Article
Clinical Neurology
Balachandran Mani, Pradeep Pankajakshan Nair, Anamika Sekhar, Sadishkumar Kamalanathan, Sunil K. Narayan, Ramasamy Kesavan
Summary: The study found that people with epilepsy carrying CYP2C19 polymorphisms (*1/*2) and (*2/*2) had 3 times higher risk of VPA-induced weight gain compared to the wild type (*1/*1), with CYP2C19*2 being an independent predictor of weight gain.
Article
Cell Biology
Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C. Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M. Kusminski, Ningyan Zhang, Zhiqiang An, Joel K. Elmquist, Olivia Osborn, Chen Liu, Philipp E. Scherer
Summary: Antipsychotic drugs can cause weight gain and diabetes, and hyperleptinemia plays a key role. Suppression of leptin rise can reduce the adverse effects of these drugs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Erika Cortes-Macias, Marta Selma-Royo, Karla Rio-Aige, Christine Bauerl, Maria Jose Rodriguez-Lagunas, Cecilia Martinez-Costa, Francisco J. Perez-Cano, Maria Carmen Collado
Summary: The study aimed to evaluate the impact of milk microbiota, cytokine, and adipokine profiles on the risk of overweight in infants at 12 months of life and identify possible mechanisms of host-microbe interactions. The findings indicated that milk microbiota and cytokines were associated with infant development. Further research is needed to understand the specific effects of milk microbiota and cytokines on infant growth and the risk of overweight.
Article
Medicine, General & Internal
Jenny W. Sun, Jessica G. Young, Aaron L. Sarvet, L. Charles Bailey, William J. Heerman, David M. Janicke, Pi-I Debby Lin, Sengwee Toh, Jason P. Block
Summary: In this cohort study, the use of valproate in adults was associated with the highest risk of developing type 2 diabetes (T2D). The comparative safety of anticonvulsant mood stabilizers was generally similar in children, but the estimates were small and variable. Emulating target trials within health care databases can provide important age-specific drug safety data for decision-making.
Review
Endocrinology & Metabolism
Douglas Tremblay, Mikaela Dougherty, John Mascarenhas, Emily Jane Gallagher
Summary: Weight gain is a common side effect of ruxolitinib, and this study suggests that it may be related to changes in whole body energy expenditure.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Psychiatry
Yuying Qiu, Meijuan Li, Yonghui Zhang, Ying Liu, Yongping Zhao, Jing Zhang, Qiong Jia, Jie Li
Summary: Berberine could reduce weight gain in schizophrenia patients, with significant weight loss observed in the berberine group compared to placebo. The effect may be related to the regulation of leptin levels.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Beibei Dong, Jinfang Sun, Mengmeng Zhi, Manman Han, Hao Lin, Hong Yu, Ling Li
Summary: The study found that gestational weight gain in the third trimester was positively correlated with serum leptin concentrations and HOMA-IR indices, but not with adiponectin concentrations. Multivariate analysis revealed that weight gain and leptin concentration were independently associated with HOMA-IR levels, and mediation analysis showed that the association between weight gain and HOMA-IR was mediated by serum leptin concentrations.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Pediatrics
Huseyin Kilic, Atalay Demirel, Serap Uysal
Summary: This study found higher levels of leptin in epileptic children receiving VPA treatment, despite similar BMI values. VPA-treated patients showed lower levels of total and LDL cholesterol compared to the control group.
PEDIATRICS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Shan Luo, Brendan C. Angelo, Ting Chow, John R. Monterosso, Paul M. Thompson, Anny H. Xiang, Kathleen A. Page
Summary: Children exposed to gestational diabetes mellitus (GDM) or maternal obesity in utero have increased propensity to develop obesity, affecting daily energy intake, brain responses to food cues within reward regions, and adiposity.
