Article
Neurosciences
Meta N. Eek, Annika Blomkvist, Kristina Olsson, Karin Lindh, Kate Himmelmann
Summary: This study successfully measured the sitting position of children with cerebral palsy and severe motor impairment using pressure mapping and 2D motion analysis. Children with cerebral palsy had more movements in sitting compared to typically developing children. Differences were also found between different subgroups of cerebral palsy. After treatment with intrathecal baclofen, involuntary movements decreased and improvement in sitting was reported by parents. The two measurement systems showed consistent results and proved to be feasible for objective assessment of sitting position in this population.
Article
Rehabilitation
Laura A. Bonouvrie, Helga Haberfehlner, Jules G. Becher, Johan S. H. Vles, R. Jeroen Vermeulen, Annemieke Buizer
Summary: This study assessed the achievement of individual treatment goals one year after intrathecal baclofen pump implantation in patients with dyskinetic cerebral palsy. The study found that 71% of individuals fully achieved one or more treatment goals, while 97% partially achieved one or more treatment goals. The attainment of treatment goals was associated with baseline dyskinesia impairment score and improvement in pain during treatment.
DISABILITY AND REHABILITATION
(2023)
Review
Clinical Neurology
Amogh Kudva, Mickey E. Abraham, Justin Gold, Neal A. Patel, Julian L. Gendreau, Yehuda Herschman, Antonios Mammis
Summary: Cerebral palsy is a chronic congenital disorder caused by abnormal brain development. Recent literature has focused on chronic spasticity in children with CP. Various neuromodulation procedures, such as selective dorsal rhizotomy, intrathecal baclofen pumps, and extracorporeal shockwave therapy, have been found to effectively improve spasticity, but further studies are needed to determine optimal frequencies and application sites for these treatments.
NEUROSURGICAL REVIEW
(2021)
Article
Orthopedics
Ali Asma, Jason J. Howard, Armagan Can Ulusaloglu, Kenneth J. Rogers, Freeman Miller, M. Wade Shrader
Summary: This study aimed to determine the risk factors for reconstructive hip surgery after intrathecal baclofen pump application in children with cerebral palsy. The results showed that male sex, pre-intrathecal baclofen migration percentage, age at intrathecal baclofen application, and delta migration percentage were significant risk factors for requiring reconstruction.
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
(2023)
Article
Clinical Neurology
Adeel S. Zubair, Matthew Raymond, Huned S. Patwa
Summary: ITB is a safe and effective treatment for spasticity in PLS patients, with most patients experiencing significant improvement after treatment although a few may experience pump-related complications. The duration of treatment varies depending on individual cases, but the majority of patients benefit from it.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Janina Gburek-Augustat, Matthias Krause, Matthias Bernhard, Ina Sorge, Daniel Grafe, Manuela Siekmeyer, Ulf Nestler, Andreas Merkenschlager
Summary: This study presents six pediatric patients who experienced unusual mechanical failures of intrathecal baclofen pump systems. Through these case-vignettes, a systematic approach on interpreting the symptoms of ITB complications and recommendations for further diagnostic and therapeutic steps are provided. The seriousness of baclofen overdose, underdosing, or withdrawal is emphasized.
CHILDS NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Ricky T. Mohon, Kim Sawyer, Kaci Pickett, Samantha Bothwell, John T. Brinton, Michelle Sobremonte-King, Lourdes M. DelRosso
Summary: The study found a high prevalence of sleep-related breathing disorders in cerebral palsy patients receiving ITB treatment, with no significant improvement or worsening of the condition observed before and after treatment.
NEUROREHABILITATION
(2021)
Article
Rehabilitation
Soolim Lee, Cheolhwan Hyun, Kyungmin Kim, Hyo Eun Kwon, Minwoo Woo, Seong-Eun Koh
Summary: This systematic review examined the effect of intrathecal baclofen pump insertion on scoliosis in children with cerebral palsy (CP). Four retrospective comparative studies were included in the analysis, and the results showed that intrathecal baclofen pump insertion accelerated the progression of scoliosis. Therefore, the advantages and disadvantages of using intrathecal baclofen pumps in children with CP should be carefully evaluated.
ANNALS OF REHABILITATION MEDICINE-ARM
(2023)
Article
Clinical Neurology
Bernardo Assumpcao de Monaco, Pablo Ramon Fruett da Costa, Paulo Roberto Franceschini
Summary: Limited therapies are available for severe cerebral palsy children (CP) with complex movement disorders. In this publication, we present the improvement of a child with severe CP after intracerebroventricular baclofen therapy. The treatment not only impacts the movement disorders but also improves the quality of life of the child and caregivers. Global functional improvements can be observed on the 6-month follow-up.
