Article
Endocrinology & Metabolism
Johan Roikjer, Suganthiya Santhiapillai Croosu, Tine Maria Hansen, Jens Brondum Frokjaer, Christina Brock, Carsten Dahl Morch, Niels Ejskjaer
Summary: This study aims to investigate the co-existence of diabetic peripheral neuropathy (DPN), painful diabetic peripheral neuropathy (PDPN), and cardiac autonomic neuropathy (CAN), and establish a model to predict CAN based on peripheral measurements. The results showed that CAN predominantly co-exists with DPN and the prediction model based on logistic regression has a certain accuracy.
ACTA DIABETOLOGICA
(2023)
Review
Anatomy & Morphology
Laura Josephine Bubenzer, Lena Konsolke, Elena Enax-Krumova, Frederic Eberhardt, Martin Tegenthoff, Oliver Hoeffken, Oezuem Simal Oezguel
Summary: This systematic review compared and summarized the study results of pain-related evoked potentials with concentric surface electrodes (PREP with CE) in healthy subjects and patients, and identified possible influencing factors. The results showed that patients with polyneuropathies had consistent PREP results, while findings in other patient groups and healthy subjects were more heterogeneous. Factors such as age, height, and emotions were found to have an influence on the results, which should be considered in further studies. More systematic research is needed to analyze PREP results based on individual and disease-specific factors and develop optimal normative values.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Multidisciplinary Sciences
A. Di Lionardo, G. Di Stefano, C. Leone, G. Di Pietro, E. Sgro, E. Malara, C. Cosentino, C. Mollica, A. J. Blockeel, O. Caspani, L. Garcia-Larrea, A. Mouraux, R. D. Treede, K. G. Phillips, M. Valeriani, Andrea Truini
Summary: This neurophysiological study demonstrated that capsaicin-induced central sensitization modulated N13 SEP amplitude, which was prevented by pregabalin, suggesting N13 SEP as a potential biomarker for changes in dorsal horn excitability during central sensitization.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Marilia Trindade, Jessica Castro de Vasconcelos, Gabriel Ayub, Alex Treiger Grupenmacher, Delma Regina Gomes Huarachi, Marina Viturino, Maria Lucia Correa-Giannella, Yeelen Ballesteros Atala, Denise Engelbrecht Zantut-Wittmann, Maria Candida Parisi, Monica Alves
Summary: This study aimed to evaluate ocular disease and its associations with peripheral neuropathy (PN) or cardiac autonomic neuropathy (CAN) in type 2 diabetes (T2D) and Charcot arthropathy (CA) patients. The results showed significant differences in various ocular variables between T2D patients, controls, and patients with both T2D and CA, highlighting the potential impact of CA on ocular findings and the association of DED with PN and CAN.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Alice Duque, Mauro Felippe Felix Mediano, Andrea De Lorenzo, Luiz Fernando Rodrigues Jr
Summary: Cardiovascular autonomic neuropathy (CAN) is a debilitating microvascular complication that primarily affects long-standing type 2 diabetes patients but can also manifest early in the disease progression. The pathophysiology of CAN is complex, involving various risk factors and clinical complications, and early identification and treatment of CAN may help reduce mortality rates for affected individuals.
WORLD JOURNAL OF DIABETES
(2021)
Article
Cardiac & Cardiovascular Systems
Christian S. Hansen, Daniel G. K. Rasmussen, Tine W. Hansen, Signe Holm Nielsen, Simone Theilade, Morten A. Karsdal, Federica Genovese, Peter Rossing
Summary: This study identified previously undescribed associations between markers of collagen turnover and the risk of cardiovascular autonomic neuropathy and distal symmetrical polyneuropathy in patients with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Pharmacology & Pharmacy
Miguel Angel Garcia-Gonzalez, Veronica Vallejo-Ruiz, Fausto Atonal-Flores, Jorge Flores-Hernandez, Oswaldo Torres-Ramirez, Alfonso Diaz-Fonsecae, Francisco Perez Vizcaino, Jose Gustavo Lopez-Lopez
Summary: Chronic treatment with sildenafil has beneficial effects on pulmonary arterial pressure, right ventricular hypertrophy, and heart rate variability in rats with secondary pulmonary hypertension caused by type 1 diabetes.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Endocrinology & Metabolism
Gidon J. Bonhof, Alexander Strom, Maria Apostolopoulou, Yanislava Karusheva, Theresia Sarabhai, Dominik Pesta, Michael Roden, Dan Ziegler
Summary: The study showed that in individuals with type 2 diabetes, a 12-week supervised high-intensity interval training program led to improvements in resting heart rate, heart rate variability, and orthostatic blood pressure regulation, but had limited effects on somatic nerve function and structure.
