Article
Chemistry, Multidisciplinary
Dongjun Li, Ang Zhao, Jiafei Zhu, Chunjie Wang, Jingjing Shen, Zixuan Zheng, Feng Pan, Zhuang Liu, Qian Chen, Yang Yang
Summary: By evaluating the sustainability of various components, researchers found that neutral liposomes are suitable for delivering metformin and nintedanib for pulmonary fibrosis treatment. Moreover, repeated noninvasive aerosol inhalation of metformin and nintedanib loaded liposomes can effectively reduce fibrosis development and improve lung function.
Article
Microbiology
Suresh Ambati, Emma C. Ellis, Tuyetnhu Pham, Zachary A. Lewis, Xiaorong Lin, Richard B. Meagher
Summary: The use of Dectin-2-targeted liposomes to deliver amphotericin B has shown significant efficacy in reducing fungal burden at infection sites in the lungs and prolonging survival in mice with pulmonary aspergillosis. This targeted delivery system has the potential to improve treatment outcomes for various fungal diseases by enhancing the efficacy of antifungal drugs at lower doses.
Article
Instruments & Instrumentation
Shruti S. Sawant, Suyash M. Patil, Snehal K. Shukla, Nishant S. Kulkarni, Vivek Gupta, Nitesh K. Kunda
Summary: Inhalable OB liposomes were developed to limit systemic toxicity and locally accumulate at tumor sites. Active loading of OB into liposomes resulted in higher cytotoxicity and potential for inhibiting lung cancer growth compared to passive loading methods.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jianqing Peng, Zimin Cai, Qin Wang, Jia Zhou, Jinzhuan Xu, Di Pan, Tingting Chen, Guangqiong Zhang, Ling Tao, Yi Chen, Xiangchun Shen
Summary: Pulmonary emphysema is a fatal lung disease characterized by progressive thinning, enlargement, and destruction of alveoli. Oxymatrine (OMT), a bioactive substance derived from traditional Chinese herbal Sophora flavescens, shows potential for alleviating pulmonary emphysema through its anti-inflammatory and antioxidative activities. The study developed OMT-loaded liposomes with carboxymethyl chitosan (CMCS) modification to improve in vivo stability and pulmonary retention of OMT. The CMCS-modified liposomes exhibited superior ameliorative effects on emphysema and OMT further enhanced its anti-inflammatory and antioxidative effects. Pulmonary administration of OMT is a potential strategy for emphysema treatment and can be further improved by CMCS-modified liposomes.
Article
Nanoscience & Nanotechnology
Hongfei Xu, Hongyu Ji, Zerong Li, Wenmei Qiao, Chenghao Wang, Jingling Tang
Summary: The study developed IM-loaded liposomes for pulmonary delivery to treat PAH, showing potential applications and promising outcomes. The IM-LPs demonstrated nanosized ranges and sustained release of IM, indicating potential for therapeutic use in pulmonary delivery.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ekaterina P. Kolesova, Vera S. Egorova, Anastasiia O. Syrocheva, Anastasiia S. Frolova, Dmitry Kostyushev, Anastasiia Kostyusheva, Sergey Brezgin, Daria B. Trushina, Landysh Fatkhutdinova, Mikhail Zyuzin, Polina A. Demina, Evgeny V. Khaydukov, Andrey A. Zamyatnin, Alessandro Parodi
Summary: Proteolytic activity plays a crucial role in cell homeostasis and function, with implications in cancer progression and treatment response. Endosomes, which are often the final destination of internalized nanoparticles, are major sites of cellular proteolytic activity. However, little is known about the impact of nanoparticles on endosomal biology. In this study, we generated albumin nanoparticles with varying resistance to proteolysis and demonstrated a relationship between their sensitivity to proteases and drug delivery properties, irrespective of the degree of proteolytic degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Zimin Cai, Qin Wang, Jinzhuan Xu, Jia Zhou, Zhaohui Jiang, Di Pan, Yanyan Zhang, Ling Tao, Jianqing Peng, Yi Chen, Xiangchun Shen
Summary: Quantitative pulmonary administration of 1,8-cineole (CIN) can alleviate the progression of emphysema, and the therapeutic effects are further improved by the hyaluronic acid-coated liposome carrier.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Engineering, Chemical
Archana Shrestha, Md Anamul Haque, George Mattheolabakis
Summary: Administration through the respiratory tract can provide advantages in drug delivery, particularly for genetic material. Despite challenges, such as physiological barriers and lung metabolism, pulmonary delivery of nucleic acids shows therapeutic potential. This review focuses on the delivery of micro-RNAs (miRs) through the lungs, providing updates on nanocarriers, barriers, and current research on targeted diseases.