Review
Endocrinology & Metabolism
Francesca Mainieri, Veronica Maria Tagi, Francesco Chiarelli
Summary: Lipodystrophy is a rare disease characterized by adipose tissue loss and metabolic complications. Therapy primarily consists of conventional treatments and leptin replacement therapy has shown promising results. Metreleptin has been approved for treatment, but further research is needed for new therapeutic options.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Leticia Manuel-Apolinar, Leticia Damasio-Santana, Eulalia Garrido-Magana, Aleida de Jesus Rivera-Hernandez
Summary: In girls with central precocious puberty (CPP) undergoing GnRH analogs treatment, leptin levels and higher leptin/adiponectin ratio (LAR) are associated with greater weight gain. This association is particularly evident in girls with BMI < 94th percentile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Johanna Molin, Eszter Vanky, Tone S. Lovvik, Eva Dehlin, Marie Bixo
Summary: Excessive gestational weight gain (GWG) is associated with enhanced leptin resistance and attenuated physiological increase in serum allopregnanolone levels during pregnancy. Metformin reduces the risk of excessive GWG in pregnant women with PCOS and improves leptin sensitivity.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Clinical Neurology
Sandra K. Bopp, Urs Heilbronner, Peter Schlattmann, Pichit J. Buspavanich, Undine E. Lang, Andreas Heinz, Thomas G. Schulze, Mazda Adli, Thomas W. Muhleisen, Roland Ricken
Summary: Patients treated with lithium often experience weight gain, and genetic variations at the leptin gene locus may be involved in lithium augmentation-associated weight gain in major depressive disorder. A recent study identified a polymorphism at the leptin gene locus associated with circulating leptin protein levels.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Min Zhang, Marine Thieux, Clara Odilia Inocente, Noemie Vieux, Laura Arvis, Carine Villanueva, Jian-Sheng Lin, Sabine Plancoulaine, Aurore Guyon, Patricia Franco
Summary: This study characterizes the rapid weight gain (RWG) phenotype associated with childhood narcolepsy and suggests that RWG could be a marker of disease severity. Patients with RWG had a younger age at diagnosis, higher sleepiness levels, and a higher prevalence of obesity compared to non-RWG patients. Furthermore, RWG patients had a higher risk of long-term obesity despite improvement in narcoleptic symptoms.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Chemistry, Medicinal
Anna Partyka, Katarzyna Gorecka, Joanna Gdula-Argasinska, Natalia Wilczynska-Zawal, Magdalena Jastrzebska-Wiesek, Anna Wesolowska
Summary: Patients taking antipsychotic drugs have a higher likelihood of developing metabolic syndrome, characterized by abdominal obesity, elevated glucose levels, and dyslipidemia. Current treatments for the metabolic side effects of antipsychotic drugs are not satisfactory. Ligands of the serotonin 6 receptor may offer a promising supplement to antipsychotic therapy. This study examined the effects of different antipsychotic drugs alone and in combination with a selective 5-HT6 agonist or antagonist on weight gain, food intake, lipid profile, glucose level, and adipose and gastrointestinal hormones in rats.
Article
Clinical Neurology
Sherifa Hamed, Khaled Mohamed, Sameer Abd Elhameed, Ehab Moussa, Hossam Abozaid, Anthony Lang, Amany Mohamed, Jacklin Moussa
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2020)
Article
Neurosciences
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Mohamad Fawzy
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2020)
Article
Genetics & Heredity
Lucia Schottlaender, Rosella Abeti, Zane Jaunmuktane, Carol Macmillan, Viorica Chelban, Benjamin O'Callaghan, John McKinley, Reza Maroofian, Stephanie Efthymiou, Alkyoni Athanasiou-Fragkouli, Raeburn Forbes, Marc P. M. Soutar, John H. Livingston, Bernardett Kalmar, Orlando Swayne, Gary Hotton, Alan Pittman, Joao Ricardo Mendes de Oliveira, Maria de Grandis, Angela Richard-Loendt, Francesca Launchbury, Juri Althonayan, Gavin McDonnell, Aisling Carr, Suliman Khan, Christian Beetz, Atil Bisgin, Sevcan Tug Bozdogan, Amber Begtrup, Erin Torti, Linda Greensmith, Paola Giunti, Patrick J. Morrison, Sebastian Brandner, Michel Aurrand-Lions, Henry Houlden
AMERICAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Clinical Neurology
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Romany Hosny Gabra, Tahra Kamel Sherif
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)
Article
Endocrinology & Metabolism
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Refaat Fathy Abd Elaal, Mohamed Fawzy
Summary: Females with CAH exhibit frequent and severe behavioral symptoms, with excess androgenization linked to suboptimal steroid therapy as a potential cause. The study highlights the importance of early optimization of CAH management to prevent psychological consequences.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Psychiatry
Sherifa Ahmed Hamed, Mohamed Fawzy, Enas Ahmed Hamed
Summary: This study found an association between PMNE and behavioral problems, particularly emotional and hyperactivity-inattention symptoms, indicating externalizing and internalizing issues. Early interventions and treatments are necessary to prevent persistent enuresis and the development of psychiatric disorders in the future.
