Article
Orthopedics
Rosa Visscher, Nadine Hasler, Marie Freslier, Navrag B. Singh, William R. Taylor, Reinald Brunner, Erich Rutz
Summary: SEMLS can improve the overall gait pattern in children with BSCP, however, certain aspects of the gait cycle may deteriorate post-surgery; additional surgeries were needed for the majority of participants to maintain improvements after 10 years.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Clinical Neurology
Anne A. Koy, Andrea Kuehn, Petra Schiller, Julius Huebl, Gerd-Helge Schneider, Matthias Eckenweiler, Cornelia Rensing-Zimmermann, Volker Arnd K. Coenen, Joachim Krauss, Assel Saryyeva, Hans Hartmann, Delia Lorenz, Jens Volkmann, Cordula Matthies, Alfons Schnitzler, Jan Vesper, Alireza Gharabaghi, Daniel Weiss, Andrea Bevot, Warren Marks, Angela Howser, Elegast Monbaliu, Joerg Mueller, Reinhild Prinz-Langenohl, Veerle Visser-Vandewalle, Lars Timmermann
Summary: This study assessed the efficacy and safety of deep brain stimulation (DBS) in pediatric patients with dyskinetic cerebral palsy (DCP). The results showed that DBS significantly improved dyskinesia, but other outcome parameters did not change significantly. Investigations of larger homogeneous cohorts are needed to further ascertain the impact of DBS and guide treatment decisions in DCP.
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Vincent Tarazona, David Kirouchena, Pascal Clerc, Florence Pinsard-Laventure, Bastien Bourrion
Summary: This study demonstrates a decrease in the health-related quality of life for COVID-19 outpatients one year after infection. The impact is evident in areas such as pain or discomfort and daily activities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Isabel Garrido, Margarida Marques, Rodrigo Liberal, Helder Cardoso, Susana Lopes, Guilherme Macedo
Summary: This study evaluated a large cohort of Wilson disease patients from Northern Portugal over a 20-year follow-up period. The results showed favorable outcomes and long overall survival in these patients, assuming adherence to therapy and lack of other insults to their liver.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Pediatrics
Eleonore S. V. de Sonnaville, Marsh K. Konigs, Cornelieke S. H. Aarnoudse-Moens, Job B. M. van Woensel, Jaap Oosterlaan, Hennie Knoester
Summary: This study aimed to investigate the long-term impact of pediatric intensive care unit (PICU) admission on daily life functioning and the potential mediating role of neurocognitive outcome. The study compared children aged 6-12 years with previous PICU admission for bronchiolitis requiring mechanical ventilation to healthy peers. The results showed that children admitted to the PICU had poorer academic performance and school-related quality of life compared to the control group. Lower intelligence was found to contribute to academic difficulties after PICU admission. The findings highlight the importance of monitoring daily life and neurocognitive functioning after PICU admission.
JOURNAL OF PEDIATRICS
(2023)
Article
Surgery
Hanna Koppatz, Ville Sallinen, Heikki Makisalo, Arno Nordin
Summary: This study reports outcomes and quality of life after repair of major bile duct injury (BDI) and compares repairs by hepatobiliary surgeons to non-hepatobiliary surgeons. The findings suggest that initial repair of severe BDI should be performed by a hepatobiliary surgeon, but long-term quality of life is not affected by even severe BDI, and quality of life is not associated with the grade of the outcome.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Clinical Neurology
Lina Benhassine, Sae-Yeon Won, Natalie Filmann, Umniye Balaban, Marcel A. Kamp, Gerhard Marquardt, Markus Czabanka, Christian A. Senft, Volker Seifert, Nazife Dinc
Summary: This study assessed the quality of life (QoL) in patients with ruptured and non-ruptured arteriovenous malformation (AVM) in long-term follow-up and found no significant difference in QoL between the two groups. The study highlights the importance of evaluating depression and anxiety symptoms in AVM patients.
NEUROSURGICAL REVIEW
(2022)
Article
Gastroenterology & Hepatology
Ehab E. Abdel-Khalek, Mohamed Abdel-Wahab, Mohamed H. Elgazzar, Mahmoud A. Khattab, Abdel-Hady El-Gilany, Hesham M. Elgouhari, Ahmed Shehta
Summary: This study examined the long-term health consequences of living liver donation and found that living liver donors had lower scores in physical functioning, role limitations, energy/fatigue, and bodily pain compared to non-donors. However, donors whose recipients received a liver transplant had higher scores on health-related quality of life measures.