Review
Medicine, Research & Experimental
Uday K. Baliga, David A. Dean
Summary: Delivery of genetic material to the lung remains a practical problem clinically, and is considered the major obstacle for gene therapy. There are currently four main strategies for in vivo gene delivery to the lung: viral vectors, liposomes, nanoparticles, and electroporation. Each of these vectors can be used for different gene delivery applications based on mechanisms of action, side-effects, and other factors.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Jingjing Lin, Xingying Song, Hang Yin, Nijia Song, Yanchao Wang, Zhen Li, Feng Luo, Hong Tan, Xueling He, Jiehua Li
Summary: Regulating the immune microenvironment around central neurons is challenging. In this study, double local drug delivery systems were prepared to address this issue, including CDPC-liposome composite scaffolds and CDPC blending directly waterborne polyurethane scaffolds. The results showed that CDPC-liposome composite scaffolds were more effective in inhibiting microglia inflammation and promoting axon elongation.
JOURNAL OF MATERIALS SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Yaqeen Nadheer Al Badri, Cheng Shu Chaw, Amal Ali Elkordy
Summary: Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that can encapsulate a broad range of small and large drug molecules. While there are FDA-approved liposomal-based medicines, including an inhalable therapy, asymmetric liposomes have not yet been approved due to formulation and stability challenges. This review explores the potential of asymmetric liposomes as future carriers for enhancing drug delivery, particularly in pulmonary nanotherapeutics.
Article
Biochemistry & Molecular Biology
Claudia Bonechi, Fariba Fahmideh Mahdizadeh, Luigi Talarico, Simone Pepi, Gabriella Tamasi, Gemma Leone, Marco Consumi, Alessandro Donati, Agnese Magnani
Summary: Glaucoma, a group of neurodegenerative diseases, is the second leading cause of irreversible blindness worldwide. The limited penetration of drugs through the ocular barrier reduces the systemic bioavailability, leading to the need for frequent drug administration and potential toxic effects. Liposomes and other novel drug-delivery systems can enhance the therapeutic efficacy of antiglaucomatous drugs by improving drug penetration, bioavailability, sustained release, tissue targeting, and reduction in intraocular pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Cristina Loira-Pastoriza, Kevin Vanvarenberg, Bernard Ucakar, Maria Machado Franco, Aurelie Staub, Muriel Lemaire, Jean-Christophe Renauld, Rita Vanbever
Summary: Immunotherapy using immunostimulatory agents delivered intratumorally has shown promising efficacy in the treatment of lung cancer. Encapsulation of unmethylated oligodeoxynucleotides containing CpG motifs (CpG) and polyinosinic-polycytidylic acid (poly I:C) double-stranded RNA in liposomes can enhance their antitumor activity by increasing uptake by lung phagocytes and activating toll-like receptors. CpG encapsulation in DOTAP/DPPC liposomes significantly enhances its antitumor effects in lung cancer by inducing immune responses and delaying tumor growth.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Polymer Science
Ali Al-Jipouri, Samah Hamed Almurisi, Khater Al-Japairai, Latifah Munirah Bakar, Abd Almonem Doolaanea
Summary: This review discusses the progress in LPs and EVs, as well as hybrid vesicles, for pulmonary drug delivery. It compares LPs and EVs in terms of composition, preparation/extraction, drug loading, and large-scale manufacturing, and discusses the future prospects for inhaled therapeutics. Additionally, the challenges in scaling up production and the clinical translation of laboratory findings into commercial products are also addressed.
Article
Medicine, Research & Experimental
Olivia Amanda Oest Mullertz, Peter Andersen, Dennis Christensen, Camilla Foged, Aneesh Thakur
Summary: The mucosal surfaces of the lungs are a major site for entry of airborne pathogens and pulmonary vaccination can induce protective mucosal immunity. Researchers found that altering the surface charge of liposomes can enhance specific T-cell responses, but the impact on mucosal immunity remains unclear.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Karin Kornmueller, Bernhard Lehofer, Claudia Meindl, Eleonore Froehlich, Gerd Leitinger, Heinz Amenitsch, Ruth Prassl
Article
Chemistry, Physical
J. Peters, N. Martinez, B. Lehofer, R. Prassl
EUROPEAN PHYSICAL JOURNAL E
(2017)
Article
Multidisciplinary Sciences
Helmut Bischof, Markus Rehberg, Sarah Stryeck, Katharina Artinger, Emrah Eroglu, Markus Waldeck-Weiermair, Benjamin Gottschalk, Rene Rost, Andras T. Deak, Tobias Niedrist, Nemanja Vujic, Hanna Lindermuth, Ruth Prassl, Brigitte Pelzmann, Klaus Groschner, Dagmar Kratky, Kathrin Eller, Alexander R. Rosenkranz, Tobias Madl, Nikolaus Plesnila, Wolfgang F. Graier, Roland Malli
