Article
Biochemistry & Molecular Biology
Sang Yean Kim, Qingyu Shen, Keunhong Son, Hyung Seok Kim, Hee Doo Yang, Min Jeong Na, Eunbi Shin, Suji Yu, Keunsoo Kang, Jueng Soo You, Kyung-Rok Yu, Seung Min Jeong, Eun Kyung Lee, Young Min Ahn, Won Sang Park, Suk Woo Nam
Summary: The SWI/SNF complex plays a crucial role in regulating gene expression in eukaryotes, with certain subunit genes, particularly SMARCA4, being overexpressed in HCC. This overexpression may lead to the activation of oncoproteins Gankyrin and AKR1B10, contributing to hepatocarcinogenesis.
Article
Medicine, Research & Experimental
Wenzhe Duan, Wenwen Liu, Shengkai Xia, Yang Zhou, Mengyi Tang, Mingxin Xu, Manqing Lin, Xinyu Li, Qi Wang
Summary: The high expression of AKR1B10 in lung cancer brain metastasis (BM) contributes to increased resistance to PEM chemotherapy. The study reveals that AKR1B10 mediates PEM resistance through metabolic reprogramming, specifically by promoting glycolysis and lactate production which activates the CCNB1 pathway. This finding provides novel strategies to improve PEM response in lung cancer patients with BM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Zhengnan Huang, Yilin Yan, Zhen Zhu, Jiakuan Liu, Xiao He, Sumiya Dalangood, Meiqian Li, Mingyue Tan, Jinming Cai, Pengfei Tang, Ruimin Huang, Bing Shen, Jun Yan
Summary: CBX7 is frequently downregulated in urinary bladder cancer due to promoter hypermethylation, leading to poor prognosis. Its ectopic expression suppresses UBC cell aggressiveness and tumor development by downregulating AKR1B10 and inactivating ERK signaling, providing a potential therapeutic target against UBC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Arezki Chekaoui, Hildegund C. J. Ertl
Summary: The PPAR alpha agonist fenofibrate was shown to improve cancer vaccine efficacy by reprogramming tumor cells to increase fatty acid metabolism and provide T cells access to glucose in the tumor microenvironment. Timing of treatment with fenofibrate was crucial in modifying tumor-infiltrating lymphocyte metabolism and enhancing the vaccine's ability to slow tumor progression.
Article
Biochemistry & Molecular Biology
Yuanqing Zeng, Jia Li, Wangyuan Guo, Weihao Luo, Xiangting Liu, Rongzhang He, Zheng Hu, Lili Duan, Chenglai Xia, Dixian Luo
Summary: AKR1B10 is found to protect cells from UVC-induced DNA damage and is involved in the pathway of DNA double-strand break repair, providing new insights into its role in DNA damage repair and pointing towards a new direction in tumorigenesis and cancer drug resistance.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Oncology
Zhe Cao, Kristin Delfino, Vivek Tiwari, Xin Wang, Abdul Hannan, Fawwad Zaidi, Andrew McClintock, Kathy Robinson, Yun Zhu, John Gao, Deliang Cao, Krishna Rao
Summary: This case-controlled pilot study found that serum AKR1B10 was significantly elevated in breast cancer patients, and it was correlated with its expression in tumor tissues. After surgical removal of primary tumors, the serum AKR1B10 levels rapidly decreased and became similar to those of healthy individuals. ROC curve analysis suggested that serum AKR1B10 could serve as a biomarker for breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Dengyan Zhu, Yunfei Nie, Yang Zhao, Xiaoming Chen, Zhichang Yang, Yang Yang
Summary: This study identified the tumor suppressive role of RNF152 in LUAD by promoting IRAK1 ubiquitination and IRAK1-mediated down-regulation of AKR1B10.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi Wu, Yanjie Hao, Qing'xin Zhuang, Xiaoli Ma, Chao Shi
Summary: This study found that M2 macrophage polarization is the main immune infiltration pattern in gastric cancer, and low expression of AKR1B10 induces M2 macrophage polarization and promotes the malignant transformation of gastric cancer.
BIOSCIENCE REPORTS
(2023)
Article
Cell Biology
Xinyu Shao, Jue Wu, Shunying Yu, Yuqing Zhou, Chunli Zhou
Summary: AKR1B10 functions as a tumor suppressor in gastric cancer, with its expression level significantly impacting patient prognosis. Reduced AKR1B10 expression enhances proliferation and migration of GC cells.
Article
Oncology
Yanze Yin, Huijuan Dai, Xicheng Sun, Zhifeng Xi, Jiang Zhang, Yixiao Pan, Yongxin Huang, Xueyun Ma, Qiang Xia, Kang He
Summary: This study reveals that liver cancer promotes tumor lung metastasis by regulating neutrophil recruitment and NETs formation in the metastatic microenvironment through reducing HRG secretion. The findings of this study will contribute to the development of possible strategies for treating metastases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia, Dixian Luo
Summary: Elevated expression of AKR1B10 in breast cancer tissues was associated with lymph node metastasis, tumor size, Ki67 expression, and p53 expression, while inversely correlated with overall and disease-free survival rates. AKR1B10 promotes proliferation, migration, and invasion of breast cancer cells via the PI3K/AKT/NF-kappa B signaling pathway, indicating its potential as a prognostic indicator and therapeutic target in breast cancer.
CELL AND BIOSCIENCE
(2021)
Article
Cell Biology
Wanyun Li, Cong Liu, Zilan Huang, Lei Shi, Chuanqi Zhong, Wenwen Zhou, Peipei Meng, Zhenyu Li, Shengyu Wang, Fanghong Luo, Jianghua Yan, Ting Wu
Summary: This study reveals a novel mechanism of NRP1 in regulating autophagy through AKR1B10 during colorectal cancer development. NRP1 regulates autophagy by modulating the expression of AKR1B10, which in turn interacts with and inhibits GAPDH, ultimately repressing autophagy.
