Review
Biochemistry & Molecular Biology
Jung-Hyun Alex Lee, Qiyu Chen, Min Zhuo
Summary: This review summarizes recent progress in synaptic mechanisms of different forms of cortical long-term potentiation (LTP) and their potential contribution to behavioral pain and emotional changes.
Article
Neurosciences
Kyeongmin Kim, Guanghai Nan, Leejeong Kim, Minjee Kwon, Kyung Hee Lee, Myeounghoon Cha, Bae Hwan Lee
Summary: This study aimed to investigate the effects of insular cortex stimulation (ICS) on neuropathic pain and determine how ICS modulates pain. The results showed that the most effective pain relief was achieved with ICS at 50 Hz-120 μA in a single trial, and its effects lasted for 4 days after repetitive ICS termination. The expression levels of phosphorylated extracellular signal-regulated kinase (pERK), astrocytes, and microglia were increased in neuropathic rats, but they were decreased after ICS, particularly in layers 2-3 of the insular cortex where pERK and neurons colocalize.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Sachie Matsumura, Kiyofumi Yamamoto, Yuka Nakaya, Kazunori O'Hashi, Keisuke Kaneko, Hiroki Takei, Hiromasa Tsuda, Tetsuo Shirakawa, Masayuki Kobayashi
Summary: The study shows that SP suppresses excitatory synaptic transmission in the insular cortex by activating NK1 receptors, possibly through activating the nitric oxide synthesis pathway in a subtype of GABAergic neurons.
Article
Biochemistry & Molecular Biology
Georgii Krivoshein, Abdulhameed Bakreen, Arn M. J. M. van den Maagdenberg, Tarja Malm, Rashid Giniatullin, Jukka Jolkkonen
Summary: This study assessed the changes in meningeal afferent activity after stroke in mice. The results showed increased activity of mechanosensitive Piezo1 channels and nociceptive TRPV1 channels in meningeal afferents, which may be associated with trigeminal headache pain responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ning Wang, Yu-Han Zhang, Jin-Yan Wang, Fei Luo
Summary: Neuropathic pain is challenging to treat and often involves emotional and psychological changes. The insular cortex is implicated in the processing of neuropathic pain, with studies indicating a potential role in emotional motivation, neural plasticity, cognitive evaluation, and psychosocial aspects. Further understanding of the involvement of the insular cortex could lead to new pharmacotherapy and psychotherapy treatments for neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Songyeon Choi, Kyeongmin Kim, Minjee Kwon, Sun Joon Bai, Myeounghoon Cha, Bae Hwan Lee
Summary: Inhibition of neuroglia activity in the insular cortex can alleviate chronic pain, and purinergic receptors in glial cells are closely related to chronic pain development.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Tolulope Adeyelu, Tanya Gandhi, Charles C. Lee
Summary: Researchers have identified a prominent contralateral corticothalamic projection originating in the insular cortex, which differs from the traditional unilateral thalamo-cortico-thalamic loops and suggests a unique bilateral mechanism for refining ascending sensory information.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Clinical Neurology
Richard B. Lipton, Agustin Melo-Carrillo, Mark Severs, Michael Reed, Sait Ashina, Timothy Houle, Rami Burstein
Summary: This real-world study suggests that treatment with narrow band green light during migraine attacks can relieve pain and photophobia, reduce anxiety, and improve sleep.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Minoo Karimi, Saeid Farahani, Farinaz Nasirinezhad, Shohreh Jalaei, Helnaz Mokrian, Ali Shahbazi
Summary: This study aimed to investigate the effect of excitotoxic lesions limited to the insular cortex on the ability to detect a gap in background noise in rats. The results showed that the ability to detect the gap in background noise was impaired in rats following insular lesions, while hearing sensitivity remained intact. This suggests that the insular cortex may have a role in the development of tinnitus.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Anesthesiology
Kazuaki Nagasaka, Ichiro Takashima, Keiji Matsuda, Noriyuki Higo
Summary: In this study, using a macaque model, the researchers found that inactivating the posterior insular cortex (PIC) and secondary somatosensory cortex (SII) can reduce hypersensitivity to thermal stimuli, indicating the potential therapeutic approach for thermal hyperalgesia in central post-stroke pain (CPSP).
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Multidisciplinary Sciences
Mario A. Acuna, Fernando Kasanetz, Paolo De Luna, Marta Falkowska, Thomas Nevian
Summary: The perception of pain is a complex experience and understanding how the brain distinguishes pain from other sensory stimuli has been a challenge. In this study, researchers used calcium imaging in mice to investigate the coding of pain in the anterior cingulate cortex. They found that population activity, rather than single-cell responses, allowed the discrimination of painful stimuli. Additionally, they discovered that chronic neuropathic pain led to changes in sensory processing, which were restored by analgesic treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Ming-Ming Zhang, An-Qi Geng, Kun Chen, Jian Wang, Pan Wang, Xin-Tong Qiu, Jun-Xiang Gu, Hong-Wei Fan, Da-Yu Zhu, Shan-Ming Yang, Qi-Yu Chen, Zhao-Xiang Zhou, Bo-Yuan Fan, Yang Bai, Ke-Ke Xing, Jia-Ming Feng, Jun-Da Wang, Yan Chen, Ya-Cheng Lu, Ying Liang, Peng Cao, Bong-Kiun Kaang, Min Zhuo, Yun-Qing Li, Tao Chen
Summary: This study established a long-term observational pain model in mice and identified the glutamatergic projection from the insular cortex to the basolateral amygdala as critical for the formation of observational pain. Synaptotagmin-2 and RIM3 were found to be key signals in controlling the increased synaptic glutamate transmission in this projection pathway.
