klerk, Daniel Ernst, Lianne R. de Haan, Leonardo P. Franchi, Albert C. van Wijk, Enzo M. Scutigliani, Jose E. B. Cavaco, Antonio C. Tedesco, Xuan Huang, Weiwei Pan, Baoyue Ding, Przemek M. Krawczyk, Michal Heger
Summary: In this study, liposomal aluminum phthalocyanine (AlPC) was found to be the most potent photosensitizer for oncological PDT, while ZnPCS4 showed minimal photodynamic activity in A431 cells. AlPC demonstrated no dark toxicity at concentrations up to 1.5 mu M, which is more favorable for clinical use. The intracellular distribution and cell death dynamics varied among different metallated phthalocyanines, suggesting potential for combining different PSs to enhance PDT efficacy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Engineering, Environmental
Yanli Zhang, Yulin Zhang, Ye Lei, Junrong Wu, Yiyuan Kang, Shuo Zheng, Longquan Shao
Summary: During pregnancy, the human body is vulnerable to external stimuli, including zinc oxide nanoparticles (ZnO-NPs). This study investigates the effects of prenatal ZnO-NP exposure on fetal brain tissue development. The findings suggest that ZnO-NPs can cross the blood-brain barrier and enter fetal brain tissue, causing mitochondrial damage, autophagosome overaccumulation, microglial inflammation, and neuronal damage. These findings highlight the importance of understanding the effects of prenatal ZnO-NP exposure on fetal brain development and raising awareness of the use of ZnO-NPs among pregnant women.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Emil Rudolf, Kamil Rudolf
Summary: This study investigates the effects of acute chelation of free intracellular zinc pools in melanoma cells and tissues. The results show that the acute loss of free zinc leads to reduced cell proliferation, cell death, oxidative stress, lysosomal damage, and premature senescence. The responses to zinc loss vary among individual melanoma models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Christina Doxaki, Konstantinos Palikaras
Summary: Disruption of mitochondrial homeostasis in neurons, particularly through impaired mitophagy, can lead to neurodegenerative disorders, while excessive mitophagy may reduce mitochondrial content and ultimately trigger neuronal cell death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Environmental Sciences
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Kaviyarasi Renu, Balachandar Vellingiri, Abilash Valsala Gopalakrishnan
Summary: Studies have shown that heavy metals and metalloids have severe adverse effects on the human reproductive system, potentially leading to infertility. Moderate to minute quantities of lead may affect several reproductive parameters and even semen quality. Ecological and industrial exposures to heavy metals and metalloids have disastrous effects on the reproductive system.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Plant Sciences
Muhammad Ahsan Altaf, Yuanyuan Hao, Chengyao He, Muhammad Ali Mumtaz, Huangying Shu, Huizhen Fu, Zhiwei Wang
Summary: Globally, heavy metal pollution of soil has remained a problem for food security and human health. This study characterized the toxicity symptoms of different concentrations of nickel (Ni) on pepper seedlings. The results showed that excess Ni reduced growth and biomass production, affected gas exchange elements and pigment molecules, and disrupted photosystem function. Higher Ni concentrations increased antioxidant enzyme activity and metabolites, but decreased nitrogen, potassium, and phosphorus levels. The uptake of Ni was higher in roots than shoots. Ni concentrations equal to or greater than 30 mg L-1 had a detrimental impact on pepper seedlings.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Plant Sciences
Harmanjit Kaur, Neera Garg
Summary: This review provides a comprehensive overview of the most recent research on zinc phytotoxicity in plants, focusing on the physiological, biochemical, and molecular impacts of high levels of zinc, as well as the mechanisms plants use to cope with zinc stress and the significance of this in agricultural sustainability.
