Review
Chemistry, Applied
Changhoon Chai, Jinhyung Park
Summary: This review examines the structure, components, stability, and applicability of liposomes, and discusses different preparation methods. Emphasis is placed on the role of phospholipids and liposome modulators in achieving desired structure and size. The potential of liposomes to enhance food value through encapsulation and delivery of functional substances is also discussed. The importance of research on lecithin properties and modulators that improve liposome stability is highlighted. The need for cost-effective and rapid preparation methods to improve the marketability of food liposomes and promote their use in foods is identified.
Article
Food Science & Technology
Wahyudiono, Jiayang He, Xin Hu, Siti Machmudah, Keiji Yasuda, Seiichi Takami, Hideki Kanda, Motonobu Goto
Summary: Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO2)-ultrasound environment system. The operating conditions influenced the size of liposome products and the encapsulation efficiency of curcumin. This innovative method does not require organic solvents and is practical for generating liposomes.
Article
Biophysics
Cristina Pavan, Matthew J. Sydor, Chiara Bellomo, Riccardo Leinardi, Stefania Canana, Rebekah L. Kendall, Erica Rebba, Marta Corno, Piero Ugliengo, Lorenzo Mino, Andrij Holian, Francesco Turci
Summary: This study identifies and proposes the molecular recognition mechanism between membrane epitopes and nearly free silanols (NFS) as a novel explanation for the unique activity of inhaled crystalline silica. The results demonstrate that NFS content is the primary determinant of membrane disruption, leading to red blood cell lysis and changes in lipid order. These findings provide insights for the safer design of materials and potential treatments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Research & Experimental
Wei He, Yawei Du, Tao Wang, Ji Wang, Lei Cheng, Xinsong Li
Summary: A novel anticancer drug carrier based on dARTPC encapsulated with Ir was developed, showing high encapsulation efficiency and controllable drug loading. In vitro experiments demonstrated that dARTPC-based liposomes can effectively release DHA and Ir in a weakly acidic environment, exhibiting significant antitumor activity. In vivo studies revealed that Ir encapsulated with dARTPC exhibited a high tumor inhibition rate with minimal toxicity.
MOLECULAR PHARMACEUTICS
(2021)
Article
Thermodynamics
Kosuke Shido, Mariko Noguchi, Ami Hayashi, Atsushi Nagoe, Hiroki Fujimori
Summary: The effect of precooling treatments on the phase behaviors of OHMBBA was investigated using DSC and DSC-XRD measurements. DSC-Raman spectroscopy was also performed to distinguish various crystalline phases and a glassy N phase. The results demonstrated the usefulness of DSC-Raman spectroscopy in detecting phase transitions and identifying phases.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Chemistry, Physical
Boyang Sun, Sanjana Ghosh, Xuedan He, Wei-Chiao Huang, Breandan Quinn, Meiling Tian, Dushyant Jahagirdar, Moustafa T. Mabrouk, Joaquin Ortega, Yumiao Zhang, Shuai Shao, Jonathan F. Lovell
Summary: This study explores the potential of photodynamic therapy (PDT) combined with chemotherapy for tumor ablation. Liposomes loaded with a photosensitizer and a potent anti-cancer drug were successfully developed and demonstrated effective tumor ablation in in vivo experiments. This liposome delivery system shows versatility and potential for achieving enhanced tumor treatment.
