Article
Rehabilitation
Michael A. Crary, Giselle D. Carnaby, Lies Mathijs, Sofie Maes, Greet Gelin, Els Ortibus, Nathalie Rommel
Summary: This study evaluated the relationships between spontaneous swallowing frequency, dysphagia, and drooling in children with cerebral palsy. The results showed that spontaneous swallowing frequency was inversely related to dysphagia and showed a trend towards correlation with resting drooling in children with cerebral palsy. The pattern of relationships between spontaneous swallowing frequency and drooling was different between children with cerebral palsy and younger healthy children.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Corinne P. A. Delsing, Stijn Bekkers, Corrie E. Erasmus, Karen van Hulst, Frank J. A. van den Hoogen
Summary: Posterior drooling in children with neurological impairment can be effectively controlled with treatments such as submandibular gland excision, with a greater effect compared to BoNT-A injections and 2-DL.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Review
Medicine, General & Internal
Wei Xiong, Ling Cheng, Genhua Tang, Xinju Hou, Manhua Zhu, Lunbin Lu, Zhiying Zhong
Summary: The aim of this study is to evaluate the effectiveness and safety of acupuncture therapy for treating drooling in children with cerebral palsy. The methods include a comprehensive search of multiple international and domestic databases for randomized controlled trials, and the final results will be synthesized through meta-analysis.
Article
Nutrition & Dietetics
Mustapha Mouilly, Adil El Midaoui, Aboubaker El Hessni
Summary: This study evaluated the effects of swallowing disorders and oral malformations on the nutritional status of children with cerebral palsy. The results showed that growth retardation is closely related to gross motor function, and swallowing disorders and oral malformations affect the nutritional indices of the children.
Review
Pediatrics
Shang-A Hung, Chung-Lun Liao, Wei-Pin Lin, Jason C. Hsu, Yao-Hong Guo, Yu-Ching Lin
Summary: BoNT-A injections are shown to be safe and effective for controlling drooling in children with cerebral palsy, with effects lasting over 3 months, but the dosage should not exceed 4 units/kg. Further studies are needed to determine the optimal dosage and target glands.
Article
Medicine, General & Internal
Saskia E. Kok, Joris Lemson, Frank J. A. van den Hoogen
Summary: The aim of this study was to evaluate the airway management and complications after submandibular duct relocation (SMDR). A historic cohort of 96 patients who underwent SMDR for excessive drooling were analysed. Postoperative swelling of the floor of the mouth or tongue was reported in 31 patients (32.3%). The airway was compromised in 4.2% of the patients. Overall, SMDR is a well-tolerated procedure, but careful monitoring of postoperative swelling is necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Larissa Alice Dreier, Tugba Kapanci, Katharina Lonnemann, Margarete Koch-Hogrebe, Lucia Wiethoff-Ubrig, Markus Rauchenzauner, Markus Blankenburg, Boris Zernikow, Julia Wager, Kevin Rostasy
Summary: This study found that the sleep problems in children with CP are correlated with the severity of their motor and fine motor disabilities, rather than with the subtype or comorbidities of CP.
Article
Clinical Neurology
Natsuko Ishida, Shunsuke Ono, Ryohei Suzuki, Kei Nojiri, Shinnosuke Ootsuki, Nobuyuki Zakoji
Summary: Drooling is a common symptom in patients with IND and CP, and it can significantly impact their QOL and increase the risk of death. This study assessed the prevalence of drooling and identified the factors and drugs associated with it in patients with IND and CP. The results showed that the factors and drugs affecting drooling differed between IND and CP cases, highlighting the importance of individualized screening and considering the impact of drugs on drooling in these patients.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Pediatrics
Nobukazu Tanaka, Kanji Nohara, Chisato Uota, Nami Fujii, Aya Obana, Katsuji Tanaka, Takayoshi Sakai
Summary: Swallowing frequency may serve as an index for assessing swallowing difficulties and the risk of pneumonia in patients with severe cerebral palsy.
Article
Medicine, General & Internal
Kalsoom Altaf, Amir Waheed Butt, Sikander Ghayas Khan, Fazaila Ehsaan, Arshad Mehmood, Faiza Yousaf, Anila Irshad
Summary: This study investigates the occurrence of language and swallowing problems in individuals with cerebral palsy. The results show that language problems are more prevalent than swallowing difficulties in children with cerebral palsy. The majority of participants had difficulties in various language tasks, particularly in sentence structure and pragmatics.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2022)
Article
Otorhinolaryngology
Gonul Acar, Nasim Ejraei, Dilsad Turkdogan, Necati Enver, Gulten Ozturk, Gulcin Aktas
Summary: The structured Neurodevelopmental Therapy Method-Bobath (NDT-B) approach had a positive impact on the feeding and swallowing activities of patients with cerebral palsy, particularly in trunk control and oral motor functions. After receiving the combined treatment of OMIS + NRCT + NDT-B, eating function in children with CP improved further, suggesting the importance of incorporating NDT-B-based neck and trunk stabilization exercises into treatment programs.
