Article
Biochemistry & Molecular Biology
Max Lenz, Christoph Kaun, Konstantin A. Krychtiuk, Patrick Haider, Mira Brekalo, Nadine Maier, Laura Goederle, Christoph J. Binder, Kurt Huber, Christian Hengstenberg, Johann Wojta, Philipp J. Hohensinner, Walter S. Speidl
Summary: The study found that nicorandil has a positive effect on stabilizing atherosclerotic plaque by reducing apoptosis.
Article
Cardiac & Cardiovascular Systems
W. Coles Keeter, Alina K. K. Moriarty, Rachel Akers, Shelby Ma, Marion Mussbacher, Jerry L. L. Nadler, Elena V. V. Galkina
Summary: This study investigates the role of signal transducer and activator of transcription 4 (STAT4) in neutrophils during advanced atherosclerosis. STAT4 deficiency reduces plaque burden and improves plaque stability in mice. Additionally, STAT4 deficiency decreases neutrophil activation and attenuates neutrophil trafficking to atherosclerotic plaques.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Lia Farahi, Satyesh K. Sinha, Aldons J. Lusis
Summary: Atherosclerosis is a chronic inflammatory disease that involves the recruitment and differentiation of monocytes into macrophages in response to inflammatory insults. Macrophages play critical roles in tissue damage, wound healing, and regression of atherosclerotic lesions, and their phenotypes are influenced by various stimuli. Recent advances in single-cell sequencing have revealed the heterogeneity of macrophages in lesions, shedding light on potential macrophage-based therapies for atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Cheng Yuan Xue, Meng Qi Zhou, Qi Yan Zheng, Jin Hui Zhang, Wei Ting Cheng, Xue Hui Bai, Fen Zhou, Ai Ming Wu, Bo Nie, Wei Jing Liu, Li Xia Lou
Summary: TZDs drugs have shown inhibiting effects on plaque progression and protective effects on vascular endothelium in diabetic patients with coronary atherosclerosis, potentially contributing to a protective effect on myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Mulugeta M. Zegeye, Ljubica Matic, Mariette Lengquist, Assim Hayderi, Magnus Grenegard, Ulf Hedin, Allan Sirsjo, Liza U. Ljungberg, Ashok K. Kumawat
Summary: IL-6 trans-signaling regulates the expression of laminin alpha chains in endothelial cells and inhibits the migration of granulocytic cells across endothelial cells. The expression of laminin alpha chains is altered in human atherosclerotic plaques and is related to the abundance of leukocyte subpopulations.
Review
Cardiac & Cardiovascular Systems
Ling-bing Meng, Yuan-meng Zhang, Yue Luo, Tao Gong, De-ping Liu
Summary: Atherosclerosis is a chronic vascular inflammatory disease characterized by lipid accumulation and immune response cells in artery walls, with chronic stress potentially playing a significant role in its progression. Social, environmental, and genetic factors collectively influence the development of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Evangelia Gkougkoudi, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Georgia Valsami
Summary: Dabigatran etexilate and exercise training have complementary effects on the development and stability of atherosclerotic lesions in diabetic mice, mediated by anti-inflammatory modulation.
Article
Cardiac & Cardiovascular Systems
Weiyu Chen, Sergey Tumanov, Christopher P. Stanley, Stephanie M. Y. Kong, James Nadel, Niv Vigder, Darren L. Newington, Xiao Suo Wang, Louise L. Dunn, Roland Stocker
Summary: This study shows that deficiency of bilirubin is associated with increased risk of atherosclerosis and cardiovascular disease. In the experiments, mice deficient in bilirubin showed higher burden of atherosclerotic plaques, increased systemic oxidative stress, endothelial dysfunction, and hyperlipidemia. Furthermore, the study found that bilirubin deficiency selectively enhanced neutrophil-mediated inflammation and destabilization of unstable plaques.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Joseph Kamtchum-Tatuene, Luca Saba, Mirjam R. Heldner, Michiel H. F. Poorthuis, Gert J. de Borst, Tatjana Rundek, Stavros K. Kakkos, Seemant Chaturvedi, Raffi Topakian, Joseph F. Polak, Glen C. Jickling
Summary: This study demonstrates that circulating IL-6 levels predict carotid plaque severity, vulnerability, and progression. A cutoff of 2.0 pg/mL for IL-6 levels could facilitate the selection of individuals that would benefit from anti-IL-6 drugs for stroke prevention.
