期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 88, 期 1, 页码 40-47出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2014.04.015
关键词
Genistein; Solid lipid nanoparticles; Nanostructured lipid carriers; Characterization; Stability; Lipid dynamic; Flexibility; Electron paramagnetic resonance; Skin permeation
资金
- CNPq
- CAPES
- FAPEG
- FINEP
- FUNAPE-UFG
The aim of this study was to develop lipid nanoparticles to deliver genistein (GEN) to deeper skin layers. To do so, the impact of lipid dynamic behavior (nanoparticle flexibility) on stability, release and skin permeation studies was verified. GEN-loaded solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were obtained and characterization was undertaken. Freshly prepared nanoparticles were produced with similar features (i.e., drug loading). However, a higher level of crystallization in GEN-SLN formulation was observed in differential scanning calorimetry experiments. Electron paramagnetic resonance measurements, showed a lower mobility of the spin labels in the SLN, which would indicate that NLC could be more flexible than SLN. Despite the fact that NLC demonstrated more fluidity, GEN was released more slowly from NLC than from SLN. Skin permeation studies demonstrated that lipid nanoparticles increased GEN skin retention. More flexible particles (NLC) also favored drug penetration into deeper skin layers. GEN-NLC would seem to be a promising formulation for GEN topical delivery. (C) 2014 Elsevier B.V. All rights reserved.
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