Article
Biochemistry & Molecular Biology
Mariacristina Gagliardi, Sara Chiarugi, Chiara De Cesari, Giulia Di Gregorio, Alessandra Diodati, Laura Baroncelli, Marco Cecchini, Ilaria Tonazzini
Summary: The study presents a method to obtain stable and cytocompatible crosslinked chitosan nanoparticles for intranasal drug delivery. The nanoparticles showed a stable size and surface charge, and exhibited good cytocompatibility in vitro. This synthetic system has potential as a drug carrier for intranasal delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ling Yuan Chin, Joyce Yi Pei Tan, Hira Choudhury, Manisha Pandey, Sreenivas Patro Sisinthy, Bapi Gorain
Summary: This study successfully formulated and characterized telmisartan mucoadhesive nanoemulgel (TMNEG) for intranasal delivery, showing potential as a platform for extended drug release and improved permeation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Polymer Science
Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Ameeduzzafar Zafar, Omar Awad Alsaidan, Nabil K. Alruwaili, Sadaf Jamal Gilani, Md. Rizwanullah
Summary: The review discusses the loading of phytochemicals in biodegradable and biocompatible nanoparticles based on chitosan for improved bioavailability and bioactivity. Chitosan's properties such as mucoadhesiveness, non-toxicity, stability in harsh gastrointestinal conditions, and enhanced intestinal permeability make it suitable for oral delivery of phytochemicals.
Article
Pharmacology & Pharmacy
Muhammet Davut Arpa, Neslihan Ustundag Okur, Mehmet Koray Gok, Saadet Ozgumusc, Erdal Cevher
Summary: In this study, buccal patches were prepared using chitosan glutamate (Chi-Glu) and novel chitosan azelate (Chi-Aze) to enhance the bioavailability of TZN. Chi-Aze patches showed longer integrity and higher drug permeability compared to Chi-Glu patches. In vivo studies revealed that buccal formulation with Chi-Aze showed approximately 3 times higher bioavailability than the orally administered commercial product.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Hassan A. Albarqi, Anuj Garg, Mohammad Zaki Ahmad, Abdulsalam A. Alqahtani, Ismail A. Walbi, Javed Ahmad
Summary: Glaucoma is a chronic degenerative eye disease that leads to irreversible vision loss due to high intraocular pressure. Traditional ocular drug delivery systems have low bioavailability, making glaucoma therapy challenging. Chitosan-based nanoparticulate systems have shown promise in overcoming these limitations. This manuscript reviews recent research on chitosan-based nanoparticulate systems for glaucoma treatment, discussing their significance in improving drug residence time and ocular bioavailability. It also analyzes the impact of chitosan-based nanomedicine on corneal permeability, ocular bioavailability, and therapeutic performance of loaded antiglaucoma agents.
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Hala N. ElShagea, Rana R. Makar, Alaa H. Salama, Nermeen A. Elkasabgy, Emad B. Basalious
Summary: This study focuses on delivering the hydrophilic drug, rasagiline mesylate (RSM), directly to the brain through intranasal administration. Transferosomes were formed to encapsulate RSM and incorporated into an in situ gel. The optimized transferosomal in situ gel showed safety and biocompatibility, with enhanced brain bioavailability and direct nose-to-brain drug delivery.
Review
Biochemistry & Molecular Biology
Vanessa Falchetti Lopes, Camila Nascimento Giongo, Lais de Almeida Campos, Wolf-Rainer Abraham, Rubiana Mara Mainardes, Najeh Maissar Khalil
Summary: The development of biodegradable nanoparticles, particularly chitosan-based systems, has shown promising results in improving the biological transport of chemical compounds. These nanoencapsulated systems enhance the properties of loaded drugs, including permeation, stability, and bioactivity, offering potential benefits for targeted drug delivery.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Rinada H. Hassan, Heba A. Gad, Sahar Badr El-Din, Dalia S. Shaker, Rania A. H. Ishak
Summary: In this study, chitosan nanoparticles loaded with olmesartan medoxomil were synthesized and delivered via the nasal route. The results showed that these nanoparticles had high bioavailability and low oral side effects, and they were able to efficiently permeate across the nasal mucosa.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Roberta Corsaro, Rosamaria Lombardo, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Daniele Bani, Angela Bonaccorso, Rosario Pignatello
Summary: Intranasal administration has become increasingly important as an alternative route for drug absorption in recent years. Various technological strategies, such as the use of bioadhesive polymers, have been investigated to improve drug absorption. This study focused on the preparation of polymeric nanoparticles loaded with drugs and evaluated their properties for intranasal application.