Article
Nutrition & Dietetics
Israt Jahan, Mohammad Muhit, Mahmudul Hassan Al Imam, Ratul Ghose, Amir Banjara Chhetri, Nadia Badawi, Gulam Khandaker
Summary: A study in Gorkha district, Nepal found high rates of undernutrition among children with cerebral palsy, indicating the need for intervention to improve their nutritional outcomes.
Article
Pediatrics
Hillary Brenda Nguyen, Neha Mulpuri, Danielle Cook, Michael Greenberg, M. Wade Shrader, Ryan Sanborn, Kishore Mulpuri, Benjamin J. Shore
Summary: The COVID-19 pandemic has posed significant challenges in caring for children with cerebral palsy and other neuromuscular complex chronic conditions. This study investigated the direct impact of the pandemic on healthcare delivery, finding a decrease in in-person clinic visits, surgical cases, and an increase in telemedicine usage for NCCC patients.
Article
Medicine, General & Internal
Alev Basaran, Zehra Kilinc, Hidir Sari, Ercan Gunduz
Summary: This study aimed to evaluate the etiological risk factors of cerebral palsy, with a focus on preventable factors. Face-to-face interviews were conducted with the mothers of 210 children with cerebral palsy registered at the Mardin Guidance and Research Center. The findings revealed that most of the children were premature, had low birth weight, had parents who were relatives, had mothers with low education level, and came from families with low socioeconomic status. These risk factors, which were largely preventable, were significant.
Article
Pediatrics
Antonella Riva, Elisabetta Amadori, Maria Stella Vari, Alberto Spalice, Vincenzo Belcastro, Maurizio Viri, Donatella Capodiferro, Antonino Romeo, Alberto Verrotti, Pasquale Striano
Summary: This study highlights the importance of a multidisciplinary approach to the management of drooling and suggests that progressive treatment can improve the quality of life for patients and caregivers while saving healthcare resources.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Florentine Schepers, Karen van Hulst, Bea Spek, Corrie E. Erasmus, Lenie van den Engel-Hoek
Summary: This study aimed to assess dysphagia limits in children with cerebral palsy, finding that the dysphagia limit is associated with the Eating and Drinking Ability Classification System level, and typically developing children have significantly higher dysphagia limits than children with cerebral palsy.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Clinical Neurology
Jelte Helfferich, Joyce Roodbol, Marie-Claire de Wit, Oebele F. Brouwer, Bart C. Jacobs
Summary: By comparing clinical features and diagnostic criteria in children with AFM and GBS, we found distinct differences in disease progression, limb weakness presentation, and sensory deficits between AFM and GBS patients. Additionally, spinal cord lesions on MRI were only found in AFM patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Karlijn Bouman, Madelief Gubbels, Frederik M. A. van den Heuvel, Jan T. Groothuis, Corrie E. Erasmus, Robin Nijveldt, Floris E. A. Udink ten Cate, Nicol C. Voermans
Summary: LAMA2-related muscular dystrophy (LAMA2-MD) and SELENON(SEPN1)-related myopathy (SELENON-RM) are rare neuromuscular diseases caused by mutations in the LAMA2 and SELENON (SEPN1) gene, respectively. This scoping review found that primary left ventricular dysfunction is frequently reported in LAMA2-MD, while secondary right ventricular dysfunction is most prevalent in SELENON-RM. Optimal cardiorespiratory surveillance is necessary for early detection and treatment of cardiac manifestations in these diseases.
NEUROMUSCULAR DISORDERS
(2022)
Article
Clinical Neurology
Danielle K. Franken, Karlijn Bouman, Stacha F. I. Reumers, Frederik Braun, Jennifer Spillane, Maartje Pennings, Saskia L. S. Houwen, Corrie E. Erasmus, Ulrike Schara-Schmidt, Erik-Jan Kamsteeg, Heinz Jungbluth, Nicol C. Voermans
Summary: This study investigated the clinical spectrum of neuromuscular features in X-linked myotubular myopathy (XL-MTM) carriers. The results showed that 52% of carriers exhibited muscle weakness, with some cases previously being misclassified. These findings are important for understanding the neuromuscular manifestations of XL-MTM carrier state and for future clinical trials.
Meeting Abstract
Clinical Neurology
K. Bouman, J. Groothuis, J. Doorduin, N. van Alfen, F. Udink ten Cate, F. van den Heuvel, R. Nijveldt, A. Dittrich, J. Draaisma, M. Janssen, B. van Engelen, C. Erasmus, N. Voermans
NEUROMUSCULAR DISORDERS
(2022)
Review
Clinical Neurology
Karlijn Bouman, Anne T. M. Dittrich, Jan T. Groothuis, Baziel G. M. van Engelen, Mirian C. H. Janssen, Nicol C. Voermans, Jos M. T. Draaisma, Corrie E. Erasmus
Summary: This scoping review summarizes the evidence on bone quality in congenital myopathies and provides recommendations for bone quality management, including bone mineral density assessment, vitamin D and calcium supplementation, and referral to internal medicine or pediatrics for consideration of additional therapies to prevent complications of low bone mineral density.
