Review
Dermatology
Ashley Riddle, Linnea Westerkam, Cynthia Feltner, Christopher Sayed
Summary: Hidradenitis suppurativa (HS) is a chronic dermatologic condition that often requires surgical treatment. This study summarizes the literature on HS surgery, comparing different surgical approaches and their efficacy in terms of recurrence rates. It was found that wide excision and flap-based reconstruction are associated with lower postsurgical recurrence, but this must be balanced against the potentially higher morbidity of extensive procedures.
DERMATOLOGIC SURGERY
(2021)
Article
Surgery
Erin M. Taylor, Ryoko Hamaguchi, Kimberly M. Kramer, Alexa B. Kimball, Dennis P. Orgill
Summary: After studying this article, participants will be able to understand the pathogenesis of hidradenitis suppurativa, perioperative multimodal therapy, and surgical planning, as well as the importance of multidisciplinary teamwork for successful treatment.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Dermatology
Y. Yao, J. W. Frew, S. F. Thomsen, H. C. Ring
Summary: The review highlights the diversity of AMPs in HS, with consistent findings of dysregulation of AMPs in HS skin. The included studies demonstrate an overexpression of certain AMPs in HS, while others show a decreased expression.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Dermatology
Isaac Weber, Josie Giefer, Kari L. Martin
Summary: Hidradenitis suppurativa affects a significant portion of the population and has numerous treatment options. However, these options often come with side effects. Exercise, weight loss, and dietary modifications may offer simple and inexpensive alternatives or adjuncts to treatment. This study aimed to summarize the evidence on the effects of these interventions and provide guidance for clinicians on dietary changes and exercise modalities.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Puneet Agarwal, Snehal Balvant Lunge, Nandini Sundar Shetty, Priyanka Karagaiah, Steven Daveluy, Alex G. Ortega-Loayza, Thrasyvoulos Tzellos, Jacek C. Szepietowski, Christos C. Zouboulis, Stephan Grabbe, Mohamad Goldust
Summary: Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory disease that causes painful, inflammatory nodules, abscesses, and tunnels in the apocrine gland-bearing areas of the skin. Pain and drainage are the main symptoms that affect the quality of life in HS patients. Itch, which is often overlooked in quality of life studies, is also an important symptom and is associated with reduced quality of life, depression, and impairment of social life. Mast cells and mTor signaling are elevated in both lesional and perilesional skin. Brodalumab, a monoclonal antibody against IL-17A receptor, has shown significant improvements in itch, pain, quality of life, and depression in patients with moderate to severe HS. Statins have shown some reduction in itch intensity score. Further studies are needed to better understand the etiopathogenesis and optimal therapeutic modalities for itch in HS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Edyta Lelonek, Dorra Bouazzi, Gregor Jemec, Jacek Szepietowski
Summary: Hidradenitis suppurativa (HS) is a chronic skin disease that severely affects the quality of life. The disease is characterized by persistent purulent lesions and involves inflammation, genetics, the microbiome, and environmental factors. Research suggests a potential role for pathogenic bacteria in HS, but the exact mechanisms of gut-skin microbial interactions remain unclear.
Review
Biochemistry & Molecular Biology
Nessr Abu Rached, Thilo Gambichler, Johannes W. Dietrich, Lennart Ocker, Caroline Seifert, Eggert Stockfleth, Falk G. Bechara
Summary: This article introduces the pathogenesis of hidradenitis suppurativa (HS), in which hormones play an important role. Research has shown that HS patients have dysregulated adipokines and insulin resistance, leading to more severe cardiovascular diseases. Androgens also play an important role in certain female patients. Anti-androgen therapy may be helpful for some patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Nikolai Paul Pace, Dillon Mintoff, Isabella Borg
Summary: This review provides a comprehensive overview of the role of genetics in various aspects of hidradenitis suppurativa, including pathophysiology, diagnosis, and clinical application.
FRONTIERS IN GENETICS
(2022)
Review
Dermatology
Terri Shih, Katrina Lee, Justine R. Seivright, Devea R. De, Vivian Y. Shi, Jennifer L. Hsiao
Summary: This study systematically reviewed literature on the efficacy and tolerability of hyperhidrosis treatments in patients with hidradenitis suppurativa (HS). Results showed that botulinum toxin treatments improved HS severity, quality of life, and hyperhidrosis, while microwave-based energy devices may pose harm in HS patients. More prospective studies are needed to further examine the utility of these treatments in HS.
DERMATOLOGIC THERAPY
(2022)
Review
Dermatology
Alyssa M. Thompson, Justine Seivright, Swetha Atluri, Amanda Ederle, Joanna Jaros, Jennifer L. Hsiao, Vivian Y. Shi
Summary: This systematic review examines the efficacy of radiotherapy in treating patients with Hidradenitis suppurativa, summarizing patient demographics, treatment regimens, efficacy, and adverse effects. The review highlights changes in management recommendations over time, improvements in standardized outcome measures, and advancements in treatment options. While radiotherapy may be a viable option for patients with treatment-resistant HS or those who are not suitable for surgery, there is still a lack of consensus on proper candidate selection, dosing, efficacy, and safety of short- and long-term effects.