LIVER TRANSPLANTATION
(2022)
Article
Surgery
Tommaso Giuliani, Matteo De Pastena, Salvatore Paiella, Giovanni Marchegiani, Luca Landoni, Michele Festini, Marco Ramera, Veronica Marinelli, Luca Casetti, Alessandro Esposito, Claudio Bassi, Roberto Salvia
Summary: The aim of this study was to assess the short- and long-term outcomes including quality of life (QoL) following pancreatic enucleation (PE). The results of the retrospective analysis showed that despite the risk of complications, PE provides excellent long-term outcomes and a comparable quality of life to the general population.
Article
Clinical Neurology
Anni Rissanen, Mathias Hamalainen, Johan Marjamaa, Jari Siironen, Seppo Koskinen, Juho Konsti, Jussi Numminen, Anniina Koski-Palken
Summary: This study retrospectively analyzed the clinical data of 340 patients who underwent cervical laminectomy for cervical spondylotic myelopathy. The results showed that the rate of further cervical surgeries after laminectomy was low. The patients experienced decreased health-related quality of life, and some patients had cervical misalignments.
WORLD NEUROSURGERY
(2022)
Article
Orthopedics
Ville Turppo, Reijo Sund, Jukka Huopio, Heikki Kroger, Joonas Sirola
Summary: The study shows that patients who undergo total hip or knee arthroplasty experience a decline in physical capabilities and subjective well-being over time, with the overall levels lower compared to a control group who did not undergo arthroplasty. Total hip arthroplasty appears to be more effective in maintaining physical capabilities than total knee arthroplasty.
Article
Rehabilitation
Laura A. Bonouvrie, Helga Haberfehlner, Jules G. Becher, Johan S. H. Vles, R. Jeroen Vermeulen, Annemieke Buizer
Summary: This study assessed the achievement of individual treatment goals one year after intrathecal baclofen pump implantation in patients with dyskinetic cerebral palsy. The study found that 71% of individuals fully achieved one or more treatment goals, while 97% partially achieved one or more treatment goals. The attainment of treatment goals was associated with baseline dyskinesia impairment score and improvement in pain during treatment.
DISABILITY AND REHABILITATION
(2023)
Article
Multidisciplinary Sciences
Lan-Ping Xu, Zheng-Li Xu, Shun-Qing Wang, De-Pei Wu, Su-Jun Gao, Jian-Min Yang, Ling-Hui Xia, Qi-Fa Liu, Ming Jiang, Hai Bai, Xi Zhang, Xin Wang, Xiao-Jun Huang
Summary: In recent years, haploidentical stem cell transplantation has made significant progress in treating severe aplastic anemia. Through a multicenter prospective study, it was found that salvage transplantation with haploidentical donors can achieve favorable long-term outcomes, including high survival rates and quality of life recovery.
Article
Clinical Neurology
Ramon Luengo-Fernandez, Linxin Li, Louise Silver, Sergei Gutnikov, Nicola C. Beddows, Peter M. Rothwell
Summary: Urgent assessment and treatment of patients with transient ischemic attack or minor stroke can lead to a long-term reduction in recurrent stroke risk, improved outcomes, and the early benefits are maintained over time with little decline.
Article
Clinical Neurology
Patricia Krause, Daniel Kroneberg, Doreen Gruber, Kristin Koch, Gerd-Helge Schneider, Andrea A. Kuehn
Summary: This observational study evaluates the long-term effects of deep brain stimulation of the globus pallidus internus (GPi-DBS) in patients with treatment-refractory tardive syndromes. The results show that GPi-DBS is a safe and effective long-term treatment for tardive dyskinesia and tardive dystonia, with significant improvements in involuntary movements and dystonia. Furthermore, three patients were able to stop stimulation after several years without relapse.
