Review
Pediatrics
Yan Pan, Qihong Fan, Luoyi Hu
Summary: This study aimed to gather evidence on the efficacy and safety of available treatments for IVIG-resistant Kawasaki disease in children. A network meta-analysis was performed, and infliximab was found to be the best option against IVIG-resistant KD. Infliximab showed remarkable antipyretic activity, but was more prone to causing hepatomegaly. Second IVIG infusions were more likely to result in haemolytic anaemia, and IVMP treatment was associated with bradycardia, hyperglycaemia, hypertension, and hypothermia. The three treatment options showed no significant differences in the risk of developing CAA.
FRONTIERS IN PEDIATRICS
(2023)
Article
Rheumatology
Maria Mossberg, Aladdin J. Mohammad, Fredrik Kahn, Marten Segelmark, Robin Kahn
Summary: This study found a significantly high risk of CAA development in young children diagnosed with iKD, highlighting the importance of rapid intense treatment and vigilance in infants to reduce the frequency of CAA.
Article
Pediatrics
I-Hsin Tai, Kai-Sheng Hsieh, Ho-Chang Kuo
Summary: Kawasaki disease (KD) is a febrile systemic vasculitis that mainly affects children aged under five years old. The formation of coronary aneurysm is the most common complication after KD.
Article
Cardiac & Cardiovascular Systems
Yasutaka Nakashima, Yasunari Sakai, Yumi Mizuno, Kenji Furuno, Keiichi Hirono, Shinichi Takatsuki, Hiroyuki Suzuki, Yoshihiro Onouchi, Tohru Kobayashi, Kazuhiro Tanabe, Kenji Hamase, Tomofumi Miyamoto, Ryohei Aoyagi, Makoto Arita, Kenichiro Yamamura, Tamami Tanaka, Hisanori Nishio, Hidetoshi Takada, Shouichi Ohga, Toshiro Hara
Summary: Through lipidomics analysis of 105 KD patients and 65 disease controls, the study found that oxidized phospholipids are associated with the development of coronary arteritis in KD, playing a significant role in its pathogenesis.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ryusuke Ae, Ryan A. Maddox, Joseph Y. Abrams, Lawrence B. Schonberger, Yosikazu Nakamura, Masanari Kuwabara, Nobuko Makino, Koki Kosami, Yuri Matsubara, Daisuke Matsubara, Teppei Sasahara, Ermias D. Belay
Summary: Detection of CALs at initial echocardiography in patients with KD was associated with younger age, delayed hospital visits, and having 3 or 4 principal KD signs. Timely diagnosis could be beneficial for patients, but those with specific risk factors were still at higher risk of CAL detection.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Rheumatology
Manphool Singhal, Rakesh Kumar Pilania, Ankur Kumar Jindal, Aman Gupta, Avinash Sharma, Sandesh Guleria, Nameirakpam Johnson, Muniraju Maralakunte, Pandiarajan Vignesh, Deepti Suri, Manavjit Singh Sandhu, Surjit Singh
Summary: Objective evaluation of coronary artery abnormalities (CAAs) in patients with Kawasaki disease (KD) is important. This study investigates the role of CT coronary angiography (CTCA) in detecting CAAs in the distal segments of coronary arteries in KD patients. The results show that CTCA can identify CAAs in the distal segments, including branches, of the coronary arteries, which cannot be detected by transthoracic echocardiography (TTE).
Article
Hematology
Yue Peng, Qijian Yi
Summary: This study aimed to determine the incidence, timing, and risk factors of coronary thrombosis in Kawasaki disease (KD) patients with giant coronary artery aneurysm (GCAA). The study found that male gender, involvement of the left anterior descending artery (LAD), and coronary absolute diameter ≥ 8 mm were associated with a higher risk of coronary thrombosis. These findings provide important insights for the thromboprophylaxis management of KD patients with GCAA.
THROMBOSIS RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Hongying Shi, Fengfeng Weng, Chen Li, Zengyou Jin, Junyong Hu, Maoping Chu, Huixian Qiu
Summary: The study found that the prevalence of overweight/obesity among KD patients was 18.5%, and overweight/obesity was significantly associated with CAL. Some laboratory indices may modify this association.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Immunology
Mindy Ming-Huey Guo, Ying-Hsien Huang, Feng-Sheng Wang, Ling-Sai Chang, Kuang-Den Chen, Ho-Chang Kuo
Summary: CD36 plays a crucial role in the immunopathogenesis of Kawasaki disease by clearing plasma mitochondrial DNA and amplifying the immune response via the AIM2 pathway. Additionally, the expression level of CD36 is associated with the development of coronary artery lesions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Maoling Yang, Qiongfei Pei, Jing Zhang, Haobo Weng, Fengchuan Jing, Qijian Yi
Summary: Kawasaki disease (KD) is an acute systemic vasculitis in children. Adropin, a new biopeptide, seems to be involved in the pathogenesis of KD and CALs. Serum adropin level can be used as an auxiliary diagnostic biomarker to predict CALs in children with KD.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Xingzhu Liu, Yanfei Chen, Yanfei Yang, Zhongjian Su, Feng Wang, Chenghao Zhanghuang, Yuqin Wu, Xing Zhang
Summary: This study investigated the correlation between FGA gene polymorphisms and coronary artery lesion in Kawasaki disease. The concentrations of serum MMPs and FG-α were significantly higher in KD patients, suggesting that FGA gene polymorphisms affect coronary artery lesion in children with KD.
FRONTIERS IN MEDICINE
(2023)
Article
Pediatrics
Haobo Weng, Yue Peng, Qiongfei Pei, Fengchuan Jing, Maoling Yang, Qijian Yi
Summary: The study found that serum ANXA1 levels were significantly decreased in Kawasaki disease patients, especially those with coronary artery aneurysms. ANXA1 may be involved in the pathogenesis of Kawasaki disease and its downregulation could contribute to hypercoagulability. This highlights ANXA1 as a potential therapeutic target for Kawasaki disease patients.
PEDIATRIC RESEARCH
(2021)
Article
Immunology
Kazuki Iio, Yoshihiko Morikawa, Koichi Miyata, Tetsuji Kaneko, Masahiro Misawa, Hiroyuki Yamagishi, Masaru Miura
Summary: This study aimed to identify the characteristics of Kawasaki disease patients with a low risk of coronary artery aneurysm (CAA) development. Using multivariable logistic regression analysis and decision tree creation, a subgroup of KD patients with a low CAA risk was identified. This subgroup accounted for approximately one quarter of the entire study cohort.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Jinling Hu, Weidong Ren
Summary: Kawasaki disease is a common form of systemic vasculitis in children, with the main complication being coronary artery lesions. Factors such as age, immunoglobulins, and the number of coronary arteries involved are important predictors of poor prognosis in children with CALs.
FRONTIERS IN PEDIATRICS
(2021)
Article
Public, Environmental & Occupational Health
Sixian Lao, Tao Zhou, Ho-Chang Kuo, Guoping Zhong, Weiwei Zeng
Summary: This study aimed to investigate the impact of antibiotics on Kawasaki disease patients with coronary artery lesions (CAL) and identify independent risk factors. The results showed that neutrophil granulocyte percentage, lymphocyte percentage, and total protein were independent risk factors for CAL in KD without antibiotics use history.
FRONTIERS IN PUBLIC HEALTH
(2022)