期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 592, 期 1-3, 页码 158-159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2008.06.107
关键词
inflammation; pain; estrogen receptor beta
To understand the contribution of the estrogen receptor beta, the potent and selective agonist ERb-131 was evaluated in animal models of inflammatory pain. In paradigms of acute and persistent inflammatory pain, ERb-131 did not alleviate the nociception induced by either carrageenan or formalin. However, in the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components. Thus, ERb-131 is sufficient to alleviate chronic but not acute inflammatory pain states. (C) 2008 Elsevier B.V. All rights reserved.
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