JOURNAL OF CELL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Mei-sa Wang, Qiu-shuang Han, Zhi-rong Jia, Chuan-sheng Chen, Chen Qiao, Qian-qian Liu, Ya-meng Zhang, Kai-wei Wang, Jie Wang, Kang Xiao, Xuan-sheng Ding
Summary: Studies have shown that fenofibrate promotes apoptosis by regulating the PPAR alpha/AMPK/AKT/FoxO1 pathway, reducing cholesterol levels and enhancing the anti-proliferative effects of gefitinib in NSCLC cells. Combination treatment of gefitinib and fenofibrate significantly inhibits tumor growth in mouse xenograft models compared to single-drug therapy.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Engineering, Biomedical
Su Kyeom Kim, Yu Heun Kim, Sewon Park, Seung-Woo Cho
Summary: Advancements in organoid technology have allowed for better replication of in vivo organ environments, overcoming limitations of existing disease models. Integration of engineering approaches such as microfluidics and biomaterials is necessary for more precise disease modeling. Combined with organoids, these engineered disease models provide a powerful platform for personalized medicine research.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Satoshi Endo, Toshiyuki Matsunaga, Toru Nishinaka
Summary: AKR1B10 is highly expressed in epithelial cells of the stomach and intestine, but down-regulated in gastrointestinal cancers and inflammatory bowel diseases. It is lowly expressed in other tissues, but upregulated in cancers, non-alcoholic fatty liver disease, and several skin diseases. The enzyme's expression is elevated in cancer cells resistant to clinical anti-cancer drugs.
Article
Biochemistry & Molecular Biology
Changjun You, Pengcheng Wang, Stephanie L. Nay, Jianshuang Wang, Xiaoxia Dai, Timothy R. O'Connor, Yinsheng Wang
ACS CHEMICAL BIOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Andrew A. Beharry, Sandrine Lacoste, Timothy R. O'Connor, Eric T. Kool
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Multidisciplinary Sciences
Sandrine Lacoste, Smita Bhatia, Yanjun Chen, Ravi Bhatia, Timothy R. O'Connor
Article
Biochemistry & Molecular Biology
Thai Q. Tran, Mari B. Ishak Gabra, Xazmin H. Lowman, Ying Yang, Michael A. Reid, Min Pan, Timothy R. O'Connor, Mei Kong
Article
Chemistry, Multidisciplinary
David L. Wilson, Andrew A. Beharry, Avinash Srivastava, Timothy R. O'Connor, Eric T. Kool
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Article
Oncology
Liang Liu, Weiying Zhou, Chun-Ting Cheng, Xiubao Ren, George Somlo, Miranda Y. Fong, Andrew R. Chin, Hui Li, Yang Yu, Yang Xu, Sean Timothy Francis O'Connor, Timothy R. O'Connor, David K. Ann, Jeremy M. Stark, Shizhen Emily Wang
MOLECULAR CANCER RESEARCH
(2014)
Article
Oncology
Caroline C. Clark, Jeffrey N. Weitzel, Timothy R. O'Connor
MOLECULAR CANCER THERAPEUTICS
(2012)
Article
Multidisciplinary Sciences
Li Z. Luo, Sailesh Gopalakrishna-Pillai, Stephanie L. Nay, Sang-Won Park, Steven E. Bates, Xianmin Zeng, Linda E. Iverson, Timothy R. O'Connor
Article
Multidisciplinary Sciences
Sandrine Lacoste, Ravi Bhatia, Smita Bhatia, Timothy R. O'Connor
Article
Biochemistry & Molecular Biology
Avinash C. Srivastava, Yesenia Guadalupe Thompson, Jyotsana Singhal, Jordan Stellern, Anviksha Srivastava, Juan Du, Timothy R. O'Connor, Arthur D. Riggs
Article
Chemistry, Analytical
Sarah C. Shuck, Cu Nguyen, Yin S. Chan, Timothy O'Connor, Alexandra K. Ciminera, Michael Kahn, John Termini
ANALYTICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Deepa Akula, Timothy R. O'Connor, Roy Anindya
Summary: ALKBH5, known as a RNA N6-methyladenine demethylase, is also found to have weak DNA repair activity and can demethylate DNA 3-methylcytosine. Overexpression of ALKBH5 reduces the level of 3-methylcytosine in genomic DNA and decreases the cytotoxic effects of the DNA damaging alkylating agent. This suggests that demethylation by ALKBH5 may play a supporting role in maintaining genome integrity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Meeting Abstract
Oncology
Kimlin Ashing, Cary Presant, Sophia Yeung, Jonjon Macalintal, Brian Tiep, Argelia Sandoval, Dan Raz, Ravi Salgia, Loretta Erhunmwunsee, Arya Amini, Amar Merla, Heather Graves, Steven Rosen
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Oncology
Roberto Gutierrez, Timothy R. O'Connor
Summary: DNA direct reversal repair (DRR) corrects errors without DNA synthesis, and is carried out in humans through two pathways. While alkylating agents are commonly used for cancer treatment, resistance can be a hindrance, prompting exploration of potential solutions for overcoming it.
CANCER DRUG RESISTANCE
(2021)
Article
Chemistry, Medicinal
Richard Jararnillo, Sarah C. Shuck, Yin S. Chan, Xueli Liu, Steven E. Bates, Punnajit P. Lim, Daniel Tamae, Sandrine Lacoste, Timothy R. O'Connor, John Termini
CHEMICAL RESEARCH IN TOXICOLOGY
(2017)