Review
Endocrinology & Metabolism
Svetlana Lebedeva, Arus Margaryan, Elena Smolyarchuk, Andrey Nedorubov, Maria Materenchuk, Alexander Tonevitsky, Kerim Mutig
Summary: Diabetic kidney disease is the major cause of chronic kidney disease, and enhanced plasma vasopressin levels have been associated with it. Vasopressin has diuretic effects in the kidneys and adaptive effects in other organs. Overactivation of certain vasopressin receptors can lead to kidney problems and worsen diabetic kidney disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Xu-Dong Zhang, Zhong-Yuan Liu, Mao-Sen Wang, Yu-Xiang Guo, Xiang-Kun Wang, Kai Luo, Shuai Huang, Ren-Feng Li
Summary: Regulation of cell mortality for disease treatment has been a focus of research, with the iron-dependent regulated cell death called Ferroptosis being extensively studied. Studies have shown that regulation of ferroptosis brings new treatment strategies for various diseases. Genes involved in iron and lipid metabolism can regulate ferroptosis by controlling iron overload and lipid peroxidation. Glutathione (GSH), the body's primary non-enzymatic antioxidant, also plays a crucial role in combating lipid peroxidation by assisting glutathione peroxidase 4 (GPX4). This review summarizes recent research on the mechanism of ferroptosis and comprehensively analyzes the regulation of ferroptosis through iron and lipid metabolism, as well as the metabolism of GPX4 and GSH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xu Xiao, Youngjae Kim, Beatriz Romartinez-Alonso, Kristupas Sirvydis, Daniel S. Ory, John W. R. Schwabe, Michael E. Jung, Peter Tontonoz
Summary: Aster proteins mediate nonvesicular plasma membrane to endoplasmic reticulum cholesterol transport, with 20 alpha-hydroxycholesterol and U18666A identified as potential small molecule modulators. However, they target other sterol homeostatic proteins, limiting their utility.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Nathan Favalier, Vincent Veron, Michael Marchand, Anne Surget, Patrick Maunas, Nicolas Turonnet, Stephane Panserat, Lucie Marandel
Summary: The study found that glucose and lipid metabolism in rainbow trout were regulated by nutritional status in all sexes, regardless of carbohydrate intake. Short-term carbohydrate intake at low temperature did not induce specific metabolic changes in broodstock. Additionally, sex differences were demonstrated for the first time regarding the consequences of two days of feeding on glucose and lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Haidong Wei, Luming Zhen, Shiquan Wang, Liufei Yang, Shuyue Zhang, Yuanyuan Zhang, Pengyu Jia, Tianyue Wang, Kui Wang, Yan Zhang, Lei Ma, Jianrui Lv, Pengbo Zhang
Summary: The study suggests that treatment with GTA can enhance lipid synthesis and IL-33 expression after ischemic stroke, thus improving blood-brain barrier repair and functional recovery.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Hematology
Shilei Chen, Kangfu Sun, Baichuan Xu, Songlin Han, Song Wang, Yang Xu, Fang Chen, Mo Chen, Mingqiang Shen, Yukai Lu, Changhong Du, Mengjia Hu, Fengchao Wang, Junping Wang
Summary: Platelet shedding from mature megakaryocytes is crucial for increasing circulating platelets rapidly, and this study investigates the mechanisms behind it and identifies new therapeutic targets for thrombocytopenia.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Wangkuk Son, Katie Brown, Aaron Persinger, Ashley Pryke, Jason Lin, Zereque Powell, Noah Wallace, Marie van der Merwe, Melissa Puppa
Summary: The aim of this study was to examine whether the fat composition resulting from a high-fat diet affects glucocorticoid-induced changes in lipid metabolism in the liver and skeletal muscle. The results demonstrated that a high omega-3 polyunsaturated fatty acid (PUFA) diet attenuated fatty accumulation and prevented glucocorticoid-induced increases in liver lipid metabolism markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Raquel da Ana, Anna Gliszczynska, Elena Sanchez-Lopez, Maria L. Garcia, Karolline Krambeck, Andjelka Kovacevic, Eliana B. Souto
Summary: Oxidation of lipids and lipoproteins contributes to inflammation processes that promote the development of eye diseases. Targeting lipid metabolism to treat ocular diseases is an interesting and effective approach.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Magdalene K. Montgomery, Amanuiel Z. Taddese, Jacqueline Bayliss, Shuai Nie, Nicholas A. Williamson, Matthew J. Watt
Summary: Hepatic HexA expression is influenced by lipid availability and steatosis, with overexpression leading to increased hepatic GM3 content and upregulation of enzymes involved in glycated sphingolipid degradation, ultimately resulting in sphingomyelin accumulation in the liver. Additionally, overexpression of HEXA in the liver causes significant changes in cell surface lipid rafts, affecting VLDL processing and secretion, leading to hypertriglyceridemia and ectopic lipid accumulation in peripheral tissues. This study highlights the important role of HEXA in modulating hepatic sphingolipid and lipoprotein metabolism.