Article
Neurosciences
Fu-Chao Zhang, Ying-Xue Wei, Rui-Xia Weng, Qi-Ya Xu, Rui Li, Yang Yu, Guang-Yin Xu
Summary: This study identified a novel PVT-IC neural circuit playing a critical role in colorectal visceral pain in a mouse model of IBS. This work will strengthen fundamental research on the involvement of central nervous system in visceral hyperalgesia and provide potential therapeutic targets toward effective treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Grace J. Lee, Yea Jin Kim, Sang Wook Shim, Kihwan Lee, Seog Bae Oh
Summary: Feeding behaviors have a close relationship with chronic pain in adult rodents. A recent study found that refeeding after fasting can attenuate pain behavior under chronic inflammatory pain conditions. Neural activities in the nucleus accumbens shell (NAcS) and anterior insular cortex (aIC) were increased in a CFA-induced chronic inflammatory pain condition, but decreased after refeeding. Refeeding also reduced the enhanced excitability of aIC(CaMKII)-NAcSD2R projecting neurons in this model.
Review
Behavioral Sciences
Anne Margarette S. Maallo, Eric A. Moulton, Christine B. Sieberg, Donald B. Giddon, David Borsook, Scott A. Holmes
Summary: This study examines the association between pain and depression, highlighting overlapping neural substrates; it suggests monitoring left-sided pain symptoms in individuals diagnosed with depression; and recommends psychological evaluation as part of standard practice in pain treatment for patients with pain.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Behavioral Sciences
Angelica Almanza, Karina Simon-Arceo, Ulises Coffeen, Ruth Fuentes-Garcia, Bernardo Contreras, Francisco Pellicer, Francisco Mercado
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2015)
Article
Behavioral Sciences
L. Puga, V. Alcantara-Alonso, U. Coffeen, O. Jaimes, P. de Gortari
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Anesthesiology
U. Coffeen, A. Canseco-Alba, K. Simon-Arceo, A. Almanza, F. Mercado, M. Leon-Olea, F. Pellicer
EUROPEAN JOURNAL OF PAIN
(2018)
Article
Plant Sciences
Karina Simon-Arceo, Ma. Eva Gonzalez-Trujano, Ulises Coffeen, Rodrigo Fernandez-Mas, Francisco Mercado, Angelica Almanza, Bernardo Contreras, Orlando Jaimes, Francisco Pellicer
JOURNAL OF ETHNOPHARMACOLOGY
(2017)
Article
Clinical Neurology
Abraham Ochoa-Aguilar, Rosa Ventura-Martinez, Marco Antonio Sotomayor-Sobrino, Ruth Jaimez, Ulises Coffeen, Ariadna Jimenez-Gonzalez, Luis Gerardo Balcazar-Ochoa, Rafael Perez-Medina-Carballo, Rodolfo Rodriguez, Ricardo Plancarte-Sanchez
JOURNAL OF PAIN RESEARCH
(2018)
Article
Cell Biology
Francisco Mercado, Angelica Almanza, Karina Simon-Arceo, Omar Lopez, Rosario Vega, Ulises Coffeen, Bernardo Contreras, Enrique Soto, Francisco Pellicer
Article
Geriatrics & Gerontology
Karina Simon-Arceo, Bernardo Contreras, Martha Leon-Olea, Ulises Coffeen, Orlando Jaimes, Francisco Pellicer
FRONTIERS IN AGING NEUROSCIENCE
(2014)
Review
Clinical Neurology
Ulises Coffeen, Francisco Pellicer
JOURNAL OF PAIN RESEARCH
(2019)
Article
Clinical Neurology
Ulises Coffeen, Marco Antonio Sotomayor-Sobrino, Ariadna Jimenez-Gonzalez, Luis Gerardo Balcazar-Ochoa, Pamela Hernandez-Delgado, Ana Fresan, Ricardo Plancarte-Sanchez, Samantha Daniela Arias-Munoz, Abraham Ochoa-Aguilar
JOURNAL OF PAIN RESEARCH
(2019)
Article
Neurosciences
Angelica Almanza, Pedro Segura-Chama, Leon-Olea Martha Leon-Olea, Enoch Luis, Garduno-Gutierrez Rene Garduno-Gutierrez, Jonathan Mercado-Reyes, Simon-Arceo Karina Simon-Arceo, Ulises Coffeen, Hernandez-Cruz Arturo Hernandez-Cruz, Francisco Pellicer, Francisco Mercado
Article
Neurosciences
Ivan Perez-Neri, Doris Parra, Guillermo Aquino-Miranda, Ulises Coffeen, Camilo Rios
NEUROSCIENCE LETTERS
(2020)
Article
Pharmacology & Pharmacy
Yarim Elideth De la Luz-Cuellar, Ulises Coffeen, Francisco Mercado, Vinicio Granados-Soto
Summary: This study investigated the impact of sex on the antiallodynic activity of spinal dopamine D1 and D2-like receptors in a model of fibromyalgia-type pain in rats. The results showed that drugs targeting these receptors had a greater effect on female rats compared to male rats. Sex differences were also observed in a nerve injury model. These findings suggest that the antiallodynic effect of dopamine receptors in fibromyalgia-type pain is influenced by hormonal receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)