Article
Behavioral Sciences
Veronika Potockova, Sarka Mala, Lucie Hoskovcova, Vaclav Capek, Tomas Nedelka, Lucie Riedlbauchova, Daniel Baumgartner, Livie Mensova, Radim Mazanec
Summary: This study aimed to investigate whether thermal quantitative sensory testing (TQST) can be used as a screening tool to identify patients with diabetes at a higher risk of cardiac autonomic neuropathy (CAN). The results showed that TQST can accurately diagnose CAN with high specificity and positive predictive value. Therefore, TQST can be used as a rapid screening method before performing time-consuming cardiovascular autonomic reflex tests (CART).
BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Catherine R. Jutzeler, Lukas D. Linde, Jan Rosner, Michele Hubli, Armin Curt, John L. K. Kramer
Summary: The study found that analyzing nociceptive evoked potentials through single-trial averaging can improve the associations with physiological outcomes and should be incorporated as a standard technique in future studies.
Article
Endocrinology & Metabolism
Anna Vagvolgyi, Agnes Maroti, Monika Szocs, Csongor Poczik, Dora Urban-Pap, Istvan Baczko, Attila Nemes, Eva Csajbok, Krisztian Sepp, Peter Kempler, Andrea Orosz, Tamas Varkonyi, Csaba Lengyel
Summary: The study found early signs of peripheral sensory neurological impairments in young T1DM patients at the time of transition to adult diabetes care, providing valuable feedback for future follow-up care.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Susumu Z. Sudo, Tadeu L. Montagnoli, Bruna de S. Rocha, Aimee D. Santos, Mauro P. L. de Sa, Gisele Zapata-Sudo
Summary: Cardiovascular autonomic neuropathy (CAN) is a severe complication of advanced diabetes, which can have various clinical manifestations. Current treatment options for CAN are limited, but potential targets for therapy include inflammatory and endothelial dysfunction as well as oxidative stress.
Article
Clinical Neurology
Massimo Leandri, Giulia Di Stefano, Andrea Truini, Lucio Marinelli
Summary: This study investigated early cortical responses to nociceptive stimulation, confirming the presence of the N40 component possibly conducted by fast A delta fibers. It is the first report of such early responses in humans, with important implications for future experimental and clinical neurophysiology.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Ana Raquel Souza de Azevedo Vieira, Lara Benigno Porto-Dantas, Flaviene Alves do Prado Romani, Patricia Souza Carvalho, Rodica Pop-Busui, Hermelinda Cordeiro Pedrosa
Summary: This study aimed to evaluate diabetic autonomic neuropathy (DAN) in people with diabetes using practical tools. The results showed a high frequency of symptomatic DAN, which was associated with factors such as age, blood sugar, and abdominal circumference. Using a digital app to assess DAN symptoms proved to be a practical and easy-to-use method, and there is a need to assess metabolic syndrome in larger samples for DAN evaluations.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Sondre Meling, Erling Tjora, Heike Eichele, Rasmus Bach Nedergaard, Niels Ejskjaer, Christina Brock, Eirik Softeland
Summary: This study aimed to explore a novel method for investigating the autonomic nerves of the gastrointestinal tract by measuring visceral sensory evoked potentials (EPs) in response to rectal balloon distention. The results showed that the pressure at earliest sensation was higher in people with diabetes and correlated with signs of peripheral neuropathy.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emily Steinkohl, Soren Schou Olesen, Tine Maria Hansen, Asbjorn Mohr Drewes, Jens Brondum Frokjaer
Summary: This study investigated the correlation between magnetic resonance elastography (MRE)-derived stiffness and T1 relaxation times with gland volume and pancreatic functions in patients with chronic pancreatitis (CP). The results showed a positive correlation between MRE-derived stiffness and T1 relaxation times, but no correlation was found between MRE-derived stiffness and gland volume. T1 relaxation time was correlated with gland volume in CP patients but not in the healthy controls. The study suggests that MRE-derived stiffness and T1 relaxation times may be useful for the non-invasive and early identification of CP.
