Article
Chemistry, Multidisciplinary
Sudeshna Mondal, Chandan Kumar Giri, Mahiuddin Baidya
Summary: The weakly coordinating enaminone functionality is essential for the ruthenium-catalyzed C-H bond activation strategy, enabling the regioselective coupling of arenes with diazonaphthoquinones to produce polycyclic benzocoumarins in high yields. The protocol operates through a Ru(II)/Ru(IV) catalytic pathway and allows for the diversification of various pharmacophore-coupled substrates.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Xue Li, Haohua Chen, Qingqing Xuan, Shaoyu Mai, Yu Lan, Qiuling Song
Summary: Inspired by the body circulation of Omeprazole, a novel carbenetriggered cascades for synthesizing 2-aminobenzofuran derivatives from N-sulfonyl-1,2,3-triazoles or benzothioazole-bearing thiocarbamates was disclosed, representing an unprecedented imine derivative migration process. Additionally, desulfurizing reagent-free Barton-Kellogg-type reactions starting from N-sulfonyl-1,2,3-triazoles were achieved for the first time, with elemental sulfur confirmed as a byproduct. Experimental data and DFT calculations further explained the unique reactivity observed in these reactions.
Article
Chemistry, Organic
Yunlong Li, Wenchao Jiang, Jie Lin, Juan Ma, Bao-Hua Xu, Yong-Gui Zhou, Zhengkun Yu
Summary: In this study, triple C-H bond activation of aryl enaminones was achieved to access naphtho[1,8-bc]pyrans through oxidative annulation. Depending on the steric and/or electronic environment around the aryl moiety of the enaminones or the electronic impact from the alkynes, 1-naphthols might be formed as the sole products. By using propargyl alcohols as masked terminal alkynes, functionalized but-2-ene-1,4-diones were obtained through rhodium(III)- or rhodium(I)-catalyzed internal alkenyl C-H bond activation. The resulting naphtho[1,8-bc]pyrans exhibited high fluorescence and could be further transformed by chlorination, bromination, and difluoromethylation, demonstrating the potential applicability of the synthetic protocol.
Article
Chemistry, Organic
Jianzhong Lu, Mengzhen Zhang, Xinxin Zheng, Pei Shen, Yuemeng Xu, Qian Zhang, Yixin Tang, Guozhu Zhang, Rui Guo
Summary: A highly enantioselective ring-opening and isomerization reaction of cyclobutanols catalyzed by rhodium(I) has been developed. This reaction provides a mild, atom-economical, and redox-neutral approach for the synthesis of chiral acyclic ketones with a β-tertiary stereocenter. Cyclobutanols with alkoxy substituents at the C3 position can achieve excellent enantioselectivities and high yields. Mechanistic studies reveal that cyclobutanol only undergoes intramolecular hydrogen migration, and the formation of a (Z)-unsaturated ketone intermediate is crucial for achieving high enantioselectivity.
Article
Chemistry, Organic
Danqing Ji, Xingwei Li
Summary: A rhodium-catalyzed C-H bond activation of propargyl carbamates with benzamides has resulted in the decarboxylative annulation, leading to the synthesis of two distinct classes of heterocycles in high efficiency and selectivity under substrate control. This protocol provides a direct synthetic method for the preparation of functionalized 1,8-naphthyridines and isoindolinones.
Article
Chemistry, Multidisciplinary
Ryota Shimotsukue, Kohei Fujii, Yu Sato, Yuki Nagashima, Ken Tanaka
Summary: We have developed a rhodium-catalyzed intermolecular [2+2+2] cycloaddition reaction with excellent selectivity, producing chiral cyclohexadienylamines. The reaction involves the reaction of two arylacetylenes with a cis-enamide or a silylacetylene to yield the desired products with complete regio- and diastereoselectivity and high yields and enantioselectivity. Mechanistic studies suggest the formation of a rhodacyclopentadiene intermediate from the terminal alkynes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Swagata Baruah, Sabera Sultana, Pratiksha Bhorali, Pallabi Saikia, Sanjib Gogoi
Summary: A novel Ru(ii)-catalyzed decarbonylative annulation and direct C-H functionalization reaction of phthalic anhydrides with acrylates is reported, providing an efficient route for the synthesis of 3,7-disubstituted phthalides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Yasunori Toda, Kayo Sato, Kensuke Sato, Kazuma Nagasaki, Hirotaka Nakajima, Ayaka Kikuchi, Kimiya Sukegawa, Hiroyuki Suga
Summary: This paper reports on the chiral binaphthyldiimine-Ni(II)-catalyzed asymmetric 1,3-dipolar cycloaddition reactions between acyclic carbonyl ylides generated from donor-acceptor oxiranes and aldehydes. Both aromatic and aliphatic aldehydes can be used as dipolarophiles, providing cis-1,3-dioxolanes with high diastereo- and enantioselectivities. Mechanistic studies suggest that a monomeric chiral Ni(II) complex acts as the active species for the cycloaddition, and the high levels of asymmetric induction can be explained by a concerted-asynchronous endo Si-face approach of the aldehyde.
Article
Chemistry, Organic
Ali Nikbakht, Kamran Amiri, Hormoz Khosravi, Yirong Zhou, Saeed Balalaie, Bernhard Breit
Summary: This novel copper-catalyzed cycloisomerization reaction provides a practical and efficient method for the synthesis of hexahydropyrrolo[3,4-b]azepin-5(4H)-ones by simultaneously forming four new bonds in a single step.