CIRCULATION RESEARCH
(2022)
Review
Environmental Sciences
Chiara Macchi, Cesare R. Sirtori, Alberto Corsini, Pier Mannuccio Mannucci, Massimiliano Ruscica
Summary: According to the WHO, the entire global population is exposed to air pollution levels higher than recommended for health preservation. Air pollution, a complex mixture of particles and gases, poses a major global threat to public health. Particulate matter PM2.5 has been identified as a causal factor for cardiovascular diseases such as hypertension, coronary artery disease, stroke, heart failure, arrhythmias, and cardiovascular mortality. This review explores the proatherogenic effects of PM2.5, including endothelial dysfunction, chronic inflammation, reactive oxygen species, mitochondrial dysfunction, and arterial plaque instability.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Boce Song, Yulong Bie, Haoxin Feng, Beili Xie, Mingwang Liu, Fuhai Zhao
Summary: Coronary atherosclerosis is a chronic inflammatory disease that affects the occurrence of cardiovascular disease. Inflammatory factors play a key role in the process of the disease, and different stages of lesions are regulated by different inflammatory cells.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Review
Cell Biology
Benjamin Bartlett, Herbert P. Ludewick, Silvia Lee, Shipra Verma, Roslyn J. Francis, Girish Dwivedi
Summary: This paper reviews the efficacy of different PET imaging radiotracers in characterizing and assessing the risk of vulnerable plaques in acute coronary syndrome. It also discusses the translational potential of novel radiotracers in animal studies and the challenges encountered in murine PET imaging.
Review
Pharmacology & Pharmacy
Chih-Feng Lien, Sy-Jou Chen, Min-Chien Tsai, Chin-Sheng Lin
Summary: PKC activation plays a significant role in diabetes-induced atherosclerosis, regulating lipid metabolism, oxidative stress, inflammatory response, and apoptosis. PKC beta and PKC delta are potential therapeutic targets for diabetic vascular complications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Shaohong Fang, Song Sun, Hengxuan Cai, Xiaoyi Zou, Shanjie Wang, Xinran Hao, Xin Wan, Jiangtian Tian, Zhaoying Li, Zhongze He, Wei Huang, Chenchen Liang, Zhenming Zhang, Liming Yang, Jinwei Tian, Bo Yu, Bo Sun
Summary: The research suggests that serum IRGM levels may be related to plaque rupture in STEMI patients, and deficiency of IRGM/Irgm1 can increase plaque stability by suppressing macrophage apoptosis through inhibiting ROS generation and MAPK signaling transduction. Targeting IRGM may represent a new treatment strategy for the prevention and treatment of acute cardiovascular deaths caused by plaque rupture.
Review
Cell Biology
Aleksa Petkovic, Sanja Erceg, Jelena Munjas, Ana Ninic, Sandra Vladimirov, Aleksandar Davidovic, Luka Vukmirovic, Marko Milanov, Dane Cvijanovic, Tijana Mitic, Miron Sopic
Summary: Despite efforts to develop new therapies, atherosclerotic cardiovascular diseases (ASCVD) remain a leading cause of death worldwide. However, current approaches to prognosis, diagnosis, and classification of acute coronary syndrome do not consider the diversity of plaque phenotypes.
Review
Medicine, General & Internal
Feng Wang, Jie Kong, Yi-Yao Cui, Peng Liu, Jian-Yan Wen
CHINESE MEDICAL JOURNAL
(2018)
Article
Surgery
Jie Kong, Feng Wang, Jianbin Zhang, Yiyao Cui, Lin Pan, Wenjian Zhang, Jianyan Wen, Peng Liu
JOURNAL OF SURGICAL RESEARCH
(2018)
Article
Surgery
Jie Kong, Peng Liu, Jinyong Li, Xueqiang Fan, Jianyan Wen, Jianbin Zhang, Rongwei Xu, Yiyao Cui, Xia Zhen, Zhidong Ye
INTERNATIONAL JOURNAL OF SURGERY
(2018)
Article
Physiology
Jianbin Zhang, Qiangqiang Nie, Chaozeng Si, Cheng Wang, Yang Chen, Weiliang Sun, Lin Pan, Jing Guo, Jie Kong, Yiyao Cui, Feng Wang, Xueqiang Fan, Zhidong Ye, Jianyan Wen, Peng Liu
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Physiology
Cui Yiyao, Lv Xiaoshuo, Wang Feng, Kong Jie, Zhao Hao, Ye Zhidong, Si Chaozeng, Pan Lin, Liu Peng, Wen Jianyan
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Cell Biology