Article
Biochemistry & Molecular Biology
Criselda Mendoza-Milla, Fernanda Isabel Macias Macias, Kimberly Abigail Velazquez Delgado, Manuel Alejandro Herrera Rodriguez, Zaira Colin-Val, Maria del Pilar Ramos-Godinez, Agustina Cano-Martinez, Anita Vega-Miranda, Diana Xochiquetzal Robledo-Cadena, Norma Laura Delgado-Buenrostro, Yolanda Irasema Chirino, Jose Ocotlan Flores-Flores, Rebeca Lopez-Marure
Summary: Zinc oxide nanoparticles are widely used in the cosmetic industry due to their antimicrobial properties. This study found that ZnO NPs are toxic to cardiac cells, potentially causing heart damage and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Helena Farese, Melissa Noack, Pierre Miossec
Summary: The study found that PVNS synoviocytes show resistance to Cd-induced cell death and decreased inflammation, suggesting that Cd could be a potential therapeutic tool in treating PVNS.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Rui Mao, Ningning Zong, Yujie Hu, Ying Chen, Yun Xu
Summary: The mechanisms of neuronal death following ischemic stroke involve various pathological events, including excitotoxicity, oxidative stress, and inflammatory responses. Understanding the mechanisms of these events is critical for developing new neuroprotective strategies, and some progress has been made in pharmacological research.
NEUROSCIENCE BULLETIN
(2022)
Review
Chemistry, Medicinal
Qing-zhang Tuo, Shu-ting Zhang, Peng Lei
Summary: Ischemic stroke caused by arterial occlusion is a common type of stroke that involves multiple cell death pathways such as apoptosis, necroptosis, and autophagy. Understanding these pathways may reveal new neuroprotective interventions for ischemic stroke.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Microbiology
Sarfraz Hussain, Maryam Khan, Taha Majid Mahmood Sheikh, Muhammad Zahid Mumtaz, Talha Ali Chohan, Saba Shamim, Yuhong Liu
Summary: Zinc is an abundant heavy metal in the Earth's crust and is essential for the growth of living beings. It can be both beneficial and toxic. While it can be obtained from vegetables, beef, and dairy products, excessive intake of zinc supplements can lead to toxicity. In the environment, excessive levels of zinc can affect soil and water microbial diversity and the bioavailability of other metals. Certain bacteria have been identified as promising agents for zinc bioremediation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Guy C. Brown
Summary: After a stroke, rapid necrosis of cells in the infarct occurs, followed by delayed loss of neurons due to microglial phagocytosis, which may be prevented by targeting phagocytic receptors on microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michal Hershfinkel
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Cell Biology
Noam Levaot, Michal Hershfinkel
Article
Biochemistry & Molecular Biology
Moshe Levy, Nadav Elkoshi, Shiran Barber-Zucker, Eitan Hoch, Raz Zarivach, Michal Hershfinkel, Israel Sekler
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Cell Biology
Maayan Mero, Hila Asraf, Israel Sekler, Kathryn M. Taylor, Michal Hershfinkel
Correction
Cell Biology
M. Mero, H. Asraf, I. Sekler, K. M. Taylor, M. Hershfinkel
Article
Biochemistry & Molecular Biology
Ridge Dershem, Raghu P. R. Metpally, Kirk Jeffreys, Sarathbabu Krishnamurthy, Diane T. Smelser, Michal Hershfinkel, David J. Carey, Janet D. Robishaw, Gerda E. Breitwieser, G. Abecasis, A. Baras, M. Cantor, G. Coppola, A. Economides, J. D. Overton, J. G. Reid, A. Shuldiner, C. Beechert, C. Forsythe, E. D. Fuller, Z. Gu, M. Lattari, A. Lopez, T. D. Schleicher, M. S. Padilla, K. Toledo, L. Widom, S. E. Wolf, M. Pradhan, K. Manoochehri, R. H. Ulloa, X. Bai, S. Balasubramanian, L. Barnard, A. Blumenfeld, Y. Chai, G. Eom, L. Habegger, Y. Hahn, A. Hawes, S. Khalid, E. K. Maxwell, J. Penn, J. C. Staples, A. Yadav, P. M. Guzzardo, M. B. Jones, L. J. Mitnaul
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Eitan Hoch, Moshe Levy, Michal Hershfinkel, Israel Sekler
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Rebecca F. Krall, Aubin Moutal, Matthew B. Phillips, Hila Asraf, Jon W. Johnson, Rajesh Khanna, Michal Hershfinkel, Elias Aizenman, Thanos Tzounopoulos
Article
Cell Biology
Moumita Chakraborty, Hila Asraf, Israel Sekler, Michal Hershfinkel
Summary: Activation of ZnR/GPR39 by Zn2+ regulates cell volume through K+/Cl- co-transporter KCC3, promoting cell proliferation and migration. Additionally, upregulation of KCC3 by ZnR/GPR39 enhances the activity of matrix metalloproteases MMP2 and MMP9.
