Article
Endocrinology & Metabolism
Yongjing Cheng, Jianhui Xu, Ruixin Zeng, Xi Zhao, Wenmin Gao, Junru Quan, Xiaosong Hu, Ziling Shen, Jie Zhang
Summary: The LPBN plays a role in fever induced by LPS through the upregulation of COX-2 and mPGES-1, with PGE(2) mediating fever by modulating the firing rate of neurons in different LPBN subnuclei.
NEUROENDOCRINOLOGY
(2022)
Article
Engineering, Chemical
Zohreh Akbari Jonoush, Abbas Rezaee, Ali Ghaffarinejad
Summary: The present study proposes an effective system for Escherichia coli (E. coli) disinfection using an electrocatalytic system with a Ni-Fe/Fe3O4 nanocomposite cathode. The system enhances the inactivation of bacteria using Fe3O4 nanoparticles and humic acid (HA). The experimental results show that the proposed system achieves complete E. coli inactivation in 12 minutes with low energy consumption. Adding nitrate to the system increases the time required for disinfection due to the reaction of chlorine compounds with byproducts of nitrate reduction. The study highlights the capability of the Ni-Fe/Fe3O4 nanocomposite electrode for water disinfection and nitrate reduction.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luigi Santacroce, Marica Colella, Ioannis Alexandros Charitos, Marina Di Domenico, Raffaele Palmirotta, Emilio Jirillo
Summary: Fever is an elevation of body temperature that protects against pathogens. Innate immune cells and neurons regulate body temperature. Pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharides (LPS) and peptidoglycan/lipoteichoic acid (PGN/LTA) from bacteria bind to Toll-like receptors (TLRs) on immune and non-immune cells, leading to the release of pro-inflammatory cytokines (IL-1, IL-6, TNF-alpha) and the generation of fever through the production of prostaglandin E2 (PGE2) by neurons in the pre-optic area. Besides traditional non-steroidal anti-inflammatory drugs, botanicals are used as antipyretic agents, and their mechanisms of action are being investigated.
Article
Engineering, Environmental
Yanyan Zhang, Jinxia Liu, Subhasis Ghoshal, Audrey Moores
Summary: In this study, the reaction path of 6:2 FTSA initiated by (OH)-O-center dot was mapped using density functional theory (DFT) calculations and experimentally verified. It was found that the parallel addition of (OH)-O-center dot and O-2 to CnF2n+1 center dot was essential to producing C2-C6 PFCAs. The generation of alkoxyl radicals and chain cleavage were identified as critical steps in the transformation process.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Environmental Sciences
Monserrat Castaneda-Juarez, Ivonne Linares-Hernandez, Veronica Martinez-Miranda, Elia Alejandra Teutli-Sequeira, Luis Antonio Castillo-Suarez, Ana Gabriela Sierra-Sanchez
Summary: This review summarizes research data on pharmaceutical drugs used to treat the novel SARS-CoV-2 virus, their characteristics, environmental impacts, and the advanced oxidation processes (AOP) used to remove them. The results show that AOPs are a promising solution for minimizing the environmental impact of these compounds. Photocatalysis is currently the main technology used for removing these drugs, but there are limitations in large-scale practical applications. Additionally, the diverse and complex nature of pharmaceuticals in the environment is discussed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Hernan D. Rojas-Mantilla, Saidy C. Ayala-Duran, Raquel F. Pupo Nogueira
Summary: This study characterized Nontronite, a clay mineral with high content of structural iron, before and after iron incorporation and 600 degrees C heat treatment. It was found to be a mesoporous material with high absorption and a band gap energy indicative of superficial hematite. Heat treatment promoted structure rearrangement, converting other iron phases to hematite and creating irregular surface sites, enhancing catalytic activity in the degradation of antibiotics with hydroxylation as the main degradation route.
Article
Endocrinology & Metabolism
Yongjing Cheng, Jianhui Xu, Ruixin Zeng, Xi Zhao, Wenmin Gao, Junru Quan, Xiaosong Hu, Ziling Shen, Jie Zhang
Summary: The enzymes COX-2 and mPGES-1 were upregulated in the LPBN, and pharmacological inhibition attenuated LPS-induced fever. Direct administration of PGE(2) in the LPBN induced a febrile response with increased EE, BAT thermogenesis, and shivering. Neurons in different LPBN subnuclei showed varied responses to PGE(2) modulation, indicating its role in LPS-induced fever.
NEUROENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dimitrios Kotsos, Konstantinos Tziomalos
Summary: Nonalcoholic fatty liver disease (NAFLD) is common in the general population and even more prevalent in obese and diabetic patients. NAFLD, especially nonalcoholic steatohepatitis (NASH), increases the risk for liver-related and cardiovascular morbidity. The development and progression of NAFLD involve complex and multifactorial pathogenesis, with potential involvement of microsomal prostaglandin E synthase-1 and -2. Targeting these enzymes may offer a novel therapeutic approach for NAFLD. This review discusses the association between microsomal prostaglandin E synthase-1 and -2 and NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Yang Li, Shitong Han, Zhanguo Li, Zhen Liu, Longhui Liang, Keping Yan, Anna Zhu
Summary: By using atmospheric pressure plasma jet to decontaminate 2-Chloroethyl ethyl sulfide, the chemical pollutant can be completely removed in a relatively short time with reduced toxicity. Helium APPJ was more effective, generating more .OH and slowly raising the skin surface temperature to 30.4 degrees Celsius within 15 minutes without causing damage.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Physical
Yanan Sun, Junfang Yao, Yizhen Tang, Yunju Zhang, Wenzhong Wu, Jingyu Sun
Summary: E,E-2,4-hexadienal is likely a precursor of secondary organic aerosol (SOA) and is important in atmospheric chemistry. Quantum chemical calculations were used to study its reaction mechanism with hydroxyl radical, revealing multiple pathways and products that impact atmospheric radical cycling, ozone production, and SOA formation. The theoretical rate constant of the reaction at 298 K matches experimental data, with an atmospheric lifetime of about 2.6 h.
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY
(2021)
Article
Immunology
Ali Attiq, Juriyati Jalil, Khairana Husain, Jamia Azdina Jamal, Elysha Nur Ismail
Summary: The study isolated two new compounds with anti-inflammatory activities from Cyathocalyx pruniferus, where 2-octaprenyl-1,4-benzoquinone (5) showed potent inhibition of inflammatory mediators without cytotoxicity, indicating potential applications in acute and chronic inflammation.
INFLAMMOPHARMACOLOGY
(2021)
Article
Immunology
Kuo-Chen Wu, Chih-Yu Lee, Yijuang Chern, Chun-Jung Lin
Summary: The study suggests that deleting the ENT2 gene can alleviate LPS-induced neuroinflammation and blood-brain barrier breakdown, as well as improve cognitive functions such as spatial memory and hippocampal long-term potentiation. Further experiments revealed that neuronal survival was preserved in Ent2 KO mice, while WT mice exhibited synaptic and neuronal damage.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Engineering, Environmental
Wei Hong, Yan Liu, Xinxin Jiang, Chenguang An, Tianle Zhu, Ye Sun, Haining Wang, Fangxia Shen, Xiang Li
Summary: Appropriate introduction of alkali metal can improve the formation ability of hydroxyl radicals (center dot OH) during catalytic ozonation process, leading to enhanced toluene degradation. The introduction of 5.9wt% K+ resulted in the formation of the highest amount of center dot OH and exhibited excellent catalytic activity and selectivity. The deactivated catalyst can be regenerated through water washing and heat treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Gabriel Robert, J. Richard Wagner, Jean Cadet
Summary: Molecular oxygen sensitizes DNA to damage induced by ionizing radiation and other free radical-mediated reactions. It converts carbon-centered radicals within DNA into peroxyl radicals, leading to the formation of oxidized products and strand breaks. Reactive peroxyl radicals can also propagate damage to neighboring components in DNA strands, causing tandem or double lesions. This review highlights the formation and biological implications of oxidatively generated DNA tandem lesions.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Physical
Avinash Kumar, Koushik Mondal, B. Rajakumar
Summary: The reactivity of 2-ethoxy ethanol with OH radicals was experimentally and computationally studied, with Arrhenius expressions derived for the reaction kinetics. The feasibility of each reaction pathway was determined, and atmospheric implication parameters were calculated and discussed.
JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Review
Toxicology
Rong-Jane Chen, Yu-Hsuan Lee, Tzu-Hao Chen, Yu-Ying Chen, Ya-Ling Yeh, Ching-Ping Chang, Chien-Cheng Huang, How-Ran Guo, Ying-Jan Wang
Summary: Carbon monoxide, known as a silent killer, can reduce oxygen carrying capacity in the body by binding to hemoglobin. While toxic at high concentrations, CO has cyto- and tissue-protective effects at low concentrations, modulating inflammatory responses through regulation of cytokine production. Understanding the interplay between mitochondria, autophagy, exosomes, and the inflammasome is crucial for understanding the health effects of CO and potential treatment strategies for inflammation-related diseases.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Pei-Hsuan Lin, Kuan-Hua Huang, Yu-Feng Tian, Cheng-Hsien Lin, Chien-Ming Chao, Ling-Yu Tang, Kun-Lin Hsieh, Ching-Ping Chang
Summary: This study examined the effects of exertional heat stroke (EHS) on fertility, erectile function, and testicular morphology in male rats. The results showed that EHS caused testicular temperature disruption, damage to testicular tissues, and erectile dysfunction in the rats.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Shu-Chun Kuo, Chung-Ching Chio, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
Summary: In vivo and in vitro studies showed that A beta(1-42) oligomer affects retinal morphology and cell viability, leading to dysmorphological changes and decreased expression of tight junction proteins. Conditioned medium from mesenchymal stem cells protected against A beta-induced retinal pathology by influencing various signaling pathways and protein expressions. Secretomes from MSC-CM might have potential therapeutic implications in age-related macular degeneration.
Correction
Neurosciences
Yu-Lin Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Yu-Ling Wang, Chung-Ching Chio, Shu-Chun Kuo, Chao-Hung Yeh, Jui-Ti Ma, Wen-Pin Liu, Mao-Tsun Lin, Kao-Chang Lin, Ching-Ping Chang
Summary: This study aims to investigate the beneficial effects of exercise rehabilitation and/or astragaloside in counteracting amyloid-beta pathology. The results showed that exercise rehabilitation and/or astragaloside reversed the neurobehavioral disorders and neuropathology caused by amyloid-beta. The application of BDNF and/or astragaloside also reversed the cytotoxicity and mitochondrial distress induced by amyloid-beta in cortical neurons. The combined therapy of exercise rehabilitation (or BDNF) and astragaloside showed superior therapeutic effects compared to individual treatments. The results indicate that exercise rehabilitation (or BDNF) and astragaloside attenuate amyloid-beta pathology by reversing BDNF/TrkB signaling deficits and mitochondrial dysfunction, and their combination potentiates each other's therapeutic effects. Astragaloside can be an alternative therapy to replace exercise rehabilitation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Materials Science, Coatings & Films
W. T. Lin, Z. W. Lin, T. Y. Kuo, C. S. Chien, J. W. Huang, Y. L. Chung, C. P. Chang, M. Z. Ibrahim, H. T. Lee
Summary: The addition of CNTs improves the indentation fracture toughness of Ta2O5 coatings deposited by atmospheric plasma spraying, without degrading their surface morphology and roughness. However, higher CNT content increases the coating porosity and reduces the microhardness.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Chi-Chun Chen, Yu-Lin Wang, Ching-Ping Chang
Summary: This study developed an optimised rehabilitation training system for rats with various stroke severities and used a modified ladder-climbing method for training. The results showed that this method was effective in promoting recovery for subjects with different stroke severities.
IET CIRCUITS DEVICES & SYSTEMS
(2022)
Article
Public, Environmental & Occupational Health
Chien-Cheng Huang, Tzu-Hao Chen, Chung -Han Ho, Yi-Chen Chen, Rong-Jane Chen, Ying-Jan Wang, Chien -Chin Hsu, Hung -Jung Lin, Jhi-Joung Wang, Ching -Ping Chang, How-Ran Guo
Summary: This study investigated the effects of CO poisoning on the development of diabetes and on existing diabetes through epidemiologic analyses and animal experiments. The results showed that CO poisoning increased the risks of diabetes and hyperglycemic crisis, which may be attributable to damages in the pancreas and hypothalamus.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Chemistry, Physical
Kuan-Ting Chen, Jun-Wei Huang, Wei-Ting Lin, Tsung-Yuan Kuo, Chi-Sheng Chien, Ching-Ping Chang, Yung-Ding Lin
Summary: The micro-arc oxidation (MAO) process was used to prepare hydroxyapatite-containing flower-like structure coatings on commercially pure titanium substrates. The morphology of the coatings depended on the applied voltage, with 330 V resulting in a flower-like/plate-like structure, and 390 V and 450 V resulting in a flower-like structure and a porous morphology respectively. The applied current and duration time affected the coating formation speed and petal size of the flower-like structures. The coatings with flower-like/plate-like or flower-like structures exhibited higher roughness, increased hydrophilicity, and superior bioactivity and biocompatibility. The 390 V coating had the optimal biomedical performance due to its flower-like structure and high HA/DCPD ratio.
Article
Biology
Kuan-Hua Huang, Ching-Ping Chang, Lan-Hsiang Chien, Chien-Feng Li, Ling-Yu Tang, Yu-Yi Chan, Ting-Feng Wu
Summary: This study aimed to investigate the inhibitory molecular process of pomegranate peel on urinary bladder urothelial carcinoma using a proteomics strategy. The results revealed that pomegranate peel extract can regulate various proteins involved in cell apoptosis, cell proliferation, and signaling pathways, thus inhibiting the growth and spread of cancer cells. These findings suggest that pomegranate might serve as a potential chemopreventive resource for UBUC carcinogenesis.
Article
Medicine, Research & Experimental
Chien-Ming Chao, Lin-Yu Wang, Chien-Cheng Huang, Wei-Ting Chang, Ling-Yu Tang, Mao-Tsun Lin, Chang Ching-Ping
Summary: Using a survival male rat model of acute exertional heat stroke (EHS), this study investigated the effects of EHS on myocardium structure and function. It was found that EHS caused skeletal muscle and myocardial damage, with myocardial damage lasting for at least 14 days post-EHS. This study is significant as it provides key findings on the pathophysiology and risk factors of EHS, as well as highlighting the need for further research.
Article
Neurosciences
Tian-Hoe Tan, Shih-Wen Li, Chih-Wei Chang, Yuan-Chih Chen, Yu-Hsuan Liu, Jui-Ti Ma, Ching-Ping Chang, Pao-Chi Liao
Summary: In this study, hair was found to undergo metabolic changes in rats induced with beta-amyloid, which were associated with cognitive impairments. Furthermore, these changes observed in the hair of beta-amyloid-induced rats showed a similar trend to the metabolites found in the cerebrospinal fluid of Alzheimer's disease patients. Therefore, hair can be a valuable biospecimen for assessing endogenous metabolic disturbances and identifying biomarkers of Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Chien-Liang Liu, Hung-Wen Tsai, Shu-Ling Peng, Ching-Ping Chang, Yu-Hao Chang, Huei-Sheng Huang
Summary: Urine-based cytology is commonly used for clinical diagnosis of urothelial carcinoma (UC), but its sensitivity is limited for low-grade UC detection. This study found that CDCP1 expression was significantly higher in UC patients, especially those with low-grade UC, compared to normal individuals. CDCP1 expression in urinary UC cells was also detected using immunocytochemistry. The overexpression and knockdown of CDCP1 in UC cells influenced migration ability, suggesting its potential role in the malignant progression of UC.
Article
Cell Biology
Tzong-Bor Sun, Kuo-Feng Huang, Ko-Chi Niu, Cheng-Hsien Lin, Wen-Pin Liu, Chao-Hung Yeh, Shu-Chun Kuo, Ching-Ping Chang
Summary: Hyperbaric oxygen preconditioning can reverse oxygen-glucose deprivation-induced retinal pigment epithelial cell injury by activating PPAR-a signaling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Meeting Abstract
Urology & Nephrology
Kun-Lin Hsieh, Ching-Ping Chang, Kuan-Hua Huang, Allen W. Chiu
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