NATURE COMMUNICATIONS
(2017)
Article
Chemistry, Physical
Bernhard Lehofer, Maksym Golub, Karin Kornmueller, Manfred Kriechbaum, Nicolas Martinez, Gergely Nagy, Joachim Kohlbrecher, Heinz Amenitsch, Judith Peters, Ruth Prassl
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2018)
Article
Multidisciplinary Sciences
M. Golub, B. Lehofer, N. Martinez, J. Ollivier, J. Kohlbrecher, R. Prassl, J. Peters
SCIENTIFIC REPORTS
(2017)
Article
Integrative & Complementary Medicine
Andreas Stoetter, Michael E. Harrer, Wilhelm Mosgoeller, Peter Christian Endler, Christian Haring
COMPLEMENTARY MEDICINE RESEARCH
(2019)
Article
Nanoscience & Nanotechnology
Anna-Laurence Schachner-Nedherer, Oliver Werzer, Karin Kornmueller, Ruth Prassl, Andreas Zimmer
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Chemistry, Physical
Aline Cisse, Anna-Laurence Schachner-Nedherer, Markus Appel, Christian Beck, Jacques Ollivier, Gerd Leitinger, Ruth Prassl, Karin Kornmueller, Judith Peters
Summary: This study focused on the molecular dynamics of apo B-100 through elastic and quasi-elastic incoherent neutron scattering experiments, presenting a framework for QENS studies of protein-detergent complexes. The introduction of a combined model including the experimental apo B-100/NP40 ratio allowed for sensitive analysis of both contributions, identifying apo B-100 slow dynamics and the acceleration of NP40 dynamics in its presence. This methodology opens up the possibility of investigating more membrane proteins using neutron spectroscopy.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Carolina Alva, Ivan Vidakovic, Barbara Lorber, Anna-Laurence Schachner-Nedherer, Manuel Zettl, Johannes Khinast, Ruth Prassl, Wen-Kai Hsiao
Summary: This study aims to verify the suitability of inkjet printing technology for liposomes. The results show that the concentration and size distribution of liposomes are largely unaffected by the shear forces during the jetting process.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Physics, Applied
Marko Simic, Doris Auer, Christian Neuper, Nikola Simic, Gerhard Prossliner, Ruth Prassl, Christian Hill, Ulrich Hohenester
Summary: This article proposes and demonstrates a scheme for optical nanoparticle characterization, which achieves real-time optical counting with single-particle sensitivity and high throughput. By monitoring the trajectories and velocity changes of each tracked particle, detailed information about the particle size distribution can be obtained. The experimental results show that this method is suitable for various applications.
PHYSICAL REVIEW APPLIED
(2022)
Article
Pharmacology & Pharmacy
Anna-Laurence Schachner-Nedherer, Julia Fuchs, Ivan Vidakovic, Oliver Hoeller, Gebhard Schratter, Gunter Almer, Eleonore Froehlich, Andreas Zimmer, Martin Wabitsch, Karin Kornmueller, Ruth Prassl
Summary: Obesity and type 2 diabetes are significant health burdens without effective treatment options. This study explores the use of PEG-LNPs to deliver anti-adipogenic miRNAs (miR26a and miR27a) in order to regulate gene expressions and balance adipose tissue metabolic functions. The findings demonstrate that upregulating miR27a inhibits adipogenesis in preadipocytes, while transfecting miR26a induces white adipocyte browning. Selective delivery of miRNAs to adipocytes through PEG-LNPs may offer new possibilities for treating obesity and related metabolic diseases.
Article
Biochemistry & Molecular Biology
Ines Foessl, Christoph Walter Haudum, Ivan Vidakovic, Ruth Prassl, Joakim Franz, Selma Mautner, Sonja Kainz, Elisabeth Hofmann, Barbara Obermayer-Pietsch, Thomas Birngruber, Petra Kotzbeck
Summary: The study identified 43 miRNAs as potential regulators of the early burn response, with miR-497-5p being stably downregulated in tissue and dISF in the early phase after a burn injury. The altered levels of miRNAs in dISF of thermally injured skin suggest them as new biomarker candidates for burn injuries. This is the first study to report miRNAs altered in the dISF in the early phase of deep partial-thickness burns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Friedrich-Anton Weiser, Michael Fang, Wilhelm Mosgoeller
NEUROENDOCRINOLOGY LETTERS
(2018)
Article
Dentistry, Oral Surgery & Medicine
Birgit J. Teubl, Biljana Stojkovic, Dominic Docter, Elisabeth Pritz, Gerd Leitinger, Igor Poberaj, Ruth Prassl, Roland H. Stauber, Eleonore Froehlich, Johannes G. Khinast, Eva Roblegg
CLINICAL ORAL INVESTIGATIONS
(2018)
Article
Endocrinology & Metabolism
Claus Muss, Wilhelm Mosgoeller, Thomas Endler
NEUROENDOCRINOLOGY LETTERS
(2016)