Article
Chemistry, Organic
Shengke Wang, Yitu Wang, Kun Hu, Kai Wang, Xigeng Zhou
Summary: A versatile approach for selective reduction of unstrained C(sp(3))-C(sp(3)) bonds of ketones has been reported, without requiring protecting groups or hydrogen gas. The C-C cleavage occurs via a bimetallic pathway, and nucleophile trapping of the resulting enone is crucial for C-C reduction relay. Additionally, a practical strategy for intramolecular C-C cascade reorganization has been established, enabling cyclizative degradation of poly(vinylketone) to trisubstituted cyclohexanes. These findings have potential implications for unstrained C(sp(3))-C(sp(3)) bond disconnection and reconstruction.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
XinXin Li, Qingxing Yang, Yuna Zhang, Tao Xu
Summary: Here, we describe a RhI3-catalyzed intramolecular carboamination reaction for the synthesis of polysubstituted indoles. The method exhibits a wide substrate scope (>20 examples), good functional group compatibility, and can be carried out with a low catalyst loading (5 mol% Rh). Excellent yields (up to 98%) were achieved. Control experiments suggest a novel C-N bond cleavage mode through a six-membered transition state sigma-bond metathesis mechanism. The synthesis of C3-allylated indole derivatives demonstrates the potential of this catalytic route for the preparation of polysubstituted indoles.
Article
Chemistry, Physical
Samuel Hruby, Jan Ulc, Ivana Cisarova, Martin Kotora
Summary: The scope of Rh-catalyzed C-C bond cleavage/annulation of biphenylene with various aromatic nitriles was investigated. Further Rh- and Ir-catalyzed C-H bond activation/annulation sequence of the resulting 9-arylphenanthridines with alkynes led to the formation of cationic [4], [5], [6] helical quinolizinium salts. The helical arrangement of these compounds was confirmed by single-crystal X-ray analysis. Most of the prepared quinolizinium salts exhibited fluorescence emission with a maximum wavelength in the range of 525-623 nm and absolute quantum yields up to 25%.
Article
Chemistry, Organic
Yuhang Wang, Peng Ma, Ning Ma, Jianhui Wang
Summary: Ligand-controlled nickel-catalyzed selective cleavage of the C1-C2 or C1-C8 bond of benzocyclobutenones (BCBs) is reported. The delicate selection of dpppe or PMe3 as the ligand led to the predictable synthesis of a wide range of 1-naphthols and 2-naphthols without C2 and C3 substituents, respectively, from BCBs and potassium alkynyltrifluoroborate, and the increase in the amount of PMe3 resulted in tandem reaction of 2 equiv of BCB with the borate to afford 3,4,5-trisubstituted 2-naphthols. The fabulous ligand effect resulted in the facile and unique construction of multisubstituted naphthols with well-controlled regioselectivity and a high degree of structural diversity.
Article
Chemistry, Multidisciplinary
Binsen Rong, Gaochen Xu, Huan Yan, Sai Zhang, Qinghuan Wu, Ning Zhu, Jindian Duan, Kai Guo
Summary: A copper-catalyzed [3+2]-type condensation reaction of alpha,beta-unsaturated ketoximes with activated ketones was described for the synthesis of dihydrooxazoles, especially trifluoromethyl-decorated dihydrooxazoles. This method is characterized by its broad substrate scope, good functional group tolerance, and simple operation.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Bin Li, Jiang-Ling Shi, Ying Xia
Summary: The construction of all-carbon quaternary centers in small-ring systems is an important yet challenging task in organic synthesis. In this study, we developed a practical method for building all-carbon quaternary centers in gem-difluorinated cyclopropanes (DFCs) by utilizing gem-difluorocyclopropyl bromides (DFCBs) as general and versatile building blocks. The reaction involves the participation of a gem-difluorocyclopropyl radical intermediate, which undergoes coupling with a wide range of nucleophiles under copper catalysis.
Article
Chemistry, Multidisciplinary
Yukimasa Aida, Yu Shibata, Ken Tanaka
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Jin Tanaka, Yu Shibata, Anton Joseph, Juntaro Nogami, Jyunichi Terasawa, Ryo Yoshimura, Ken Tanaka
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Shunsuke Suzuki, Yu Shibata, Ken Tanaka
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Ryo Yoshimura, Ken Tanaka
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Suzuka Kinoshita, Ryota Yamano, Yu Shibata, Yusuke Tanaka, Kyoichi Hanada, Takashi Matsumoto, Kazunori Miyamoto, Atsuya Muranaka, Masanobu Uchiyama, Ken Tanaka
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Eiki Tomita, Kodai Yamada, Yu Shibata, Ken Tanaka, Masahiro Kojima, Tatsuhiko Yoshino, Shigeki Matsunaga
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Yukimasa Aida, Juntaro Nogami, Haruki Sugiyama, Hidehiro Uekusa, Ken Tanaka
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Juntaro Nogami, Yusuke Tanaka, Haruki Sugiyama, Hidehiro Uekusa, Atsuya Muranaka, Masanobu Uchiyama, Ken Tanaka
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Li-Hsiang Wang, Norihiko Hayase, Haruki Sugiyama, Juntaro Nogami, Hidehiro Uekusa, Ken Tanaka
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Organic
Hiroto Takahashi, Yusaku Honjo, Yu Shibata, Yuki Nagashima, Ken Tanaka
Summary: The dienylation of unfunctionalized arenes with 1,6-diynes, possessing aryl groups at the diyne termini, was found to proceed in the presence of an electron-deficient cyclopentadienyl rhodium(III) complex and a stoichiometric amount of silver carbonate. Experimental and theoretical mechanistic studies indicated the possible catalytic role of a (CpRh)-Rh-E(I) complex generated in situ in this reaction.
SYNTHESIS-STUTTGART
(2021)