期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2018, 期 43, 页码 5972-5979出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201801058
关键词
Iodine-mediated reactions; Arenes; C-H activation; Hypervalent iodinium reagents; Reaction mechanisms; Steric control
资金
- National Natural Science Foundation of China [21502046]
- Natural Science Foundation of Heilongjiang Province [B2016008]
- University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2017124]
- Fundamental Research Funds for the Central Universities from Harbin Engineering University [HEUCFD1412, HEUCFJ161002, HEUCFJ 171006, HEUCFJ181008]
A practical para-C-H functionalization of aniline derivatives has been developed using an in situ generated bulky hypervalent iodinium reagent. Para-iodo, bromo, chloro, nitro, trifluormethyl aniline derivatives can be obtained efficiently, in many cases in 10 min in a transition metal-free manner. Medicinal chemicals or intermediates can be purified without column chromatography or recrystallization, which significantly reduces the waste and simplifies the work-up process.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