COMPREHENSIVE PSYCHIATRY
(2021)
Article
Clinical Neurology
Manuela Wiessner, Reza Maroofian, Meng-Yuan Ni, Andrea Pedroni, Juliane S. Muller, Rolf Stucka, Christian Beetz, Stephanie Efthymiou, Filippo M. Santorelli, Ahmed A. Alfares, Changlian Zhu, Anna Uhrova Meszarosova, Elham Alehabib, Somayeh Bakhtiari, Andreas R. Janecke, Maria Gabriela Otero, Jin Yun Helen Chen, James T. Peterson, Tim M. Strom, Peter De Jonghe, Tine Deconinck, Willem De Ridder, Jonathan De Winter, Rossella Pasquariello, Ivana Ricca, Majid Alfadhel, Bart P. van de Warrenburg, Ruben Portier, Carsten Bergmann, Saghar Ghasemi Firouzabadi, Sheng Chih Jin, Kaya Bilguvar, Sherifa Hamed, Mohammed Abdelhameed, Nourelhoda A. Haridy, Shazia Maqbool, Fatima Rahman, Najwa Anwar, Jenny Carmichael, Alistair Pagnamenta, Nick W. Wood, Frederic Tran Mau-Them, Tobias Haack, Maja Di Rocco, Isabella Ceccherini, Michele Iacomino, Federico Zara, Vincenzo Salpietro, Marcello Scala, Marta Rusmini, Yiran Xu, Yinghong Wang, Yasuhiro Suzuki, Kishin Koh, Haitian Nan, Hiroyuki Ishiura, Shoji Tsuji, Laetitia Lambert, Emmanuelle Schmitt, Elodie Lacaze, Hanna Kuepper, David Dredge, Cara Skraban, Amy Goldstein, Mary J. H. Willis, Katheryn Grand, John M. Graham, Richard A. Lewis, Francisca Millan, Ozgur Duman, Nihal Dundar, Gokhan Uyanik, Ludger Schols, Peter Nuernberg, Gudrun Nuernberg, Andrea Catala Bordes, Pavel Seeman, Martin Kuchar, Hossein Darvish, Adriana Rebelo, Filipa Boucanova, Jean-Jacques Medard, Roman Chrast, Michaela Auer-Grumbach, Fowzan S. Alkuraya, Hanan Shamseldin, Saeed Al Tala, Jamileh Rezazadeh Varaghchi, Maryam Najafi, Selina Deschner, Dieter Glaeser, Wolfgang Huettel, Michael C. Kruer, Erik-Jan Kamsteeg, Yoshihisa Takiyama, Stephan Zuchner, Jonathan Baets, Matthis Synofzik, Rebecca Schuele, Rita Horvath, Henry Houlden, Luca Bartesaghi, Hwei-Jen Lee, Konstantinos Ampatzis, Tyler Mark Pierson, Jan Senderek
Summary: This study identified families with neurological diseases caused by HPDL variants, showing various phenotypes ranging from juvenile-onset pure hereditary spastic paraplegia to infantile-onset spastic tetraplegia. Experimental evidence suggested a role of HPDL in the nervous system and supported its link to neurological disease.
Article
Neurosciences
Sherifa Ahmed Hamed, Samir Kamal Abdulhamid, Ali Farrag El-Hadad, Mohamed Fawzy, Mohamed Ahmed Abd-Elhamed
Summary: This study aimed to determine the prevalence of restless leg syndrome (RLS) due to chronic kidney disease (CKD) and its predictors. A cross-sectional study was conducted on 520 patients, and RLS diagnosis was done according to International RLS Study Group criteria. The prevalence of RLS with CKD was found to be 22.31%, with higher rates in end-stage kidney disease (ESKD) patients. Factors such as ESKD, inadequate dialysis, hyperparathyroidism, and peripheral neuropathy were found to be independently associated with RLS.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Samir Kamal Abdulhamid, Mohamed Fawzy
Summary: This study found that children with Graves' disease (GD) exhibited higher frequencies and severities of anxiety, depression, and inattention during periods of thyroid hormone elevation as well as when thyroid hormones were normalized with anti-thyroid drugs (ATDs). Early diagnosis and optimized management are necessary to improve social life for children with GD.
Article
Audiology & Speech-Language Pathology
Sherifa A. Hamed, Ali F. ElHadad, Amira M. Oseily
Summary: This study revealed that VDs are prevalent in children with T1D and correlated with the duration and severity of diabetes as well as the occurrence of hypoglycemic attacks.
