Conformational Regulation of Substituted Azepanes through Mono-, Di-, and Trifluorination

Stereoelectronic Effect of Curved Aromatic Structures: Favoring the UnexpectedendoConformation of Benzylic-Substituted Sumanene

(2013) Shuhei Higashibayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselectively fluorinatedN-heterocycles: a brief survey

(2013) Xiang-Guo Hu et al.   Beilstein Journal of Organic Chemistry

Integrated Approach to Structure-Based Enzymatic Drug Design: Molecular Modeling, Spectroscopy, and Experimental Bioactivity

(2013) Bahareh Honarparvar et al.   CHEMICAL REVIEWS

Proline Editing: A General and Practical Approach to the Synthesis of Functionally and Structurally Diverse Peptides. Analysis of Steric versus Stereoelectronic Effects of 4-Substituted Prolines on Conformation within Peptides

(2013) Anil K. Pandey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational regulation of substituted azepanes through selective monofluorination

(2013) Alpesh Ramanlal Patel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor

(2012) Lorien J. Parker et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The conformational locking of asparagine

(2012) Carlos Cabezas et al.   CHEMICAL COMMUNICATIONS

3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) Stereoisomers as Conformational Probes for Exploring Agonist Binding at NMDA Receptors

(2012) Poh Wai Chia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Conformational Analysis of Fluorinated Pyrrolidines Using19F-1H Scalar Couplings and Heteronuclear NOEs

(2012) Lorraine E. Combettes et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Enantiopure 7-Substituted Azepane-2-carboxylic Acids as Templates for Conformationally Constrained Peptidomimetics

(2012) Elena Cini et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structural Insights into the Molecular Basis of the Ligand Promiscuity

(2012) Noé Sturm et al.   Journal of Chemical Information and Modeling

Methyl Effects on Protein–Ligand Binding

(2012) Cheryl S. Leung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

(2012) Diego Núñez-Villanueva et al.   JOURNAL OF ORGANIC CHEMISTRY

Organofluorine Chemistry: Synthesis and Conformation of Vicinal Fluoromethylene Motifs

(2012) David O’Hagan   JOURNAL OF ORGANIC CHEMISTRY

Conformational analysis of seven-membered 1-N-iminosugars by NMR and molecular modelling

(2012) Javier Pérez-Castells et al.   NEW JOURNAL OF CHEMISTRY

Access to l- and d-Iminosugar C-Glycosides from a d-gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy

(2012) Martine Mondon et al.   ORGANIC LETTERS

Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds

(2012) David O'Hagan et al.   PURE AND APPLIED CHEMISTRY

Novel chiral bridged azepanes: stereoselective ring expansion of 2-azanorbornan-3-yl methanols

(2012) Elżbieta Wojaczyńska et al.   TETRAHEDRON

Diastereospecific fluorination of substituted azepanes

(2012) Alpesh Ramanlal Patel et al.   TETRAHEDRON

Convenient strategy for the synthesis of highly functionalizable hydroxylated unsaturated azepanes

(2012) Sophie Goumain et al.   TETRAHEDRON LETTERS

Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

(2011) Susan D. Orwig et al.   BIOCHEMISTRY

Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABAC receptors

(2011) Izumi Yamamoto et al.   CHEMICAL COMMUNICATIONS

The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABACreceptor

(2011) Izumi Yamamoto et al.   CHEMICAL COMMUNICATIONS

Dynamics, flexibility and ligand-induced conformational changes in biological macromolecules: a computational approach

(2011) Lars Skjærven et al.   Future Medicinal Chemistry

3-fluoro-GABA enantiomers: exploring the conformation of GABA binding to GABAA receptors and GABA aminotransferase

(2011) David O’Hagan   Future Medicinal Chemistry

Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors of Two Ether-Bridged Iminosugars

(2011) Bo Luo et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Conformational analysis of a seven-membered ring azasugar, (3R,4R,6S)-trihydroxyazepane: Comparison of GIAO calculation and experimental NMR spectra on 13C chemical shifts

(2011) Pao-Ling Yeh et al.   JOURNAL OF MOLECULAR STRUCTURE

Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides

(2011) Diego Núñez-Villanueva et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA

(2011) Nancy H. Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Morpholinosulfur Trifluoride (Morph-DAST)-Mediated Rearrangement in the Fluorination of Cyclic α,α-Dialkoxy Ketones toward 1,2-Dialkoxy-1,2-difluorinated Compounds

(2010) Riccardo Surmont et al.   ADVANCED SYNTHESIS & CATALYSIS

The C–F bond as a conformational tool in organic and biological chemistry

(2010) Luke Hunter   Beilstein Journal of Organic Chemistry

Towards a stable noeuromycin analog with a d-manno configuration: Synthesis and glycosidase inhibition of d-manno-like tri- and tetrahydroxylated azepanes

(2010) Julia Deschamp et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of polyhydroxy 7- and N-alkyl-azepanes as potent glycosidase inhibitors

(2010) Tzenge-Lien Shih et al.   CARBOHYDRATE RESEARCH

Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

(2010) Carl Diehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoelectronic and steric effects in side chains preorganize a protein main chain

(2010) M. D. Shoulders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: Potent and selective β-N-acetylhexosaminidase inhibitors

(2009) Hongqing Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Vanilloid Receptor (TRPV1) Activity of the Enantiomers of α-Fluorinated Capsaicin

(2009) Margit Winkler et al.   CHEMBIOCHEM

Fluorinated Quinine Alkaloids: Synthesis, X-ray Structure Analysis and Antimalarial Parasite Chemotherapy

(2009) Christoph Bucher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights

(2009) Robert Filler et al.   Future Medicinal Chemistry

Molecular Basis for Inhibition of GH84 Glycoside Hydrolases by Substituted Azepanes: Conformational Flexibility Enables Probing of Substrate Distortion

(2009) Filipa Marcelo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Peptidic Peptidomimetics

(2008) Dieter Seebach et al.   ACCOUNTS OF CHEMICAL RESEARCH

New Synthetic Seven-Membered 1-Azasugars Displaying Potent Inhibition Towards Glycosidases and Glucosylceramide Transferase

(2008) Hongqing Li et al.   CHEMBIOCHEM

Comprehensive Structural Studies of 2′,3′-Difluorinated Nucleosides: Comparison of Theory, Solution, and Solid State

(2008) Joseph J. Barchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Preparation and conformational study of CF3-containing enkephalin-derived oligopeptide

(2007) Takamasa Kitamoto et al.   TETRAHEDRON