Review
Dermatology
C. Cuenca-Barrales, T. Montero-Vilchez, J. C. Szepietowski, L. Matusiak, A. Molina-Leyva
Summary: Sexual and erectile dysfunction are common in HS patients, significantly impacting their quality of life. Potential risk factors mainly relate to disease activity, symptoms, and partners. Healthcare professionals should play an active role in identifying and treating these issues.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Angelo Ruggiero, Fabrizio Martora, Vincenzo Picone, Laura Marano, Gabriella Fabbrocini, Claudio Marasca
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with unclear pathogenesis. Recent research has improved our understanding of the mechanisms behind HS lesions, including follicular occlusion and rupture, immune response activation, and imbalanced cytokine production. Paradoxical HS occurrences have been increasingly reported during treatment with biologic drugs.
Review
Medicine, General & Internal
Maria-Angeles Ferrer-Alcala, Manuel Sanchez-Diaz, Salvador Arias-Santiago, Alejandro Molina-Leyva
Summary: Psoriasis and hidradenitis suppurativa have an impact on pregnancy and fertility, including decreased fertility and unpredictable disease evolution during pregnancy. Treatment during pregnancy may change, but biologic therapies do not appear to increase the risk of adverse events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Dermatology
Samuel Yeroushalmi, Alexander Ildardashty, Kareem G. Elhage, Mimi Chung, Erin Bartholomew, Marwa Hakimi, Peggy Tahir, Haley B. Naik, Tina Bhutani, Wilson Liao
Summary: Chronic inflammatory skin disorders like hidradenitis suppurativa (HS) have been found to affect sleep quality. This systematic review of seven studies involving 343,870 subjects revealed that HS patients have a higher likelihood of having sleep disorders, such as obstructive sleep apnea, and report worse sleep quality due to symptoms like pruritus and pain. This suggests that HS patients may be at risk for additional cardiovascular comorbidities and poorer quality of life due to these sleep disorders and poor sleep quality.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Immunology
Dillon Mintoff, Isabella Borg, Nikolai Paul Pace
Summary: Hidradenitis suppurativa is a chronic disease of the pilosebaceous unit with complex pathophysiology. The human microbiome plays an extensive and relevant role in HS, with potential impact on treatment and diagnosis.
Article
Dermatology
N. Goldfarb, M. A. Lowes, M. Butt, T. King, A. Alavi, J. S. Kirby
Summary: Results from the clinometric assessment of the HASI-R are promising, with moderate inter-rater reliability and high intra-rater reliability, good construct validity, and known-groups validity. The HASI-R was also the most preferred tool by all raters.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
S. Narla, M. Azzam, S. Townsend, G. Vellaichamy, A. Marzano, A. Alavi, M. A. Lowes, I. H. Hamzavi
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by painful nodules and abscesses, with neutrophil recruitment playing a crucial role in its development. Pharmacological manipulation of neutrophil recruitment pathways could help control the disease and achieve remission.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
Alison H. Kohn, Afsaneh Alavi, April W. Armstrong, Folawiyo Babalola, Amit Garg, Alice B. Gottlieb, Lesley Grilli, Gregor Borut Ernst Jemec, John Latella, Kendall Marcus, Joseph F. Merola, Alex G. Ortega-Loayza, Daniel M. Siegel, Vibeke Strand, Jerry K. L. Tan, Lourdes M. Perez-Chada
Summary: This report summarizes the work presented by each IDEOM workgroup (psoriasis, psoriatic arthritis, hidradenitis suppurativa, acne, pyoderma gangrenosum, and actinic keratosis) at the 2020 IDEOM Virtual Annual Meeting.
Review
Dermatology
Muskaan Sachdeva, Patrick Kim, Asfandyar Mufti, Khalad Maliyar, Cathryn Sibbald, Afsaneh Alavi
Summary: This study analyzed the outcomes of biologic therapy in 26 pediatric patients with HS, finding that anti-TNF alpha inhibitors were the most commonly used biologics. Approximately 73% of patients experienced partial resolution, around 23% had complete resolution, and no adverse events were reported.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2022)
Article
Dermatology
Jonathan W. Rick, Devea R. De, Terri Shih, Afsaneh Alavi, Joslyn S. Kirby, Haley B. Naik, John W. Frew, Christopher J. Sayed, Jennifer L. Hsiao, Vivian Y. Shi
Summary: This article aims to provide expert-driven consensus recommendations on COVID-19 vaccination in Hidradenitis suppurativa (HS) patients. The consensus has been reached and can serve as a resource for clinicians discussing COVID-19 vaccination with HS patients.
