期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2013, 期 35, 页码 7881-7885出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201301337
关键词
Oxidation; Esters; Thioesters; Carbenes; Dehydrogenation; Reaction mechanisms; Synthetic methods
资金
- Korea Research Foundation [2009-0094046]
- Korea CCS RD Center (KCRC)
- Korea Government (Ministry of Education, Sicence and Technology) [2012-0008935]
A versatile carbene-catalysed oxidation protocol involving N-heterocyclic carbene catalysts and 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) is described for the synthesis of esters, cinnamic acids, and thioesters. A wide range of esters, thioesters, and cinnamic acids were obtained by metal-free coupling of aldehydes with aliphatic, allylic and aromatic alcohols, benzyl mercaptan, and water. In addition to the oxidative coupling of aldehydes with nucleophiles, dehydrogenation of saturated aldehydes and oxidation of allylic alcohols were found under our oxidative coupling conditions. Unlike other TEMPO-mediated oxidative esterification reactions, this reaction does not proceed through a TEMPO ester intermediate to form esters and thioesters.
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