Article
Plant Sciences
Yeqing Wang, Shanshan Zhang, Hailai Ni, Yanjie Zhang, Xiaodong Yan, Yue Gao, Beixuan He, Wenzheng Wang, Chong Liu, Meili Guo
Summary: Nicotiflorin, a flavonoid glycoside from traditional Chinese medicine, has shown promise in treating ischemic stroke. This study found that nicotiflorin can alleviate brain damage, improve neurological deficits, and promote autophagy, which plays a significant role in the protective effect of nicotiflorin against ischemic stroke.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Tae-Hoon Park, Han-Gyul Lee, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Jung-Mi Park, Chang-Nam Ko, Ki-Ho Cho, Seungwon Kwon, Sang-Kwan Moon
Summary: This study investigated the effects of Geopung-Chunghyuldan (GCD) and its component Chunghyuldan (CD) on ischemic brain damage. The results showed that GCD significantly reduced cell death in an in vitro ischemia model, while CD did not show a significant protective effect. In an in vivo ischemia mice model, GCD and CD both reduced the infarct volume, with GCD showing a more significant effect. This suggests that GCD may have a synergistic neuroprotective effect and could be a potential alternative for the prevention and treatment of ischemic stroke.
Article
Immunology
Xiaoyan Ren, Jiangang Yu, Lili Guo, Hong Ma
Summary: The study showed that DPP3 plays a neuroprotective role in neurons injured by OGD/R by suppressing apoptosis, oxidative stress, and inflammation through modulation of the Keap1/Nrf2 signaling pathway. The findings suggest DPP3 as a potential target for providing neuroprotective effects during cerebral ischemia/reperfusion injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Musadiq A. Bhat, Abolghasem Esmaeili, Elena Neumann, Karthik Balakrishnan, Dietmar Benke
Summary: GABA(B) receptors play a crucial role in controlling neuronal excitability, and their downregulation can lead to excitotoxicity. This study found that preventing the interaction between CHOP and GABA(B) receptors can restore their normal expression and reduce neuronal death.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Ruili Wang, Lei Li, Baogong Wang
Summary: Poncirin protects cortical neurons from oxygen-glucose deprivation/reoxygenation injury by inhibiting the NOX4/ROS/NLRP3 axis. It alleviates neuronal damage caused by mitochondrial dysfunction, oxidative stress, and inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chenhong Jiang, Yina Hu, Xuewen Hou, Jie Qiu
Summary: This study investigated the effect of a novel brain-derived peptide, HIBDAP, on apoptosis in PC12 cells after OGD. The results showed that TAT-HIBDAP could resist OGD-induced PC12 cell apoptosis by regulating the Bax/Bcl-2/Caspase-3 pathway.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Nina I. Uspalenko, Natalia V. Khmil, Maria I. Shigaeva, Mikhail R. Stepanov, Mikhail A. Ananyan, Maria A. Timchenko, Maxim V. Molchanov, Galina D. Mironova, Egor A. Turovsky
Summary: Cerebral ischemia affects up to 15 million people worldwide every year, making the development of effective preventive programs and therapy methods crucial. This study compared the cytoprotective mechanisms of taxifolin (TAX) and its new water-soluble form, aqua taxifolin (aqTAX), on cultured brain cells under ischemic conditions. The results showed that aqTAX exhibited better protective effects by inhibiting cell death and reducing the increase in intracellular calcium levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Zhihong Wu, Changning Xie, Haixia Kuang, Jian Wu, Xiao Chen, Huibao Liu, Tao Liu
Summary: The study showed that oxytocin plays a critical role in attenuating neonatal neural death by facilitating GABAergic transmission, which may help regulate the excitatory-inhibitory balance in local neuronal networks in NHIE patients.
Article
Neurosciences
Hefei Fu, Jiapeng Wang, Jie Wang, Langni Liu, Jianxiong Jiang, Jiukuan Hao
Summary: This study demonstrated that 4R-cembranoid promotes the protective M2 activation and inhibits the damaging M1 activation in microglial cells. The neuroprotective effects of 4R were shown through regulation of microglial activation, with decreased TNF-a release and increased IL-10 release. These findings suggest that 4R could be a promising lead structure for the development of drugs for the treatment of ischemic stroke and other neurodegenerative diseases with an inflammatory component involved.
BRAIN RESEARCH BULLETIN
(2022)
Article
Engineering, Biomedical
Yousheng Wu, Xiaoxiong Huang, Zefeng Tan, Jiankun Zang, Min Peng, Niu He, Tao Zhang, Hongcheng Mai, Anding Xu, Dan Lu
Summary: This study systematically investigated the properties and protein composition of small extracellular vesicles (sEVs) derived from neurons under hypoxic conditions. The results showed that the involvement of these sEVs in the onset and progression of ischemic stroke is still unclear. Through various analyses, the study identified the characteristics and therapeutic effects of these hypoxia-induced EVs, demonstrating their potential for neuroprotection against ischemic stroke.
BIOACTIVE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Qian Zhang, Jinwei Dai, Zhibing Song, Yuchen Guo, Shanshan Deng, Yongsheng Yu, Tiejun Li, Yuefan Zhang
Summary: The study showed that MQ improved neurobehavior, reduced cerebral infarction areas, altered blood flow, and morphological changes in the cortex and hippocampus in a rat model of brain ischemia-reperfusion injury. Additionally, it decreased neuronal apoptosis and malondialdehyde levels, while increasing superoxide dismutase levels. In vitro studies demonstrated that MQ enhanced cell survival rates and decreased reactive oxygen species levels. Furthermore, protein and mRNA expressions involved in apoptosis were significantly decreased, suggesting a neuroprotective effect of MQ in cerebral ischemia by blocking the p-JNK/Bax pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Nicholas P. DeAdder, Hannah J. Gillam, Brian C. Wilson
Summary: The study showed that H2 and H3 relaxin treatments have a protective effect on cell death caused by oxygen and glucose deprivation, with the effect of H3 relaxin being partially attenuated by L-NIL, and antagonism of RXFP3 affecting the action of H3 relaxin.
Article
Neurosciences
Hyuk Sung Kwon, Jungsoon Ha, Ji Young Kim, Hyun-Hee Park, Eun-Hye Lee, Hojin Choi, Kyu-Yong Lee, Young Joo Lee, Seong-Ho Koh
Summary: The study showed that telmisartan attenuated the activation of the NLRP3 inflammasome by triggering the PI3K pathway, contributing to neuroprotection in neural stem cells.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Sofia Ramirez-Guerrero, Santiago Guardo-Maya, German J. Medina-Rincon, Eduardo E. Orrego-Gonzalez, Ricardo Cabezas-Perez, Rodrigo E. Gonzalez-Reyes
Summary: Taurine, the most abundant free amino acid in the brain, is synthesized primarily in astrocytes and plays a crucial role in maintaining calcium homeostasis, antioxidation, osmoregulation, and anti-inflammatory responses in the central nervous system. Its neuroprotective effects are mediated through both extracellular and intracellular mechanisms.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Fang Yang, Ruping Chen
Summary: The study demonstrates that Sesn1 exerts neuroprotective effects on neurons following cerebral ischemia/reperfusion injury by potentiating Nrf2 activation to ameliorate OGD/R-induced damage.