Article
Gastroenterology & Hepatology
Marco B. Mahdi, Emily Steinkohl, Vikesh K. Singh, Asbjorn M. Drewes, Jens B. Frokjaer, Soren S. Olesen
Summary: In medically managed patients with chronic pancreatitis, those with large duct CP have a higher prevalence of diabetes and exocrine insufficiency compared to small duct CP. There is also an increased risk of new-onset exocrine insufficiency and higher rates of pancreatic atrophy in patients with large duct CP.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2023)
Article
Pharmacology & Pharmacy
Tina Okdahl, Esben Bolvig Mark, Rasmus Bach Nedergaard, Cecilie Siggaard Knoph, Mathias Ellgaard Cook, Klaus Krogh, Asbjorn Mohr Drewes
Summary: Opium tincture, traditionally used for chronic diarrhea, has been found to decrease bowel movements and increase stool consistency without causing sedation. This controlled trial demonstrates that opium tincture has anti-propulsive properties in the healthy gut, making it a relevant and safe treatment option for chronic diarrhea.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Sigrid Breinholt Vestergaard, Andreas Gammelgaard Damsbo, Rolf Ankerlund Blauenfeldt, Soren Paaske Johnsen, Grethe Andersen, Janne Kaergaard Mortensen
Summary: The study found that prestroke physical activity was associated with depressive symptoms up to 6 months after stroke, and citalopram treatment did not modify this association.
Review
Medicine, General & Internal
Christoffer S. Graven-Nielsen, Cecilie S. Knoph, Tina Okdahl, Katrine L. Hoyer, Klaus Krogh, Per M. Hellstroem, Asbjorn M. Drewes
Summary: In patients with chronic idiopathic diarrhea resistant to standard treatment, opioids are often used as rescue therapy. This systematic review investigated the effects of opioid agonists on gut function in chronic diarrhea. The review found that opioid receptor agonists such as loperamide, asimadoline, casokefamide, and codeine reduced stool frequency and increased transit time compared with placebo, while loperamide and diphenoxylate significantly improved stool consistency. However, the evidence from clinical trials is limited and more research is needed to establish standardized endpoints and larger prospective studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Suganthiya S. Croosu, Mimoza Gjela, Johan Roikjer, Tine M. Hansen, Carsten D. Morch, Jens B. Frokjaer, Niels Ejskjaer
Summary: Previous studies suggest that cognitive impairment is more prevalent in individuals with painful and painless diabetic peripheral neuropathy (DPN). This study investigated cognitive function in adults with type 1 diabetes mellitus (T1DM) and the association to painful/painless DPN and clinical parameters. The results showed that T1DM participants had lower cognitive scores and longer reaction times compared to healthy controls, and memory scores were lower in those with painless DPN.
ENDOCRINOLOGY DIABETES & METABOLISM
(2023)
Article
Clinical Neurology
Naja H. Andersen, Rolf A. Blauenfeldt, Ronni Mikkelsen, Claus Z. Simonsen
Summary: We present a case showing the evolution of symptoms and brain MRI changes in cortical superficial siderosis. The patient initially had transient focal neurological episodes without evidence of cortical superficial siderosis. However, two weeks later, the patient developed cortical superficial siderosis adjacent to a cerebral microbleed. The case highlights the temporal development of cortical superficial siderosis.
Review
Anesthesiology
Anne-Marie Wegeberg, Trine Hyttel Sejersgaard-Jacobsen, Christina Brock, Asbjorn Mohr Drewes
Summary: Pain is a major clinical challenge, and understanding its pathophysiology is critical for optimal management. This systematic review investigates the ability of electrocardiographic-derived measures to predict pain, and finds that increased parasympathetic activity can predict pain reduction in different types of pain.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Gastroenterology & Hepatology
Mathias Ellgaard Cook, Niels Henrik Bruun, Line Davidsen, Asbjorn Mohr Drewes, Soren Schou Olesen
Summary: Understanding the nature of inflammatory pancreatic diseases is crucial for healthcare planning. This study found an increased risk of chronic pancreatitis and pancreatic cancer in patients with a history of acute pancreatitis, with most transitioning directly from a healthy state.
