期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 622, 期 1-3, 页码 45-51出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2009.09.002
关键词
Peroxisome proliferator-activated receptor delta; LDLR-/- mice; Steatosis; Inflammation
资金
- Korea National Institute of Health intramural research [4800-4845-300-210, 2008-N00406-00]
Although peroxisome proliferator-activated receptor delta (PPAR delta) has been implicated in energy metabolism and lipid oxidation process, detailed roles of PPAR delta in lipid homeostasis under pathologic conditions still remain controversial. Thus, we investigated the effect of PPAR delta ligand L-165041 on Western diet-induced fatty liver using low-density lipoprotein receptor-deficient (LDLR-/-) mice. LDLR-/- mice received either L-165041 (5 mg/kg/day) or vehicle (0.1 N NaOH) with Western diet for 16 weeks. According to our data, L-165041 drastically reduced lipid accumulation in the liver, decreasing total hepatic cholesterol and triglyceride content compared to the vehicle group. Gene expression analysis demonstrated that L-165041 lowered hepatic expression of PPAR gamma, apolipoprotein B, interleukin 1 beta (IL-1 beta), and interleukin-6. In contrast, L-165041 increased hepatic expressions of PPAR delta, lipoprotein lipase (LPL), and ATP-binding cassette transporter G1 (ABCG1). Our data suggest that L-165041 might be effective in preventing Western diet-induced hepatic steatosis by regulating genes involved in lipid metabolism and the inflammatory response. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据