JOURNAL OF NEUROMUSCULAR DISEASES
(2023)
Article
Pediatrics
Fleur van den Udenhout, Peter Merkus, Sandra Verhaagen-van den Akker, Meyke Schouten, Corrie Erasmus, Hilde Braakman
Summary: This study aimed to raise awareness of congenital myasthenic syndromes (CMS) as a cause of respiratory insufficiency in infants and preschool children. Through a retrospective case study, it was found that five children experienced severe to life-threatening episodes of respiratory insufficiency, especially during viral infections, and were eventually diagnosed with genetically proven CMS. Treatment with pyridostigmine resulted in clinical improvement.
Article
Otorhinolaryngology
Corinne P. A. Delsing, Carleen Adriaansens, Karen van Hulst, Corrie E. Erasmus, Frank J. A. van den Hoogen
Summary: This study investigates the long-term effects of submandibular gland excision (SMGE) on drooling in patients with non-progressive neurodisabilities. The study shows a long-term stable improvement in drooling after SMGE, with the majority of patients being satisfied with the procedure and recommending it to others.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Mieke Kooi-van Es, Corrie E. Erasmus, Nicoline B. M. Voet, Lenie van den Engel-Hoek, Philip J. van der Wees
Summary: This study aimed to achieve consensus and present best practice recommendations on speech-language pathology intervention in paediatric neuromuscular disorders. The results led to six core intervention components that cover various symptoms and provide guidance for speech-language pathologists working in this field.
INTERNATIONAL JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2023)
Article
Pediatrics
Lynn B. Orriens, Dilan Eker, Hilde M. H. Braakman, Peter J. F. M. Merkus, Corrie E. Erasmus
Summary: This study aimed to identify common symptoms of congenital myasthenic syndromes (CMS) in children and their manifestation, in order to aid diagnosis and early intervention. The most common symptoms observed in patients were proximal muscle weakness, ptosis, clumsy gait, difficulty eating solid foods, and recurrent respiratory tract infections. These symptoms often co-occurred and had a fluctuating character, which could be aggravated by infections or fatigue.
Review
Rehabilitation
Nathaniel B. Rasing, Willianne van de Geest-buit, On Ying A. Chan, Karlien Mul, Anke Lanser, Corrie E. Erasmus, Jan T. Groothuis, Judith Holler, Koen J. A. O. Ingels, Bart Post, Ietske Siemann, Nicol C. Voermans
Summary: This study investigates the psychosocial impact of having an altered facial expression in five neurological diseases. The findings show that patients with altered facial expression in four of the diseases had reduced psychosocial functioning. Negative effects were more prevalent in women and more severely affected patients. Future research should examine observers' judgments of patients and the effectiveness of compensation strategies in enhancing psychosocial functioning.
DISABILITY AND REHABILITATION
(2023)
Article
Pediatrics
Fieke Draaisma, Corrie E. Erasmus, Hilde M. H. Braakman, Melanie C. J. Burgers, Erika K. S. M. Leenders, Tuula Rinne, Nens van Alfen, Jos M. T. Draaisma
Summary: This study aimed to describe the findings of high-resolution nerve ultrasound in children with Noonan syndrome (NS) and related disorders experiencing leg pain. The results showed that all four children included in the study exhibited nerve hypertrophy, suggesting a possible association between pain and nerve hypertrophy. The use of high-resolution nerve ultrasound and spinal magnetic resonance imaging may provide a better understanding of the nature of leg pain in patients with NS and related disorders.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Karlijn Bouman, Jeroen L. M. van Doorn, Jan T. Groothuis, Peter J. Wijkstra, Baziel G. M. van Engelen, Corrie E. Erasmus, Jonne Doorduin, Nicol C. Voermans
Summary: The majority of LAMA2-MD and all SELENON-RM patients had respiratory impairment. SELENON-RM patients showed lower respiratory function which was progressive, more prevalent mechanical ventilation, and more severe diaphragm atrophy and dysfunction than LAMA2-MD patients. Spirometry (FVC%, dVC) and respiratory muscle strength tests (SNIP) are useful in clinical care and as outcome measure in clinical trials.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Review
Pediatrics
Lynn B. Orriens, Karen van Hulst, Jan J. W. van der Burg, Frank J. A. van den Hoogen, Michel A. A. P. Willemsen, Corrie E. Erasmus
Summary: This scoping review aimed to explore the evidence for submandibular and four-gland BoNT-A injections for paediatric anterior drooling and assess their outcomes. The review found heterogeneity in outcome measures and patient population descriptors, limiting the ability to compare treatment effectiveness.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