Jun Wu, Dingyun Song, Zhongwen Li, Baojie Guo, Yani Xiao, Wenjing Liu, Lingmin Liang, Chunjing Feng, Tingting Gao, Yanxia Chen, Ying Li, Zai Wang, Jianyan Wen, Shengnan Yang, Peipei Liu, Lei Wang, Yukai Wang, Liang Peng, Glyn Nigel Stacey, Zheng Hu, Guihai Feng, Wei Li, Yan Huo, Ronghua Jin, Ng Shyh-Chang, Qi Zhou, Liu Wang, Baoyang Hu, Huaping Dai, Jie Hao
Article
Physiology
Kong Jie, Wang Feng, Zhao Boxiang, Gong Maofeng, Zhang Jianbin, Lu Zhaoxuan, Zhou Yangyi, Chen Liang, Su Haobo, Lou Wensheng, Chen Guoping, Gu Jianping, He Xu, Wen Jianyan
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Cell Biology
Bin He, Qiangqiang Nie, Feng Wang, Yongxin Han, Bo Yang, Mingsheng Sun, Xueqiang Fan, Zhidong Ye, Peng Liu, Jianyan Wen
Summary: Atherosclerosis is a significant global cardiovascular disease, and pyroptosis is identified as a crucial inflammatory form of it. Studies have found that pyroptosis plays an important role in atherosclerosis and have clarified potential therapeutic strategies targeting pyroptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Feng Wang, Yanan Zhen, Chaozeng Si, Cheng Wang, Lin Pan, Yang Chen, Xiaopeng Liu, Jie Kong, Qiangqiang Nie, Mingsheng Sun, Yongxin Han, Zhidong Ye, Peng Liu, Jianyan Wen
Summary: In chronic thromboembolic pulmonary hypertension (CTEPH), elevated WNT5B expression regulates mitochondrial dynamics to promote vascular smooth muscle cell (VSMC) phenotype switching, with inhibitors and accelerators affecting VSMC proliferation and migration differently.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Congrui Sun, Bin He, Mingsheng Sun, Xiaoshuo Lv, Feng Wang, Jie Chen, Jianbin Zhang, Zhidong Ye, Jianyan Wen, Peng Liu
Summary: Atherosclerosis and its complications are major causes of cardiovascular morbidity and mortality globally. The Yes-associated protein (YAP) has been shown to play a crucial role in the pathogenesis and development of atherosclerosis, regulating processes such as vascular dysfunction, monocyte infiltration, and smooth muscle cell migration. Further research is needed to explore the role of YAP in atherosclerotic complications like vascular calcification and intraplaque hemorrhage.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Feng Wang, Xueqiang Fan, Jie Kong, Cheng Wang, Bo Ma, Weiliang Sun, Zhidong Ye, Peng Liu, Jianyan Wen
Summary: Arteriovenous fistulas (AVFs) are commonly used for hemodialysis, but their failure rate is high. Abnormal proliferation and migration of vascular smooth muscle cells along with increased mitochondrial fission may contribute to AVF stenosis. Inhibiting mitochondrial fission could potentially improve AVF patency.
Article
Physiology
Feng Wang, Congrui Sun, Xiaoshuo Lv, Mingsheng Sun, Chaozeng Si, Yanan Zhen, Jing Guo, Weiliang Sun, Zhidong Ye, Jianyan Wen, Peng Liu
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by thrombofibrotic obstruction of the proximal pulmonary arteries, leading to vascular remodeling of the distal pulmonary artery. The study identified molecular mechanisms, with TNF-alpha driving CTEPH pathogenesis by promoting VSMC proliferation and migration through increased FOS expression. This information may guide the development of new therapeutic targets for CTEPH.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zhan Liu, Yanan Zhen, Fan Lin, Xia Zheng, Xiaopeng Liu, Guang Sun, Zhidong Ye, Jianyan Wen, Peng Liu
Summary: Resting heart rate and age are independent preoperative risk factors for postoperative atrial fibrillation after pulmonary thromboendarterectomy. Larger scale studies are needed.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Pharmacology & Pharmacy
Qiangqiang Nie, Jianbin Zhang, Bin He, Feng Wang, Mingsheng Sun, Cheng Wang, Weiliang Sun, Jing Guo, Jianyan Wen, Peng Liu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Medicine, General & Internal
Jie Kong, Peng Liu, Xueqiang Fan, Jianyan Wen, Jianbin Zhang, Yanan Zhen, Jinyong Li, Yiyao Cui, Xia Zheng, Zhidong Ye
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2017)