JOURNAL OF NEUROLOGY
(2022)
Article
Orthopedics
Alexander Meynen, Georges Vles, Amir A. Zadpoor, Michiel Mulier, Lennart Scheys
Summary: Classification and evaluation of acetabular defects are challenging due to the lack of quantitative techniques. This study introduces a new method based on statistical shape models to quantitatively describe acetabular defects encountered during revision total hip arthroplasty. The developed approach could lead to automated and unbiased classification methods, as well as provide a basis for designing new acetabular implants based on clinical variation in acetabular defects.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Orthopedics
Wouter Schroven, G. Vles, J. Verhaegen, M. Roussot, J. Bellemans, S. Konan
Summary: In comparing PCLR with non-operative management, there was significantly less residual laxity after PCLR. Both treatment modalities achieved satisfactory functional outcomes and high return to sports rates, with lower frequency of OA occurring after PCLR.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Alexander Meynen, Georges Vles, Mark Roussot, Anthony Van Eemeren, Hazem Wafa, Michiel Mulier, Lennart Scheys
Summary: This study evaluates the effect of advanced imaging and analytic representations of acetabular defects on the reliability and classification scores in revision THA. The results show that using CT imaging and statistical shape modelling significantly improves intra- and inter-rater reliability and increases the classification scores of acetabular defects compared to standard radiographs.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Orthopedics
Mustafa Akkaya, Georges Vles, Iman Godarzi Bakhtiari, Amir Sandiford, Jochen Salber, Thorsten Gehrke, Mustafa Citak
Summary: This study provides novel insights into the microbiological changes following septic failure after a one-stage exchange for prosthetic joint infection of the knee. A higher prevalence of more difficult-to-treat bacteria might increase the complexity of subsequent procedures.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Orthopedics
Sanne Vanstockstraeten, Stijn Ghijselings, Georges Frederic Vles, Jean-Pierre Simon
Summary: This study found that the use of polished, tapered, cemented stems in total hip arthroplasty showed excellent long-term survival rates in young patients with avascular necrosis or inflammatory arthritis, making them a viable alternative to uncemented stem designs.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Iman Godarzi Bakhtiari, Georges Vles, Sophia-Marlene Busch, Lars Frommelt, Thorsten Gehrke, Jochen Salber, Mustafa Citak
Summary: The microbiological implications of septic failure after 1-stage exchange for prosthetic joint infection (PJI) of the hip are unclear. This study found that the majority of reinfections are caused by different infecting bacteria, indicating the need for a new diagnostic workup. The number of polymicrobial PJIs and high virulent microorganisms decreased, suggesting potential changes in the microbiology of septic failure after 1-stage exchange.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Chemistry, Multidisciplinary
George Athanassoulis Makris, Leonard Pastrav, Quentin Goossens, Maikel Timmermans, Michiel Mulier, Georges Frederic Vles, Wim Desmet, Kathleen Denis
Summary: This study presents a dynamic response measurement protocol for determining the insertion endpoint of an implant in cementless total hip arthroplasty, and evaluates this protocol in the presence of artificial soft tissue. The results show that the technique can produce higher fixation measurements earlier in the insertion process when artificial soft tissue is present, but the soft tissue limits the system's ability to detect fixation changes.
APPLIED SCIENCES-BASEL
(2022)
Article
Infectious Diseases
Lore Thijs, Charlotte Quintens, Lotte Vander Elst, Paul De Munter, Melissa Depypere, Willem-Jan Metsemakers, Georges Vles, Astrid Liesenborghs, Jens Neefs, Willy E. Peetermans, Isabel Spriet
Summary: This study reports the safety and efficacy of a structured vOPAT program implemented in a university hospital. The findings demonstrate that this program provides safe and effective ambulatory treatment of patients with vancomycin in continuous infusion, with high patient satisfaction.
Article
Neurosciences
Dirk J. J. Sweere, Johan J. M. Pel, Marlou J. G. Kooiker, Johannes P. van Dijk, Elizabeth J. J. M. van Gemert, Petra P. M. Hurks, Sylvia Klinkenberg, R. Jeroen Vermeulen, Jos G. M. Hendriksen
Summary: This study investigates distractibility by analyzing eye movements during task-irrelevant distraction in children with and without ADHD and neurological disorders. The results show that children with ADHD and neurological disorders spend less time fixating on target stimuli compared to their peers without these conditions. Additionally, children with neurological disorders have longer press latencies. The duration of target fixation is significantly associated with parent-reported attention problems.
Review
Neurosciences
Pien M. M. Weerkamp, Eva M. Mol, Dirk J. J. Sweere, Debby G. M. Schrans, R. Jeroen Vermeulen, Sylvia Klinkenberg, Petra P. M. Hurks, Jos G. M. Hendriksen
Summary: This study conducted a literature review and meta-analysis to investigate the intellectual functioning of males with Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD). The findings indicate that DMD patients have significantly lower intelligence scores compared to BMD patients and the general population.