Article
Food Science & Technology
Guangqiang Wang, Huaning Yu, Xin Feng, Hongyu Tang, Zhiqiang Xiong, Yongjun Xia, Lianzhong Ai, Xin Song
Summary: This study explored the importance of different bsh genes in the bile salt resistance of L. plantarum AR113, revealing that bsh 1 and bsh 3 genes are critical for BSH activity and preferentially degrade glycine-conjugated bile salts. The results suggest that bsh 1 and bsh 3 are closely related to bile salt resistance, providing valuable insights for selecting strains with high tolerance to bile salts in a rational, high-throughput manner.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Thermodynamics
J. H. F. de Jesus, R. S. Medeiros, J. A. Ellena, E. T. G. Cavalheiro
Summary: The thermal behavior and polymorphism of tert-butylhydroquinone (TBHQ) were studied using differential scanning calorimetry, infrared spectroscopy, and hot stage microscopy. Two polymorphs of TBHQ were identified depending on the thermal treatment: a commercial form and a new form obtained from melt-crystallization.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Biochemistry & Molecular Biology
Deepika Regmi, Fengyun Shen, Aleksander Stanic, Majedul Islam, Deguo Du
Summary: Misfolding and aggregation of cellular prion protein (PrPc) is a major molecular process involved in the pathogenesis of prion diseases. The aggregation of PrP(106-128) depends on concentration, pH, preformed amyloid seeds, and the lipid composition and rigidity of liposomes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Multidisciplinary Sciences
Matthew H. Foley, Sarah O'Flaherty, Garrison Allen, Alissa J. Rivera, Allison K. Stewart, Rodolphe Barrangou, Casey M. Theriot
Summary: Primary bile acids are metabolized by indigenous bacteria in the gastrointestinal tract, shaping host-microbiota interactions. Bacterial bile salt hydrolases cleave glycine or taurine from BAs, a crucial step for the production of secondary BAs. Lactobacilli harbor a diversity of BSHs, influencing their fitness and colonization in the gut, with enzymatic preferences and chemical features playing a role in determining toxicity during growth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Thermodynamics
Chuanxin Xie, Yucan Yuan, Ben Wang, Lei Du
Summary: This study investigates the thermal hazards of aniline diazonium salt through dynamic experiments using differential scanning calorimeter (DSC) and analysis of kinetic parameters using Advanced Kinetics and Technology Solutions (AKTS) software. The results show that aniline diazonium salt is prone to decomposition, with a low onset decomposition temperature and high apparent activation energy. The decomposition process of aniline diazonium salt exhibits a non-uniform reaction mechanism.
THERMOCHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Umran Ay, Martin Lenicek, Arno Classen, Steven W. M. Olde Damink, Carsten Bolm, Frank G. Schaap
Summary: The conversion of host bile salts by gut microbes generates secondary bile salt species with distinct biological and physicochemical properties. Recent research has identified a new class of microbial bile salt metabolites that can influence the composition of human gut bacteria and disease states. These microbial bile salt conjugates (MBSCs) are diverse, with almost 50 different species identified.
Article
Biotechnology & Applied Microbiology
Andrea Martinez Aguirre, Adegoke Oyeleye Adegbite, Joseph A. A. Sorg
Summary: The Clostridioides difficile pathogen can initiate infection through germination, which can be stimulated by certain amino acids and bile salts. We discovered that C. difficile strains have bile salt hydrolase activity, specifically towards taurine-derived bile salts. This activity can produce cholate, which signals the initiation of biofilm formation in C. difficile.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Microbiology
Guillaume Dejean, Heloise Tudela, Lisa Bruno, Deborah Kissi, Georges Rawadi, Sandrine P. Claus
Summary: Christensenella minuta, a key member of the gut microbiome, was found to have a novel strain (strain DSM33407) that enhances microbiota diversity and stimulates deconjugation of primary bile acids. A protein carrying potent BSH activity was identified and cloned from the genome of C. minuta, showing preference for deconjugating glycine-conjugated bile acids. The phylogenetic tree of BSH-related enzymes in the human microbiome revealed that C. minuta's BSH sequence is distinct from others with a threshold of 70% identity.
Article
Chemistry, Physical
Fan C. Wang, Philip L. Hudson, Keith Burk, Alejandro G. Marangoni
Summary: The study designed encapsulation vehicles to deliver Cycloastragenol (CA) across the skin barrier and proved its topical penetration. Transethosomes showed better delivery of CA across the skin barrier compared to ethosomes or emulsifier a-gels.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lucie Valero, Khair Alhareth, Jenifer Espinoza Romero, Warren Viricel, Jeanne Leblond, Audrey Chissey, Helene Dhotel, Caroline Roques, Danielle Campiol Arruda, Virginie Escriou, Nathalie Mignet, Thierry Fournier, Karine Andrieux
Article
Nanoscience & Nanotechnology
Dario Carradori, Claudia Balducci, Francesca Re, Davide Brambilla, Benjamin Le Droumaguet, Orfeu Flores, Alice Gaudin, Simona Mura, Gianluigi Forloni, Lara Ordonez-Gutierrez, Francisco Wandosell, Massimo Masserini, Patrick Couvreur, Julien Nicolas, Karine Andrieux
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2018)
Article
Instruments & Instrumentation
Sebastien Goutal, Oliver Langer, Sylvain Auvity, Karine Andrieux, Christine Coulon, Fabien Caille, Philippe Gervais, Salvatore Cisternino, Xavier Decleves, Nicolas Tournier
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Khair Alhareth, Lucie Valero, Khaled Elhady Mohamed, Louise Fliedel, Caroline Roques, Sophie Gil, Nathalie Mignet, Thierry Fournier, Karine Andrieux
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Plant Sciences
Susanne Bolte, Elodie Marcon, Melanie Jaunario, Lucas Moyet, Maite Paternostre, Marcel Kuntz, Anja Krieger-Liszkay
JOURNAL OF EXPERIMENTAL BOTANY
(2020)
Review
Pharmacology & Pharmacy
Priusha Ravipati, Bice Conti, Enrica Chiesa, Karine Andrieux
Summary: Dermatillomania, or skin picking disorder, is a chronic and difficult to treat neuropsychiatric disorder with underestimated prevalence and negative impacts. Current treatments are not very effective, necessitating further research into alternative strategies and the use of biomaterials.