SKIN APPENDAGE DISORDERS
(2022)
Article
Dermatology
Nimay C. Anand, Mika Takaichi, Emma F. Johnson, David A. Wetter, Mark D. P. Davis, Afsaneh Alavi
Summary: This retrospective study proposed a new classification of panniculitides based on integrating clinical morphologic features with histopathology. The study found certain types of panniculitides more likely to ulcerate, while others were less likely to do so. The updated schema may help clinicians tailor differential diagnoses based on ulceration, location, and number of lesions.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Letter
Dermatology
Afsaneh Alavi, Laura Raffals
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Letter
Dermatology
Neha Deo, Lawrence Gibson, Emma Johnson, Afsaneh Alavi
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Thrasivoulos Tzellos, Kelsey R. van Straalen, Athanassios Kyrgidis, Afsaneh Alavi, Noah Goldfarb, Wayne Gulliver, Gregor B. E. Jemec, Michelle A. Lowes, Angelo Valerio Marzano, Errol P. Prens, Christopher J. Sayed, Hessel H. van der Zee, Christos C. Zouboulis
Summary: A dichotomous outcome based on IHS4 was developed and validated for use in clinical trial settings and day-to-day clinical practice. The outcome performed similarly to HiSCR and showed significant associations with reductions in lesion counts.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
K. R. van Straalen, T. Tzellos, A. Alavi, F. Benhadou, C. Cuenca-Barrales, M. Daxhelet, M. Daoud, O. Efthymiou, E. J. Giamarellos-Bourboulis, P. Guillem, W. Gulliver, G. B. E. Jemec, A. C. Katoulis, A. Koenig, E. Lazaridou, M. A. Lowes, A. Marzano, L. Matusiak, A. Molina-Leyva, C. Moltrasio, A. Pinter, C. Potenza, E. P. Prens, J. Romani, D. M. Saunte, C. J. Sayed, N. Skroza, D. Stergianou, J. C. Szepietowski, A. Trigoni, E. Vilarrasa, A. Kyrgidis, C. C. Zouboulis, H. H. van der Zee
Summary: This study validates the novel IHS4-55 outcome measure by showing its significant association with reduction in inflammatory lesion counts and achievement of MCIDs for DLQI, NRS Pain, and NRS Pruritus in an antibiotic-treated cohort. These findings support the use of IHS4-55 as a novel primary outcome measure in clinical trials.
Editorial Material
Dermatology
Afsaneh Alavi, Edward V. Loftus Jr
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Alexa B. Kimball, Maurizio Podda, Afsaneh Alavi, Megan Miller, Yaung-Kaung Shen, Shu Li, Yan Xu, Chenglong Han, Steven Fakharzadeh, Ya-Wen Yang, Samuel DePrimo, Ernesto Munoz, Yanqing Chen, Thierry Passeron, Kim Papp
Summary: This study aimed to evaluate the effect of guselkumab on the treatment of hidradenitis suppurativa (HS). The results showed that although there were modest improvements in HiSCR in the guselkumab group compared to the placebo group at Week 16, statistical significance was not achieved. Numerically greater improvements in patient-reported outcomes were also observed in the guselkumab group. However, the overall findings do not support the efficacy of guselkumab in the treatment of HS.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Nimay C. Anand, Elliott H. Campbell, Christian L. Baum, Lawrence E. Gibson, Austin Todd, Jennifer L. Bradt, Afsaneh Alavi
Summary: This study found that patients with lymphedema of a lower extremity have a greater risk of skin cancer compared to those without lymphedema. For patients with unilateral lymphedema, the lymphedematous extremity is 2.65 times more likely to develop skin cancer than the nonlymphedematous lower extremity.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Dermatology
Mika Yamanaka-Takaichi, Laura E. Raffals, Eric C. Ehman, Edward V. V. Loftus Jr, Afsaneh Alavi
Summary: This study aimed to analyze anemia and systemic inflammation biomarkers in patients with hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD). The study found a high prevalence of anemia in IBD patients, and the highest prevalence in patients with both HS and IBD. Additionally, noninvasive biomarkers using complete blood counts could be useful in differentiating between HS and IBD, as well as guiding treatment selection.
Article
Dermatology
Rahul Masson, Terri Shih, Sarah Park, Devea R. De, Athena Gierbolini, Afsaneh Alavi, Amit Garg, Robert G. Micheletti, Vivian Y. Shi, Jennifer L. Hsiao
Summary: This study investigates the impact of hidradenitis suppurativa (HS) on female reproductive health and the effects of fertility treatments on HS and fertility. The results show that females with HS have a higher rate of infertility compared to the general population, and most individuals do not experience changes in HS symptoms after receiving fertility treatments.