Article
Agriculture, Multidisciplinary
Chao Tang, Hongyuan Zhao, Liangyu Kong, Fanqiang Meng, Libang Zhou, Zhaoxin Lu, Yingjian Lu
Summary: This study investigated the effects of Lactobacillus acidophilus NX2-6-fermented yogurt (LA-Y) on lipid and glucose levels in high-fat diet-fed mice. The results showed that LA-Y improved lipid profile, reduced fasting blood glucose levels, and enhanced insulin sensitivity. LA-Y also alleviated glucose metabolism disorders by activating the insulin signaling pathway, reducing inflammation, and promoting glycolysis and gluconeogenesis in the small intestine. Additionally, LA-Y promoted fat browning and increased energy expenditure through adiponectin/AMPK alpha/PGC-1 alpha/UCP1 pathway and mitochondrial biogenesis via adiponectin/AdipoR1/APPL1/AMPK alpha/PGC-1 alpha pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Oncology
Xianlei Cai, Chao Liang, Miaozun Zhang, Yuan Xu, Yihui Weng, Xueying Li, Weiming Yu
Summary: N6-methyladenosine (m6A) modification plays a significant role in the metabolic reprogramming of digestive system malignancies.
Editorial Material
Oncology
Jose Pedro Friedmann Angeli, Thamara Nishida Xavier da Silva, Bastian Schilling
Summary: In this study, Liao et al. show that CD8(+) T cell-secreted IFN-γ rewires cancer cell lipid metabolism via ACSL4, activating polyunsaturated fatty acids and sensitizing cancer cells to ferroptosis in immunotherapy-relevant settings.
Article
Gastroenterology & Hepatology
Jonas Norskov Sondergaard, Christian Sommerauer, Ionut Atanasoai, Laura C. Hinte, Keyi Geng, Giulia Guiducci, Lars Brautigam, Myriam Aouadi, Lovorka Stojic, Isabel Barragan, Claudia Kutter
Summary: By globally characterizing RNA-binding proteins (RBPs), we revealed the perturbation of RBP gene expression in hepatocellular carcinoma (HCC) and identified their additional functions in tumor growth regulation, particularly in lipid metabolism. Furthermore, the interaction between non-canonical RBP CCT3 and LINC00326 was found to be involved in the regulation of lipid accumulation and degradation, affecting HCC cell phenotype and tumour growth in vivo.
Article
Chemistry, Analytical
Yingjie Lu, Yuqi Cao, Li Zhang, Yuanyuan Lv, Ying Zhang, Yue Su, Yinlong Guo
Summary: Mass spectrometry imaging is a hot research field that can reflect the distribution of multiple metabolites in tissue. However, not all types of metabolites have high ionization efficiency in mass spectrometry imaging. This study developed a platform that combines online quaternized derivatization and laser ablation carbon fiber ionization mass spectrometry imaging, achieving significant increase in mass signals of monoglycerides and diglycerides, and readily acquiring high-quality mass images of these metabolites.
ANALYTICAL CHEMISTRY
(2022)
Article
Fisheries
Lijuan Yu, Juan Tian, Chenxi Zhang, Zhiyong Xue, Xing Lu, Hua Wen, Ming Jiang, Fan Wu
Summary: This study investigated the effects of different levels of acetylferulic paeonol ester (APE) on the growth performance, body composition, serum biochemical indicators, and lipid and glucose metabolism of Nile tilapia. The results showed that APE supplementation improved weight gain and decreased liver lipid content. It also affected serum biochemical parameters related to lipid and glucose metabolism. Transcriptome analysis revealed changes in gene expression related to fatty acid oxidation and degradation. APE influenced the hepatic glucose and lipid metabolism of tilapia at both enzymatic and mRNA levels.
