Amphiphilic Cyclic Peptoids That Exhibit Antimicrobial Activity by DisruptingStaphylococcus aureusMembranes

In Vivo Biodistribution and Small Animal PET of 64Cu-Labeled Antimicrobial Peptoids

(2012) Jiwon Seo et al.   BIOCONJUGATE CHEMISTRY

Peptoids: Bio-Inspired Polymers as Potential Pharmaceuticals

(2012) Michelle T. Dohm et al.   CURRENT PHARMACEUTICAL DESIGN

De Novo Cyclic Pseudopeptides Containing Aza-β3-amino Acids Exhibiting Antimicrobial Activities

(2012) Mathieu Laurencin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Activity of Peptidomimetics against Multidrug-Resistant Escherichia coli: A Comparative Study of Different Backbones

(2012) Rasmus D. Jahnsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear

(2012) Jevgenij A. Raskatov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multivalent Peptidomimetic Conjugates: A Versatile Platform for Modulating Androgen Receptor Activity

(2012) Paul M. Levine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Antibacterial Studies of Cationic Polymers with Alternating, Random, and Uniform Backbones

(2011) Airong Song et al.   ACS Chemical Biology

Functional Synergy between Antimicrobial Peptoids and Peptides against Gram-Negative Bacteria

(2011) Nathaniel P. Chongsiriwatana et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents

(2011) Mia Lace Huang et al.   ChemMedChem

Protein epitope mimetics as anti-infectives

(2011) John A Robinson   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis and Characterization of the Arylomycin Lipoglycopeptide Antibiotics and the Crystallographic Analysis of Their Complex with Signal Peptidase

(2011) Jian Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo

(2011) Francis Alonzo III et al.   MOLECULAR MICROBIOLOGY

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity

(2011) Suzanne E. Howson et al.   Nature Chemistry

Damage of the Bacterial Cell Envelope by Antimicrobial Peptides Gramicidin S and PGLa as Revealed by Transmission and Scanning Electron Microscopy

(2010) M. Hartmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural determinants of antimicrobial activity in polymers which mimic host defense peptides

(2010) Edmund F. Palermo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Design, synthesis and antimicrobial properties of non-hemolytic cationic α-cyclopeptoids

(2010) Daniela Comegna et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs

(2010) Christian A. Olsen et al.   CHEMBIOCHEM

Synthetic Membrane-Targeted Antibiotics

(2010) S.K. Vooturi et al.   CURRENT MEDICINAL CHEMISTRY

Health Care–Associated Invasive MRSA Infections, 2005-2008

(2010) Alexander J. Kallen   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

(2009) Gregory N. Tew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Antibacterial cyclic d,l-α-glycopeptides

(2009) Leila Motiei et al.   CHEMICAL COMMUNICATIONS

Structure−activity Relationships among Random Nylon-3 Copolymers That Mimic Antibacterial Host-Defense Peptides

(2009) Brendan P. Mowery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure–function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function

(2009) Sarah A. Fowler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

(2009) S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs

(2008) Artem Cherkasov et al.   ACS Chemical Biology

The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives

(2008) Kenichi Kuroda et al.   CHEMISTRY-A EUROPEAN JOURNAL

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids

(2008) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

(2008) N. P. Chongsiriwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemic community-associated methicillin-resistant Staphylococcus aureus: Recent clonal expansion and diversification

(2008) A. D. Kennedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA