期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 585, 期 2-3, 页码 436-440出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2008.01.057
关键词
psychiatric disorder; genetic; animal model; pharmacology; quantitative trait loci mapping; synteny
The pharmacological treatment of mood and anxiety disorders has for long relied on the serendipitous findings of monoaminergic and benzodiazepine drugs more than 50 years ago. These treatments, however, are therapeutically insufficient and even though more recently developed drugs are particularly improving side effects, the efficacy or response rate of the drugs has fundamentally not improved. Therefore it is necessary to develop new methods to identify novel mechanisms not based on merely the symptomatology, but on biologically relevant (endo) phenotypes. This review examines the option of integrating mouse and human behavioural genetics to aid the identification of the putative underlying pathophysiological mechanisms and pharmacological targets for psychiatric disorders. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据