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Elisabet Rodby-Bousquet, Atli Agustsson
Summary: The use of assistive devices and postural asymmetries were common in adults with cerebral palsy, with a higher proportion of individuals using assistive devices in sitting compared to lying or standing. Most adults displayed postural asymmetries, and these asymmetries were strongly associated with the inability to change or maintain position.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Gunnar Hagglund, Sandra Julsen Hollung, Matti Ahonen, Guro L. Andersen, Guobjorg Eggertsdottir, Mark S. Gaston, Reidun Jahnsen, Ira Jeglinsky-Kankainen, Kirsten Nordbye-Nielsen, Ilaria Tresoldi, Ann Alriksson-Schmidt
Summary: There are significant differences between countries in the proportion of children and adolescents with CP treated with the three spasticity-reducing methods, the mean age for treatment, and treatment related to GMFCS level. These differences may be due to variations in treatment availability and preferences among professionals and patients across countries.
Article
Clinical Neurology
Robert J. Bollo, Paul H. Gross, Brandon G. Rocque, Samuel R. Browd, Jeffrey S. Raskin, Jeffrey R. Leonard, Lama Albarqawi, Amy F. Bailes
Summary: This study describes the first multicenter quality improvement initiative aimed at reducing surgical site infection (SSI) in children with cerebral palsy undergoing intrathecal baclofen (ITB) pump surgery. By implementing a standardized surgical protocol and using quality improvement methodology, the study achieved a protocol compliance rate of 75% and a 90-day infection rate of 4.4%.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Ahmad Zaheer Qureshi, Hasan Shacfe, Amara Ilyas, Saeed Bin Ayaz, Khalid Yousef Aljamaan, Imad Saeed Moukais, Mohammed Jameel, Waqas Sami, Sami Ullah
Summary: This retrospective cohort study analyzes the complications of intrathecal baclofen pump (ITB) treatment. The results indicate that catheter-related complications are the most common, and there is a significant relationship between catheter occlusion and the pattern of spastic quadriparesis.
Article
Orthopedics
Aneesh Samineni, Susan E. Eklund, Patricia E. Miller, Kristin Buxton, Brian D. Snyder, Travis H. Matheney, Colyn J. Watkins, Scellig S. D. Stone, Walid Alrayashi, Roland Brusseau, Benjamin J. Shore
Summary: This retrospective study investigated the rate of serious complications and the efficacy of epidural analgesia compared to lumbar plexus blocks (LPBs) for pain management in children with cerebral palsy (CP) and intrathecal baclofen pump (ITB) undergoing hip reconstruction surgery. The results showed that epidural anesthesia provided improved analgesia compared to LPB analgesia, without increasing the risk of complications.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Clinical Neurology
Ann Mansur, Benjamin Morgan, Alexandre Lavigne, Nicolas Phaneuf-Garand, Jocelyne Diabira, Han Yan, Unni G. Narayanan, Darcy Fehlings, Golda Milo-Manson, Blythe Dalziel, Sara Breitbart, Claude Mercier, Dominic Venne, Pierre Marois, Alexander G. Weil, Jeffrey S. Raskin, Sruthi P. Thomas, George M. Ibrahim
Summary: The study compared the care needs, symptom burden, and complications in nonambulatory children with predominantly spastic cerebral palsy who underwent surgical treatment with either intrathecal baclofen pump insertion or selective dorsal rhizotomy. The results showed significant baseline differences between patients treated with these two surgical options, highlighting the importance of considering individual patient factors when determining the appropriate treatment.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2021)
Article
Clinical Neurology
Karlijn Bouman, Jeroen L. M. van Doorn, Jan T. Groothuis, Peter J. Wijkstra, Baziel G. M. van Engelen, Corrie E. Erasmus, Jonne Doorduin, Nicol C. Voermans
Summary: The majority of LAMA2-MD and all SELENON-RM patients had respiratory impairment. SELENON-RM patients showed lower respiratory function which was progressive, more prevalent mechanical ventilation, and more severe diaphragm atrophy and dysfunction than LAMA2-MD patients. Spirometry (FVC%, dVC) and respiratory muscle strength tests (SNIP) are useful in clinical care and as outcome measure in clinical trials.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Oliviero Bruni, Maria Breda, Emanuela Malorgio, Paolo Brambilla, Flavia Ceschin, Andrea Di Pilla, Maurizio Elia, Raffaele Ferri
Summary: This study aimed to describe the use of melatonin by Italian pediatricians in healthy children with chronic insomnia. The results showed that a high percentage of pediatricians prescribed melatonin, especially in children aged 1-2 years. The most common dosage was 1 mg/day and it was usually recommended to be taken 30 minutes before bedtime. Melatonin was often combined with sleep hygiene and was found to be effective in reducing difficulties falling asleep.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Lucie Sedlackova, Katalin Sterbova, Marketa Vlckova, Pavel Seeman, Jana Zarubova, Petr Marusic, Pavel Krsek, Hana Krijtova, Alena Musilova, Petra Lassuthova
Summary: In this study, whole exome sequencing (WES) was performed to identify causal variants for developmental and epileptic encephalopathies (DEEs) in patients whose genetic diagnosis was not determined by gene panel testing. The results showed that WES can successfully identify disease-causing variants, even after inconclusive gene panel testing. Detailed clinical evaluations and phenotype-genotype correlation studies were conducted to better understand the rare subtypes of DEEs.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