Article
Orthopedics
Mustafa Akkaya, Georges Vles, Rudy Sangaletti, Luigi Zanna, Thorsten Gehrke, Mustafa Citak
Summary: Patients with multiple joint arthroplasties are at increased risk of ipsilateral metachronous periprosthetic joint infection, especially those of shorter stature with shorter stem-to-stem distance. Adequate positioning of the cement restrictor and maintaining a safe distance between knee and hip implants are crucial in reducing the risk of metachronous infection.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Medicine, General & Internal
Catherine V. M. Steinbusch, Anke Defesche, Bertie van der Leij, Eugene A. A. Rameckers, Annemarie C. S. Knijnenburg, Jeroen R. J. Vermeulen, Yvonne J. M. Janssen-Potten
Summary: A study found that intensive bimanual training can not only improve motor abilities but also sensory impairments in children with unilateral spastic CP. Through 80-90 hours of intensive functional training, the somatosensory function of the more affected hand can be improved, leading to better coordination in daily activities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Louis Follet, Lieven Moke, Stijn Ghijselings, Hazem Wafa, Georges Vles
Summary: We report a case of a 56-year-old male with an ankylosed right hip due to combined neurogenic and traumatic heterotopic ossifications. Due to the complexity of multiple ossifications, proximity to important structures, and chronic ulcers, resection was considered unsafe. A new articulation was created distal to the ossifications by performing a partial femoral diaphysectomy and rotating the vastus lateralis muscle. Postoperatively, the patient regained hip mobility and was able to sit. This procedure appears to be a feasible option for paraplegic patients with extensive heterotopic ossifications in close proximity to neurovascular structures.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Matthias Papen, Stijn Ghijselings, Georges Vles
Summary: Prosthetic joint infections (PJIs) remain a severe challenge for patients and the healthcare system. Infection, particularly PJI, is a known cause of reactive thrombocytosis. We present a case of reactive thrombosis and recurrent arterial thrombosis due to streptococcal PJI, which ultimately led to the amputation of the patient's leg. Early recognition of thrombocytosis, use of anti-platelet agents, and timely surgical treatment of the underlying infection could have prevented this life-threatening complication.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Orthopedics
Georges Vles, Jeroen Bossen, Johannes Kloos, Philippe Debeer, Stijn Ghijselings
Summary: This study simulated the clean phase of one-step exchanges in infected total hip arthroplasty (THA). The results showed that a clean phase with full additional measures significantly reduced contamination on gloves, instrument table, drapes, and wound. However, the re-implanted implants still had some level of contamination.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2022)
Article
Clinical Neurology
Karlijn Bouman, Jeroen L. M. van Doorn, Jan T. Groothuis, Peter J. Wijkstra, Baziel G. M. van Engelen, Corrie E. Erasmus, Jonne Doorduin, Nicol C. Voermans
Summary: The majority of LAMA2-MD and all SELENON-RM patients had respiratory impairment. SELENON-RM patients showed lower respiratory function which was progressive, more prevalent mechanical ventilation, and more severe diaphragm atrophy and dysfunction than LAMA2-MD patients. Spirometry (FVC%, dVC) and respiratory muscle strength tests (SNIP) are useful in clinical care and as outcome measure in clinical trials.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Oliviero Bruni, Maria Breda, Emanuela Malorgio, Paolo Brambilla, Flavia Ceschin, Andrea Di Pilla, Maurizio Elia, Raffaele Ferri
Summary: This study aimed to describe the use of melatonin by Italian pediatricians in healthy children with chronic insomnia. The results showed that a high percentage of pediatricians prescribed melatonin, especially in children aged 1-2 years. The most common dosage was 1 mg/day and it was usually recommended to be taken 30 minutes before bedtime. Melatonin was often combined with sleep hygiene and was found to be effective in reducing difficulties falling asleep.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Lucie Sedlackova, Katalin Sterbova, Marketa Vlckova, Pavel Seeman, Jana Zarubova, Petr Marusic, Pavel Krsek, Hana Krijtova, Alena Musilova, Petra Lassuthova
Summary: In this study, whole exome sequencing (WES) was performed to identify causal variants for developmental and epileptic encephalopathies (DEEs) in patients whose genetic diagnosis was not determined by gene panel testing. The results showed that WES can successfully identify disease-causing variants, even after inconclusive gene panel testing. Detailed clinical evaluations and phenotype-genotype correlation studies were conducted to better understand the rare subtypes of DEEs.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