Article
Pharmacology & Pharmacy
Xiaojing Liu, Badr Bahloul, Rene Lai Kuen, Karine Andrieux, Caroline Roques, Daniel Scherman
Summary: Microfluidization is a promising method for producing cationic lipid nanoparticles for delivering siRNAs. Optimized characteristics in size reduction and polydispersity can be achieved through experimental design. Positive charge ratio and stability are key factors in determining the structure and efficacy of siRNA lipoplexes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Ziyad Chaker, Pierre Chervy, Yves Boulard, Stephane Bressanelli, Pascal Retailleau, Maite Paternostre, Thibault Charpentier
Summary: Understanding the self-assembly process of peptides is crucial for designing new nanostructures with unique properties. This study synthesized and examined diphenylalanine self-assembling crystals in different solvents, developing a numerical method for unambiguous classification based on structural similarities revealed by infrared spectra analysis. The implementation of this method paved the way for systematic, fast, and accurate classification of various experimental spectroscopic data.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Pharmacology & Pharmacy
Morgane Renault-Mahieux, Victoire Vieillard, Johanne Seguin, Philippe Espeau, Dang Tri Le, Rene Lai-Kuen, Nathalie Mignet, Muriel Paul, Karine Andrieux
Summary: An optimized liposomal formulation co-encapsulating fisetin and cisplatin was successfully developed, showing effective inhibition against GBM cells and promising potential for further in vivo experiments.
Article
Pharmacology & Pharmacy
Guillaume Le Guyader, Bernard Do, Ivo B. Rietveld, Pascale Coric, Serge Bouaziz, Jean-Michel Guigner, Philippe-Henri Secretan, Karine Andrieux, Muriel Paul
Summary: The study finds that polymeric micelles improve the bioavailability of rapamycin, with TPGS significantly enhancing solubility and stability, while poloxamer has a more significant influence on skin bioavailability. The formulation of a hydrogel containing 0.1% rapamycin shows stability for up to 3 months and better biodistribution on human skin compared to hydroalcoholic gel formulations.
Review
Biochemistry & Molecular Biology
Louise Fliedel, Khair Alhareth, Nathalie Mignet, Thierry Fournier, Karine Andrieux
Summary: This review explores the use of nanocarriers for pregnancy-associated therapies, focusing on placental-based models for evaluation. Through categorizing and studying different types of placental models, it offers guidance on research and treatment in this field.
Article
Biochemistry & Molecular Biology
Louise Fliedel, Khair Alhareth, Johanne Seguin, Marwa El-Khashab, Audrey Chissey, Nathalie Mignet, Thierry Fournier, Karine Andrieux
Summary: Pregnant women are in need of new medications, and nanomedicines show promise in controlling drug distribution for both the mother and fetus. This study examined the behavior of fluorescent liposomes and lipoplexes in human placental tissue, and found that the liposome's lipid composition and charge surface play a key role in their penetration and internalization in the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Morgane Renault-Mahieux, Nathalie Mignet, Johanne Seguin, Khair Alhareth, Muriel Paul, Karine Andrieux
Summary: Flavonoids are promising molecules for cancer treatment due to their various properties, but vectorization is necessary due to their lipophilic properties and chemical instability. Co-encapsulation with other anti-cancer agents can achieve synergistic effects, delay drug resistance, or reduce toxicity. However, co-encapsulation may affect the properties and stability of nanoparticles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Rene Rebollo, Feras Oyoun, Yohann Corvis, Mazen M. El-Hammadi, Bruno Saubamea, Karine Andrieux, Nathalie Mignet, Khair Alhareth
Summary: This study utilized a microfluidic system to fabricate liposomes with different molar ratios, and optimized the process and conditions using design of experiments (DoE) principles. An artificial neural network (ANN) model was constructed to predict the size and polydispersity index (PDI) of the liposomes. The results demonstrated the feasibility of producing optimized liposomes with high reproducibility using microfluidic manufacturing processes, DoE, and Artificial Intelligence (AI), enabling faster development and clinical transfer of nanobased medications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Guillaume Le Guyader, Bernard Do, Victoire Vieillard, Karine Andrieux, Muriel Paul