Article
Medicine, General & Internal
Martin Bendszus, Jens Fiehler, Fabien Subtil, Susanne Bonekamp, Anne Hege Aamodt, Blanca Fuentes, Elke R. Gizewski, Michael D. Hill, Antonin Krajina, Laurent Pierot, Claus Z. Simonsen, Kamil Zelenak, Rolf A. Blauenfeldt, Bastian Cheng, Angelique Denis, Hannes Deutschmann, Franziska Dorn, Fabian Flottmann, Susanne Gellissen, Johannes C. Gerber, Mayank Goyal, Jozef Haring, Christian Herweh, Silke Hopf-Jensen, Vi Tuan Hua, Maerit Jensen, Andreas Kastrup, Christiane Fee Keil, Andrej Klepanec, Egon Kurca, Ronni Mikkelsen, Markus Moehlenbruch, Stefan Mueller-Huelsbeck, Nico Muennich, Paolo Pagano, Panagiotis Papanagiotou, Gabor C. Petzold, Mirko Pham, Volker Puetz, Jan Raupach, Gernot Reimann, Peter Arthur Ringleb, Maximilian Schell, Eckhard Schlemm, Silvia Schoenenberger, Bjorn Tennoe, Christian Ulfert, Katerina Valis, Eva Vitkova, Dominik F. Vollherbst, Wolfgang Wick, Goetz Thomalla
Summary: Endovascular thrombectomy is associated with improved functional outcome and lower mortality in patients with acute ischemic stroke from large vessel occlusion using non-contrast CT as the primary imaging modality for patient selection.
Article
Gastroenterology & Hepatology
Mikael Parhiala, Camilla Nojgaard, Andreas Bartholdy, Anne Waage, Povilas Ignatavicius, Trond Engjom, Georg Dimcevski, Ingrid Kvale Nordaas, Evangelos Kalaitzakis, Asbjorn M. Drewes, Amer Hadi, Soren S. Olesen, Jakob L. Poulsen, Johanna Laukkarinen, Scandinavian Baltic Pancreatic Club
Summary: This study aimed to determine the frequency of endoscopic procedures (EP) in chronic pancreatitis (CP) patients and analyze their pain and quality of life (QoL) after the procedures. The study found that 20% of CP patients underwent EP, and these patients had higher QoL scores and improved symptoms. Patients who had pancreatic stenting had similar pain patterns to the reference population.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Clinical Neurology
Cecilie Siggaard Knoph, Rasmus Bach Nedergaard, Soren Schou Olesen, Louise Kuhlmann, Asbjorn Mohr Drewes
Summary: Abdominal pain is common in patients with chronic pancreatitis and is difficult to manage due to altered pain processing in the central nervous system. We hypothesized that patients with painful chronic pancreatitis have generalized hyperalgesia and increased central neuronal excitability. Our study confirmed somatic hyperalgesia in these patients, highlighting the importance of targeting central mechanisms for management.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Martin Gude, Hans Kirkegaard, Rolf Blauenfeldt, Anne Behrndtz, Jeppe Mainz, Ingunn Riddervold, Claus Z. Simonsen, Niels Hjort, Soren P. Johnsen, Grethe Andersen, Jan Brink Valentin
Summary: This study examined the agreement between emergency medical service providers, neurology residents, and neurology consultants in using the CPSS and PASS scales. The results showed high relative and absolute inter-rater agreement, indicating the robustness and widespread applicability of these scales.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Ophthalmology
Christina Brock, Anne-Marie Wegeberg, Thomas Arendt Nielsen, Bassam Karout, Per M. Hellstrom, Asbjorn Mohr Drewes, Henrik Vorum
Summary: The thickness of the retinal nerve fiber layer can serve as an indicator for systemic neurodegeneration in diabetes, correlating with peripheral and autonomic neuropathy as well as cognitive comorbidity.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Soren Schou Olesen, Emily Steinkohl, Tine Maria Hansen, Asbjorn Mohr Drewes, Jens Brondum Frokjaer
Summary: The study aimed to evaluate the performance of advanced magnetic resonance imaging (MRI) techniques for diagnosing and grading the severity of chronic pancreatitis (CP), with a focus on detecting CP with preserved pancreatic function. The results showed that quantitative assessments of T1 relaxation time and MRE-derived stiffness hold promise in diagnosing CP at different functional stages, and when combined with a multiparametric MRI-index, can be used for early identification, staging, and monitoring of CP.
ABDOMINAL RADIOLOGY
(2023)