AUDIOLOGY AND NEURO-OTOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sherifa Ahmed Hamed, Amira Mohamed Osiely
Summary: Vestibular dysfunctions are common in children with epilepsy, with bilateral peripheral dysfunction being more prevalent than central dysfunction, suggesting a potential adverse effect of valproate on the vestibular system.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Sherifa Ahmed Hamed, Dalia Fahim Mohammed Fahim
Summary: This study found that dysfunction of the saccule of the otolith organ in adults with type 1 diabetes is prevalent and correlated with the duration and severity of the disease. Therefore, optimal glycemic control is essential.
HEARING BALANCE AND COMMUNICATION
(2023)
Article
Medicine, General & Internal
Sherifa Ahmed Hamed, Hosam Abozaid Yousef
Summary: This study presents the case of a 4-year-old girl with acute stroke and recurrent seizures, who was diagnosed with Moyamoya disease. The patient exhibited bilateral fronto-parietal ischemic infarctions and occlusion of the internal carotid arteries. During the 3-year follow-up, the patient's condition improved and stabilization was observed. Revascularization surgery was postponed.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Medicine, General & Internal
Sherifa Ahmed Hamed, Fadia Ahmed Attiah, Mohamed Fawzy, Mohamed Azzam
Summary: This study is the first to evaluate the causal relationship between psychological factors and the onset, severity, and persistence of tinnitus in our culture. Tinnitus could be the earliest and dominant somatic symptom induced by life stressors and psychological vulnerabilities. Therefore, multidisciplinary consultation (psychologists, psychiatrists, and neurologists) is important to acknowledge among the audiologists and otolaryngologists who primarily consult patients.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Genetics & Heredity
Pasquelena De Nittis, Stephanie Efthymiou, Alexandre Sarre, Nicolas Guex, Jacqueline Chrast, Audrey Putoux, Tipu Sultan, Javeria Raza Alvi, Zia Ur Rahman, Faisal Zafar, Nuzhat Rana, Fatima Rahman, Najwa Anwar, Shazia Maqbool, Maha S. Zaki, Joseph G. Gleeson, David Murphy, Hamid Galehdari, Gholamreza Shariati, Neda Mazaheri, Alireza Sedaghat, Gaetan Lesca, Nicolas Chatron, Vincenzo Salpietro, Marilena Christoforou, Henry Houlden, William F. Simonds, Thierry Pedrazzini, Reza Maroofian, Alexandre Reymond
Summary: Research shows that loss of the Gnb5 gene in mice results in abnormal heart function, characterized by increased baseline heart rate and significant bradycardia. Knocking out the Gnb5 gene affects gene expression related to cardiac muscle contraction, leading to an increase in arrhythmia frequency. The study also expanded the cohort of IDDCA syndrome patients, indicating the important role of Gnb5 signaling in autonomic control of the heart.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Clinical Neurology
Karlijn Bouman, Jeroen L. M. van Doorn, Jan T. Groothuis, Peter J. Wijkstra, Baziel G. M. van Engelen, Corrie E. Erasmus, Jonne Doorduin, Nicol C. Voermans
Summary: The majority of LAMA2-MD and all SELENON-RM patients had respiratory impairment. SELENON-RM patients showed lower respiratory function which was progressive, more prevalent mechanical ventilation, and more severe diaphragm atrophy and dysfunction than LAMA2-MD patients. Spirometry (FVC%, dVC) and respiratory muscle strength tests (SNIP) are useful in clinical care and as outcome measure in clinical trials.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Oliviero Bruni, Maria Breda, Emanuela Malorgio, Paolo Brambilla, Flavia Ceschin, Andrea Di Pilla, Maurizio Elia, Raffaele Ferri
Summary: This study aimed to describe the use of melatonin by Italian pediatricians in healthy children with chronic insomnia. The results showed that a high percentage of pediatricians prescribed melatonin, especially in children aged 1-2 years. The most common dosage was 1 mg/day and it was usually recommended to be taken 30 minutes before bedtime. Melatonin was often combined with sleep hygiene and was found to be effective in reducing difficulties falling asleep.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Lucie Sedlackova, Katalin Sterbova, Marketa Vlckova, Pavel Seeman, Jana Zarubova, Petr Marusic, Pavel Krsek, Hana Krijtova, Alena Musilova, Petra Lassuthova
Summary: In this study, whole exome sequencing (WES) was performed to identify causal variants for developmental and epileptic encephalopathies (DEEs) in patients whose genetic diagnosis was not determined by gene panel testing. The results showed that WES can successfully identify disease-causing variants, even after inconclusive gene panel testing. Detailed clinical evaluations and phenotype-genotype correlation studies were conducted to better understand the rare subtypes of DEEs.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2024)