Review
Biochemistry & Molecular Biology
Moumita Chakraborty, Michal Hershfinkel
Summary: Zinc (Zn2+) plays a critical role in cell proliferation, wound healing, gastrointestinal and reproductive systems, as well as in secretory organs, with vital importance in supporting infant growth in the mammary gland and in breast cancer progression.
Article
Neurosciences
Milos Bogdanovic, Hila Asraf, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel
Summary: Tight regulation of neuronal Zn2+ is critical for physiological function. Multiple Zn2+ transporters, such as ZIP1 and ZIP3, are involved in the uptake and distribution of Zn2+. In this study, we found that the expression of ZIP1 and ZIP3 was developmentally regulated in mouse hippocampal neurons, with higher levels of expression in mature neurons. ZIP1 and ZIP3 were ubiquitously expressed on somas and most neuronal processes in cultured neurons, while in adult mouse hippocampal brain, ZIP1 was predominantly expressed in the CA3 stratum pyramidale, and ZIP3 primarily localized in the stratum lucidum. Silencing of ZIP1 or ZIP3 reduced Zn2+ uptake in vitro, and silencing of ZIP3 protected CA3 neurons from neurodegeneration following seizures in vivo. These findings suggest that distinct Zn2+ transporters play different roles in regulating Zn2+ accumulation and toxicity in different neuronal populations in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Hila Asraf, Milos Bogdanovic, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel
Summary: This study demonstrates that the interaction between the neuronal K+/Cl- cotransporter 2 (KCC2) protein and the SNARE protein synaptosome-associated protein 23 (SNAP23) mediates the G-protein-coupled receptor (mZnR/GPR39)-dependent regulation of KCC2 activity. These findings provide insights into the mechanisms of neuronal function regulation.
Article
Cell Biology
Tomer Katoshevski, Lior Bar, Eliav Tikochinsky, Shimon Harel, Tsipi Ben-Kasus Nissim, Ivan Bogeski, Michal Hershfinkel, Bernard Attali, Israel Sekler
Summary: Mitochondrial Ca2+ efflux through NCLX is regulated by CKII and plays a crucial role in fast neuronal plasticity.
Review
Neurosciences
Michal Hershfinkel
Summary: Zinc is crucial for various physiological functions, especially in the digestive system, skin health, and learning and memory. At the cellular level, zinc plays a role in cell proliferation and cell death. The ZnR/GPR39 receptor acts as a mediator between changes in extracellular Zn2+ concentration and cellular Ca2+ signaling, which regulates ion transporter activity and therefore affects transepithelial gradients or neuronal membrane potential. This review focuses on the role of Ca2+ signaling, particularly ZnR/GPR39, in the regulation of NHE1, a Na+/H+ exchanger, and KCC1-3, K+/Cl- cotransporters, and discusses the physiological implications of this regulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Toxicology
V. Reffatto, J. D. Rasinger, T. S. Carroll, T. Ganay, A. -K. Lundebye, I. Sekler, M. Hershfinkel, C. Hogstrand
ARCHIVES OF TOXICOLOGY
(2018)