APPLIED SCIENCES-BASEL
(2022)
Review
Polymer Science
Mahwash Mukhtar, Eszter Fenyes, Csilla Bartos, Mahira Zeeshan, Rita Ambrus
Summary: Chitosan, a natural biopolymer, is commonly used in drug delivery due to its biodegradability and biocompatibility. Its derivatives have been synthesized to enhance mucoadhesion and solubility, while nano and micro particles of chitosan have been reported to improve drug bioavailability. Chitosan has also shown promise in active targeted drug and gene delivery, thanks to its tunable surface modifications.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Andelka Racic, Danina Krajisnik
Summary: Dry eye syndrome and allergic conjunctivitis are common inflammatory disorders of the eye surface. The use of biopolymers in liquid ophthalmic preparations has advantages such as increasing tear film viscosity, exhibiting bioadhesive properties, and improving therapeutic effects. Methods for assessing mucoadhesiveness have been suggested, and this review provides an overview of the development of mucoadhesive liquid ophthalmic formulations for treating dry eye and allergic conditions.
Article
Chemistry, Applied
Mai Bay Stie, Heidi Oblom, Anders Christian Norgaard Hansen, Jette Jacobsen, Ioannis S. Chronakis, Jukka Rantanen, Hanne Morck Nielsen, Natalja Genina
Summary: The study designed a multi-layered nanofiber-on-foam-on-film (NFF) drug delivery system with mucoadhesive properties and saliva-repelling ability, which improved drug absorption and permeability through oral mucosa. This system has great potential for non-invasive drug administration.
CARBOHYDRATE POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Ameeduzzafar Zafar, Muhammad Afzal, Anwarulabedin Mohsin Quazi, Mohd Yasir, Imran Kazmi, Fahad A. Al-Abaasi, Nabil K. Alruwaili, Khalid Saad Alharbi, Sami Alzarea, Shaveta Sharma, Rupinder Kaur
Summary: The study focused on developing CH-EC based microspheres for nasal delivery of DOM to improve its bioavailability. In vivo experiments showed that the optimized DOM microspheres had higher relative bioavailability compared to nasally administered DOM solution and orally administered DOM-Sol & ComTab.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Young Hwa Lee, Hae In Park, Woo-Suk Chang, Joon Sig Choi
Summary: A vector for mitochondria-targeted drug delivery was developed by synthesizing TPP-modified glycol chitosan polymeric microspheres. The microspheres possess the potential to effectively deliver drugs to mitochondria. Various analysis and experiments confirmed their efficacy as drug delivery carriers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Rania A. Hashad, Rania A. H. Ishak, Sherif Fahmy, Samar Mansour, Ahmed S. Geneidi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Article
Biochemistry & Molecular Biology
Rania A. Hashad, Rania A. H. Ishak, Ahmed S. Geneidi, Samar Mansour
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Article
Biochemistry & Molecular Biology
Mamdouh Abdel Mouez, Maha Nasr, Mona Abdel-Mottaleb, Ahmed S. Geneidi, Samar Mansour
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Review
Chemistry, Multidisciplinary
Mina Mehanny, Rania M. Hathout, Ahmed S. Geneidi, Samar Mansour
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Biochemical Research Methods
M. A. Motaleb, I. T. Ibrahem, V. R. Ayoub, A. S. Geneidi
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2016)
Article
Chemistry, Physical
Mina Mehanny, Rania M. Hathout, Ahmed S. Geneidi, Samar Mansour
JOURNAL OF MOLECULAR LIQUIDS
(2016)
Article
Pharmacology & Pharmacy
Rania A. Hashad, Rania A. H. Ishak, Ahmed S. Geneidi, Samar Mansour
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Pharmacology & Pharmacy
Shaimaa S. Ibrahim, Rihab Osman, Gehanne A. S. Awad, Nahed D. Mortada, Ahmed-Shawky Geneidi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Engineering, Biomedical
Mina Mehanny, Rania M. Hathout, Ahmed S. Geneidi, Samar Mansour
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Review
Chemistry, Multidisciplinary
Reham S. Elezaby, Heba A. Gad, Abdelkader A. Metwally, Ahmed S. Geneidi, Gehanne A. Awad
JOURNAL OF CONTROLLED RELEASE
(2017)
Review
Pharmacology & Pharmacy
Noha M. Zaki
Article
Chemistry, Applied
Rania A. H. Ishak, Nahed D. Mortada, Noha M. Zaki, Abd El-Hamid A. El-Shamy, Gehanne A. S. Awad
JOURNAL OF MICROENCAPSULATION
(2014)
Review
Medicine, General & Internal
William W. L. Wong, Petros Pechivanoglou, Josephine Wong, Joanna M. Bielecki, Alex Haines, Aysegul Erman, Yasmin Saeed, Arcturus Phoon, Mina Tadrous, Mona Younis, Noha Z. Rayad, Valeria Rac, Harry L. A. Janssen, Murray D. Krahn
SYSTEMATIC REVIEWS
(2019)
Article
Chemistry, Medicinal
Hanaa A. Abdel Messih, Rania A. H. Ishak, Ahmed S. Geneidi, Samar Mansour
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2017)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)